Thu.May 23, 2024

article thumbnail

Could a modified cold sore virus cure brain cancer?

Drug Discovery World

A team of scientists in the US and the UK are combining a genetically modified cold sore virus with a cancer vaccine to treat an aggressive type of brain cancer in children. The three-year survival rate for children with high-grade gliomas, without further complications, is only 11-22%, and the currently available treatments, radiotherapy and chemotherapy, can harm the child’s developing brain.

Virus 147
article thumbnail

Scientists map networks regulating gene function in the human brain

Science Daily: Pharmacology News

A consortium of researchers has produced the largest and most advanced multidimensional maps of gene regulation networks in the brains of people with and without mental disorders. These maps detail the many regulatory elements that coordinate the brain's biological pathways and cellular functions. The research used postmortem brain tissue from over 2,500 donors to map gene regulation networks across different stages of brain development and multiple brain-related disorders.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Trending Sources

article thumbnail

CAS BioFinder Discovery Platform offers drug discovery insights

Drug Discovery World

CAS, a division of the American Chemical Society, has launched the CAS BioFinder Discovery Platform, designed to reveal novel drug discovery insights through data connections. The offering provides drug discovery scientists with the ability to explore known and predicted data, find answers to their questions, and potentially accelerate the preclinical drug discovery process.

Drugs 147
article thumbnail

Birth of universe's earliest galaxies observed for first time

Science Daily: Pharmacology News

Researchers have now seen the formation of three of the earliest galaxies in the universe, more than 13 billion years ago. The sensational discovery contributes important knowledge about the universe.

Research 128
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

Podcast: The future climate and landscape for drug discovery

Drug Discovery World

This is the latest episode of the free DDW narrated podcast, titled “The future climate and landscape for drug discovery” which covers three written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: Pharma’s important climate and What will the 2023 drug discovery landscape look like ? In the first article, DDW editor Reece Armstrong comments of the impact of climate change in the drug discovery sector.

Drugs 130
article thumbnail

Costs, Side Effects Drive Folks to Quit New Weight-Loss Meds

Drugs.com

THURSDAY, May 23, 2024 -- Three months after starting one of the new GLP-1 weight-loss drugs, more than a quarter of patients have already quit the medications, and by a year from first use more than a third have stopped, new research shows.Reasons.

Research 124

More Trending

article thumbnail

Mental disorders may spread in young people's social networks

Science Daily: Pharmacology News

A recently completed study demonstrates that mental disorders may be transmitted between individuals within social networks. The finding was the most evident in the case of mood, anxiety and eating disorders.

124
124
article thumbnail

$225m to advance novel immune checkpoint enhancer programme

Drug Discovery World

AltruBio has closed an oversubscribed Series B financing of up to $225 million, which will be used to advance the clinical development of the first-in-class, novel immune checkpoint enhancer (ICE) PSGL-1 agonist antibody, ALTB-268. The funds will be used to support ongoing and planned Phase II clinical trials in ulcerative colitis (UC), one of many immunological disorders where the mechanism has been clinically validated.

article thumbnail

1 in 9 U.S. Children Have Been Diagnosed With ADHD

Drugs.com

THURSDAY, May 23, 2024 -- About 1 in 9 American children have ever received an ADHD diagnosis, slightly more than the number of kids currently being treated for the disorder, a new study shows.About 7.1 million kids (11.4%) have ever been.

122
122
article thumbnail

$120m raised to develop differentiated ADC pipeline 

Drug Discovery World

Pheon Therapeutics has completed a $120m Series B financing to fund the development of its pipeline of next generation ADCs for a wide range of hard-to-treat cancers. The new financing will be used to further advance Pheon’s differentiated ADC pipeline through clinical proof of concept. The first three assets are aimed at an undisclosed novel target which is highly overexpressed in a wide range of solid tumours.

article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

Study explains why the brain can robustly recognize images, even without color

Science Daily: Pharmacology News

New research offers a possible explanation for how the brain learns to identify both color and black-and-white images. The researchers found evidence that early in life, when the retina is unable to process color information, the brain learns to distinguish objects based on luminance, rather than color.

