Sat.Apr 19, 2025 - Fri.Apr 25, 2025

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Researchers use machine learning to engineer 'bespoke enzymes' for gene editing

Science Daily: Pharmacology News

Genome editing has advanced at a rapid pace with promising results for treating genetic conditions -- but there is always room for improvement. A new paper showcases the power of scalable protein engineering combined with machine learning to boost progress in the field of gene and cell therapy. In their study, authors developed a machine learning algorithm -- known as PAMmla -- that can predict the properties of about 64 million genome editing enzymes.

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Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria

Covalent Modifiers

Genhui Xiao, Yumeng Cui, Liangliang Zhou, Chuya Niu, Bing Wang, Jinglan Wang, Shaoyang Zhou, Miaomiao Pan, Chi Kin Chan, Yan Xia, Lan Xu, Yu Lu, Shawn Chen mLife , 2025 DOI: [link] The caseinolytic protease complex ClpP1P2 is crucial for protein homeostasis in mycobacteria and stress response and virulence of the pathogens. Its role as a potential drug target for combating tuberculosis (TB) has just begun to be substantiated in drug discovery research.

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Novo says it’s submitted obesity pill for FDA approval

BioPharma Drive: Drug Pricing

A spokesperson confirmed the Danish drugmaker has asked U.S. regulators to clear an oral version of its weight loss drug Wegovy two years after reporting initial Phase 3 results.

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Novavax COVID Vaccine Moves Closer to Full FDA Approval

Drugs.com

FRIDAY, April 25, 2025 Novavaxs COVID-19 vaccine could soon receive full approval from the U.S. Food and Drug Administration (FDA), the company said Wednesday.The update sent Novavaxs stock up more than 21% in early trading. It also helped ease.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Scientific path to recouping the costs of climate change

Science Daily: Pharmacology News

A new study lays out a scientific framework for holding individual fossil fuel companies liable for the costs of climate change by tracing specific damages back to their emissions. The researchers use the tool to provide the first causal estimate of economic losses due to extreme heat driven by emissions. They report that carbon dioxide and methane output from just 111 companies cost the world economy $28 trillion from 1991 to 2020, with the five top-emitting firms linked to $9 trillion of those

Research 328

More Trending

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Biohaven stock slides on withdrawal of European marketing application

BioPharma Drive: Drug Pricing

The drug, being developed for a rare genetic disorder and currently under review in the U.S., is seen by some investors as critical to Biohaven’s future.

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HHS Announces Plans to Pay Moderna $176 Million for mRNA Flu Vaccine

Drugs.com

FRIDAY, April 25, 2025 -- On Tuesday, the U.S. Department of Health and Human Services announced that the government will invest $176 million in Moderna to expedite the creation of a pandemic influenza vaccine, according to a report from the.

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Newborns living near trees tend to be healthier: New data suggests it's not because healthier people reside near parks

Science Daily: Pharmacology News

The link between proximity to greenspace -- including trees and parks-- and healthy birth outcomes is well established. Now new data adds to our understanding of these health benefits, accounting for other factors that may influence this link, such as education, income and body mass index, but also taking the body of knowledge a step further by exploring the effect of residing near newly planted trees.

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Discovery and Optimization of a Covalent AKR1C3 Inhibitor

Covalent Modifiers

R. Justin Grams, Wesley J. Wolfe, Robert J. Seal, James Veccia, and Ku-Lung Hsu Journal of Medicinal Chemistry 2025 [link] Aldo-keto reductase family 1 member C3 (AKR1C3) is a member of the AKR superfamily of enzymes that metabolize androgen, estrogen, and prostaglandin substrates that drive proliferation in hormone-dependent cancers. Interest in developing selective inhibitors has produced tool compounds for the inactivation or degradation of AKR1C3 with varying degrees of selectivity among the

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Roche, answering tariff threat, pledges $50B to US drug production

BioPharma Drive: Drug Pricing

The big pharma joined several of its peers in committing to invest billions of dollars in new and expanded manufacturing facilities in the U.S.

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Supreme Court Case Targets Free Preventive Care Provided By The Affordable Care Act

Drugs.com

MONDAY, April 21, 2025 -- Colonoscopy for younger adults. Chest CT scans for lung cancer. Statin meds to lower cholesterol. Screening for drug addiction.More than 150 million Americans might lose no-cost access to these and other preventive care.

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Study shows addressing working memory can help students with math difficulty improve word problem-solving skills

Science Daily: Pharmacology News

Working memory is like a mental chalkboard we use to store temporary information while executing other tasks. Scientists worked with more than 200 elementary students to test their working memory, assess its role in word-problem solving and if interventions could boost it and thereby improve their word problem solving skills. Results showed that improving working memory helped both students with and without math difficulties and can help educators more effectively by helping teach the science of

Science 259
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Network Pharmacology Integrated Experimental Validation Uncover Quercetin as the Key Ingredient of Hedyotis diffusa Anti‐BRCA

Chemical Biology and Drug Design

Quercetin is the core component of Hedyotis diffusa against breast cancer (BRCA). CDK1, BIRC5, and HSP90AA1 play key roles in the anti-BRCA effect of Hedyotis diffusa. ABSTRACT Hedyotis diffusa , a famous Traditional Chinese Medicine (TCM), has been extensively used clinically for thousands of years. Although the therapeutic effect of Hedyotis diffusa on tumors has attracted wide attention, components, and mechanisms against breast cancer (BRCA) have not been fully understood.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Merck takes $200M tariff hit, trimming its gross profits

BioPharma Drive: Drug Pricing

The drugmaker absorbed additional tariff-related costs in the first quarter, but has taken steps to lower the financial impact it’ll have for the rest of the year and beyond.

