Mon.Jun 09, 2025

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Combo Drug Treatment More Effective For Kidney Disease in Type 2 Diabetics

Drugs.com

MONDAY, June 9, 2025 — Prompt treatment with a drug combo can effectively manage chronic kidney disease in people with type 2 diabetes, a new clinical trial shows. Patients prescribed the combination of finerenone and empagliflozin.

Treatment 227
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Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells

Covalent Modifiers

Charlotte M. Zammit, Cory M. Nadel, Ying Lin, Sajjan Koirala, Elnaz Ahani, Patrick Ryan Potts, and Daniel K. Nomura Journal of the American Chemical Society 2025 DOI: 10.1021/jacs.5c02801 Androgen-independent prostate cancers, correlated with heightened aggressiveness and poor prognosis, are caused by mutations or deletions in the androgen receptor (AR) or the expression of truncated variants of AR that are constitutively activated.

DNA 130
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Scientists reveal the hidden pause that keeps bee colonies alive

Science Daily: Pharmacology News

Bumblebee queens don t work nonstop. UC Riverside scientists discovered that queens take strategic reproductive breaks early in colony formation likely to conserve energy and increase the chance of survival. These pauses aren t due to stress but are a built-in response to brood development stages. The study shows queen behavior is far more flexible and dynamic than previously thought, potentially offering new insights into how to protect declining bee populations.

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Discovery of Small Molecule PD‐L1 Inhibitors via Optimization of Solvent‐Interaction Region for Cancer Immunotherapy

Chemical Biology and Drug Design

A series of small molecule PD-L1 inhibitors was discovered via optimization of the solvent-interaction region. GJ19 showed the most potent anti-PD-L1 effects with an IC 50 of 32.06 nM. GJ19 (i.p., 15 mg/kg) effectively suppressed tumor growth with a TGI of 56.8% in a B16-F10 melanoma mouse model. ABSTRACT Despite extensive research, the topic of anti-PD-L1 small-molecule inhibitors remains elusive.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Concentra to acquire Elevation in bid to eliminate another biotech ‘zombie’

BioPharma Drive: Drug Pricing

The offer is the latest in a series of deals by Concentra, an entity controlled by Tang Capital Partners, to buy struggling biotechs and shut them down.

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CPAP Or Zepbound? Patients, Doctors Debate Sleep Apnea Treatment

Drugs.com

MONDAY, June 9, 2025 — A clash is brewing between doctors and patients when it comes to treatment for sleep apnea in those with obesity, a new study reports. Doctors favor treatment with continuous positive airway pressure (CPAP) machines.

Doctors 236

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The dopamine clock: How your brain predicts when you’ll feel good

Science Daily: Pharmacology News

Deep within the brain, the ventral tegmental area does more than signal when we re rewarded it forecasts exactly when we ll be rewarded. This discovery came from an elegant collaboration between neuroscientists and AI researchers, revealing that VTA neurons not only predict the likelihood of future rewards but also their precise timing.

Research 197
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New tRNA tech aims to rewrite rare disease treatment

Drug Target Review

The landscape of genetic medicine is undergoing a profound transformation, driven by innovative approaches that challenge the traditional, disease-specific paradigms. One company leading the charge in this revolution is Alltrna , whose pioneering work in engineered transfer RNA (tRNA) therapeutics is offering new hope for patients with rare genetic diseases.

Disease 80
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Planets may start forming before their stars are even done

Science Daily: Pharmacology News

Planets may begin forming much earlier than scientists once believed during the final stages of a star s birth, not afterward. This bold new model, backed by simulations from researchers at SwRI, could solve a long-standing mystery: why so many exoplanet systems have tight clusters of similarly sized planets orbiting close to their stars. These compact systems seem to emerge naturally if planets start forming amid the swirling chaos of gas and dust still feeding the star.

Research 208
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Erianin Protects Human Umbilical Vein Endothelial Cells From Oxidized Low‐Density Lipoprotein‐Induced Apoptosis and Oxidative Stress Through Activation of Nuclear Factor E2‐Related Factor 2 Signaling

Chemical Biology and Drug Design

Erianin suppresses ox-LDL-induced apoptosis and oxidative stress by regulating Nrf2 signaling in HUVECs. ABSTRACT Oxidized low-density lipoprotein (ox-LDL)-induced endothelial cell damage plays an important role in the pathogenesis of atherosclerosis (AS). This study aimed to investigate the ability of Erianin to protect human umbilical vein endothelial cells (HUVECs) against ox-LDL-induced oxidative stress and its underlying mechanisms.

RNA 100
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Fewer People Seeking Treatment For Cannabis Use Disorder

Drugs.com

MONDAY, June 9, 2025 — Fewer people are receiving treatment for cannabis use disorder these days, even as weed becomes more potent and widely used throughout the U.S., a new study says. The percentage of people in treatment for cannabis use.

