Covalent Modifiers

NOVEMBER 15, 2024

Fereshte Ghorbani, Shaochen You, Gennadii A. Grabovyi, Mannkyu Hong, Garrett Lindsey, Arnab K. Chatterjee, and Michael J. Bollong Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.4c05711 Cysteine reactive groups are a mainstay in the design of covalent drugs and probe molecules, yet only a handful of electrophiles are routinely used to target this amino acid.

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Small Molecule Drugs 173

BioPharma Drive: Drug Pricing

NOVEMBER 15, 2024

At an event hosted by BioPharma Dive, drugmaker executives and investors discussed the importance of focus, smart spending and maintaining lines of sight to the clinic.

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Science Daily: Pharmacology News

NOVEMBER 15, 2024

Scholars for the first time identified chemical signatures of the components of a liquid concoction contained in a Bes mug. A new technique helped identify a sample flavored with honey, sesame seeds, pine nuts, licorice and grapes -- commonly used to make the beverage look like blood.

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Drugs.com

NOVEMBER 15, 2024

FRIDAY, Nov. 15, 2024 -- Waning vaccine coverage has fueled a 20% spike in measles cases worldwide, with 10.3 million people struck by the preventable illness in 2023, health officials reported Wednesday."Inadequate immunization coverage globally.

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Vaccine 290

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Clinical Trials

Science Daily: Pharmacology News

NOVEMBER 15, 2024

In what could one day become a new treatment for epilepsy, researchers have used pulses of light to prevent seizure-like activity in neurons.

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Treatment Research 286

Science Daily: Pharmacology News

NOVEMBER 15, 2024

From the Carnival in Rio de Janeiro to the shoulders of pirates: parrots are synonymous with color for people across the world. In a new study, scientists uncover a 'switch' in the DNA of parrots that controls their wide gamut of colors.

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DNA 264

Drugs.com

NOVEMBER 15, 2024

FRIDAY, Nov. 15, 2024 -- There have been a slew of studies recently supporting the notion that the same mechanisms that help folks lose weight with Ozempic and its kin also work to curb problem drinking.Now, a new study out of Britain adds to that.

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Drug Channels

NOVEMBER 15, 2024

Today’s guest post comes from Kala Bala, SVP, Enterprise Access & Data Expertise, MMIT, a Norstella company and Dinesh Kabaleeswaran, SVP, Advisory Services at MMIT, a Norstella company. The authors outline the challenges that manufacturers face when integrating internal and external datasets to build market access and commercialization strategies.

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Marketing International Drugs 98

Drugs.com

NOVEMBER 15, 2024

FRIDAY, Nov. 15, 2024 -- AI can’t yet help doctors improve their ability to diagnose complex conditions, a sobering new study has found.Doctors had about the same diagnostic accuracy whether or not they were using ChatGPT Plus, according to results.

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Doctors 264

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

BioPharma Drive: Drug Pricing

NOVEMBER 15, 2024

Trace Neuroscience, which launched this week with $101 million, benefited from last year’s approval of Qalsody. Its CEO spoke with BioPharma Dive about how the company came together.

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Drugs 176

Drugs.com

NOVEMBER 15, 2024

FRIDAY, Nov. 15, 2024 -- If you're over 40 and raise your levels of exercise to that of the top 25% of your peers, you might gain an average of five more years of life, a new study calculates.For over-40 folks in the lowest level of daily activity.

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BioPharma Drive: Drug Pricing

NOVEMBER 15, 2024

The San Diego biotech made an unsolicited bid to buy Evotec for 2 billion euros. Elsewhere, Bluebird recorded its first Lyfgenia revenue and Leerink built up its M&A team.

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Drugs.com

NOVEMBER 15, 2024

FRIDAY, Nov. 15, 2024 -- Cases of the autoimmune skin condition eczema appear to rise in areas most plagued by air pollution, new research shows.Since data has long shown that rates of eczema -- clinically known as atopic dermatitis -- increase.

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Research 245

Advertisement

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Alta Sciences

NOVEMBER 15, 2024

4 Essential Topics to Cover in Your First CRO Meeting pmjackson Fri, 11/15/2024 - 19:22 Starting a partnership with a contract research organization (CRO) is a sometimes intimidating—yet exciting—first step in your drug development journey. Whether you’re at the discovery phase or gearing up for a clinical trial , your first conversation with a CRO is an excellent opportunity to assess the cultural fit and collaborative potential. 4 Talking Points to Expect in Your First CRO Meeting To help you

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Drugs.com

NOVEMBER 15, 2024

FRIDAY, Nov. 15, 2024 -- Four out of five men and women in the United States will be overweight or obese by 2050 if current trends hold, a new study warns.About 213 million Americans aged 25 and older will be carrying around excess weight within 25.

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BioPharma Drive: Drug Pricing

NOVEMBER 15, 2024

“Many companies just iterate indefinitely without ever making progress toward an actual drug,” said one biotech VC on a panel hosted by BioPharma Dive.

