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Researchers devise new way to target and correct disease-related proteins

Broad Institute

Also featured are the FKBP12 binding motif (light blue triangle), the DNA barcode (red double helix), and the combinatorial library element (red hexagon). Related groups Xavier lab Over the past two decades, large genetic studies have linked tens of thousands of DNA variants to thousands of human traits and diseases.

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NGS is evolving: collaboration and tech lead the way

Drug Target Review

Their latest assay processes four to 24 libraries per batch and detects gene amplifications, fusions, deletions and other cancer biomarkers from both DNA and RNA inputs. Their latest assay processes four to 24 libraries per batch and detects gene amplifications, fusions, deletions and other cancer biomarkers from both DNA and RNA inputs.

RNA
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New study aims to uncover the genetics of anorexia and other eating disorders

Broad Institute

Researchers at the Broad Institute Ben Neale and Mark Daly are co-leading the study, which allows people across the US to sign up to have their DNA analyzed as part of this effort. The team then sequences the DNA using an approach called the Blended Genome Exome , an efficient and cost-effective alternative to whole-genome sequencing.

DNA
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Genomic score predicts patients' progression to multiple myeloma

Broad Institute

To make the MM-like score more clinically accessible, the team is developing a test based on liquid biopsies instead of bone marrow biopsies to collect DNA. The score, called an MM-like score, assesses the severity of disease and risk of progression to active cancer, with higher scores indicating faster progression.

DNA
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Q&A: One scientist’s bold vision to make on-demand treatments routine for life-threatening rare genetic diseases

Broad Institute

Related groups Liu Group Related news New CRISPR genome editing system offers a wide range of versatility in human cells Researchers extend power of gene editing by developing a new class of DNA base editors In May 2025, researchers announced that K.J. The team that treated K.J. Some of these treatments, like K.J.’s, Today, K.J.

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Gene editing disrupts Huntington’s mutation in mice

Broad Institute

Gene editing disrupts Huntingtons mutation in mice By Allessandra DiCorato May 27, 2025 Breadcrumb Home Gene editing disrupts Huntingtons mutation in mice Making single-letter edits in stretches of repeated DNA stopped or reversed the genetic change that causes Huntingtons disease and Friedreichs ataxia.

DNA
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Researchers identify source of a brain cancer’s deadly transformation

Broad Institute

In a study published in Nature Cancer , researchers at the Broad Institute of MIT and Harvard, Dana-Farber Cancer Institute, and Massachusetts General Hospital investigated the evolution of these tumors, many of which are known to be initiated by mutations in an enzyme known as IDH.