Fri.Apr 18, 2025

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Pioneering cellular therapies for age-related diseases

Drug Target Review

Recent years have witnessed remarkable advancements in cellular therapies, particularly in the development of treatments that harness the power of stem cells and the immune system. At the forefront of these innovations is Dr Thomas Ichim, a distinguished expert in biotechnology and stem cell therapy at Immorta Bio. With an extensive background in these fields, Ichim is dedicated to advancing personalised cellular therapies aimed at addressing age-related diseases, with a special focus on cancer

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Crinecerfont

New Drug Approvals

Crinecerfont CAS 752253-39-7 SSR125543 SSR 125543 SSR-125543, WHO 10958 , UNII-MFT24BX55I , 06-RORI,NBI-74788 (S)-4-(2-chloro-4-methoxy-5-methylphenyl)-N-(2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl)-5-methyl-N-(prop-2-yn-1-yl)thiazol-2-amine 2-Thiazolamine, 4-(2-chloro-4-methoxy-5-methylphenyl)-N-((1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl)-5-methyl-N-2-propynyl- 2-Thiazolamine, 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-

FDA 62
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FDA cuts outlined in draft HHS budget

BioPharma Drive: Drug Pricing

The leaked budget draft, if approved by Congress, would reduce the FDA’s budget authority, indicating more disruption could be in store for an agency already shaken by large-scale layoffs.

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CDD Vault Update (April 2025 #2): Pharmacokinetic (PK) and Michaelis-Menten Kinetics (Km/Kd) Curve Fit Equations, Donut Charts, TIFF Image Previews, and Parallel Reactions

Collaborative Drug

CDD Update March #2 2025 Full Atom Layout of Macromolecules New Dataset for AI Similarity Searching Import Inventory Locations by Unique Box Names:

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Pregnancy Complications Affect Future Heart Health

Drugs.com

FRIDAY, April 18, 2025 -- Complications during pregnancy can mean a womans future heart health is at risk, particularly if she is overweight or obese, a new study says.Women who are carrying excess weight prior to pregnancy are more likely to d.

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Generative AI's diagnostic capabilities comparable to non-specialist doctors

Science Daily: Pharmacology News

A research team conducted a meta-analysis of the diagnostic capabilities of generative AI in the field of medicine using 83 research papers.

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A wearable smart insole can track how you walk, run and stand

Science Daily: Pharmacology News

A new smart insole system that monitors how people walk in real time could help users improve posture and provide early warnings for conditions from plantar fasciitis to Parkinson's disease.

Disease 201
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Allergy Expert Gives Tips On Seasonal Allergies

Drugs.com

FRIDAY, April 18, 2025 -- Spring has sprung, and the battle with seasonal allergies is underway in earnest.But theres a lot folks can do to manage their pollen-produced misery, according to Dr. Zachary Rubin, a Chicago-area pediatrician and a.

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Makary seeks to limit industry’s role in FDA advisory panels

BioPharma Drive: Drug Pricing

Commissioner Martin Makary said the agency would, whenever possible, restrict drug company employees from participating as industry representatives on advisory committees.

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Psoriatic Arthritis Diagnoses Are Lagging, Patients Undertreated

Drugs.com

FRIDAY, April 18, 2025 -- Its taking too long for people with psoriatic arthritis to be diagnosed and treated, a new study argues.Visible signs of psoriatic arthritis appear months and even years before a person develops the full-blown i.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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GSK prepares to relaunch Blenrep; Activists challenge another ‘zombie’ biotech

BioPharma Drive: Drug Pricing

U.K. regulators cleared a multiple myeloma drug GSK withdrew from market three years ago. Elsewhere, an investment firm pressed Elevation Oncology to liquidate and the FDA relaxed risk monitoring requirements for Camzyos.

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First Weight-Loss Pill From Lilly Shows Promising Results

Drugs.com

FRIDAY, April 18, 2025 A new pill designed to help with weight loss and blood sugar control is showing promise in early studies.Eli Lilly said its experimental drug, orforglipron, helped people with type 2 diabetes lower their blood sugar and l.

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An investment fund sets out to free biotech’s ‘trapped capital’

BioPharma Drive: Drug Pricing

Alis Biosciences says its goal is to return to investors billions of dollars stuck on the balance sheets of “moribund” biotech companies that have suffered significant setbacks.

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Air, Light Pollution Increase Risk Of Thyroid Cancer In Children

Drugs.com

FRIDAY, April 18, 2025 -- Babies exposed to air and light pollution have a higher risk of developing childhood thyroid cancer, a new study says.Airborne particle pollution and outdoor artificial light both increased babies risk of developing t.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Scientists probe the mystery of Titan's missing deltas

Science Daily: Pharmacology News

New research finds that despite large rivers and seas of liquid methane, Saturn's moon Titan seems mostly devoid of river deltas, raising new questions about the surface dynamics on this alien world.

Research 160
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HHS Fires Team That Sets Federal Poverty Guidelines

Drugs.com

FRIDAY, April 18, 2025 A federal team responsible for setting poverty guidelines that determine who qualifies for health and food assistance has been fired, according to former employees.The Department of Health and Human Services (HHS) laid off t.

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Sanofi, Regeneron win FDA nod for Dupixent in chronic hives

BioPharma Drive: Drug Pricing

The partners overcame an earlier rejection to win a seventh use for Dupixent, though some analysts are skeptical of its sales potential compared to other emerging medicines for the condition.

