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Building Korro Bio: A CEO’s Perspective on Innovation and Risk Management

LifeSciVC

Josh’s work at the Marine Biological Laboratory unlocked the potential of utilizing an endogenous protein to make a single alphabet change on RNA (RNA editing), a process that was precise, reversible and had druglike characteristics. The experiment worked and showed the precision of RNA editing.

RNA 68
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What Biology Can Learn from Physics

Codon

The Higgs boson was discovered at CERN, a sprawling particle physics laboratory that cost more than $10 billion to build. Such a model would make it possible to discover protein functions by scraping metagenomic databases , or to create proteins with functions that exist nowhere in nature.

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What Biology Can Learn from Physics

Codon

The Higgs boson was discovered at CERN, a sprawling particle physics laboratory that cost more than $10 billion to build. Such a model would make it possible to discover protein functions by scraping metagenomic databases , or to create proteins with functions that exist nowhere in nature.

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Key considerations before commencing cell line development

Drug Target Review

This selectable marker enables the identification of cells which have taken up the GOIs and aids the initial selection of recombinant protein expressing cell lines. However, some groups will decide to complete this stage within their own laboratories. We talk about personalised medicine; how about personalised host cell lines?

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The Role of Oncology Biomarkers in Personalizing Hematology Treatment Plans

Conversations in Drug Development Trends

The analysis of circulating tumor DNA (ctDNA) in a liquid biopsy can also permit genotyping and help monitor the effectiveness of chemotherapy. Proteomics Proteomics involves studying the entire set of proteins expressed in a cell or tissue.

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Proteogenomics reveals markers of chemotherapy resistance and outcome in triple negative breast cancer

Broad Institute

Data from standard DNA and RNA sequencing approaches were integrated with mass spectrometry-based proteomics and phosphoproteomic analyses to derive more complete molecular portraits of treatment-responsive versus treatment-resistant tumors. These data suggest a multi-omics predictor for chemotherapy response is within reach.

DNA 52
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Rapid delivery of toxicological material

Drug Target Review

The current landscape of protein drug development is characterised by accelerated timelines where new drugs are approved in months rather than years. For example, advances in media and feeds have contributed to higher cell protein expression by optimising nutrient availability and reducing accumulation of waste products within a culture.