Sat.Dec 14, 2024 - Fri.Dec 20, 2024

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Chart of life extended by nearly 1.5 billion years

Science Daily: Pharmacology News

Fossilized skeletons and shells clearly show how evolution and extinction unfolded over the past half a billion years, but a new analysis extends the chart of life to nearly 2 billion years ago. The chart shows the relative ups and downs in species counts, telling scientists about the origin, diversification, and extinction of ancient life. With this new study, the chart of life now includes life forms from the Proterozoic Eon, 2,500 million to 539 million years ago.

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How AI will reshape pharma by 2025

Drug Target Review

Artificial intelligence (AI) has revolutionised many industries, yet its adoption in pharmaceutical drug development has been notably slower. Concerns surrounding data security, the complexity of AI systems, and the rigorous regulatory frameworks in this field have caused the pharmaceutical industry to approach these technologies with caution. For years, AI and machine learning (ML) were often dismissed as little more than advanced statistics with little practical value in drug development.

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Covalent inhibitors of the RAS binding domain of PI3Ka impair tumor growth driven by RAS and HER2

Covalent Modifiers

Joseph E Klebba, Nilotpal Roy, Steffen M Bernard, Stephanie Grabow, Melissa A. Hoffman, Hui Miao, Junko Tamiya, Jinwei Wang, Cynthia Berry, Antonio Esparza-Oros, Richard Lin, Yongsheng Liu, Marie Pariollaud, Holly Parker, Igor Mochalkin, Sareena Rana, Aaron N. Snead, Eric J. Walton, Taylor E. Wyrick, Erick Aitichson, Karl Bedke, Jacyln C. Brannon, Joel M.

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Novo’s next-gen obesity drug misses expectations in closely watched trial

BioPharma Drive: Drug Pricing

Novo shares lost nearly a quarter of their value after an experimental combination treatment called cagrisema fell short of the bar set by executives.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Can the heart heal itself? New study says it can

Science Daily: Pharmacology News

Physician-scientists found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure heart failure.

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2025: Perspectives and Predictions From Advarra Thought Leaders

Advarra

2024 has been a year of growth and evolution in clinical research. The coming year is expected to be no different. As we look to 2025, Advarra thought leaders have compiled predictions and perspectives on key topics shaping the industry. These topics include perspectives on how artificial intelligence (AI) will be leveraged in clinical research, key regulatory trends shaping the industry, the movements of site consolidation, the continued challenges (and potential solutions) of study startup, an

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Zepbound, Mounjaro shortages are resolved, FDA confirms

BioPharma Drive: Drug Pricing

The FDA’s decision will close a lucrative market opportunity for compounding pharmacies, although the agency will give a limited grace period before taking any enforcement actions.

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Laser-based artificial neuron mimics nerve cell functions at lightning speed

Science Daily: Pharmacology News

Researchers developed a laser-based artificial neuron that fully emulates the functions, dynamics and information processing of a biological graded neuron, which could lead to new breakthroughs in advanced computing. With a processing speed a billion times faster than nature, chip-based laser neuron could help advance AI tasks such as pattern recognition and sequence prediction.

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Study Supports Tamoxifen for DCIS Early Breast Cancers

Drugs.com

MONDAY, Dec. 16, 2024 -- The established hormone therapy drug tamoxifen can significantly decrease the risk of cancer recurring in women with an early, low-risk form of breast cancer, a new study says. Women who took tamoxifen after undergoing a.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Effective Drug Patent Prosecution Strategies: Securing Your Pharmaceutical Innovations

Drug Patent Watch

Protecting your intellectual property is paramount. Drug patent prosecution is a complex and critical process that can make or break the success of a new medication. As a business professional in the pharmaceutical industry, understanding and implementing effective strategies for drug patent prosecution can be the difference between market domination and missed opportunities.

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Merck calls quits on two immunotherapies for cancer

BioPharma Drive: Drug Pricing

The company is scrapping two drugs aimed at targets called TIGIT and LAG-3, both of which were in the middle of Phase 3 testing.

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Carnivorous squirrels documented in California

Science Daily: Pharmacology News

California ground squirrels hunt, kill and eat voles, reveals a new study documenting evidence of widespread carnivorous behavior among squirrels.

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Tainted Cucumbers Now Linked to 100 Salmonella Cases in 23 States

Drugs.com

FRIDAY, Dec. 20, 2024 -- An outbreak of salmonella linked to cucumbers has now been tied to 100 known cases of the illness across 23 states, the U.S. Food and Drug Administration reported Thursday. That's up from 68 cases reported in the FDA's last.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Universal Design for Visual Disabilities in Healthcare – Addressing Complete Blindness – 6

Perficient: Drug Development

Welcome to our ongoing series on Universal Design for Healthcare! In this segment, well explore the importance of Visual Disabilities in Healthcare. Creating an inclusive healthcare environment for individuals with complete blindness is a fundamental aspect of universal design. These individuals rely heavily on non-visual cues to navigate, access information, and communicate effectively.

