Sat.Mar 09, 2024 - Fri.Mar 15, 2024

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A healthier diet is linked with a slower pace of aging, reduced dementia risk, study shows

Science Daily: Pharmacology News

A healthier diet is associated with a reduced dementia risk and slower pace of aging, according to a new study. The findings show that a diet-dementia association was at least partially facilitated by multi-system processes of aging. Until now, the biological mechanism of this protection was not well understood.

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Madrigal wins FDA approval of first drug for MASH

BioPharma Drive: Drug Pricing

Rezdiffra’s clearance is a turning point in the fight against the liver disease. But its sales potential is unclear, and competition could emerge from popular weight loss drugs.

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Zepbound Helps Obese People Shed Pounds, Regardless of Starting Weight

Drugs.com

THURSDAY, March 14, 2024 -- The blockbuster weight-loss medication Zepbound (tirzepatide) appears to help folks quickly shed pounds regardless of how overweight they are, or how long they've lived being overweight or obese. Those are the findings.

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Recap of CDD User Group Meeting – Berlin 2024

Collaborative Drug

CDD User Group Meeting in Berlin. Contributions from experts at Bayer Co.Lab, PROTEROS biostructures GmbH, Refoxy Pharma, PROSION Therapeutics, Schrödinger.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Milk to the rescue for diabetics? Cow produces human insulin in milk

Science Daily: Pharmacology News

An unassuming brown bovine from the south of Brazil has made history as the first transgenic cow capable of producing human insulin in her milk. The advancement could herald a new era in insulin production, one day eliminating drug scarcity and high costs for people living with diabetes.

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Vitamin D Plus Calcium: Good News, Bad News for Older Women

Drugs.com

TUESDAY, March 12, 2024 -- Women who've gone through menopause and hope that supplemental vitamin D plus calcium might shield them from disease may be disappointed by new data.A follow-up analysis of data from the landmark Women's Health Initiative.

Disease 290
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Drug Discovery Industry Roundup with Barry Bunin — March 15, 2024

Collaborative Drug

“Long Covid ‘Brain Fog’ May Be Due to Leaky Blood-Brain Barrier Ozempic Taking off in China? Is Exercise More Effective For Women than Men?

Drugs 264
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New research suggests that our universe has no dark matter

Science Daily: Pharmacology News

A new study challenges the current model of the universe by showing that, in fact, it has no room for dark matter.

Research 335
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German biotech Tubulis cashes in on ADC ‘momentum’ with €128M financing

BioPharma Drive: Drug Pricing

The funding for the startup, which partnered with Bristol Myers Squibb last year, adds to a surge of recent investments in developers of antibody-drug conjugates.

Drugs 315
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Poor Trial Results May Prompt Maker to Pull ALS Drug, Relyvrio, From Market

Drugs.com

MONDAY, March 11, 2024 -- Following disappointing trial results, the maker of a controversial ALS drug may pull the medication off the market. In a statement issued Friday, Amylyx Pharmaceuticals said that Relyvrio failed to help patients in a.

Marketing 289
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Upcoming Webinar: Trends & Better Practices for the Use of Gen AI & LLMs & Round Table, Hosted by 20/15 Visioneers

Collaborative Drug

Upcoming Webinar: Agenda CDD Vault – Susana Tomasio Elucidata – Abhishek Jha Revvity Signals – Pierre Morieux HitchhikersAI – Raminderpal Singh Round Table Discussion with Panelists

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Drought, soil desiccation cracking, and carbon dioxide emissions: an overlooked feedback loop exacerbating climate change

Science Daily: Pharmacology News

Soil stores 80 percent of carbon on earth, yet with increasing cycles of drought, that crucial reservoir is cracking and breaking down, releasing even more greenhouse gases creating an amplified feedback loop that could accelerate climate change.

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Madrigal, FDA approval in hand, outlines plan to sell MASH drug

BioPharma Drive: Drug Pricing

The company expects initial uptake of Rezdiffra, which costs $47,400 per year, to be slow as doctors and insurers establish the protocols needed to find patients eligible for treatment.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Precautions Needed When Folks Taking Ozempic, Wegovy Undergo Anesthesia

Drugs.com

WEDNESDAY, March 13, 2024 — Nurses who specialize in anesthesia have issued new guidelines to reduce the risk that patients taking weight-loss drugs like Ozempic or Wegovy throw up during surgery."These medications have exploded in.

