Sat.Mar 23, 2024 - Fri.Mar 29, 2024

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Research uncovers how to target dormant breast cancer cells

Drug Discovery World

Scientists have discovered how breast cancer cells can ‘hibernate’ to avoid treatment and ‘wake up’ years later – causing a relapse that is more difficult to treat. Their research, published in the journal Cancer Discovery , reveals the role of epigenetics in controlling how cancer cells can become dormant – and suggests a strategy to target it before the cells wake up.

Research 264
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Robot, can you say 'cheese'?

Science Daily: Pharmacology News

What would you do if you walked up to a robot with a human-like head and it smiled at you first? You'd likely smile back and perhaps feel the two of you were genuinely interacting. But how does a robot know how to do this? Or a better question, how does it know to get you to smile back?

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U.S. Mpox Cases Rising Again as Vaccinations Lag

Drugs.com

THURSDAY, March 28, 2024 -- Mpox cases are climbing again in the United States, with the number of reported infections now twice as high as they were at this time last year, new government data shows.In response, public health experts have raised.

Vaccine 134
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Unlocking the potential of natural products in drug discovery

Drug Target Review

Between 2000 and 2020, approximately 30 percent of the newly introduced small molecule drugs were derived from natural products. 1 Surprisingly, however, less than one percent of the natural world’s chemical composition has been identified or studied by scientists. While plant-derived molecules (phytochemicals) have long played an essential role in drug discovery due to their diverse biological activities and chemical properties, the reliance on time-consuming and expensive screening techniques

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Conversations from ESMO Targeted Anticancer Therapies Congress 2024 

Drug Discovery World

DDW’s Megan Thomas caught up with Oliver Rausch, Chief Scientific Officer at Storm Therapeutics, following the ESMO Targeted Anticancer Therapies Congress 2024, a global meeting focusing on promising new anticancer targets and agents, focusing on those in early phase clinical development. Rausch gave an update on the latest developments from the conference and scientific findings the company presented at the meeting.

Therapies 162
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New imaging method illuminates oxygen's journey in the brain

Science Daily: Pharmacology News

A new bioluminescence imaging technique has created highly detailed, and visually striking, images of the movement of oxygen in the brains of mice. The method, which can be easily replicated by other labs, will enable researchers to more precisely study forms of hypoxia in the brain, such as the denial of oxygen to the brain that occurs during a stroke or heart attack.

Disease 134

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High-Strength Lidocaine Skin Creams Can Cause Seizures, Heart Trouble, FDA Warns

Drugs.com

FRIDAY, March 29, 2024 -- Some pain-relieving skin products contain potentially harmful doses of the numbing agent lidocaine and should be avoided, the U.S. Food and Drug Administration warns.These creams, gels, sprays and soaps are marketed for.

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Read the Spring issue of DDW now

Drug Discovery World

The Spring issue of Drug Discovery World (DDW) is out now. It looks at where we are in the fight against antimicrobial resistance, explores how structural biology is informing vaccine design, and offers advice on approaching dealmaking in biopharma. Read the digital version here. Other features in the Spring issue include: A market report on the drug discovery hotspots in Europe.

Therapies 162
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Alcohol raises heart disease risk, particularly among women

Science Daily: Pharmacology News

Young to middle-aged women who reported drinking eight or more alcoholic beverages per week--more than one per day, on average--were significantly more likely to develop coronary heart disease compared with those who drank less, finds a study presented at the American College of Cardiology's Annual Scientific Session. The risk was highest among both men and women who reported heavy episodic drinking, or 'binge' drinking, and the link between alcohol and heart disease appears to be especially str

Disease 133
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Gilead bets on Xilio cancer drug as biotech restructures

BioPharma Drive: Drug Pricing

Xilio will get just over $40 million from Gilead in return for a license to its experimental IL-12 immunotherapy. The biotech is also discontinuing other work and laying off staff.

Licensing 115
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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CDC Warns of Spike in Bacterial Illness That Can Cause Meningitis

Drugs.com

FRIDAY, March 29, 2024 -- There has been a troubling rise in cases of a rare bacterial illness that can cause meningitis, U.S. health officials warned Thursday.In an alert issued to doctors, the U.S. Centers for Disease Control and Prevention said.

