Mon.Dec 16, 2024

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Naughty or Nice? Many parents rely on threats to manage misbehavior -- from no dessert to no Santa

Science Daily: Pharmacology News

When young children's behavior becomes challenging, many parents resort to threats -- from taking away toys to threatening that Santa will skip their house, a national poll suggests.

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Merck calls quits on two immunotherapies for cancer

BioPharma Drive: Drug Pricing

The company is scrapping two drugs aimed at targets called TIGIT and LAG-3, both of which were in the middle of Phase 3 testing.

Drugs 284
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Study Supports Tamoxifen for DCIS Early Breast Cancers

Drugs.com

MONDAY, Dec. 16, 2024 -- The established hormone therapy drug tamoxifen can significantly decrease the risk of cancer recurring in women with an early, low-risk form of breast cancer, a new study says. Women who took tamoxifen after undergoing a.

Therapies 278
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Does the exoplanet Trappist-1 b have an atmosphere after all?

Science Daily: Pharmacology News

Recent measurements with the James Webb Space Telescope (JWST) cast doubt on the current understanding of the exoplanet Trappist-1 b's nature. Until now, it was assumed to be a dark rocky planet without an atmosphere, shaped by a billion-year-long cosmic impact of radiation and meteorites. The opposite appears to be true. The surface shows no signs of weathering, which could indicate geological activity such as volcanism and plate tectonics.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Friendships Are Especially Powerful Late in Life, Poll Says

Drugs.com

MONDAY, Dec. 16, 2024 -- Close friendships are incredibly important to the mental health of middle-aged folks and seniors, a new study finds. Older adults with worse mental or physical health were twice as likely to say they don’t have any.

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More Trending

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As Daily Steps Rise, Depression Levels Fall

Drugs.com

MONDAY, Dec. 16, 2024 -- Can you literally step away from depression? A new global review of data found that "increasing the number of daily steps, even at modest levels, was associated with a reduction in depressive symptoms." The Spanish study.

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The Real Cost of Complexity: What Every Drug Developer Needs to Know

PPD

Our annual look at the state of the drug development industry highlights a dual set of challenges complicating progress. The drug development industry faces rising costs and increasingly complex protocols as top challenges, with 49% of developers citing costs as their primary concern and 39% pointing to protocol complexity as a key hurdle, according to a recent survey of 150 drug developers worldwide by the PPD clinical research business of Thermo Fisher Scientific.

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Patient in Louisiana Hospitalized With First Bird Flu Case in That State

Drugs.com

MONDAY, Dec. 16, 2024 -- Louisiana has reported what appears to be the state's first case of bird flu. In a health alert issued Friday, state officials said the case involves “a resident of southwestern Louisiana. The individual had exposure.

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Jazz to search for new chief as CEO plans retirement

BioPharma Drive: Drug Pricing

Bruce Cozadd, who co-founded the company two decades ago, will step down once a successor is found. Jazz aims to complete its search within one year.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Colon Cancer Rates Are Up Among the Young Worldwide

Drugs.com

MONDAY, Dec. 16, 2024 -- More young people around the world are falling prey to colon cancer, a new study shows. Colon cancer rates in young adults have risen in 27 out of 50 countries around the world, including the United States, researchers.

Research 244
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Novo builds up manufacturing; Pepgen Duchenne trial put on hold

BioPharma Drive: Drug Pricing

Novo Nordisk is investing more than $1 billion in a new production facility in Denmark. Elsewhere, drugs from Neurocrine Biosciences, Checkpoint and Galderma won new FDA approvals.

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Omega-3 Rich Diet May Help Slow Prostate Cancer Growth

Drugs.com

MONDAY, Dec. 16, 2024 -- Men who opt for "watchful waiting" instead of treatment for a low-risk prostate cancer might improve their odds if they take fish oil supplements, early research suggests. “Many men are interested in lifestyle.

Treatment 147
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Edgewise weighs fast approval path for muscular dystrophy drug

BioPharma Drive: Drug Pricing

The biotech company will meet with regulators to discuss Phase 2 biomarker data that sent its shares climbing by more than 20% Monday.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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AI Guided Breath Test Could Speed COPD Diagnosis

Drugs.com

MONDAY, Dec. 16, 2024 -- Folks with difficulty breathing can learn if they have COPD from a new AI-guided lung test, a new study suggests. The newly developed AI can accurately diagnose COPD using data from a single chest CT scan performed as a.

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In vivo CAR T: Faster, cheaper, and more effective cancer care

Drug Target Review

Since their first approvals in 2017, autologous CAR T-cell therapies have revolutionised the treatment of blood cancers, offering hope where previous options had failed. However, in their current ex vivo form, a patients cells are collected and then modified over weeks or months in a distant manufacturing site. Consequently, these therapies come with significant burdens and are often underutilised despite their transformative patient outcomes.

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Prenatal Exposure to Air Pollution May Hurt Baby's Brain

Drugs.com

MONDAY, Dec. 16, 2024 -- Air pollution could be harming the brain development of children before they are even born, a new study warns. A 10 parts-per-billion increase in ozone exposure during the second trimester of pregnancy was associated with a.

