PLOS: DNA Science

APRIL 17, 2025

When their pediatrician saw the child walking on her tiptoes and unable to manage stairs, the next step was Children’s Hospital of Philadelphia. The post Nixing the Newborn Screening Advisory Committee Is Ill-Advised appeared first on DNA Science. Developmental delays accrued, therapists descended, tests began.

Therapies

PLOS: DNA Science

JULY 24, 2025

Diverse mutations in several genes cause the disease, from single-DNA-base changes, to extra or missing stretches of genetic material, to errors in how a gene’s parts are cut and pasted. Impaired DNA Repair In the disease, cells lose the ability to repair errors in DNA replication – which typically happens as DNA copies itself.

Treatment

Broad Institute

AUGUST 16, 2023

Nuclear DNA influences variation in mitochondrial DNA By Allessandra DiCorato August 16, 2023 Breadcrumb Home Nuclear DNA influences variation in mitochondrial DNA Whole genomes from hundreds of thousands of people reveal new complexity in how the nuclear and mitochondrial genomes interact, which may influence how cells produce energy.

DNA

Broad Institute

JANUARY 18, 2024

McAlpine January 18, 2024 Credit: Susanna Hamilton, Broad Communications One of the new "priming agents" works by preventing immune cells from engulfing tumor DNA circulating in the bloodstream. Liquid biopsies promise to transform how cancers are diagnosed, monitored, and treated by detecting DNA that tumors shed into the blood.

DNA

Broad Institute

OCTOBER 23, 2023

This result was striking and it inspired us to build a resource to understand the drivers of this risk,” said Amit Khera, co-principal investigator of OurHealth, a cardiologist at Brigham and Women’s Hospital, and vice president of genomic medicine at Verve Therapeutics.

Disease

Broad Institute

OCTOBER 23, 2024

The DNA change underlying Emma’s disorder is now known, thanks to years of work by an international team of scientists and physicians at the Broad Institute of MIT and Harvard, Northwestern University, University of Nantes, the Weizmann Institute of Science, and the Baylor College of Medicine.

DNA

NIH Director's Blog: Drug Development

MARCH 11, 2014

Credit: Jane Ades, National Human Genome Research Institute, NIH Type 2 diabetes (T2D) tends to run in families, and over the last five years the application of genomic technologies has led to discovery of more than 60 specific DNA variants that contribute to risk.

DNA

Broad Institute

OCTOBER 3, 2024

Since URVs are so rare, and because the scientists wanted to understand many different types of epilepsy, the researchers analyzed DNA from people across the world with a range of different genetic ancestries to find meaningful signals. The study’s 54,000 participants included about 21,000 patients with epilepsy and 33,000 controls.

DNA

Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

DNA

Broad Institute

FEBRUARY 16, 2024

The way that clinicians subdivide diabetes patients now is based on symptoms, but in this study, the frequency of genetic risk factors seems to vary among patients with youth-onset T2D,” said Jason Flannick , Broad associate member and assistant professor at Boston Children’s Hospital and Harvard Medical School. “We

Medical Schools

Broad Institute

JUNE 28, 2023

Such large-scale changes in DNA have been difficult to study. Since the deleted or duplicated DNA regions involved in an aneuploidy can include hundreds or thousands of genes, pinning down any molecular mechanism by which an aneuploidy impacts tumor growth has been difficult.

DNA

Broad Institute

APRIL 2, 2024

Now, a team of researchers at the Broad Institute of MIT and Harvard along with Massachusetts General Hospital has found that microbes in the gut may affect cardiovascular disease as well. He is also a professor at Harvard Medical School and Massachusetts General Hospital.

Disease

PLOS: DNA Science

NOVEMBER 30, 2023

The new cat study compared the DNA sequences of a gene commonly used in evolutionary investigations, to identify bacterial species residing in domestic feline anal glands. The post Why Cats Sniff Each Other’s Butts appeared first on DNA Science. I love when chemistry explains biology.

DNA

Broad Institute

AUGUST 8, 2024

Postdoctoral scholar Shervin Tabrizi is a physician-scientist and postdoctoral scholar at the Gerstner Center for Cancer Diagnostics at the Broad Institute of MIT and Harvard, and a radiation oncologist at Massachusetts General Hospital. He is co-advised by Chris Love at the Koch Institute at MIT.

Medical Schools

The Pharma Data

DECEMBER 23, 2020

” Dr. Stanley Plotkin , Professor Emeritus at The Wistar Institute, said, “INOVIO’s DNA vaccine appeared to be quite safe with few significant reactions but yet induced both antibody and T cell responses to SARS-CoV-2.” About INOVIO’s DNA Medicines Platform. mg and 2.0

DNA

Broad Institute

DECEMBER 13, 2023

One study was led by senior authors Evan Macosko , an institute member at the Broad and associate professor and attending psychiatrist at Massachusetts General Hospital, and Fei Chen , a core institute member at the Broad and an assistant professor in the Department of Stem Cell and Regenerative Biology at Harvard University.

DNA

The Pharma Data

SEPTEMBER 1, 2020

The 20,000-member Hospital Authority Employees Alliance said more effort should be put into focused tests rather than mass testing. This mass testing system will be voluntary and utilise medical staff from mainland China, which has sparked fears the programme could be used for mass surveillance. .

DNA

DrugBank

JUNE 13, 2024

This approach targets the fundamental instructions within a cell's DNA, either by correcting faulty genes or introducing entirely new ones to combat disease. These viral vectors act as microscopic shuttles, carrying the therapeutic DNA into the host cell's nucleus, where it can integrate into the genome.

