Chemical Biology and Drug Design

DECEMBER 5, 2024

It plays a key role in cancer cell survival and proliferation and regulates immune responses in cancer. ABSTRACT Mer-tyrosine kinase (MERTK), a member of the AXL, TYRO3, and MERTK (TAM) family, is one of the promising targets for cancer treatment.

Immune Response

Drug Target Review

JUNE 16, 2025

Moreover, GPCRs have a complex pharmacology, with each acting as a kind of signalling hub for an array of downstream signals, in contrast to simpler receptors which are generally responsible for one signal.

Disease

Chemical Biology and Drug Design

JANUARY 30, 2025

A pyrazolopyrimidine, 2-((4-methoxyphenyl)amino)-7-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile exhibits TLR7 agonistic activity and stimulates an innate immune response in RAW264.7 These findings suggest that the title compound acts as a TLR7 agonist and enhances the innate immune response. macrophages.

Immune Response

Drug Target Review

NOVEMBER 11, 2024

This is partly because cancer cells are shrewd and often develop ways to evade immune detection. To overcome these escape mechanisms researchers are exploring a wider arsenal of therapeutic strategies. Prior attempts to target CD40 have been limited to varying degrees by unwanted immune activation causing side effects.

Immune Response

Drug Target Review

MAY 23, 2025

As the biotech sector races to improve the tolerability of these revolutionary treatments, Poolbeg Pharma has a novel solution: an oral therapy, POLB 001, to block the development of CRS, by limiting inflammation without affecting the anti-cancer immune responses that are vital for effective immunotherapies.

Immune Response

Alta Sciences

FEBRUARY 19, 2025

Researchers must characterize the anti-drug-antibody (ADA) response in preclinical and clinical studies and report any ADA-positive samples as a risk-based approach. These interactions may disrupt protein function, trigger immune responses, or contribute to other toxicological risks.

Drug Development

Drug Target Review

JULY 18, 2025

With over two decades of experience in biomedical research, he is leading efforts to translate breakthrough GPCR biology into differentiated therapeutic strategies that can overcome immune resistance and offer new hope to patients with limited treatment options. This strategy is exemplified by its flagship programme: DT-7012.

Medical Chemistry

keypoint

JULY 17, 2025

She works in the Institute of Virology, where she characterizes HIV-specific T cell responses in people living with HIV, and endometrial immune responses in the context of infectious diseases and infertility. see photo below)

Immune Response

Broad Institute

MAY 21, 2025

The Merkin Prize recognizes novel technologies that have improved human health and is administered by the Broad Institute, one of the worlds leading biomedical research institutes. He showed that these synthetic CAR T cells could launch an immune response when they encountered the corresponding tumor protein, called CD19.

Therapies

Drug Target Review

APRIL 7, 2025

Involved in various physiological processes, such as vision, taste, smell, immune response and neurotransmission, GPCRs are activated by various molecules including hormones, neurotransmitters and environmental stimuli, which trigger a cascade of cellular events that help regulate bodily functions.

Fragment Screening

The Pharma Data

JUNE 15, 2025

This independent expert panel will aid in evaluating a new, enhanced immunosuppressive regimen meant to help ease the body’s adaptive immune response — a process suspected to contribute to the elevated liver enzyme abnormalities and related events that have been observed in a small number of patients following treatment with AAV-based gene therapy.

Immune Response

The Pharma Data

JUNE 25, 2025

It arises when the recipient’s immune system produces antibodies that attack the transplanted organ. Despite ongoing research and improvements in immunosuppressive therapy, there remains no FDA-approved treatment specifically for AMR , leaving clinicians with limited tools to prevent or manage the condition effectively.

FDA

Codon

JULY 28, 2025

Researchers have identified nearly 10,000 monogenic diseases , or conditions caused by errors in a single gene. Researchers cannot extract, edit, and replace neurons the way they do blood cells, so diseases involving the brain, muscles, or liver require vectors that reach and fix cells in their natural environments.

Immune Response

Drug Target Review

NOVEMBER 7, 2024

Agonist antibodies of immune checkpoint regulators These represent a groundbreaking class of immunotherapeutic agents that mimic the natural function of endogenous ligands by binding to specific cell-surface receptors. In these conditions, the goal of therapy is typically to suppress or mitigate immune activity.

Disease

Drug Target Review

APRIL 18, 2025

He continues to detail how research has uncovered the role of various cell types in tumour development, including macrophages, fibroblasts and, more recently, senescent cells. Further investigation into the mechanism behind SenoVax revealed that CD8+ T, also known as cytotoxic T cells, are central to the immune response.

Therapies

Codon

NOVEMBER 3, 2024

Even after microbiologists discovered the bacterium that causes the illness in 1882, it wasn’t until the 1920s that researchers were able to develop a vaccine for TB. Chilean research participants aged 15 to 35 who received the vaccine during a case-control study , for example, only showed a 10 percent reduced risk of pulmonary TB.

Vaccine

Codon

JUNE 5, 2025

The core of the CRISPR immune response is a guide RNA (gRNA) that binds to a CRISPR-associated (Cas) protein. Researchers have since discovered variants of the protein with additional useful qualities. Researchers have also discovered a slew of small Cas9s — some less than half the size of the S.

