Remove Immune Response Remove Laboratories Remove RNA
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Decoding stem cells for personalised regenerative medicine

Drug Target Review

In research published in Scientific Reports , 1 investigators focused on mesenchymal stem cells (MSCs), known for their potential in treating cell defects and regulating immune responses. The experiment comprised two components: computational methodology development and laboratory experiments.

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Phages could help to tackle antimicrobial resistance

Drug Target Review

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. In bacteria , cGAS-like cyclases are central parts of the CBASS immune response.

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Understanding how macrophages direct tissue regeneration

Drug Target Review

Adult laboratory mice heal injuries with scar tissue, but spiny mice have the unique ability to regrow lost skin and regenerate musculoskeletal tissues in their body. A study 1 from Seifert’s group, published last year, demonstrated how ERK signalling acts as a crucial switch balancing the healing response. Wiley Online Library.

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Johnson & Johnson’s One-Dose COVID Vaccine Promising in Early Trial

The Pharma Data

The vaccine produced an immune response of all 805 clinical trial participants within two months of inoculation, according to results published Jan. More than 90% of participants mounted an immune response within a month, and all had levels of neutralizing antibodies by day 57. WEDNESDAY, Jan. vaccination efforts.

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A Visual Guide to Genome Editors

Codon

The core of the CRISPR immune response is a guide RNA (gRNA) that binds to a CRISPR-associated (Cas) protein. In wild microbes, Cas9 cuts DNA using two separate RNA molecules, called the CRISPR RNA (crRNA) and trans-activating RNA (tracrRNA). Visit our website to get a copy. Join Asimov Press.

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A therapy candidate for fatal prion diseases turns off disease-causing gene

Broad Institute

CRISPRoff silences the targeted gene by adding methyl groups, chemical tags that prevent the gene from being transcribed or read into RNA and so from being expressed as protein. ZFPs are also common in human cells, meaning they are less likely to trigger an immune response against themselves than the bacterial Cas9.

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Synthetic Origins

Codon

But in those early years, everything in the laboratory was so slow and difficult. AP: We can’t even grow most types of cells in the laboratory. Like, if we start thinking about therapeutic circuits, how can we design the components in such a way that they are not going to cause an immune response? Elowitz: Exactly.

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