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Drugs 129

Drugs.com

NOVEMBER 15, 2024

FRIDAY, Nov. 15, 2024 -- Florida resident Joshua Walker isn’t concerned his health will take a hit from all the cakes, pies, cookies and candy that will tempt him during holiday gatherings.That’s because he’s armed with a solid diet and exercise rou.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Common Sense for Drug Policy Blog

NOVEMBER 15, 2024

Misrepresentation of Drugs in the Unregulated Market "The misrepresentation of illicit drugs is a persistent problem in unregulated markets ( Barratt et al., 2024 , Marshman and Gibbins, 1969 ). Misrepresentation can take several forms, including dilution of alleged drugs with inactive fillers, adulteration with other active drugs or contaminants, and substitution with other substances.

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Marketing Drugs 52

Perficient: Drug Development

NOVEMBER 15, 2024

Our experts are closely monitoring eight healthcare trends that are shaping industry leaders’ strategies in 2025. And this year is especially interesting, as 2024’s U.S. election results could significantly shift healthcare policy and impact healthcare access, affordability, regulation, and innovation. As such, forward-looking healthcare organizations (HCOs) that are on-track to differentiate their brand in the modern marketplace demonstrate some key characteristics: Pragmatically progress

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ProRelix Research

NOVEMBER 15, 2024

Patients are the heart of all clinical trials ranging from recruitment, retention, protocol adherence, assessments, and safety data, making it necessary to ensure that patients are well-informed on trial protocol, […] The post Clinical Trials: Information for Patients and Caregivers appeared first on ProRelix Research.

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Clinical Trials Trials Research 52

Perficient: Drug Development

NOVEMBER 15, 2024

Our experts are closely monitoring eight healthcare trends that are shaping industry leaders’ strategies in 2025. And this year is especially interesting, as 2024’s U.S. election results could significantly shift healthcare policy and impact healthcare access, affordability, regulation, and innovation. As such, forward-looking healthcare organizations (HCOs) that are on-track to differentiate their brand in the modern marketplace demonstrate some key characteristics: Pragmatically progress

Regulations 52

Regulations Compliance Production Nurses 52

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Alta Sciences

NOVEMBER 15, 2024

Insights Care: Altasciences—An Advanced Approach to Drug Development (2024 CRO Innovator Excellence) aasimakopoulos Fri, 11/15/2024 - 21:02 Category News Weight 1

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Drug Development Drugs 40

Science Daily: Pharmacology News

NOVEMBER 15, 2024

More time spent sitting, reclining or lying down during the day may increase the risk of cardiovascular disease (CVD) and death, according to a new study. More than roughly 10-and-a-half hours of sedentary behavior per day was significantly linked with future heart failure (HF) and cardiovascular (CV) death, even among people meeting recommended levels of exercise.

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Disease 335

Drugs.com

NOVEMBER 15, 2024

FRIDAY, Nov. 15, 2024 -- Time spent sitting, reclining or lying down during the day could increase a person’s risk of heart disease and death, a new study warns.More than 10 and a half hours of sedentary behavior is significantly linked with future.

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Disease 264

Covalent Modifiers

NOVEMBER 15, 2024

Sijie Wang, Emily C. Woods, Jeyun Jo, Jiyun Zhu, Althea Hansel-Harris, Matthew Holcomb, Nichole J. Pedowitz, Tulsi Upadhyay, John Bennett, Matthias Fellner, Ki Wan Park, Anna Zhang, Tulio A. Valdez, Stefano Forli, Alix I Chan, Christian N. Cunningham, Matthew Bogyo bioRxiv 2024.11.06.622387; doi: [link] Staphylococcus aureus (S. aureus) is an opportunistic human pathogen that causes over one million deaths around the world each year.

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Drugs.com

NOVEMBER 15, 2024

FRIDAY, Nov. 15, 2024 -- College students who use dating apps are more likely to engage in risky sex, endangering their health, a new study shows.Those using a dating app were 2.2 times to have had more than one sexual partner over the past year.

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Common Sense for Drug Policy Blog

NOVEMBER 15, 2024

Adulteration of MDMA in the Unregulated Market "Most of the concern with MDMA adulteration focuses on the plethora of other substances that have been detected in the MDMA supply. This includes novel designer drugs with potentially serious health risks such as synthetic piperazine and cathinone compounds, which were detected in about 5 % of samples overall.

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Antidote

NOVEMBER 15, 2024

Looking toward 2025, clinical trial sponsors must plan now and rethink their patient recruitment strategies to stay ahead of evolving technologies, regulations, and shifting patient expectations. The landscape of clinical trials is changing rapidly, and recruitment will require a more agile, data-driven, and patient-centric approach than ever before.

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Clinical Trials Trials Regulations 52

Drug Target Review

NOVEMBER 15, 2024

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? Reflecting on my career, I did not initially recognise it as a journey. My entry into science during my childhood was almost unexpected, sparked by an inspiring teacher, as is often the case. Initially, I wasn’t the strongest student, but my perseverance compensated for what I lacked, which would serve me well throughout my career in STEM.

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