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With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks

Broad Institute

They found significant associations between the thinning of different retinal layers and increased risk of developing ocular, cardiac, pulmonary, metabolic, and neuropsychiatric diseases and identified genes that are associated with retinal layer thickness. Their findings are published in Science Translational Medicine. “We

Disease 124
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Automated red blood cell exchange: bridging treatment gaps in sickle cell disease care

Drug Target Review

Despite recent advances in gene therapy for sickle cell disease (SCD) , automated red blood cell exchange (aRBCX) remains a cornerstone therapy that plays a vital yet underutilised role in managing complications and enhancing quality of life for millions living with this devastating condition worldwide.

Disease 52
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Danielle Pace

Broad Institute

She develops machine learning models that use large clinical datasets, including medical images, electronic health records, ECGs, and genetics, to better understand disease, learn useful data representations, and predict disease risk. Pace earned her Ph.D. She also holds a B.Cmp.H.

Doctors 52
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Genomic score predicts patients' progression to multiple myeloma

Broad Institute

The score, called an MM-like score, assesses the severity of disease and risk of progression to active cancer, with higher scores indicating faster progression. The MM-like score defined in this study focuses on the presence and progressive evolution of genetic abnormalities to assess the state of the disease.

DNA 52
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Largest-ever genetic study of epilepsy finds possible therapeutic targets

Broad Institute

In the future, the results could also help doctors tailor treatments to a patient’s genome. Epilepsy also has several subtypes, and while one group called developmental encephalopathies have been connected to several genes, other forms of the disease are less well understood. Epilepsy is one of the most common neurological disorders.

DNA 133
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AC102 Eliminates Tinnitus in Preclinical Study

The Pharma Data

The results, recently published in the International Journal of Molecular Sciences , come from a collaborative effort between researchers at Erlangen University Hospital and Berlin-based biotech firm AudioCure. This would be a great relief for patients and doctors who currently have no approved drug treatment available.”

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How AI is accelerating the future of precision medicine

Drug Target Review

How does the integration of Real-World Data (RWD) with genomic biomarker data contribute to a more comprehensive understanding of disease progression and treatment response? Biomarker information is also useful for tracking progression of the disease and treatment response. Most drugs do not work in all people.

Doctors 111