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Magnetic Stimulation Aids Speech Recovery Following Stroke

Drugs.com

FRIDAY, April 18, 2025 -- Lucy Mulloor woke one morning to find she couldnt call out to her two daughters, who were bustling about the kitchen.She also couldnt move the right side of her body, and only attracted her girls attention by falling to.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Unlocking the genetic basis of adaptive evolution: study reveals complex chromosomal rearrangements in a stick insect

Science Daily: Pharmacology News

Scientists report adaptive divergence in cryptic color pattern is underlain by two distinct, complex chromosomal rearrangements, where millions of bases of DNA were flipped backwards and moved from one part of a chromosome to another, independently in populations of stick insects on different mountains.

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Top NIH Nutrition Researcher Quits, Citing Censorship Under Kennedy

Drugs.com

FRIDAY, April 18, 2025 A senior government health researcher has announced his retirement, accusing the National Institutes of Health (NIH) of censoring his latest findings on ultra-processed food.Kevin Hall made the announcement Wednesday on X, e.

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Navigating FDA Layoffs: How Policy Layoffs May Impact Generic Drug Development

thought leadership

Explore how FDA layoffs affecting the OGDP may impact generic development & how experienced regulatory consultants can help you stay on track.

FDA 69
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Stroke Among Younger Adults Linked To Non-Traditional Risks

Drugs.com

FRIDAY, April 18, 2025 -- Migraines, blood clots in veins, kidney or liver disease, and cancer arent typically considered conditions that put a person at increased danger for stroke.But these less-common risk factors can more than double the odds o.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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What are the five pillars of drug development consulting services?

DS in Pharmatics

Discover the five pillars of drug development consulting: regulatory compliance, clinical trials, preclinical research, CMC, and market access.

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Trump Administration Plans Deep Cuts to Federal Health Budget

Drugs.com

FRIDAY, April 18, 2025 The Trump administration is weighing a plan to cut nearly a third of the federal health budget and eliminate or consolidate dozens of programs.An internal memo was sent from White House budget officials to the U.S. D.

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Navigating the Digital Transformation Landscape in 2025

Perficient: Drug Development

Keeping up with today’s fast-paced technological environment, with businesses undergoing a significant transformation in operations, customer interactions, and innovation, can be challenging. Partnering with the right digital transformation service provider is essential for success. A proven track record in guiding businesses through digital complexities is crucial for unlocking their full potential, driving efficiency, and ensuring exceptional customer experiences, leading to long-term su

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Berberine Ameliorates Pulmonary Fibrosis by Inactivating the Thrombospondin 2/Smad Homolog 2/3 Pathway

Chemical Biology and Drug Design

BBR treatment inhibited THBS2 expression to inactivate the Smad2/3 pathway, consequently inhibiting pulmonary fibrosis by repressing the proliferation, migration, invasion, inflammation, and oxidative stress of human lung fibroblast-like cells. ABSTRACT Pulmonary fibrosis (PF) is a progressive and irreversible lung disease. Previous studies have shown that berberine (BBR) ameliorates PF; however, the mechanism of BBR regulating PF remains unclear. mRNA expression of thrombospondin 2 (THBS2) was

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Iomeprol

New Drug Approvals

Iomeprol 78649-41-9 Iomeprolum Iomeron Iomeprolo WeightAverage: 777.089 Monoisotopic: 776.8541 Chemical FormulaC 17 H 22 I 3 N 3 O 8 FDA APPROVED, 11/27/2024, Iomervu , For use as a radiographic contrast agent 1- N ,3- N -bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-methylamino]-2,4,6-triiodobenzene-1,3-dicarboxamide N1,N3-Bis(2,3-dihydroxypropyl)-5-(2-hydroxy-N-methylacetamido)-2,4,6-triiodoisophthalamide 1-N,3-N-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-methylamino]-2,4,6-triiodobenzene-1

FDA 52
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25I-NBOMe ("N-Bomb")

Common Sense for Drug Policy Blog

25I-NBOMe ("N-Bomb") "In 2010, a potent new synthetic hallucinogen known as N-Bomb emerged on the international recreational drug market [ 1 ]. First synthesized in 2003 by German chemist Ralph Heim, 2-(4-Iodo-2,5-dimethoxyphenyl)- N -[(2-methoxyphenyl)methyl]ethanamine, or 25I-NBOMe, was discovered to be a potent serotonin 2A (5-HT2A) receptor agonist [ 2 ].

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How the Change to TLS Certificate Lifetimes Will Affect Sitecore Projects (and How to Prepare)

Perficient: Drug Development

TLS certificate lifetimes are being significantly reduced over the next few years as part of an industry-wide push toward greater security and automation. Here’s the phased timeline currently in place: Now through March 15, 2026 : Maximum lifetime is 398 days Starting March 15, 2026 : Reduced to 200 days Starting March 15, 2027 : Further reduced to 100 days Starting March 15, 2029 : Reduced again to just 47 days For teams managing Sitecore implementations, this is more than a policy shifti

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NBOMes

Common Sense for Drug Policy Blog

NBOMes "Derived from, and thus similar to, the 2C class of amphetamines made popular by the late self-experimenting chemist Alexander Shulgin, NBOMes are now used recreationally by adolescents and young adults for their sympathomimetic and serotonergic effects. Often sold in microgram doses on blotter paper and marketed as legal or natural LSD, NBOMes are also available as liquid, powder, capsules, tablets, or sprays [ 2 ].