Research 120
article thumbnail

Orna, a circular RNA specialist, acquires a buzzy startup

BioPharma Drive: Drug Pricing

After laying off staff late last year, Orna is expanding through the purchase of ReNAgade Therapeutics, which was built around technology designed to more effectively deliver RNA-based medicines.

RNA 120
article thumbnail

Shared Fentanyl Pipe Residue a New Overdose Danger

Drugs.com

THURSDAY, May 23, 2024 -- San Francisco researchers report that smoking has now replaced injections as the most common way of ingesting illicit fentanyl.That switch has created a potentially deadly new danger, however, as fentanyl residues slowly.

Research 116
article thumbnail

ASCO24: An early look at cancer drug study results

BioPharma Drive: Drug Pricing

Clinical trial abstracts posted by ASCO Thursday give a peek at anticipated datasets from Immunocore, Merck & Co., J&J and Arcus Biosciences.

article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

Stroke Rates Are Rising, Especially Among the Young

Drugs.com

THURSDAY, May 23, 2024 -- The rate at which Americans under the age of 65 suffered a stroke rose by about 15% between 2011 and 2022, new government data shows.That was true even among the young: The rate of stroke jumped 14.6% among people ages 18.

article thumbnail

Planet hunters unveil massive catalog of strange worlds

Science Daily: Pharmacology News

While thousands of planets have been discovered around other stars, relatively little is known about them. A NASA catalog featuring 126 exotic, newly discovered worlds includes detailed measurements that allow for comparisons with our own solar system.

113
113
article thumbnail

Certain menopausal hormone therapy could raise ovarian cancer risk, study finds

BioPharma Drive: Drug Pricing

The findings, from two trials involving tens of thousands of women, could influence guidelines around the use of hormonal treatment for menopausal symptoms.

Therapies 117
article thumbnail

Foraging ants navigate more efficiently when given energy-drink-like doses of caffeine

Science Daily: Pharmacology News

Ants who receive a caffeine-laced sugary reward become more efficient at navigating back to the reward's location compared to ants that only receive sugar. Caffeinated ants move toward the reward via a more direct path but do not increase their speed, suggesting that caffeine improved their ability to learn. The study was conducted on Argentine ants (Linepithema humile), a globally invasive species, and the researchers say that incorporating caffeine into ant baits could aid efforts to control t

Research 112
article thumbnail

Ultra-Processed Foods Could Be Harming Your Brain

Drugs.com

THURSDAY, May 22, 2024 -- Ultra-processed foods are bad for more than your waistline: New research shows they seem to raise the risk of stroke and dementia-related memory or thinking problems.A 10% increase in the amount of ultra-processed foods a.

Research 105
article thumbnail

Birdsong and human voice built from same genetic blueprint

Science Daily: Pharmacology News

Humans have been long fascinated by bird song and the cacophony of other avian sounds -- from coos and honks to quacks and peeps. But little is known about how the unique vocal organ of birds -- the syrinx -- varies from species to species or its deeper evolutionary origins. A trio of recent studies is changing that. The studies include high-resolution anatomical scans of syrinxes from hummingbirds and ostriches -- the world's smallest and largest bird species -- and the discovery that the syrin

110
110
article thumbnail

CDC Reports Second Dairy Worker Infected With Bird Flu

Drugs.com

THURSDAY, MAY 23, 2024 -- A second case of bird flu has been detected in another dairy worker, this time in Michigan, U.S. health officials reported Wednesday.The first case was reported in a dairy worker in Texas in early April.Officials said the.

105
105
article thumbnail

A promising approach to develop a birth control pill for men

Science Daily: Pharmacology News

Researchers show in animal models that a novel, non-hormonal sperm-specific approach offers a promising option for reversible human male contraception.

