Wed.Jun 05, 2024

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UK research partners team up to accelerate MND drug discovery

Drug Discovery World

UK charity LifeArc has pledged £1.5 million to fund a new two-year collaborative partnership with King’s College London (KCL) to validate a portfolio of human genetic driven therapeutic targets for motor neuron disease (MND). The new partnership, which will involve scientists from both organisations working closely together, is part of LifeArc’s MND Translational Challenge, aimed at discovering innovative and potentially disease-modifying treatments for MND, a key component of the new UK MND Res

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Father's diet before conception influences children's health

Science Daily: Pharmacology News

A recent study provides new insights into how fathers' diets and overweight can affect their children's health even before conception. The findings of the study can help develop preventive health measures for men wishing to become fathers: The healthier the father's diet, the lower the risk for their children to develop obesity or diseases such as diabetes later in life.

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Discover the latest innovations in organoid model development

Drug Discovery World

Developing new drugs is a complex and often lengthy process. A major roadblock lies in the limitations of traditional preclinical models, which often fail to accurately represent the intricate biology of human patients. Join DDW for a free event on 18 June, 3PM BST to learn more about how patient-derived organoids are revolutionising drug discovery.

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Poor quality diet makes our brains sad

Science Daily: Pharmacology News

Eating a poor quality diet might lead to brain changes that are associated with depression and anxiety. This is according to a first-of-its-kind study into the brain chemistry and structure, and diet quality of 30 volunteers.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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[Podcast] The Power of Persistence: From Biotech Incubator to Product Launch

BioPharma Drive: Drug Pricing

How can small and mid-sized biotech companies better manage pharmacovigilance during clinical trials? Listen to the podcast to learn how strategic alliances are helping.

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Oral insulin drops offer relief for diabetes patients

Science Daily: Pharmacology News

Diabetes rates continue to rise. Scientists have now created a pain-free drug delivery method to help people with diabetes manage the disease and maintain their health more easily. Researchers have developed oral insulin drops that when placed under the tongue are quickly and efficiently absorbed by the body, potentially replacing the need for insulin injections.

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Electrified charcoal 'sponge' can soak up CO2 directly from the air

Science Daily: Pharmacology News

Researchers have developed a low-cost, energy-efficient method for making materials that can capture carbon dioxide directly from the air. Researchers used a method similar to charging a battery to instead charge activated charcoal, which is often used in household water filters.

Research 111
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CDC Supports Use of Antibiotic, Doxycycline, as 'Morning After Pill' to Stop STDs

Drugs.com

WEDNESDAY, June 5, 2024 -- In new guidelines released Tuesday, U.S. health officials now recommend that certain people take the antibiotic doxycycline as a morning-after pill to lower the risk of some sexually transmitted diseases (STDs). The.

Disease 116
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Scientists identify 'missing piece' required for blood stem cell self-renewal

Science Daily: Pharmacology News

Blood stem cells -- key to transplants that are used as life-saving treatments for blood cancers and blood and immune disorders -- have the capacity to self-renew, but quickly lose their ability to do so in a lab dish. Scientists have identified a protein that not only enables blood stem cells to self-renew in a lab dish, but also allows these expanded cells to function effectively after being transplanted into mouse models.

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National Safety Month 2024

NIOSH Science Blog: Drugs

Each June, we bring a little extra attention to safety issues by highlighting National Safety Month®. For each week of the month, the National Safety Council (NSC) identifies a theme to focus on. This blog highlights select research and prevention efforts from the National Institute for Occupational Safety and Health (NIOSH) and NSC in this year’s focus areas of safety engagement; roadway safety; risk reduction; and slips, trips and falls.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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New Gene therapy trial shows restored hearing and speech in children born deaf, treated in both ears

Science Daily: Pharmacology News

A new clinical trial of five children with inherited deafness found administering gene therapy in both ears led to restored hearing and speech, and additional gains including sound source localization, ability to hear in noisy environments, and for two children, abillity to appreciate music. This is the first trial in the world to treat children with hereditary deafness in both ears with gene therapy.

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Innovation, Partnerships & Progress: How Life Sciences Is Booming in Maryland’s Montgomery County

Fierce BioTech

Drive or take the metro in any direction within Montgomery County, Maryland, and you'll come across a life science company responsible for a major innovation. | Drive or take the metro in any direction within Montgomery County, Maryland, and you'll come across a life science company responsible for a major innovation.

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Babies use 'helpless' infant period to learn powerful foundation models, just like ChatGPT

Science Daily: Pharmacology News

Babies' brains are not as immature as previously thought, rather they are using the period of postnatal 'helplessness' to learn powerful foundation models similar to those underpinning generative Artificial Intelligence, according to a new study.

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Experts Warn of Drug-Resistant Jock Itch, Athlete's Foot

Drugs.com

WEDNESDAY, June 5, 2024 -- Drug-resistant fungal infections are appearing in the United States, resulting in highly contagious and tough-to-treat cases of ringworm, also known as jock itch or athlete's foot, experts warn in a pair of reports. The.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Blood sausages and yak milk: Bronze Age cuisine of Mongolian nomads unveiled

Science Daily: Pharmacology News

Bronze cauldrons were used by the inhabitants of the Mongolian steppe around 2,700 years ago to process animal blood and milk. This is shown by a protein analysis of archaeological finds from this period.

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Gene Therapy in Both Ears Restores Hearing to Babies Born Deaf

Drugs.com

WEDNESDAY, June 5, 2024 -- Chlidren born deaf have had their hearing restored in both ears as a result of gene therapy, a new study reports.All five children showed hearing recovery in both ears, with dramatic improvements in speech perception and.