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Google Patents: Why It’s a Risky Tool for Finding Drug Patents

Drug Patent Watch

When it comes to researching and navigating the complex world of drug patents, inventors and researchers often turn to various tools to find relevant information. Google Patents, with its user-friendly interface and vast database, might seem like an ideal resource. However, there are several reasons why relying solely on Google Patents can be risky, especially in the context of pharmaceutical patents.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Bribing Kids With Holiday Gifts Popular With Parents, Poll Says

Drugs.com

MONDAY, Dec. 16, 2024 -- Do parents use Santa Claus to help guide kids to better behavior? It happens often, a new poll shows. One-quarter of parents of kids ages 3 to 5 said they’ve threatened misbehaving kids with no Santa or gifts if they.

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Universal Design for Visual Disabilities in Healthcare–Creating an Accessible Physical Environment-3

Perficient: Drug Development

Welcome to our ongoing series on Universal Design for Healthcare! In this segment, well explore the importance of Visual Disabilities in Healthcare. Ensuring that healthcare facilities are physically accessible to individuals with visual disabilities is a key aspect of universal design. An accessible physical environment helps patients navigate spaces safely and independently, fostering a more inclusive and supportive healthcare experience.

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A Guide to Adaptive Randomisation in Clinical Trials

Quanticate

A randomised controlled clinical trial is the most prevalent design used in Phase II and Phase III clinical trials, whereby participants are randomly assigned to a control or experimental group with a fixed probability, normally 50% for each treatment. This is the gold standard [1] for identifying the best treatment within the trial with a large degree of certainty [2].

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From Our Stocking to Your Inbox: Happy Holidays!

Alta Sciences

From Our Stocking to Your Inbox: Happy Holidays! blussier Mon, 12/16/2024 - 18:39 HTML 'Tis the season for a little extra joy, and we're thrilled to present "Questions From a Stocking: Holiday Edition!" in which Altascientists fully embrace the holiday spirit as they answer rapid-fire questions pulled from our new favorite stocking. As we share these lighthearted moments, we're filled with deep gratitude for the ideas, discoveries, trials, and successes you've shared with us this year.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults in the US

Common Sense for Drug Policy Blog

Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults in the US "In 2023, 24.3% of adults had chronic pain, and 8.5% of adults had high-impact chronic pain ( Figure 1 , Table 1 ). "Women were more likely to have chronic pain (25.4%) and high-impact chronic pain (9.6%) than men (23.2% and 7.3%, respectively)." "NOTES: Chronic pain is based on responses of most days or every day to the survey question, In the past 3 months, how often did you have pain?

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When to Slow Down or Hit the Brakes on a Development Program

The Premier Consulting Blog

New drug development is a long and expensive process that can be fraught with obstacles, including unexpected delays, poor efficacy results, safety issues, or regulatory challenges. Pharmaceutical companies may, at times, find themselves at an impasse during development, facing weighty decisions about whether to slow down or hit the brakes on a development program.

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Chronic Pain and High-Impact Chronic Pain in the US

Common Sense for Drug Policy Blog

Chronic Pain and High-Impact Chronic Pain in the US "In 2023, 24.3% of adults experienced chronic pain, and 8.5% of adults experienced high-impact chronic pain (or 34.9% of adults who had chronic pain). Women were more likely than men to experience chronic pain. Chronic pain was also generally higher in American Indian and Alaska Native adults and those age 65 and older.

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Texas Sues NY Doctor for Prescribing Abortion Pill by Telehealth

Drugs.com

MONDAY, Dec. 16, 2024 -- A New York doctor has been sued by the state of Texas for prescribing abortion pills via telehealth to a Dallas woman. In a news release announcing the filing of the lawsuit, Texas Attorney General Ken Paxton claims that.

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SPT Labtech 2024 Year in Review

sptlabtech

As the curtain falls on an incredible year, we at SPT Labtech pause to celebrate the remarkable achievements of 2024. This year has been defined by innovation, teamwork, and progress, bringing us closer to transforming the landscape of life sciences. In this reflection, were excited to share some of the standout moments that highlight how our technologies and expertise are driving the future of scientific discovery.

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Advanced Formik Techniques for Building Dynamic and Scalable Forms

Perficient: Drug Development

Formik is an excellent tool for managing forms in React, simplifying state management and validation. However, as forms become more complex, you may need to dive into some advanced techniques. In this post, well cover how to handle dynamic fields, create custom validations, integrate with third-party UI libraries, and optimize performance. 1. Dynamically Adding and Removing Fields Sometimes, the number of form fields you need depends on user input.

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FDA’s Third Party Review Program is Ready for the Next Pandemic, not the LDT Final Rule

FDA Law Blog: Biosimilars

By Adrienne R. Lenz, Principal Medical Device Regulation Expert FDA recently released 510(k) Third Party Review Program and Third Party Emergency Use Authorization (EUA) Review which finalizes the draft guidance of the same title issued in December 2023. We previously discussed the Third Party Review Program in a blog post last year when FDA mentioned its expansion as part of its plan to address the resource gap for review of laboratory developed tests (LDTs) under the LDT final rule.

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Building Forms in React with Formik: A Simple Guide

Perficient: Drug Development

Handling forms in React can get tricky, especially when managing complex states and validation. Formik is a popular library that simplifies this by managing form states, validations, and submissions with ease. In this guide, well explore how to set up a basic form using Formik. What is Formik? Formik is a small library for React forms. It helps manage form state and validation, making it easier to build reliable and maintainable forms.

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