Treatment 204
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Merck claims study success with PCSK9 cholesterol pill

BioPharma Drive: Drug Pricing

Enlicitide, which could be the first oral medication that blocks the protein PCSK9, helped cut cholesterol levels in a pair of closely watched trials.

Trials 179
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Don't Sweat The Weight — Healthy Eating Helps Your Heart Regardless

Drugs.com

MONDAY, June 9, 2025 — Don’t get frustrated if switching to a healthy diet doesn’t result in any weight loss – your heart is thanking you nonetheless, a new study says. Even without weight loss, people who adopted a healthy.

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NewAmsterdam says cholesterol drug may also combat Alzheimer’s

BioPharma Drive: Drug Pricing

A "sub-study" of a late-stage clinical trial found the drug, obicetrapib, significantly reduced levels of a certain type of tau protein linked to Alzheimer's development.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Salmonella Outbreak Triggers Egg Recall in 9 States

Drugs.com

MONDAY, June 9, 2025 — A salmonella outbreak tied to a major egg recall has sickened nearly 80 people and sent at least 21 to the hospital, health officials have said. The outbreak has been linked to brown organic and brown cage-free eggs.

Hospitals 165
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Ferulic Acid Inhibits Partial Epithelial‐Mesenchymal Transition in Renal Tubular Epithelial Cells and Mitigates Renal Interstitial Fibrosis by Regulating the HIF‐1α/Twist Signaling Pathway

Chemical Biology and Drug Design

The overall mechanism diagram of ferulic acid delaying renal interstitial fibrosis and inhibiting incomplete EMT of TECs by regulating HIF-1α. ABSTRACT Ferulic acid (FA), a natural phenolic compound, shows potential therapeutic effects on renal interstitial fibrosis, although its antifibrotic mechanism remains unclear. This study investigated the molecular mechanisms of FA by focusing on epithelial-mesenchymal transition (EMT) and related signaling pathways.

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AI Can Boost Radiologists' Efficiency Without Sacrificing Accuracy

Drugs.com

MONDAY, June 9, 2025 -- Artificial intelligence (AI) can boost radiologists’ ability to quickly and accurately assess people’s X-rays, a new study says. Some radiologists became 40% more efficient at reviewing images with the help of a.

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Navigating Complex Regulatory Environments in Drug Portfolio Management

Drug Patent Watch

"Navigating the Maze of Regulations: How Pharmaceutical Companies Can Safeguard Their Drug Portfolios As the pharmaceutical industry continues to evolve, regulatory environments are becoming increasingly complex. With new laws and guidelines emerging regularly, companies must stay agile to avoid costly delays and maintain market competitiveness.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Celebrity Diagnoses Underscore Rising Breast Cancer Rates in Young Women

Drugs.com

MONDAY, June 9, 2025 — More young women in the United States are being diagnosed with breast cancer and several celebrities have helped raise awareness by sharing their stories. Singer Jessie J, 37, said last week that she has early-stage.

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Merck antibody drug for RSV approved by FDA

BioPharma Drive: Drug Pricing

Known as Enflonsia, the drug will compete for market share with Sanofi and AstraZeneca’s in-demand Beyfortus, which quickly became a blockbuster medicine following its approval two years ago.

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Glutamine Attenuates Inflammation and Oxidative Stress in Ulcerative Colitis by Suppressing Wilms' Tumor 1 Associated Protein‐Mediated N6‐Methyladenosine Modification of Nuclear Receptor Coactivator 3

Chemical Biology and Drug Design

Glutamine reduces WTAP expression and thus upregulates NCOA3 by suppressing WTAP-mediated m6A modification of NCOA3 mRNA, thereby exerting protective activity in ulcerative colitis (UC). ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory condition. Glutamine (Gln) has shown an improved effect on UC. However, its molecular determinants are incompletely understood.

RNA 100
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Metsera shares climb on early data for amylin-targeting obesity shot

BioPharma Drive: Drug Pricing

Early-stage study results suggest that a single shot of the company’s therapy, which works differently than GLP-1 medicines, might have effects that last at least four weeks.

Therapies 146
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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New Therapeutic Targets: The Role of IL17-Related Genes in Precision Medicine

Reprocell

Psoriasis is a common chronic skin disease that causes a rash on affected individuals, characterised by itchy, scaly patches. 1 Currently, there is no cure for this disease that affects 2-3% of the worldwide population. 2 Instead, treatment options are focused on management and control rather than healing or eradication. Individuals affected by psoriasis have a few options available to them: topical, systemic and phototherapy, in an attempt to mitigate their symptoms.

