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Predicting the Intravenous Pharmacokinetics of Covalent Drugs in Animals and Humans

Covalent Modifiers

Human volume of distribution (Vd) was well predicted using allometric scaling of animal pharmacokinetic data; the most reliable results were achieved using simple allometric scaling of unbound Vd values. These results provide a quantitative framework to guide appropriate method selection for human PK prediction with covalent drugs.

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The Role of Pharmacokinetics in Generic Drugs

Drug Patent Watch

Pharmacokinetics (PK) plays a crucial role in the development and approval of generic drugs. This article delves into the importance of pharmacokinetics in generic drugs, addressing key aspects such as… Source

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Non‐Hydroxamate Inhibitors of IspC Enzyme in the MEP Pathway: Structural Insights and Drug Development Potential

Chemical Biology and Drug Design

The findings underscore the promise of these novel inhibitors in overcoming pharmacokinetic and toxicity challenges, offering new directions for antimicrobial and herbicidal drug development. This has led to increased interest in non-hydroxamate inhibitors.

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CDD Vault Update (April 2025 #2): Pharmacokinetic (PK) and Michaelis-Menten Kinetics (Km/Kd) Curve Fit Equations, Donut Charts, TIFF Image Previews, and Parallel Reactions

Collaborative Drug

CDD Update March #2 2025 Full Atom Layout of Macromolecules New Dataset for AI Similarity Searching Import Inventory Locations by Unique Box Names:

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Pharmacokinetics of panobinostat: Inter-species difference in metabolic stability [Metabolism, Transport, and Pharmacogenetics]

ASPET

The objective of this study was to examine the in vitro metabolic stability of panobinostat in different matrices and assess the influence of that metabolic stability on the in vivo pharmacokinetics and CNS delivery of panobinostat.

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Pharmacokinetic study of the interaction between luteolin and magnoflorine in rats

Chemical Biology and Drug Design

The pharmacokinetic study was performed on male Sprague–Dawley rats randomly grouped as the single administration of luteolin and the co-administration of luteolin and magnoflorine with six rats of each. Luteolin was co-administrated with magnoflorine to evaluate their potential interaction.

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An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Understand Clinical Observations [Metabolism, Transport, and Pharmacogenetics]

ASPET

The objective of this study was to mechanistically assess the pharmacokinetic goldenseal-midazolam interaction using an integrated in vitro - in vivo - in silico approach. min -1 , respectively). The objective of the current work was to evaluate fundamental mechanisms underlying the clinically observed goldenseal-midazolam interaction.