Therapies 105
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AIs are irrational, but not in the same way that humans are

Science Daily: Pharmacology News

Large Language Models behind popular generative AI platforms like ChatGPT gave different answers when asked to respond to the same reasoning test and didn't improve when given additional context, finds a new study.

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FDA Panel Says No to MDMA as Treatment for PTSD

Drugs.com

WEDNESDAY, June 5, 2024 -- A U.S. Food and Drug Administration advisory panel on Tuesday voted against recommending the psychedelic MDMA for the treatment of post-traumatic stress disorder (PTSD).In a 10-1 vote, the panel determined the evidence.

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'Missing' early sea sponges discovered

Science Daily: Pharmacology News

Geobiologists reported a 550 million-year-old sea sponge that had been missing from the fossil record. The discovery sheds new light on a conundrum that has stumped zoologists and paleontologists for years.

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Too Many Teens Are Driving Drowsy

Drugs.com

WEDNESDAY, June 5, 2024 -- Teens on the verge of falling asleep behind the wheel is a common threat to public safety on U.S. roadways, a new study reports.About 1 in 6 teenage drivers say they’ve driven while drowsy, according to a National Sleep F.

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Myelination in the brain may be key to 'learning' opioid addiction

Science Daily: Pharmacology News

Scientists have found that the process of adaptive myelination, which helps the brain learn new skills, can also promote addiction to opioids.

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Service Dogs Work Wonders for Veterans With PTSD: Study

Drugs.com

WEDNESDAY, June 5, 2024 -- Military veterans often struggle with their mental health once their service ends, but the first clinical trial of its kind has found that having a service dog helps lower the risk of PTSD for these former.

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'Weird' new planet retained atmosphere despite nearby star's relentless radiation

Science Daily: Pharmacology News

A rare exoplanet that should have been stripped down to bare rock by its nearby host star's intense radiation somehow grew a puffy atmosphere instead -- the latest in a string of discoveries forcing scientists to rethink theories about how planets age and die in extreme environments. Nicknamed 'Phoenix' for its ability to survive its red giant star's radiant energy discovered planet illustrates the vast diversity of solar systems and the complexity of planetary evolution -- especially at the end

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Two Key Steps to Curbing Your Tween's Screen Time

Drugs.com

WEDNESDAY, June 5, 2024 -- Parents frustrated with kids who are seemingly glued to their phones, take heart: New research finds you can tear them away from their devices.Two approaches seem to work best: Limiting screens during meals or bedtime.

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AI approach elevates plasma performance and stability across fusion devices

Science Daily: Pharmacology News

Fusion researchers have successfully deployed machine learning methods to suppress harmful plasma edge instabilities without sacrificing plasma performance.

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Many U.S. Women Unhappy With With Maternal Health Care, Poll Finds

Drugs.com

THURSDAY, June 6, 2024 -- Many women are unhappy with the state of U.S. maternal health care, but a major new poll finds most Americans don’t understand how badly the nation lags behind other wealthy countries in this area. Only about 2 in 5.

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Recce Pharmaceuticals’ synthetic approach to combatting AMR

Drug Target Review

What is the effectiveness of R327 against the full suite of ESKAPE pathogens in independent bacterial efficacy studies? R327 was studied against several Gram-negative and Gram-positive microbial species, including the ESKAPE pathogens, a group of highly resistant bacteria and the leading cause of hospital-acquired infections globally. These include E nterococcus faecium , S taphylococcus aureus , K lebsiella pneumoniae , A cinetobacter baumannii , P seudomonas aeruginosa , and E nterobacter spec

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CDC Supports Use of Antibiotic as 'Morning After Pill' to Stop STDs

Drugs.com

WEDNESDAY, June 5, 2024 -- In new guidelines released Tuesday, U.S. health officials now recommend that certain people take the antibiotic doxycycline as a morning-after pill to lower the risk of some sexually transmitted diseases (STDs).The.

Disease 98
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Breaking ground: Could geometry offer a new explanation for why earthquakes happen?

Science Daily: Pharmacology News

Researchers are adding a new wrinkle to a long-held belief about what causes earthquakes in the first place.

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Few Heart Attack Survivors Get Expert Advice on Diet

Drugs.com

WEDNESDAY, June 5, 2024 -- Less than one-quarter of people who survive serious heart conditions receive the dietary counseling needed to protect their future health, a new study finds.Only about 23% of people treated for major illnesses like heart.

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Sequential immunotherapy for functional cures in autoimmunity

Plenge Gen

Disclaimer: I am a full-time employee of Bristol Myers Squibb. When I practiced clinical rheumatology, I would often see patients with autoimmune conditions like systemic lupus erythematosus (SLE), systemic sclerosis (scleroderma), rheumatoid arthritis (RA), or myositis. A typical patient journey included an initial sense of relief when a diagnosis was established and a medicine was started.

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Drug-Linked Infant Deaths Doubled in U.S. in 4 Years

Drugs.com

WEDNESDAY, June 5, 2024 -- As an epidemic of drug abuse cuts it way through America, none are left unharmed, even the very young.New data finds that the rate of infants dying from drug-related reasons more than doubled between 2018 and 2022.In.

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Lilly details MASH data for tirzepatide; Cytokinetics comments on past sale talks

BioPharma Drive: Drug Pricing

A study abstract shed more light on tirzepatide’s potential in MASH. Elsewhere, Cytokinetics CEO spoke on deal negotiations and AbbVie started a key multiple myeloma drug study.

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Transplanted Pig Kidney Is Removed From Woman Who Received It

Drugs.com

WEDNESDAY, June 5, 2024 -- A woman who was the second person to ever receive a kidney from a genetically modified pig has had the transplanted organ removed due to complications linked to a heart pump she is using, her doctors said.Lisa Pisano, 54.

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