Disease 52
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Omada goes public in second recent digital health IPO

BioPharma Drive: Drug Pricing

The chronic condition management company’s debut comes weeks after another digital health company, Hinge Health, went public. The IPOs are a “promising bellwether” for the sector, one expert said.

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WuXi Biologics, VISEN Partner to Make Lonapegsomatropin in Chengdu

The Pharma Data

WuXi Biologics and VISEN Pharmaceuticals Expand Partnership to Localize Production of Lonapegsomatropin in China WuXi Biologics ,a global leader in Contract Research, Development, and Manufacturing Organization (CRDMO) services, and VISEN Pharmaceuticals (HKEX: 2561), a clinical-stage biopharmaceutical company dedicated to advancing endocrine disease treatments, have announced the formal launch of the technology transfer process for the commercial production of lonapegsomatropin.

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The Golden Era of GLP-1 Drugs: How Will it Impact Medicine and Society? by Dr. Gaetano Morelli MD, Chief Medical Officer and Executive Vice President Medical Affairs

Alta Sciences

The Golden Era of GLP-1 Drugs: How Will it Impact Medicine and Society? by Dr. Gaetano Morelli MD, Chief Medical Officer and Executive Vice President Medical Affairs pmjackson Mon, 06/09/2025 - 15:32 Synopsis Dr. Morelli explores how rapid advancements in GLP‑1 therapies are transforming treatment paradigms, healthcare systems, and societal health outcomes.

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Jazz Pharma Unveils Late-Stage Xywav® Data in Narcolepsy at SLEEP 2025

The Pharma Data

Jazz Pharmaceuticals Showcases Promising Phase 4 Results for Xywav® in Narcolepsy at SLEEP 2025, Underscoring Cardiovascular and Symptom Management Benefits Jazz Pharmaceuticals plc presented compelling new late-breaking data at the prestigious SLEEP 2025 conference, unveiling Phase 4 clinical results that further solidify the therapeutic benefits of Xywav® (calcium, magnesium, potassium, and sodium oxybates) oral solution in the management of narcolepsy.

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Patients, Pipeline & Promise: Software-Enhanced Drugs

Fierce BioTech

Patients, Pipeline & Promise: Software-Enhanced Drugs dwunderlin Mon, 06/09/2025 - 16:54 Thu, 07/24/2025 - 13:00 Resource Type Webinar Anthony Costello David Benshoof Klein Promotion Start Wed, 06/11/2025 - 12:45 Promotion End Thu, 12/11/2025 - 12:45 Software-Enhanced (SE) drugs open new pipelines of opportunity, and allow forward-looking leaders to differentiate their portfolios.

Drugs 52
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TransCon CNP Shows Enhanced Benefits in Children with Achondroplasia at Week 26 of COACH Trial

The Pharma Data

Ascendis Pharma Reports Promising Week 26 Results from COACH Trial: TransCon hGH Enhances TransCon CNP Benefits in Children with Achondroplasia Ascendis Pharma A/S, a global biopharmaceutical company focused on developing innovative therapies for rare diseases and endocrine disorders, has announced interim results from the Week 26 analysis of its ongoing Phase 2 COACH trial.

Trials 40
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Fueling REMS Program Success via Service and Technology

Fierce BioTech

Fueling REMS Program Success via Service and Technology pesurya Mon, 06/09/2025 - 10:26 Tue, 07/22/2025 - 11:00 Resource Type Webinar Carolyn Carr Nikki Walters Brent Weyers Justin Wilson Join Syneos Health experts at the forefront of REMS transformation to learn how leading technology, integrated strategies and operational excellence are redefining what’s possible.

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FDA Approves Merck’s ENFLONSIA™ to Prevent RSV in Infants

The Pharma Data

FDA Approves Merck’s ENFLONSIA™ to Protect Infants from Severe RSV Illness Merck operating as MSD outside the United States and Canada, has received a significant regulatory milestone with the U.S. Food and Drug Administration (FDA) granting approval for ENFLONSIA™ (clesrovimab-cfor). This new monoclonal antibody therapy is designed to prevent lower respiratory tract disease caused by respiratory syncytial virus (RSV) in neonates and infants born during or entering their first RSV season.

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Widening the Pharma Marketing Funnel with AI-Powered Engagement: Ostro's Approach to Converting Interest into Action

Fierce BioTech

Widening the Pharma Marketing Funnel with AI-Powered Engagement: Ostro's Approach to Converting Interest into Action Learn how leading pharma brands are boosting digital engagement by applying consumer-tech strategies like AI-driven personalization and intuitive UX. This whitepaper features real-world case studies showing improved HCP and patient conversions. dfarris Mon, 06/09/2025 - 07:51 Learn how leading pharma brands are boosting digital engagement by applying consumer-tech strategies like