Sat.Dec 07, 2024 - Fri.Dec 13, 2024

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Nobel Prize celebrates AI’s role in protein structure innovation

Drug Target Review

The 2024 Nobel Prize in Chemistry was awarded to Demis Hassabis and John Jumper from Google DeepMind for developing AlphaFold2, and to David Baker from the University of Washington for his work in computational protein design. These innovations have revolutionised the understanding of protein structures using artificial intelligence. Before AlphaFold, determining 3D protein structures was complex and time-consuming, and often required the use of experimental methods like X-ray crystallography an

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Early-onset colorectal cancer cases surge globally

Science Daily: Pharmacology News

Researchers show that early-onset colorectal cancer (CRC) incidence rates are rising in 27 of 50 countries/territories worldwide, 20 of which have either exclusive or faster increases for early-onset disease. In 14 countries, including the United States, rates are increasing in young adults while stabilizing in those 50 years and older.

Disease 297
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CDMO Selection: The Ultimate Checklist

Drug Patent Watch

The biopharmaceutical industry has witnessed a significant surge in the number of therapeutic molecules in development, leading to a corresponding increase in the number of contract development and manufacturing organizations (CDMOs). This growth has created a competitive landscape where pharmaceutical companies must carefully evaluate and select the right CDMO partner to ensure the success of their projects.

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Eat Less Meat, More Beans & Lentils for Protein, New USDA Guidelines Say

Drugs.com

FRIDAY, Dec. 13, 2024 -- Beans, peas and lentils take center stage in newly proposed changes to dietary guidelines for Americans. In a report released this week by an advisory committee to the Agriculture Department, experts suggest that the.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Vault Snack #27 - Hazard Codes

Collaborative Drug

Vault Snack #27 - Hazard Codes

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The Benefits of Integrated CDMO Services: Streamlining Drug Development and Manufacturing

Drug Patent Watch

The pharmaceutical industry has undergone significant changes over the past decade, with a growing trend towards outsourcing key aspects of research, development, and manufacturing to third-party vendors. This shift has led to the emergence of integrated contract development and manufacturing organizations (CDMOs), which provide end-to-end support for drug developers.

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Reiki May Help Ease the Pain of Cancer Treatment

Drugs.com

FRIDAY, Dec. 13, 2024 -- The ancient Japanese practice of reiki "energy healing" might help some cancer patients deal with the pain that can come with infusion therapies, new research shows. "Outpatients receiving reiki during infusion reported.

Treatment 246
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Vault Snack #26 - Using Saved Searches to Automate Screening

Collaborative Drug

Vault Snack #26 - Using Saved Searches to Automate Screening

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Heart of Jovian moon's volcanic rage

Science Daily: Pharmacology News

A new study points to why, and how, Io became the most volcanic body in the solar system.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Pharmacognosy and Drug Patents: Unveiling Nature’s Medicinal Treasures

Drug Patent Watch

In the vast realm of pharmaceutical research and development, there’s a fascinating intersection between ancient wisdom and modern science. This intersection is where pharmacognosy meets drug patents, creating a unique landscape that shapes the future of medicine. But what exactly is pharmacognosy, and how does it relate to the complex world of drug patents?

Drugs 97
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Breast, Ovary Removal Can Lengthen Lives of Women With Breast Cancer Genes

Drugs.com

FRIDAY, Dec. 13, 2024 -- It's a decision no woman wants to have to make, but new research shows that young breast cancer patients with high-risk genes may be able to prevent their cancer from returning if they have their breasts or ovaries.

Research 246
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Toxicology transformed: Why accuracy now leads the way

Drug Target Review

In recent years, regulatory focus has shifted from sensitivity to accuracy, marking a pivotal change in how we approach toxicological assessments. While sensitivity remains essential, our growing understanding of toxicology highlights the critical importance of precise target analysis. This shift in focus is especially critical in toxicology, where accurate target analysis plays a vital role in identifying toxic effects and ensuring patient safety, particularly as the field transitions from trad

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A new timeline for Neanderthal interbreeding with modern humans

Science Daily: Pharmacology News

Neanderthal genes make up 1-2% of the genomes of non-Africans. Scientists analyzed the lengths of regions of Neanderthal DNA in 58 ancient Eurasian genomes of early modern humans and determined that the introgressed genes result from interbreeding between Homo sapiens and Neanderthals about 47,000 years ago, over a single, extended period of about 7,000 years.

DNA 291
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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How to Identify Branded Drugs with a Low Likelihood of Generic Entry as Targets for In-Licensing

Drug Patent Watch

Identifying branded drugs with a low likelihood of generic entry has become a crucial strategy for companies looking to expand their product portfolio through in-licensing. This approach not only helps maintain market exclusivity but also ensures a steady revenue stream for pharmaceutical companies. In this comprehensive guide, we’ll explore the intricacies of identifying such drugs and leveraging them for successful in-licensing opportunities.

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Blood Test Might Alert Doctors to Problem Drinking

Drugs.com

FRIDAY, Dec. 13, 2024 -- Have you been boozing more often than usual? A new blood test might be able to tell if you’re damaging your liver from too many beers, margaritas or belts of scotch, researchers report. A blood-borne byproduct of.

