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A Visual Guide to Gene Delivery

Codon

For the former, clinicians extract a patient’s cells, engineer them in a laboratory, and then infuse them back into the body. And even if all these economic hurdles are overcome, there are still three main technical challenges to solve: cargo capacity, specificity, and immune response.

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A Visual Guide to Genome Editors

Codon

The core of the CRISPR immune response is a guide RNA (gRNA) that binds to a CRISPR-associated (Cas) protein. In wild microbes, Cas9 cuts DNA using two separate RNA molecules, called the CRISPR RNA (crRNA) and trans-activating RNA (tracrRNA). Visit our website to get a copy. Join Asimov Press.

DNA
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The Long Road to End Tuberculosis

Codon

Working at the famed Pasteur Institute, the duo began by figuring out how best to culture mycobacteria — a seemingly simple, but essential first step, given how no one at the time had yet come up with an effective way of growing these bacteria in the laboratory. tuberculosis. Many more could emerge as machine learning tools improve.

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Decoding stem cells for personalised regenerative medicine

Drug Target Review

In research published in Scientific Reports , 1 investigators focused on mesenchymal stem cells (MSCs), known for their potential in treating cell defects and regulating immune responses. The experiment comprised two components: computational methodology development and laboratory experiments.

RNA
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Phages could help to tackle antimicrobial resistance

Drug Target Review

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. In bacteria , cGAS-like cyclases are central parts of the CBASS immune response.

RNA
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Understanding how macrophages direct tissue regeneration

Drug Target Review

Adult laboratory mice heal injuries with scar tissue, but spiny mice have the unique ability to regrow lost skin and regenerate musculoskeletal tissues in their body. A study 1 from Seifert’s group, published last year, demonstrated how ERK signalling acts as a crucial switch balancing the healing response. Wiley Online Library.

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Johnson & Johnson’s One-Dose COVID Vaccine Promising in Early Trial

The Pharma Data

The vaccine produced an immune response of all 805 clinical trial participants within two months of inoculation, according to results published Jan. More than 90% of participants mounted an immune response within a month, and all had levels of neutralizing antibodies by day 57. WEDNESDAY, Jan. vaccination efforts.