DNA

The Open Targets Blog

JANUARY 30, 2025

gget consists of a collection of modules, each enabling researchers to perform common tasks in genomics, transcriptomics, and proteomics data analysis in just one line of code without exceeding the computational capabilities of a laptop.  Was there anything particularly difficult or unexpected in the process of creating gget?

Bioinformatics

Broad Institute

FEBRUARY 26, 2025

Why brain cancer is often resistant to immunotherapy By Allessandra DiCorato February 26, 2025 Breadcrumb Home Why brain cancer is often resistant to immunotherapy Researchers find four coordinated gene expression programs in immune cells from glioma tumors, including two that could lead to immunotherapy resistance.

Immune Response

The Pharma Data

JUNE 12, 2025

An interim statistical analysis confirms that the candidate is meeting its pre-established criteria for immunogenicity — meaning it stimulates a strong and desirable immune response — in trial participants. Importantly, this is a strong indicator that the vaccine could be effective in protecting children against Shigella in the future.

Licensing

Broad Institute

JUNE 25, 2025

To better understand the biological processes at play in strictures, Broad Institute and Massachusetts General Hospital researchers analyzed individual cells from the intestinal tissue of Crohn’s disease patients, measuring gene activity and mapping the cells’ location in the tissue.

Disease

PLOS: DNA Science

JULY 24, 2025

Researchers from Stanford Medicine have done just that – developed a way to prep Fanconi anemia patients for stem cell transplants without the toxic radiation and busulfan. Although they got some meds to dampen their immune response to up the odds of the transplant taking, they didn’t get radiation or busulfan.

Treatment

BioPharma Drive: Drug Pricing

JUNE 27, 2025

For some people with leukemia, lymphoma or multiple myeloma, they can prompt powerful responses and even long-lasting remission. But their administration also comes with notable risks, including a hyperactive immune response known as CRS and neurological toxicity dubbed ICANS. Its new CEO has to figure out what’s next.

Therapies

Conversations in Drug Development Trends

OCTOBER 14, 2024

Fortunately, advances in clinical research are providing hope for better treatments and outcomes. With the support of global networks like ours at Worldwide Clinical Trials (Worldwide), autoimmune and bone health research is accelerating, providing new solutions to patients around the world.

Research

Perficient: Drug Development

APRIL 15, 2025

This complex and multifaceted condition has been a topic of intense research and debate in recent years, affecting millions of Americans and creating significant burdens on healthcare systems, workplaces, and families. This suggests potential sex-based differences in immune regulation following SARS-CoV-2 infection.

Immune Response

The Pharma Data

JUNE 12, 2025

Evidence shows that NUMELVI is at least 10-fold more selective for JAK1 than for the other JAK family members , which underpins its ability to ease pruritus without causing significant side effects related to hematopoietic dysfunction or a broad dampening of the immune response.

Vaccine

PLOS: DNA Science

JUNE 12, 2025

The condition stems from a misdirected immune response to a substance – an allergen – that does not actually present a threat. To identify the gene–environment interactions behind eczema, the researchers analyzed data from 16 European studies.

DNA

Science Daily: Pharmacology News

APRIL 28, 2025

Scientists have uncovered why vaccines can elicit a stronger immune response if they are administered in the same arm.

Immune Response

Science Daily: Pharmacology News

OCTOBER 17, 2024

difficile first-time infections and relapsing infections by inducing a robust immune response, promote clearance of existing C. diff bacteria from the gut, and even overcome deficits in host immunity to protect animals after infection, according to researchers. In animal models, this first mRNA-LNP C.

Vaccine

Science Daily: Pharmacology News

OCTOBER 18, 2023

Immunotherapies, which mobilize the body's immune defenses against a cancer, have not been effective for GBM, in part because the tumor's surrounding environment is largely impenetrable to assaults from the body's immune system.

Therapies

Science Daily: Pharmacology News

DECEMBER 12, 2024

Researchers have discovered a protein variant that serves as a knob for regulating the body's innate immune response. The findings could lead to new therapies for Long COVID, autoimmune disorders, and more.

Immune Response

Science Daily: Pharmacology News

FEBRUARY 5, 2025

Researchers report that all nine patients in a clinical trial being treated for stage III or IV clear cell renal cell carcinoma (a form of kidney cancer), generated a successful anti-cancer immune response after initiation of a personalized cancer vaccine.

Vaccine

Science Daily: Pharmacology News

JUNE 18, 2024

These cells shut down inflammation and repair the collateral damage to cells caused after our immune system has responded to injury or illness. Current anti-inflammatory drugs used for this purpose suppress the body's whole immune system, making patients more vulnerable to infection.

Treatment

Drugs.com

OCTOBER 11, 2023

11, 2023 -- New research points to the potential of a COVID-19 vaccine delivered through the nose. The phase 1 clinical trial showed that the product, administered nasally in two doses, delivered a significant immune response to. WEDNESDAY, Oct.

Vaccine

SCIENMAG: Medicine & Health

DECEMBER 6, 2023

Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. Credit: Mike […]

Immune Response

Science Daily: Pharmacology News

OCTOBER 24, 2024

Researchers discovered potentially far-reaching effects of a particular gut bacterium that was linked to better growth in Bangladeshi children receiving a therapeutic food designed to nurture healthy gut microbes.

Immune Response

Science Daily: Pharmacology News

SEPTEMBER 7, 2023

By adding synergistic self-adjuvanting properties to Covid-19 RNA vaccines, researchers showed they could significantly boost the immune response generated in mice.

RNA