Drug Discovery World
MAY 23, 2024
A team of scientists in the US and the UK are combining a genetically modified cold sore virus with a cancer vaccine to treat an aggressive type of brain cancer in children. The three-year survival rate for children with high-grade gliomas, without further complications, is only 11-22%, and the currently available treatments, radiotherapy and chemotherapy, can harm the child’s developing brain.
Science Daily: Pharmacology News
MAY 23, 2024
Researchers have now seen the formation of three of the earliest galaxies in the universe, more than 13 billion years ago. The sensational discovery contributes important knowledge about the universe.
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Drug Discovery World
MAY 23, 2024
CAS, a division of the American Chemical Society, has launched the CAS BioFinder Discovery Platform, designed to reveal novel drug discovery insights through data connections. The offering provides drug discovery scientists with the ability to explore known and predicted data, find answers to their questions, and potentially accelerate the preclinical drug discovery process.
Science Daily: Pharmacology News
MAY 23, 2024
A consortium of researchers has produced the largest and most advanced multidimensional maps of gene regulation networks in the brains of people with and without mental disorders. These maps detail the many regulatory elements that coordinate the brain's biological pathways and cellular functions. The research used postmortem brain tissue from over 2,500 donors to map gene regulation networks across different stages of brain development and multiple brain-related disorders.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
MAY 23, 2024
This is the latest episode of the free DDW narrated podcast, titled “The future climate and landscape for drug discovery” which covers three written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: Pharma’s important climate and What will the 2023 drug discovery landscape look like ? In the first article, DDW editor Reece Armstrong comments of the impact of climate change in the drug discovery sector.
Science Daily: Pharmacology News
MAY 23, 2024
A recently completed study demonstrates that mental disorders may be transmitted between individuals within social networks. The finding was the most evident in the case of mood, anxiety and eating disorders.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
MAY 23, 2024
New research offers a possible explanation for how the brain learns to identify both color and black-and-white images. The researchers found evidence that early in life, when the retina is unable to process color information, the brain learns to distinguish objects based on luminance, rather than color.
Drug Discovery World
MAY 23, 2024
AltruBio has closed an oversubscribed Series B financing of up to $225 million, which will be used to advance the clinical development of the first-in-class, novel immune checkpoint enhancer (ICE) PSGL-1 agonist antibody, ALTB-268. The funds will be used to support ongoing and planned Phase II clinical trials in ulcerative colitis (UC), one of many immunological disorders where the mechanism has been clinically validated.
Drugs.com
MAY 23, 2024
THURSDAY, May 23, 2024 -- Three months after starting one of the new GLP-1 weight-loss drugs, more than a quarter of patients have already quit the medications, and by a year from first use more than a third have stopped, new research shows.Reasons.
Drug Discovery World
MAY 23, 2024
Pheon Therapeutics has completed a $120m Series B financing to fund the development of its pipeline of next generation ADCs for a wide range of hard-to-treat cancers. The new financing will be used to further advance Pheon’s differentiated ADC pipeline through clinical proof of concept. The first three assets are aimed at an undisclosed novel target which is highly overexpressed in a wide range of solid tumours.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
MAY 23, 2024
While thousands of planets have been discovered around other stars, relatively little is known about them. A NASA catalog featuring 126 exotic, newly discovered worlds includes detailed measurements that allow for comparisons with our own solar system.
Drugs.com
MAY 23, 2024
THURSDAY, May 23, 2024 -- About 1 in 9 American children have ever received an ADHD diagnosis, slightly more than the number of kids currently being treated for the disorder, a new study shows.About 7.1 million kids (11.4%) have ever been.
Science Daily: Pharmacology News
MAY 23, 2024
Humans have been long fascinated by bird song and the cacophony of other avian sounds -- from coos and honks to quacks and peeps. But little is known about how the unique vocal organ of birds -- the syrinx -- varies from species to species or its deeper evolutionary origins. A trio of recent studies is changing that. The studies include high-resolution anatomical scans of syrinxes from hummingbirds and ostriches -- the world's smallest and largest bird species -- and the discovery that the syrin
BioPharma Drive: Drug Pricing
MAY 23, 2024
After laying off staff late last year, Orna is expanding through the purchase of ReNAgade Therapeutics, which was built around technology designed to more effectively deliver RNA-based medicines.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
MAY 23, 2024
Ants who receive a caffeine-laced sugary reward become more efficient at navigating back to the reward's location compared to ants that only receive sugar. Caffeinated ants move toward the reward via a more direct path but do not increase their speed, suggesting that caffeine improved their ability to learn. The study was conducted on Argentine ants (Linepithema humile), a globally invasive species, and the researchers say that incorporating caffeine into ant baits could aid efforts to control t
Drugs.com
MAY 23, 2024
THURSDAY, May 23, 2024 -- San Francisco researchers report that smoking has now replaced injections as the most common way of ingesting illicit fentanyl.That switch has created a potentially deadly new danger, however, as fentanyl residues slowly.
