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Leveraging agonist antibodies to address immunological diseases

Drug Target Review

Introduction Therapeutic antibodies have proven to be indispensable medicines for addressing the most debilitating diseases. Agonist antibodies of immune checkpoint regulators These represent a groundbreaking class of immunotherapeutic agents that mimic the natural function of endogenous ligands by binding to specific cell-surface receptors.

Disease 52
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The first major set of genetic associations found in long COVID

Drug Target Review

Combinatorial analytics approaches identify combinations of features that together are associated with the disease phenotype in patient sub-groups, capturing the non-linear effects of interactions between multiple genes. The combinatorial approach is considerably more sensitive than GWAS and requires much smaller patient populations.

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Can a heartburn drug help doctors treat COVID-19?

The Pharma Data

In the early days of the COVID-19 pandemic, doctors in Wuhan noticed something surprising. “There’s often a phenomenon that doctors report anecdotally, or that’s mentioned in passing in a particular research paper, and that provides a clue – a hook,” he said. The next challenge was to figure out why.

Doctors 52
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FDA Returns Disappointing News for ALS Stem Cell Therapy

PLOS: DNA Science

Also recently, FDA’s Cellular, Tissue, and Gene Therapies Advisory Committe turned down a stem cell treatment for amyotrophic lateral sclerosis, aka ALS, Lou Gehrig’s disease, or motor neuron disease. ALS is a disease of adulthood, beginning typically between 40 and 70 years of age. Most ALS cases are sporadic.

Therapies 101
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Broad Discovery Series: Introducing the immune system, and expanding its cancer-fighting potential

Broad Institute

Immunologist Lloyd Bod will take us on a tour of the immune system, and discuss new insights that may help scientists and doctors leverage its cancer-fighting capabilities more effectively. But by focusing on T cells, are we missing other opportunities to combat cancer? Learn more about the Broad Discovery Series.

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Researchers decipher how a gut bacterium influences immunity

Broad Institute

Researchers decipher how a gut bacterium influences immunity By Corie Lok July 26, 2022 Breadcrumb Home News Researchers decipher how a gut bacterium influences immunity Study finds a molecule made by the bacterium that helps moderate immune responses. It gets its name from the intestinal mucus it breaks down.

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Allergists’ Group Offers Guidelines on COVID-19 Vaccines

The Pharma Data

Centers for Disease Control and Prevention, if you have a severe allergic reaction after the first shot, you should not get the second shot. Patients and doctors should balance the risks and benefits of vaccination. But such patients should be warned of the possibility that they will have a lower immune response.

Vaccine 52