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Redefining Success in IBD Drug Discovery with Human Tissue Models

Reprocell

Inflammatory bowel disease (IBD) is rising in prevalence across the globe, as the number of individuals diagnosed with the condition has increased by 95% since 1990. 1 Despite the recent scientific advances in therapies for IBD, including ulcerative colitis and Crohns disease, there are still persistent unmet medical needs due to the complexity and chronic nature of these conditions.

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Breakthrough brings body-heat powered wearable devices closer to reality

Science Daily: Pharmacology News

A research team has developed an ultra-thin, flexible film that could power next-generation wearable devices using body heat, eliminating the need for batteries.

Research 291
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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India’s Growing Importance in Generic Drug API Manufacturing

Drug Patent Watch

India has long been recognized as a significant player in the global pharmaceutical industry, particularly in the production of generic drugs. The country’s pharmaceutical sector has experienced substantial growth over the years, driven by both domestic and international demand for affordable and high-quality medicines. This article delves into India’s growing importance in generic drug API manufacturing, highlighting the key factors contributing to its success and the challenges it

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U.S. Adult Obesity Rate Fell in 2023, as Use of GLP-1 Meds Rose

Drugs.com

FRIDAY, Dec. 13, 2024 -- The U.S. obesity rate declined for the first time in a decade last year, coinciding with the rise of GLP-1 weight-loss meds, a new study finds. Data on almost 17 million adults nationwide showed the obesity rate -- which.

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Exploring Extended Warheads toward Developing Cysteine-Targeted Covalent Kinase Inhibitors

Covalent Modifiers

Zheng Zhao and Philip E. Bourne Journal of Chemical Information and Modeling 2024 DOI: 10.1021/acs.jcim.4c00890 In designing covalent kinase inhibitors (CKIs), the inclusion of electrophiles as attacking warheads demands careful choreography, ensuring not only their presence on the scaffold moiety but also their precise interaction with nucleophiles in the binding sites.

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Researchers discover new third class of magnetism that could transform digital devices

Science Daily: Pharmacology News

A new class of magnetism called altermagnetism has been imaged for the first time in a new study. The findings could lead to the development of new magnetic memory devices with the potential to increase operation speeds of up to a thousand times.

Research 291
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Overcoming challenges in biosimilar analytical characterization

Drug Patent Watch

Biosimilars have faced significant challenges in their analytical characterization. This process involves a comprehensive analysis of the biosimilar’s molecular structure, biological activity, and other quality characteristics to demonstrate similarity to the reference product. The emphasis on analytical and functional testing through sophisticated technology is crucial in overcoming these challenges.

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Newer Drug Imlunestrant Could Be Advance Against Tough-to-Treat Breast Cancers

Drugs.com

FRIDAY, Dec. 13, 2024 -- An experimental hormone therapy pill has shown promise in extending the lives of women with tough-to-treat advanced breast cancer, a new clinical trial shows. The drug, imlunestrant, improved progression-free survival in.

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#WhyIScience Q&A: A computational biologist’s world travels have shaped her approach to research

Broad Institute

#WhyIScience Q&A: A computational biologists world travels have shaped her approach to research By Corie Lok December 11, 2024 Breadcrumb Home #WhyIScience Q&A: A computational biologists world travels have shaped her approach to research Wolu Chukwu talks about how she brings a community-first focus to her work in cancer genetics. By Corie Lok December 11, 2024 Credit: Allison Colorado, Broad Communications Wolu Chukwu is a computational biologist studying cancer genetics at Broad.

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AI thought knee X-rays show if you drink beer -- they don't

Science Daily: Pharmacology News

A new study highlights a hidden challenge of using AI in medical imaging research -- the phenomenon of highly accurate yet potentially misleading results known as 'shortcut learning.' The researchers analyzed thousands of knee X-rays and found that AI models can 'predict' unrelated and implausible traits such as whether patients abstained from eating refried beans or beer.

Research 291
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How do patent thickets vary across different countries

Drug Patent Watch

Patents play a crucial role in protecting intellectual property and fostering innovation. However, the increasing complexity of patent systems has given rise to a phenomenon known as “patent thickets.” These dense webs of overlapping patent rights can significantly impact innovation, market entry, and competition across various industries and countries.

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FDA Revokes EUAs for Four Monoclonal Antibody Products

Drugs.com

December 13, 2024 -- At the request of the individual product sponsors, FDA has revoked the Emergency Use Authorizations (EUAs) for four respective monoclonal antibody (mAb) products that had been authorized for emergency use as part of the United.

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Discovery of Voreloxin as a Dual‐Selective Stabilizer for c‐Myc/Bcl‐2 G‐Quadruplexes in Leukemia

Chemical Biology and Drug Design

The stabilization of the G-quadruplex region in the c-Myc and Bcl-2 promoter genes by voreloxin leads to the downregulation of c-Myc and Bcl-2 expression, resulting in apoptosis of leukemia cells. ABSTRACT Overexpression of c-Myc is a key factor in the development of leukemia and other malignancies, highlighting the urgent need for novel drugs to inhibit c-Myc protein levels.

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Scientists transform ubiquitous skin bacterium into a topical vaccine

Science Daily: Pharmacology News

Scientists' findings in mice could translate into a radical, needle-free vaccination approach that would also eliminate reactions including fever, swelling and pain.

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