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CDC Cancels Measles Help for Texas Schools Amid Staff Layoffs

Drugs.com

MONDAY, April 21, 2025 The U.S. Centers for Disease Control and Prevention (CDC) has canceled its plans to help Texas schools stop the rapid spread of measles. The decision came after some CDC staff involved in this years outbreak response were t.

Disease 276
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Scientists have found a way to 'tattoo' tardigrades

Science Daily: Pharmacology News

If you haven't heard of a tardigrade before, prepare to be wowed. These clumsy, eight-legged creatures, nicknamed water bears, are about half a millimeter long and can survive practically anything: freezing temperatures, near starvation, high pressure, radiation exposure, outer space and more. Researchers took advantage of the tardigrade's nearly indestructible nature and gave the critters tiny 'tattoos' to test a microfabrication technique to build microscopic, biocompatible devices.

Research 259
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CDD Vault Update (April 2025 #3): AI+ Folding and Docking

Collaborative Drug

CDD Update March #2 2025 Full Atom Layout of Macromolecules New Dataset for AI Similarity Searching Import Inventory Locations by Unique Box Names:

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Partnering with Eli Lilly to Empower the Biomedical Workforce

keypoint

Keystone Symposia was founded on the idea of bringing academic and industry scientists together to accelerate translational advances that cannot be achieved without their combined expertise and resources. As such, we have a long history of partnership with industry leaders with the shared goal of integrating basic science discovery and innovation into drug development efforts to yield novel and improved targeted treatment strategies.

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Microplastics Could Be Contributing To Clogged Arteries

Drugs.com

WEDNESDAY, April 23, 2025 Microplastics could be contributing to clogged arteries, increasing peoples risk of heart attack or stroke, a new study says.Fatty plaques in neck arteries can contain more than 50 times as much microplastics as are fou.

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High-fat, high-sugar diets impact cognitive function

Science Daily: Pharmacology News

New research links fatty, sugary diets to impaired brain function. The findings build on a growing body of evidence showing the negative impact of high-fat, high-sugar (HFHS) diets on cognitive ability, adding to their well-known physical effects.

Research 341
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Etiome, a new Flagship startup, looks to catch disease before it strikes

BioPharma Drive: Drug Pricing

The biotech is using AI and a trove of health data to better understand why certain conditions progress and intervene beforehand with a targeted medication.

Disease 179
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Reports Document FDA Review Delays: What Drugmakers Should Know Now

FDA Law Blog: Drug Discovery

By John W.M. Claud & Michelle L. Butler Recent reductions in force (RIFs) and leadership changes at FDA are already affecting key agency functionsand as the administration plans a broader reorganization, the impact will likely grow. One area drawing increasing attention is how these changes will affect the drug development and review process. As reported by the Wall Street Journal last week , reviews of both innovative and follow-on drugs have been caught in a traffic jam, largely due to a

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Opioids Tough To Prescribe For Legitimate Patients, Doctors Say

Drugs.com

THURSDAY, April 24, 2025 Patients who legitimately need opioid painkillers are finding it more difficult to get the meds they need, due to guardrails established in response to the U.S. opioid crisis, a new study says.Doctors who treat patients i.

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Awkward. Humans are still better than AI at reading the room

Science Daily: Pharmacology News

Humans are better than current AI models at interpreting social interactions and understanding social dynamics in moving scenes. Researchers believe this is because AI neural networks were inspired by the infrastructure of the part of the brain that processes static images, which is different from the area of the brain that processes dynamic social scenes.

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Caribou, in reversal, scraps autoimmune cell therapy and cuts staff

BioPharma Drive: Drug Pricing

The CRISPR company is laying off about a third of its employees and stopping work on an experimental lupus treatment in a bid to focus resources on a pair of cancer cell therapies.

Therapies 177
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Inavolisib

New Drug Approvals

Inavolisib WeightAverage: 407.378 Monoisotopic: 407.140510438 Chemical FormulaC 18 H 19 F 2 N 5 O 4 GDC-0077 CAS 2060571-02-8 GDC0077 RG6114 WHO 11204 GDC 0077 GDC-0077 RG-6114 RG6114 RO-7113755 RO7113755 FDA APPROVED, 10/10/2024, Itovebi , To treat locally advanced or metastatic breast cancer Drug Trials Snapshot (2 S )-2-[[2-[(4 S )-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide (2S)-2-((2-((4S)-4-(difluoromethyl)-2-oxo-3-oxazoli

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Antibiotics Might Increase Risk of Childhood Asthma, Allergies

Drugs.com

WEDNESDAY, April 23, 2025 -- Overuse of antibiotics might increase kids risk of developing asthma and allergies, by disrupting their gut bacteria during a crucial stage of child development, a new study says.Exposure to antibiotics prior to age 2 i.

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What happens in the brain when your mind blanks

Science Daily: Pharmacology News

Mind blanking is a common experience with a wide variety of definitions ranging from feeling 'drowsy' to 'a complete absence of conscious awareness.' Neuroscientists and philosophers compile what we know about mind blanking, including insights from their own work observing people's brain activity.

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Former Neumora CEO to lead Galapagos spinout

BioPharma Drive: Drug Pricing

Henry Gosebruch is now chief executive of the spinout, which has roughly $2.5 billion and plans to use dealmaking to build a research pipeline targeting cancer, viruses and the immune system.

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