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An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations

Covalent Modifiers

Michael Westberg et al. Sci. Transl. Med. 16 , eadi0979 (2024). DOI: 10.1126/scitranslmed.adi0979 Inhibitors of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) such as nirmatrelvir (NTV) and ensitrelvir (ETV) have proven effective in reducing the severity of COVID-19, but the presence of resistance-conferring mutations in sequenced viral genomes raises concerns about future drug resistance.

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An electricity generator inspired by the drinking bird toy powers electronics with evaporated water

Science Daily: Pharmacology News

Inspired by the classic drinking bird toy, scientists have developed an engine that efficiently converts energy from water evaporation into electricity to power small electronics. The device produces energy outputs exceeding 100 volts -- much higher than other techniques that generate electricity from water -- and can operate for several days using only 100 milliliters of water as fuel, according to a new study.

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After surprise trial failure, ALS doctors brace for one less treatment option

BioPharma Drive: Drug Pricing

Physicians are preparing for tough conversations with patients on Amylyx Pharmaceuticals’ drug, Relyvrio, while holding out hope it still may help some with the disease.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Use of Legal 'Delta-8-THC' Is Rising Among Teens - Is it Safe?

Drugs.com

TUESDAY, March 12, 2024 -- They're cheap, easy to buy and now new research shows they have become the buzz of choice for American teens. Delta-8-THC products, which include gummies and vapes, are legal in 22 states and Washington, D.C. There is no.

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CDD Vault Update (March 2024)

Collaborative Drug

Redesigned Dose Response Viewer When clicking on a dose response curve from within CDD Vault, a redesigned plot now opens in a new browser tab. In addition to a new look and feel, users may also change the color of any curve displayed within this new window.

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Alaska dinosaur tracks reveal a lush, wet environment

Science Daily: Pharmacology News

A large find of dinosaur tracks and fossilized plants and tree stumps in far northwestern Alaska provides new information about the climate and movement of animals near the time when they began traveling between the Asian and North American continents roughly 100 million years ago.

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Amylyx CEOs look for a path forward following major setback

BioPharma Drive: Drug Pricing

Justin Klee and Joshua Cohen spoke to BioPharma Dive about the next steps for their company, which is considering pulling its only product from market after the drug failed a confirmatory study in ALS.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Measles Cases Climb to 4 at Chicago Migrant Shelter Outbreak

Drugs.com

TUESDAY, MARCH 12, 2024 -- As the number of measles cases at a migrant shelter in Chicago climbed to four on Monday, a team from the U.S. Centers for Disease Control and Prevention has headed to that city to help contain the outbreak.The Chicago.

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Scientists generate new targeted protein degradation system that tunes a cell’s own proteins

Broad Institute

Scientists generate new targeted protein degradation system that tunes a cell’s own proteins By Leah Eisenstadt March 14, 2024 Breadcrumb Home Scientists generate new targeted protein degradation system that tunes a cell’s own proteins Researchers have engineered a compact degron tag that can be precisely edited into a cell’s genome, enabling scientists to trigger the rapid breakdown of native target proteins.

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A new world of 2D material is opening up

Science Daily: Pharmacology News

Materials that are incredibly thin, only a few atoms thick, exhibit unique properties that make them appealing for energy storage, catalysis and water purification. Researchers have now developed a method that enables the synthesis of hundreds of new 2D materials.

Research 312
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Roche, following setbacks, turns to its next Alzheimer’s drug

BioPharma Drive: Drug Pricing

Roche said its experimental Alzheimer’s disease drug trontinemab showed it might be able to clear brain plaques faster than other medicines.

Drugs 293
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Sun Plus Certain Foods, Meds Can Bring on 'Margarita Rashes'

Drugs.com

MONDAY, March 11, 2024 -- Slicing some fresh limes for that margarita savored in the sun could be a bad combo for some people's skin, dermatologists warn. Folks can break out in what are nicknamed "margarita rashes" if they are skin-sensitive to.

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What do volunteers for research studies do after finding a trial?

Antidote

For many people, participating in a research study presents an interesting opportunity with many benefits to volunteering. While there are many types of clinical research, all with distinct goals and timelines, trial volunteers will follow a similar path when taking part. Read on to learn more about the process.

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Supply chain disruptions will further exacerbate economic losses from climate change

Science Daily: Pharmacology News

Global GDP loss from climate change will increase exponentially the warmer the planet gets when its cascading impact on global supply chains is factored in, finds a new study.

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BIO changes stance, backs bill to limit China’s role in US biotech

BioPharma Drive: Drug Pricing

Pressed by lawmakers, the lobbying group is also “taking steps” to end its relationship with Wuxi-AppTec, a major contract manufacturer to the biopharmaceutical industry.

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