DrugBank

FEBRUARY 9, 2023

1 Present address: Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Denmark. Summary: This paper discusses the use of a data science approach to synthesize current knowledge on the pharmacological implications of epigenetic regulation of gene expression.

Clinical Pharmacology 52

Clinical Pharmacology Molecular Biology DNA Licensing 52

The Pharma Data

OCTOBER 18, 2020

NASDAQ:CDXC) today highlighted a new study published in The European Molecular Biology Organization Journal looking at the effect of nicotinamide riboside (NR) on maintaining telomeres, the protective regions at the end of DNA strands. is a science-based integrated nutraceutical company devoted to improving the way people age.

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Drug Target Review

JUNE 11, 2024

When choosing my bachelor’s degree, the choice was between pursuing a career in biology or in computer science. Biology won that battle, and I pursued a bachelor’s and master’s degree in biochemistry and molecular biology. In math and life and physical sciences, women now make up nearly half of the workforce.

Engineering 64

Engineering Science Molecular Biology Doctors 64

Elrig

APRIL 29, 2024

Rising from Research Scientist to Senior Scientist, I supported early-stage DD efforts within their Protein Science group, based in Cambridge, UK. My role involved generating and characterizing complex proteins critical for biological assay development, hit discovery, and structural biology.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Alta Sciences

AUGUST 21, 2024

I have also learned a lot about the nuances of micropipettes that I would have never learned at school.” — Sheridan Moore , Research Associate Intern, Laboratory Sciences “My favorite part about interning at Altasciences is the potential for creating a long, meaningful career that I would be passionate about.

International 40

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Drug Target Review

JUNE 19, 2024

The other powerful benefit is that our cell lines can become any of the cell types of the human body – these cells have within their DNA the capability to become any of the more than 200 human cell types which you might want to manufacture. This provides some regulatory advantages, and of course, significant cost advantages.

Therapies 84

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Alta Sciences

MARCH 1, 2024

PJ: At Altasciences, we have a range of leading-edge platforms that include ligand binding assays (LBA), NAb, TAb, flow cytometry, and ELISpot, as well as on-site molecular biology instrumentation such as Bio-Rad’s ddPCR system, the NanoDropTM One spectrophotometer, and dedicated polymerase chain reaction (PCR) chambers.

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The Pharma Data

NOVEMBER 22, 2021

State-of-the-art R&D facility designed to foster collaboration across world-class science ecosystem Sustainable environmental engineering aligned to Company’s zero carbon future. Important discoveries have included Francis Crick and James Watson’s DNA advance in 1953, and Professor Sir John Gurdon’s work on stem cells in 2012.

Molecular Biology 52

Molecular Biology Laboratories Engineering Hospitals 52

The Open Targets Blog

APRIL 25, 2023

However, there are notable parallels both in the way the science was conducted and, at least for the genome project in the UK, the particular physical settings and sensibilities. Now I don’t want to claim too much. The background and impetus of the two projects were clearly very different. Left: Bletchley Park, photo by Einar H.

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Dark Matter Blog

JULY 16, 2021

The only subject in school that held my interest was biology. As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. Last stops at RNA My last roles in biotech were where my original passion began: DNA and RNA.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

Codon

JUNE 5, 2025

Certain CRISPR components can add short DNA sequences from the genomes of defeated viruses into the bacterium’s own genome, creating a type of protective “memory.” If the same virus invades the cell a second time, the gRNA’s spacer sequence will bind to the matching viral DNA sequence, then be cut by the Cas protein.

DNA 81

DNA RNA Clinical Trials Engineering 81

Codon

JULY 17, 2024

But as we pored over the photos and learned more about Sebastian’s journey, a far more interesting story emerged: one about the role of amateur science. ” Before the 19th century, virtually all science was amateur science. For the next 15 years, I hit my head against the wall trying to make science happen.

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Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Due to the nearly ubiquitous use of cloning in life science research, this lost time adds up. However, E.

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DNA RNA Laboratories Research 93

Codon

JUNE 13, 2024

billion bases of DNA which, if unfurled, would extend for more than 100 meters—taller than the Statue of Liberty. billion bases of DNA, the human genome measures just 2 meters in length when stretched end-to-end. Credit: Oriane Hidalgo Per the book Cell Biology by the Numbers , each base pair of DNA occupies 1 nm 3 of space.

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DNA Molecular Biology Virus Cell Biology 63

Codon

JULY 10, 2024

But in the 1950s, at the dawn of molecular biology, scientists gained a new appreciation for it after searching for organisms that were easy to work with and quick to grow. In 1952, when the famous Hershey-Chase experiment indicated that DNA—and not protein—was the source of genetic material, just 285 papers mentioned E.

Laboratories 93

Laboratories DNA Molecular Biology Engineering 93

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Once it detects DNA, it relocates to the Golgi body, where it begins to activate proteins that turn on genes required for interferon production. Paper Cited Liu B, Carlson R, et al.

Regulations 91

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Codon

FEBRUARY 13, 2024

doi: 10.2210/rcsb_pdb/goodsell-gallery-048 The Virus that Cures It’s been over 25 years since the science magazine Discover first ran an extraordinary article about how a long-forgotten medical treatment, used in the former Soviet country of Georgia, could save us from the growing threat of untreatable, drug-resistant infections.