Science Daily: Pharmacology News
MAY 23, 2024
Astronomers have made the rare and tantalizing discovery of an Earth-like exoplanet 40 light-years away that may be just a little warmer than our own world. The potentially-habitable planet, named Gliese 12 b, orbits its host star every 12.8 days, is comparable in size to Venus -- so slightly smaller than Earth -- and has an estimated surface temperature of 42 C (107 F), which is lower than most of the 5,000-odd exoplanets confirmed so far.
Drugs.com
MAY 23, 2024
THURSDAY, May 23, 2024 -- The rate at which Americans under the age of 65 suffered a stroke rose by about 15% between 2011 and 2022, new government data shows.That was true even among the young: The rate of stroke jumped 14.6% among people ages 18.
Science Daily: Pharmacology News
MAY 23, 2024
Researchers show in animal models that a novel, non-hormonal sperm-specific approach offers a promising option for reversible human male contraception.
BioPharma Drive: Drug Pricing
MAY 23, 2024
Clinical trial abstracts posted by ASCO Thursday give a peek at anticipated datasets from Immunocore, Merck & Co., J&J and Arcus Biosciences.
Science Daily: Pharmacology News
MAY 23, 2024
In an interdisciplinary study, researchers discovered that symbiotic bacteria communicate with legume plants through specific molecules and that this communication influences which bacteria grow near the plant roots. The findings provide insights into how plants and soil bacteria form beneficial partnerships for nutrient uptake and resilience. These results are a step towards understanding how communication between plants and soil bacteria can lead to specific beneficial associations providing p
BioPharma Drive: Drug Pricing
MAY 23, 2024
The findings, from two trials involving tens of thousands of women, could influence guidelines around the use of hormonal treatment for menopausal symptoms.
Science Daily: Pharmacology News
MAY 23, 2024
Members of the vertebrate group including anglerfishes are unique in possessing a characteristic known as sexual parasitism, in which males temporarily attach or permanently fuse with females to mate. Now, researchers show that sexual parasitism arose during a time of major global warming and rapid transition for anglerfishes from the ocean floor to the deep, open sea.
Drugs.com
MAY 23, 2024
THURSDAY, May 22, 2024 -- Ultra-processed foods are bad for more than your waistline: New research shows they seem to raise the risk of stroke and dementia-related memory or thinking problems.A 10% increase in the amount of ultra-processed foods a.
Science Daily: Pharmacology News
MAY 23, 2024
Scientists are predicting individual risks for 20 different types of cancer with a high degree of accuracy. The prediction model could help to identify people with a high risk of cancer, for whom individualized early detection programs could be tested in studies.
Drugs.com
MAY 23, 2024
THURSDAY, MAY 23, 2024 -- A second case of bird flu has been detected in another dairy worker, this time in Michigan, U.S. health officials reported Wednesday.The first case was reported in a dairy worker in Texas in early April.Officials said the.
Science Daily: Pharmacology News
MAY 23, 2024
The first scientific pictures from the Euclid satellite mission have revealed more than 1,500 billion orphan stars scattered throughout the Perseus cluster of galaxies.
Drugs.com
MAY 23, 2024
THURSDAY, May 23, 2024 -- Specific nutrients could play a pivotal role in the healthy aging of your brain, a new study finds.What’s more, those nutrients correlate closely with those found in the Mediterranean diet, an eating pattern already.
Science Daily: Pharmacology News
MAY 23, 2024
Water scarcity will intensify with climate and socioeconomic change, disproportionately impacting populations located in the Global South.
Drugs.com
MAY 23, 2024
THURSDAY, May 23, 2024 -- A mom or dad who vapes at home might be setting their child up for eczema, new research suggests.In a study involving data from over 35,000 U.S. households, children with a parent who used e-cigarettes had a 24% higher.
Crown Bioscience
MAY 23, 2024
Learn about PDX-derived organoids, including PDXO establishment and utility in a pioneering drug discovery platform combining the benefits of in vitro PDXO and highly predictive in vivo PDX models.
Drugs.com
MAY 23, 2024
THURSDAY, May 23, 2024 -- Experts are expecting this Memorial Day weekend to be the busiest yet, with nearly 44 million Americans projected to travel between Thursday and Monday.A fair number of those travelers will have a companion suffering from.
Science Daily: Pharmacology News
MAY 23, 2024
Researchers analyzed multi-omic data from 231 people with PTSD or depression to uncover distinct molecular differences that might affect systems such as the nervous and immune systems, to contribute to these mental health conditions.
Drugs.com
MAY 23, 2024
THURSDAY, May 23, 2024 -- For decades, Todd Vogt has been dedicated to the sport of rowing, believing he was in peak physical condition. Then, a series of symptoms began to emerge, turning his life upside down. "My left arm stopped swinging, and I.
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