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Sanofi, Teva say study results show gut disease drug could be ‘best in class’

BioPharma Drive: Drug Pricing

Phase 2 results in inflammatory bowel disease hinted the therapy could be more potent than similar medicines from Merck and Roche, each of which were acquired in multibillion-dollar deals.

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Large Hadron Collider regularly makes magic

Science Daily: Pharmacology News

A brotherly research duo has discovered that when the Large Hadron Collider (LHC) produces top quarks -- the heaviest known fundamental particles -- it regularly creates a property known as magic.

Research 306
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Early Research Points to Possible New Parkinson's Drug

Drugs.com

THURSDAY, Dec. 19, 2024 -- Parkinson's is a relentless disease for which few treatments, and no real cure, exists. Now, researchers say they are on the trail of a potential new therapy for the disabling neurological illness.It's early research.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Microbiological Applications: Bacterial Metabolism | BMG LABTECH

BMG Labtech

Bacterial metabolism applications Bacterial metabolism spans the complex interconnected set of chemical reactions that support life in bacteria, ancient single-celled organisms that represent one of the most diverse forms of life on Earth. Bacterial metabolism is the foundation for bacterial growth and is inextricably linked to other organisms in the ecosystem.

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Roche sticks with Parkinson’s drug despite second study failure

BioPharma Drive: Drug Pricing

Even with another mid-stage setback, Roche believes there were enough positive signs to “merit further exploration” of the drug, which it’s been developing with Prothena for more than a decade.

Drugs 261
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Massive volcanic eruptions did not cause the extinction of dinosaurs

Science Daily: Pharmacology News

While volcanism caused a temporary cold period, the effects had already worn off thousands of years before the meteorite, the ultimate cause of the dinosaur extinction event, impacted.

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Patient Hospitalized in Louisiana With First U.S. Case of Severe Bird Flu

Drugs.com

WEDNESDAY, Dec. 18, 2024 -- In a case first reported in Louisiana last Friday, a patient has now developed the first known case of bird flu so severe as to require hospitalization, according to the U.S. Centers for Disease Control and Prevention.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Universal Design for Visual Disabilities in Healthcare – Clear and Accessible Communication – 4

Perficient: Drug Development

Welcome to our ongoing series on Universal Design for Healthcare! In this segment, well explore the importance of Visual Disabilities in Healthcare. Effective communication is vital in healthcare, and ensuring that it is accessible to individuals with visual disabilities is an essential aspect of universal design. Clear and accessible communication methods help patients understand their health information, engage with their care, and make informed decisions.

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A Vertex partner — and potential rival — secures $100M to develop non-opioid pain drugs

BioPharma Drive: Drug Pricing

“Pain has really been out of favor in the industry up until very recently,” said John Mulcahy, SiteOne Therapeutics’ CEO. The company plans to use its new funds to get to “proof of concept” for its medicines.

Drugs 261
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Tinkering with the 'clockwork' mechanisms of life

Science Daily: Pharmacology News

Opening new doors for the development of nanotechnologies in medicine and other fields, scientists recreate and compare two natural mechanisms to better program the timescale of molecular communication and functionality.

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California Declares Bird Flu Emergency as Outbreak in Cows Continues

Drugs.com

THURSDAY, Dec. 19, 2024 -- California Gov. Gavin Newsom declared a public health emergency on Wednesday as bird flu continues to spread among the states dairy cattle.This proclamation is a targeted action to ensure government agencies have the res.

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Oncology advances through the lens of women in STEM

Drug Target Review

Dr Pooja Hingorani, Senior Medical Director of Oncology Early Development at AbbVie , shares her journey in STEM, from her early days in New Delhi to her impactful career in oncology research and drug development. Despite challenges as a woman in the field, Dr Hingorani built a career focused on advancing treatments for pediatric and adult cancers. In this interview, she discusses her path to becoming a physician and clinical researcher, the obstacles she faced, and her dedication to improving o

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Merck targets 2025 RSV season with antibody now under FDA review

BioPharma Drive: Drug Pricing

An FDA approval of Merck’s drug clesrovimab by June would give physicians another option for protecting newborns from respiratory syncytial virus.

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Antibody that neutralizes inhibitory factors involved in nerve regeneration leads to enhanced motor function after acute spinal cord injury

Science Daily: Pharmacology News

Antibodies can improve the rehabilitation of people with acute spinal cord injury. Researchers have investigated this with promising results. For the first time, it was possible to identify patient groups that displayed a clinically relevant treatment effect.

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What's the Link Between Memory Problems and Sexism?

Drugs.com

FRIDAY, Dec. 20, 2024 -- Sexism is incredibly toxic to womens lives, resulting in lower pay, fewer career opportunities, worse health care and a greater risk of violence.It also can be toxic to their brain health, a new study says.U.S. women born i.

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