Mon.Apr 01, 2024

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Study of different autism types reveals common underlying mechanism

Drug Discovery World

An analysis of how brains with different forms of autism develop has revealed common underlying mechanisms that may respond to existing medications. For the study, Rutgers Health researchers used induced pluripotent stem cells to transform the blood cells of people with both genetic and idiopathic autism spectrum disorder (ASD) into early brain cells called neural precursor cells.

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Chatbot outperformed physicians in clinical reasoning in head-to-head study

Science Daily: Pharmacology News

ChatGPT-4, an artificial intelligence program designed to understand and generate human-like text, outperformed internal medicine residents and attending physicians at two academic medical centers at processing medical data and demonstrating clinical reasoning.

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5 FDA decisions to watch in the second quarter

BioPharma Drive: Drug Pricing

The FDA could soon expand use of two multiple myeloma cell therapies as well as a top-selling medicine from Sanofi and Regeneron, while Pfizer’s years of gene therapy work might finally pay dividends.

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Mpox Vaccine Protection Quickly Fades; Boosters Necessary: Study

Drugs.com

MONDAY, April 1, 2024 -- Vaccine protection against mpox fades quickly in the human immune system, even in people who’ve received the full two-dose regimen, a new real-world study shows.Antibody levels fell to low or near zero within the first.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Universal brain-computer interface lets people play games with just their thoughts

Science Daily: Pharmacology News

Engineers have created a brain-computer interface that doesn't require calibration for each user, paving the way for widespread clinical applicability.

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Mouse Study Finds Brain Target to Block Alcohol Cravings

Drugs.com

MONDAY, April 1, 2024 -- For folks who have battled alcohol dependency for years, any treatment that could curb or block alcohol cravings would be a huge advance.Now, research in mice is giving a glimmer of hope that just such a therapy might be.

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Optimizely Search & Navigation: Boosting in Unified Search

Perficient: Drug Development

In the Optimizely Search & Navigation admin view, administrators can set a certain weight of different properties (title, content, summary, or document content). When an user searches for a keyword that matches to a property’s value, the higher weight of that property will make the matching pages to be more likely to appear at the top of the search result.

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Texan Has Contracted H5N1 Bird Flu; CDC Calls Threat to Public 'Low'

Drugs.com

MONDAY, April 1, 2024 -- An unnamed person in Texas had been diagnosed with the H5N1 avian flu after close contact with infected dairy cattle, the U.S. Centers for Disease Control and Prevention reported Monday. It's only the second case ever.

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I spy with my speedy eye: Scientists discover speed of visual perception ranges widely in humans

Science Daily: Pharmacology News

Using a blink-and-you'll-miss-it experiment, researchers have discovered that individuals differ widely in the rate at which they perceive visual signals. Some people perceive a rapidly changing visual cue at frequencies that others cannot, which means some access more visual information per timeframe than others. This discovery suggests some people have an innate advantage in certain settings where response time is crucial, such as in ball sports, or in competitive gaming.

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Stem Cells From Patients' Fat Can Help Treat Spinal Cord Injuries

Drugs.com

FRIDAY, March 29, 2024 -- Stem cells derived from a patient’s own fat can safely help improve sensation and movement after a spinal cord injury, a new, small study finds.Patients treated with these stem cells experienced increased sensation from.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Understanding CVS Health/McKesson and Why Pharmacies Lose Money on GLP-1s (rerun)

Drug Channels

This week, I’m rerunning some popular posts while I prepare for Friday’s live video webinar: Drug Channel Implications of the Inflation Reduction Act. Click here to see the original post from December 2023. Consider two apparently unrelated drug channel anomalies: In McKesson’s 2023 fiscal year, CVS bought $75 billion in pharmaceuticals from McKesson’s wholesale business—a jump of more than 35% compared with the previous year.

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Many Head to Unreliable Twitter as Prime Source on Birth Control

Drugs.com

MONDAY, April 1, 2024 -- Folks are turning to Twitter for advice on contraception, but it doesn’t look like they’re getting answers from informed authorities, a new study finds.Only about 6% of tweets on reversible birth control methods come.

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We've had bird evolution all wrong

Science Daily: Pharmacology News

Genomic anamolies dating back to the time of the dinosaurs misled scientists about the evolutionary history of birds.

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Dangerous Allergies? An Expert Gives Tips to Protect Yourself

Drugs.com

MONDAY, April 1, 2024 -- Allergic reactions can range from mild sneezing to life-threatening episodes where the throat closes and the airways tighten.That’s why people need to prepare themselves for any potential allergies they might have, said.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Azapeptides with unique covalent warheads as SARS-CoV-2 main protease inhibitors

Covalent Modifiers

Kaustav Khatua, Yugendar R. Alugubelli , Kai S. Yang, Veerabhadra R. Vulupala, Lauren R. Blankenship , Demonta Coleman, Sandeep Atla , Sankar P. Chaki, Zhi Zachary Geng , Xinyu R. Ma , Jing Xiao , Peng-Hsun Chen , Chia-Chuan D. Cho, Shivangi Sharma, Erol C. Vatansever, Yuying Ma, Ge Yu, Benjamin W. Neuman, Shiqing Xu , Wenshe Ray Liu Antiviral Research , 225, 2024 , 105874 [link] The main protease (MPro) of SARS-CoV-2, the causative agent of COVID-19, is a pivotal nonstructural protein critical

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Monthly Injection Curbs Opioid Cravings, But Few Treatment Centers Use It

Drugs.com

MONDAY, April 1, 2024 -- A monthly long-acting injection of buprenorphine can be an easier and more effective therapy for people struggling with opioid addiction, but treatment centers aren’t much interested in using it, a new study.