Doctors 119
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This week in drug discovery (25-29 March) 

Drug Discovery World

News round-up for 25-29 March by DDW Digital Content Editor Diana Spencer. In another busy week for drug discovery and development, we have seen the FDA approval of a monoclonal antibody for emergency use in Covid-19, the launch of trials into innovative new treatments for urea cycle disorders and alcohol use disorder, and a significant acquisition for Novo Nordisk, as well as the discovery of a new way to target dormant cancer cells.

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Risk factors for faster aging in the brain revealed in new study

Science Daily: Pharmacology News

Researchers have used data from UK Biobank participants to reveal that diabetes, traffic-related air pollution and alcohol intake are the most harmful out of 15 modifiable risk factors for dementia.

Research 129
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Antidote anecdotes: A conversation with an MS care partner

Antidote

MS is a chronic disease that is estimated to impact over a million Americans. The condition causes damage to the body’s central nervous system, leading to numbness, memory problems, sight issues, and difficulties with coordination.

Disease 116
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Another Study Warns of Surgery Risks for Folks Taking Ozempic, Wegovy

Drugs.com

FRIDAY, March 29, 2024 -- People taking weight-loss drugs like Ozempic and Wegovy need to drop them in the days or weeks prior to surgery, a new study warns.Folks on one of these drugs -- known as GLP-1 receptor agonists -- have a 33% higher risk.

Drugs 115
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Japan becomes first country to approve Astellas’ gastric cancer mAb

Drug Discovery World

Japan’s Ministry of Health, Labour and Welfare (MHLW) has approved Vyloy (zolbetuximab), an anti-claudin 18.2 (CLDN18.2) monoclonal antibody for patients with CLDN18.2 positive, unresectable, advanced or recurrent gastric cancer. Vyloy is the first and only CLDN18.2-targeted therapy approved by any regulatory agency in the world. Gastric cancer is the third deadliest cancer in Japan, with 126,724 cases diagnosed in 2022.

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Scientists extract genetic secrets from 4,000-year-old teeth to illuminate the impact of changing human diets over the centuries

Science Daily: Pharmacology News

Researchers have recovered remarkably preserved microbiomes from two teeth dating back 4,000 years, found in an Irish limestone cave. Genetic analyses of these microbiomes reveal major changes in the oral microenvironment from the Bronze Age to today. The teeth both belonged to the same male individual and also provided a snapshot of his oral health.

Research 130
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FDA rejects Regeneron lymphoma drug, setting back company’s oncology push

BioPharma Drive: Drug Pricing

The agency wants Regeneron to make more progress with a confirmatory trial before clearing odronextamab, a “bispecific” antibody being developed for multiple blood cancers.

FDA 116
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Cases of Drug-Resistant Gonorrhea Have Tripled in China, Posing a Global Threat

Drugs.com

THURSDAY, March 28, 2024 -- A strain of highly antibiotic-resistant gonorrhea first emerged in China in 2016, and cases of this tough-to-treat infection have tripled there in just five years, Chinese researchers report. It's a warning to the rest.

Drugs 116
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Breakthroughs in oncology research and drug discovery

Drug Discovery World

This 24-page eBook sponsored by Sino Biological explores the latest innovations in cancer therapeutics and where we can expect the greatest breakthroughs in the future. Download this exclusive eBook to learn more about: The opportunities and advances in cancer research Why liquid biopsies are important in precision medicine trials for cancer How genetic tuning will transform the reach for CAR-T therapies The latest developments in breast cancer therapy The post Breakthroughs in oncology research

Research 130
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Persian plateau unveiled as crucial hub for early human migration out of Africa

Science Daily: Pharmacology News

A new study combining genetic, palaeoecological, and archaeological evidence has unveiled the Persian Plateau as a pivotal geographic location serving as a hub for Homo sapiens during the early stages of their migration out of Africa. It highlights the period between 70,000 to 45,000 years ago when human populations did not uniformly spread across Eurasia, leaving a gap in our understanding of their whereabouts during this time frame.

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Bristol Myers says KRAS drug succeeds in key trial

BioPharma Drive: Drug Pricing

Confirmatory results for Krazati, which Bristol Myers acquired via its buyout of Mirati, could help the drug win full approval while Amgen has been set back.

