Engineering Molecular Biology RNA 
Codon
JUNE 5, 2025
The core of the CRISPR immune response is a guide RNA (gRNA) that binds to a CRISPR-associated (Cas) protein. This article provides a summary of the major CRISPR systems, 2 including the naturally occurring CRISPR-Cas9, -Cas12, and -Cas13 systems, as well as base editors, prime editors, and the recently uncovered bridge RNA system.
Codon
NOVEMBER 1, 2024
I’ve chosen these two because I think they are the linchpin by which we’ll be able to build broadly useful AI models for cell and molecular biology. Scientists are already building a model that can, for example, look at which RNA molecules are expressed in a cell at t=0 and predict how those molecules will change at t=1.
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Broad Institute
FEBRUARY 24, 2025
Although this ancestral replicase appears to have been lost, key aspects of RNA-catalyzed RNA replication can be studied by proxy with the use of modern RNA enzymes (ribozymes) generated by in vitro evolution. However, none of these RPRs was capable of self-replication.
The Pharma Data
JANUARY 19, 2021
In the paper, researchers from Johns Hopkins University and elsewhere found a natural long-form transactivating CRISPR RNA (tracr-L) in Streptococcus pyogenes that functions to downregulate its endogenous CRISPR-Cas9 system. But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts.
Drug Target Review
JUNE 11, 2024
When choosing my bachelor’s degree, the choice was between pursuing a career in biology or in computer science. Biology won that battle, and I pursued a bachelor’s and master’s degree in biochemistry and molecular biology. I had my first scientific encyclopaedia around the age of seven.
Elrig
APRIL 29, 2024
She has played a key role inbuilding the target identification platform and a proprietary database of transcriptome-wide, functional RNA structures. Having a combination of computational skills & scientific knowledge such as molecular biology, genomics is also important.
Drug Target Review
AUGUST 29, 2023
At Alltrna, we are developing tRNA medicines where one engineered tRNA medicine can precisely correct a type of mutation across thousands of genetic diseases driven by the same genetic mutation, thereby providing precision treatment to patients, agnostic to the prevalence of the disease. Before joining Flagship, Theonie received her Ph.D.
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