Therapies

The Pharma Data

OCTOBER 20, 2020

CureLab’s partners in the region will test the efficacy of the company’s DNA-based products against cancers and non-cancerous diseases of chronic inflammation. ” About Elenagen CureLab’s lead product, Elenagen , is a DNA encoding gene called p62/SQSTM1.

DNA

KIF1A

AUGUST 20, 2024

Trying to solve the problems with vomiting, we went to the gastroenterologist who requested some gastric exams, the results were normal, so the doctor began to suspect that as a metabolic disease and advice us to go to the HOSPITAL PEQUENO PRINCIPE (Little Prince, a children hospital), in Curitiba, to start an investigation.

Doctors

Broad Institute

JULY 11, 2024

Reporting in Science , researchers at Massachusetts General Hospital and the Broad Institute of MIT and Harvard have made a surprising discovery about these drugs. IDH1 normally facilitates the activity of enzymes called demethylases, which remove chemical flags called methylation marks from DNA, allowing genes to be transcribed into RNA.

Treatment

Broad Institute

MARCH 8, 2024

Senegal has a very strong clinical infrastructure, including a strong hospital network with incredible resources like West Africa’s Reference Center for Infectious Disease Diagnostics. Tags: Infectious Disease DNA sequencing RNA sequencing Nature Communications. Online January 25, 2024. DOI: 10.1038/s41467-024-44800-7.

Research

Broad Institute

JULY 10, 2023

At the Broad, Martin is also helping lead data analysis in two large international studies that are sequencing the DNA of people from Africa and Latin America to learn about the genetics of severe mental illness. Her parents were terrified, and the family spent the next few years in and out of the hospital.

Disease

The Pharma Data

NOVEMBER 18, 2020

Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan. Department of Hematology and Oncology, Taipei Medical University Hospital, Taipei, Taiwan. current affiliation: Department of Hematology and Oncology, Taipei Tzu Chi Hospital, Taipei, Taiwan. Presenter: Ching-Liang Ho MD, et.al.

Vaccine

The Pharma Data

DECEMBER 17, 2020

She assists both patients and physicians in completing this revolutionary gene test that determines if a patient is on the right drug, at the right dose, for their specific DNA. For a brief time, Dr. Johnson initially served as a clinical staff pharmacist at the Druid City Hospital Regional Medical Center.

Pharmacy

NIH Director's Blog: Drug Development

APRIL 18, 2017

Every person’s genetic blueprint, or genome, is unique because of variations that occasionally occur in our DNA sequences. Most of those are passed on to us from our parents. But not all variations are inherited—each of us carries 60 to 100 “new mutations” that happened for the first time in us. Saleheen D et al. 2017 April 12 544: 235-239.

Drugs

PLOS: DNA Science

APRIL 18, 2024

from Massachusetts General Hospital, told the Alzheimer’s Association. ” The post Mutations in Three Genes Protect Against Alzheimer’s appeared first on DNA Science. Quiroz, Ph.D.,

Disease

Broad Institute

JULY 20, 2023

Please register at broad.io/stanleysymposium Please register at broad.io/stanleysymposium

Medical Schools

The Pharma Data

JANUARY 21, 2021

“We were encouraged by the quick recovery (discharged from hospital in 5 days) [1] of the first hospitalized patient with severe COVID-19 who received Silmitasertib under an emergency IND with Dr. Esa Rayyan.

Trials

The Pharma Data

JANUARY 7, 2021

OraSure, together with its wholly-owned subsidiaries, DNA Genotek, Diversigen, and Novosanis, provides its customers with end-to-end solutions that encompass tools, services and diagnostics. OraSure Technologies empowers the global community to improve health and wellness by providing access to accurate, essential information.

DNA

Broad Institute

MAY 25, 2023

The findings are from scientists at the Broad Institute of MIT and Harvard, Massachusetts General Hospital (MGH), Technical University of Munich (TUM), Stanford University, and University of Chicago.

Disease

Broad Institute

AUGUST 4, 2022

To build the CLL map, the team analyzed variations in genetic sequences, gene expression patterns, and chemical modifications to DNA — or genomic, transcriptomic, and epigenomic data — from 1,148 patients. Adapted from a press release from Massachusetts General Hospital. The study was also led by José I. Nature Genetics.

Bioinformatics

Drug Target Review

MARCH 4, 2024

The BRAF-driven proximal colon cancers are associated with a very high frequency of DNA methylation in gene regulatory elements like the CpG islands. Also, there are many epigenetic differences between the two regions. In the distal colon, silencing CDX2 did not bring about much change.

Regulations

The Pharma Data

JANUARY 11, 2021

“That means it never converts into DNA,” Dr. M. Fahad Khalid, chief of hospital medicine at Penn State Health Hershey Medical Center in Hershey, Pa., This protein then appears on the surface of the cell and the immune system responds to it. While the blueprint is a genetic code, it never enters the nucleus of the cells.

Vaccine

The Pharma Data

OCTOBER 19, 2020

” The Caris Precision Oncology Alliance comprises over 40 academic, hospital and community-based cancer institutions, including 17 NCI-designated Comprehensive Cancer Centers.

Clinical Trials

PPD

AUGUST 5, 2024

Composite endpoints might include factors such as hospitalization, transplantation and worsening of clinical outcomes. Their early definition — as well as plans for recording and tracking — is a major factor in a trial’s success.

Clinical Trials

Molecule Blog

AUGUST 13, 2021

After graduation, he worked as physician at Slagelse Hospital and at Nuuk Medical Clinic in Greenland. His work focused on the cross-talk between DNA repair and mitochondrial function in aging and has been honored by a number of competitive awards. He now runs one of the largest research programmes in Europe focusing on aging.

FDA Approval