Trials 117
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Common Household Chemicals Could Harm the Brain

Drugs.com

TUESDAY, March 26, 2024 -- Chemicals found in common household products might damage the brain's wiring, a new study warns. These chemicals -- found in disinfectants, cleaners, hair products, furniture and textiles -- could be linked to.

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Teva and Daiichi Sankyo found in breach of the UK ABPI Code

Drug Discovery World

Both Teva and Daichi Sankyo have been found to be in breach of the Association of the British Pharmaceutical Industry (ABPI) Code of Practice by the Prescription Medicines Code of Practice Authority (PMCPA). Teva was ruled in breach of several clauses of the 2019 Code for failing to include the black triangle for Ajovy in an article which, in the Panel’s view, Teva was responsible for and was promotional.

Licensing 130
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Mechanism found to determine which memories last

Science Daily: Pharmacology News

Neuroscientists have established in recent decades the idea that some of each day's experiences are converted by the brain into permanent memories during sleep the same night. Now, a new study proposes a mechanism that determines which memories are tagged as important enough to linger in the brain until sleep makes them permanent.

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#WhyIScience Q&A: A cell biologist now helps recent college graduates launch their scientific careers

Broad Institute

#WhyIScience Q&A: A cell biologist now helps recent college graduates launch their scientific careers By Leah Eisenstadt March 25, 2024 Breadcrumb Home #WhyIScience Q&A: A cell biologist now helps recent college graduates launch their scientific careers Alex Navarro draws from her scientific and personal experiences to guide young researchers toward their professional goals in the Broad’s post-baccalaureate program.

Science 111
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Eli Lilly Warns That 2 Insulin Products Will Be in Short Supply

Drugs.com

MONDAY, March 25, 2024 -- Drugmaker Eli Lilly & Co is announcing a temporary shortage of two of its insulin products."The 10 mL [millilter] vials of Humalog® and Insulin Lispro Injection are or will be temporarily out of stock at wholesalers.

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Last chance to register: Enhancing collaboration in drug discovery

Drug Discovery World

Join DDW and Cresset for this free event ‘ Enhancing collaboration in drug discovery – a biotech perspective ’. The event will take place on 28 March at 2pm GMT / 3pm CET / 9am EST / 6am PST. Delivery of synthesis targets within small molecule drug discovery often involves many chemists and other collaborators, both internal and external, across multiple locations.

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Researchers turn back the clock on cancer cells to offer new treatment paradigm

Science Daily: Pharmacology News

Scientists reversed an aggressive cancer, reverting malignant cells towards a more normal state. Rhabdoid tumors are an aggressive cancer which is missing a key tumor suppressor protein. Scientists discovered that removing a second protein from cancer cells already experiencing tumor suppressor loss can reverse cancer cell identity.

Treatment 120
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FDA approves Merck lung disease drug acquired in $11B deal

BioPharma Drive: Drug Pricing

Merck is couting on Winrevair, which it acquired by buying Acceleron Pharma, to help soften the blow when Keytruda loses patent protection later this decade.

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FDA May Ban Electroshock Devices Used on Some Psychiatric Patients

Drugs.com

MONDAY, March 25, 2024 -- Federal regulators are taking a second stab at banning the controversial use of electroshock devices to manage the behavior of patients with intellectual and developmental disorders.The devices deliver electric shocks to a.

FDA 115
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World Tuberculosis Day 2024: New vaccines offer hope

Drug Discovery World

The vaccines currently in late-stage development hold promise in tackling the disease burden of tuberculosis (TB), says data and analytics company GlobalData on World Tuberculosis Day 2024. World TB Day is marked annually on 24 March, the anniversary of the discovery of the causative mycobacterium by Dr Robert Koch. The day aims to raise awareness about the devastating health, social, and economic consequences of the disease.

Vaccine 130
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Want to feel young? Protect your sleep

Science Daily: Pharmacology News

Do you ever find yourself longing for the energy and vitality of your younger years? Feeling young is not just a matter of perception it is actually related to objective health outcomes. Previous studies have shown that feeling younger than one s actual age is associated with longer, healthier lives. There is even support for subjective age to predict actual brain age, with those feeling younger having younger brains.

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Viking stays in obesity drug race with early data for weight loss pill

BioPharma Drive: Drug Pricing

The results are from a small Phase 1 study, but suggest Viking’s oral GLP-1 drug may not come with high rates of gastrointestinal side effects.

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