Research 118
article thumbnail

Science Pinpoints Nutrients Crucial to Brain Health

Drugs.com

THURSDAY, May 23, 2024 -- Specific nutrients could play a pivotal role in the healthy aging of your brain, a new study finds.What’s more, those nutrients correlate closely with those found in the Mediterranean diet, an eating pattern already.

Science 105
article thumbnail

Potentially habitable 'exo-Venus' with Earth-like temperature discovered

Science Daily: Pharmacology News

Astronomers have made the rare and tantalizing discovery of an Earth-like exoplanet 40 light-years away that may be just a little warmer than our own world. The potentially-habitable planet, named Gliese 12 b, orbits its host star every 12.8 days, is comparable in size to Venus -- so slightly smaller than Earth -- and has an estimated surface temperature of 42 C (107 F), which is lower than most of the 5,000-odd exoplanets confirmed so far.

104
104
article thumbnail

Parents' Vaping Might Help Spur Eczema in Kids

Drugs.com

THURSDAY, May 23, 2024 -- A mom or dad who vapes at home might be setting their child up for eczema, new research suggests.In a study involving data from over 35,000 U.S. households, children with a parent who used e-cigarettes had a 24% higher.

Research 105
article thumbnail

Key role of plant-bacteria communication for the assembly of a healthy plant microbiome supporting sustainable plant nutrition

Science Daily: Pharmacology News

In an interdisciplinary study, researchers discovered that symbiotic bacteria communicate with legume plants through specific molecules and that this communication influences which bacteria grow near the plant roots. The findings provide insights into how plants and soil bacteria form beneficial partnerships for nutrient uptake and resilience. These results are a step towards understanding how communication between plants and soil bacteria can lead to specific beneficial associations providing p

Research 103
article thumbnail

Tips for Traveling With a Loved One With Alzheimer's

Drugs.com

THURSDAY, May 23, 2024 -- Experts are expecting this Memorial Day weekend to be the busiest yet, with nearly 44 million Americans projected to travel between Thursday and Monday.A fair number of those travelers will have a companion suffering from.

105
105
article thumbnail

What are PDX-Derived Organoids (PDXOs)?

Crown Bioscience

Learn about PDX-derived organoids, including PDXO establishment and utility in a pioneering drug discovery platform combining the benefits of in vitro PDXO and highly predictive in vivo PDX models.

Drugs 98
article thumbnail

'Moving Forward': Battling Parkinson's, He's Rowing His Way to Paralympic Games

Drugs.com

THURSDAY, May 23, 2024 -- For decades, Todd Vogt has been dedicated to the sport of rowing, believing he was in peak physical condition. Then, a series of symptoms began to emerge, turning his life upside down. "My left arm stopped swinging, and I.

105
105
article thumbnail

The global clean water crisis looms large

Science Daily: Pharmacology News

Water scarcity will intensify with climate and socioeconomic change, disproportionately impacting populations located in the Global South.

109
109
article thumbnail

Want to Feel Less Lonely? Spend Money on Experiences, not Things

Drugs.com

THURSDAY, May 23, 2024 -- Materialism could be fueling America’s epidemic of loneliness and isolation, a new study claims.People who spend their money on experiences tend to have stronger feelings of social connection with others than those who.

104
104
article thumbnail

Sexual parasitism helped anglerfish invade the deep sea during a time of global warming

Science Daily: Pharmacology News

Members of the vertebrate group including anglerfishes are unique in possessing a characteristic known as sexual parasitism, in which males temporarily attach or permanently fuse with females to mate. Now, researchers show that sexual parasitism arose during a time of major global warming and rapid transition for anglerfishes from the ocean floor to the deep, open sea.

article thumbnail

Hot Plasmids Spring 2024

addgene Blog

Every few months we highlight some of the new plasmids, antibodies, and viral preps in our repository through our Hot Plasmids articles.

89
article thumbnail

Predicting cancer risks on the basis of national health data

Science Daily: Pharmacology News

Scientists are predicting individual risks for 20 different types of cancer with a high degree of accuracy. The prediction model could help to identify people with a high risk of cancer, for whom individualized early detection programs could be tested in studies.

88