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PLOS: DNA Science

AUGUST 22, 2024

Not Just a Volcanic Eruption – Sinister Science, Too Spoiler alert! My knowledge of the field is only what I learned in high school earth science and watching Heather barf on the volcano, but I assume his comments are accurate. TMV is a common pathogen used in early molecular biology research. BUT WAIT!!!

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DNA Virus Organic Chemistry Science 65

BMG Labtech

MARCH 8, 2023

DNA, proteins, polysaccharides, etc.). They are strongly oxidizing and, at high concentrations, are deleterious to cells damaging DNA, proteins and lipids, and eventually leading to cell death. Alberts B, How Cells Obtain Energy from Food, Molecular Biology of the Cell (4th ed.). nucleotides, monosaccharides, etc.),

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Broad Institute

MAY 14, 2024

“Bill Studier’s development of T7 phage RNA polymerase for use in preparing RNA templates for multiple uses in research labs worldwide has been a truly revolutionary technical advance for the entire field of molecular biology,” said Joan Steitz, the Sterling Professor of Molecular Biophysics and Biochemistry at Yale University.

RNA 84

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Codon

JULY 27, 2023

From an article in Science : “After 6 months, the most promising varieties had their lignin content reduced by 49.1% in Science. They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. of which had reduced lignin levels and extra cellulose.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

From an article in Science : “After 6 months, the most promising varieties had their lignin content reduced by 49.1% in Science. They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. of which had reduced lignin levels and extra cellulose.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

NOVEMBER 1, 2024

I’ve chosen these two because I think they are the linchpin by which we’ll be able to build broadly useful AI models for cell and molecular biology. Synthesizing a single human protein-coding gene costs several hundred dollars and even a simple PCR machine (used for amplifying DNA) costs between $1,500 and $50,000.

DNA 132

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Codon

JUNE 18, 2024

Jensen, reported a much more detailed analysis of gas vesicles in the journal Science. Even after a half-century of molecular biology research, scientists didn’t know until recently how gas vesicles physically trap gas while occluding water. By combining DNA from multiple organisms and inserting it into E.

Engineering 71

Engineering Laboratories International Clinical Trials 71

Codon

JULY 11, 2023

But “progress in science depends on new techniques, new discoveries and new ideas, probably in that order,” said Nobel Laureate, Sydney Brenner. That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. It is the untouchable foundation of molecular biology.

RNA 75

RNA DNA Engineering Laboratories 75

Codon

MARCH 12, 2023

Notes on Progress is a monthly roundup of papers and ideas about biology and the future. “The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. Biology is a Burrito. A new base editor to edit mitochondrial DNA.

DNA 52

DNA Engineering Therapies RNA 52

Codon

JULY 11, 2023

But “progress in science depends on new techniques, new discoveries and new ideas, probably in that order,” said Nobel Laureate, Sydney Brenner. That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. It is the untouchable foundation of molecular biology.

RNA 52

RNA DNA Engineering Laboratories 52

Codon

DECEMBER 17, 2023

Molecular biology, as the field came to be called 3 , pushed biology from an object of study, driven forward by gentleman scientists and precocious country clergymen, into a tool with which to solve urgent problems. Recombinant DNA technologies were invented in the 1970s.

Engineering 52

Engineering Molecular Biology Doctors DNA 52

Codon

MAY 8, 2025

Do you like molecular biology? If so, then here's a question: How much information is in your DNA? When I first looked into this question , I thought it was simple: Human DNA has about 3.1 All humans have almost identical DNA. DNA can be compressed. A few reminders: DNA is a polymer. billion bits.

DNA 77

DNA RNA Molecular Biology Regulations 77

Drug Target Review

MARCH 25, 2025

With the swift pace of scientific discoveries and a continuously deepening understanding of cancer biology, the oncology landscape is on the cusp of significant transformation. A strategic pivot back to DDR The need to refocus on DDR extends beyond science it is driven by an urgent necessity in patient care.

DNA 52

DNA Therapies Clinical Trials Clinical Pharmacology 52

Broad Institute

MAY 13, 2025

AI tool predicts potential drug targets by analyzing cell images By Corie Lok May 13, 2025 Breadcrumb Home AI tool predicts potential drug targets by analyzing cell images Researchers have developed a machine learning model that connects images of DNA structure to gene regulation.

DNA 52

DNA Drugs Regulations Molecular Biology 52

Drug Target Review

DECEMBER 12, 2024

Enter epigenetics Broadly speaking, epigenetics refers to the system of proteins and marks that sits atop our genome a system that modifies gene expression, guides cell differentiation, and functionally organises our DNA. Progress in molecular biology and translational science [Internet].

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Therapies DNA Molecular Biology Immune Response 59

Drug Target Review

FEBRUARY 20, 2025

Also, some young women think that in order to work in STEM, they must be good at all four elements science, technology, engineering and math which isnt the case. Sabin earned her PhD in cellular and molecular biology from the University of Pennsylvania.

Virus 52

Virus Therapies Molecular Biology Treatment 52

Broad Institute

JANUARY 7, 2025

A clinical genomicist harnesses team-based science to help rare-disease patients By Allessandra DiCorato January 7, 2025 Breadcrumb Home A clinical genomicist harnesses team-based science to help rare-disease patients Heidi Rehm convinced labs and scientists to work together and share data.

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Codon

AUGUST 10, 2023

Journal of Molecular Biology (1961). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. . & Xie X.S. Nature (2011).

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DNA Cell Biology Molecular Biology Engineering 98