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AstraZeneca gets FDA OK for rare disease drug acquired in Alexion buyout

BioPharma Drive: Drug Pricing

The clearance of Voydeya as an add-on therapy for an uncommon blood disease validates a bet Alexion made on original developer Achillion five years ago.

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Abiomed Heart Pumps Linked to 49 Deaths

Drugs.com

MONDAY, April 1, 2024 -- A new warning is being issued over a heart pump whose use could perforate the heart. The device has already been linked to over 100 injuries and 49 deaths.These left-sided Impella heart pumps are made by Abiomed, a.

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Vertex moves kidney disease drug into late-stage testing

BioPharma Drive: Drug Pricing

The drug, inaxaplin, is an important pipeline prospect for Vertex, which is working to expand beyond the cystic fibrosis medicines that made its name.

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Telehealth May Help People Stick With Alcoholism Treatment

Drugs.com

MONDAY, April 1, 2024 -- Telehealth might be a more effective way of treating alcoholism than in-person therapy sessions, a new study reports.Alcoholics who receive treatment through telehealth were more likely to engage in more therapy visits and.

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Who helps you make the best business decisions?

Fierce BioTech

Who helps you make the best business decisions? Participate in this survey to help us better understand your experience and perceptions of the commercialization support providers of whom you may be aware. lpastoria Mon, 04/01/2024 - 15:02 Trinity Life Sciences Resource Type Survey Fierce Life Sciences 250x190.

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New Federal Rule Means Hospitals Need Written Consent for Pelvic, Prostate Exams

Drugs.com

MONDAY, April 1, 2024 -- In a letter sent to teaching hospitals and medical schools across the country, the U.S. Department of Health and Human Services said Monday that written consent must be obtained from patients before performing sensitive.

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Project Risk Management – Performing a Project Premortem

Perficient: Drug Development

A powerful, forward-thinking exercise used in project risk management, the project premortem exercise preemptively addressing risks, and helps prevent costly disasters. It ensures that your project stays on track and minimizes the chances of failure. During a premortem the project team collectively imagines that the project has already failed. Instead of waiting for actual failure, they proactively explore potential causes for this failure.

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Scientists Get Closer to Realistic Replacement Human Ear

Drugs.com

MONDAY, April 1, 2024 -- Researchers say they are close to perfecting a bioengineered, 3D printed replacement human ear that looks, feels and resists injury like the real thing. Such an advance would greatly benefit people with congenitally.

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Celebrating 20 Years of Research: Highlights From NIOSH’s Nanotechnology Research Center’s Field Studies Team

NIOSH Science Blog: Drugs

As the National Institute for Occupational Safety and Health (NIOSH) Nanotechnology Research Center (NTRC) marks its 20th anniversary, we celebrate the groundbreaking work of the Field Studies Team. Organized in 2006, the team began by evaluating potential workplace exposures to engineered nanomaterials. Engineered nanomaterials (those created on purpose and not incidentally) have at least one dimension between 1 and 100 nanometers.

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Perficient’s Columbus Office Named A 2024 Top Workplace

Perficient: Drug Development

Perficient’s Columbus office has a lot to celebrate as they start off the year being granted the title of a 2024 Top Workplace by the Columbus CEO. It was just last year that Perficient was named a top workplace in both Cincinnati and Cleveland. Perficient’s office in Columbus is a lively and dynamic hub of activity. The team, comprised of a mix of talents and backgrounds, is united by a shared passion for innovation and collaboration.

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Jenn Nava

Broad Institute

Jenn Nava By Rose Circeo April 1, 2024 Jenn Nava Chief Information Officer Jennifer (Jenn) Nava is the chief information officer at the Broad Institute of MIT and Harvard, where she works side-by-side with IT and scientific teams to develop their digital capabilities. This collaborative effort leads to the development of innovative pathways in transformative technology.

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New tentative approval for MYLAN drug efavirenz, emtricitabine and tenofovir alafenamide

Drug Patent Watch

For more information on how DrugPatentWatch can help with your pharmaceutical business intelligence needs, contact admin@DrugPatentWatch.com or visit www.DrugPatentWatch.

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Identifying the Right Framework: An Inclusive Comparison of React Desktop, Flutter, and React Native

Perficient: Drug Development

Introduction: Selecting the appropriate framework is a crucial choice in the ever-changing world of app development. Each of React Desktop, Flutter, and React Native has special advantages. We’ll examine the benefits and drawbacks of these frameworks in this analysis to assist developers in making selections that are specific to their project requirements.

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Which pharmaceutical companies have the most ointment dosed drugs?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most ointment dosed drugs. For a different perspective, see the most popular dosage types.

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Microsoft Fabric: NASDAQ stock data ingestion into Lakehouse via Notebook

Perficient: Drug Development

Background Microsoft Fabric is emerging as one-stop solution to aspects revolving around the data. Before the introduction of Fabric, Power BI faced few limitations related to data ingestion, since Power Query offers limited ETL & data transformation functionality. Power Query M Language scripting lacks ease of development, compared to popular languages like Java / C# / Python etc., which might be the need for complex scenarios.