PLOS: DNA Science

JUNE 13, 2024

Ruling Out Alternate Explanations Requires Logic and Science Soon after Fauci’s grilling, Alina Chan, a molecular biologist at the Broad Institute of MIT and Harvard, succinctly explained the converging evidence in a compelling Opinion piece in the June 9 New York Times. I tuned much of that out, focusing on clues in the science. (I

Virus 52

Virus RNA DNA Science 52

Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform By Corie Lok May 14, 2024 Breadcrumb Home Merkin Prize in Biomedical Technology awarded to F. Merkin Prize in Biomedical Technology for his development of an efficient, scalable method of producing RNA and proteins in the laboratory.

RNA 84

RNA Production Molecular Biology Laboratories 84

Codon

MARCH 20, 2023

. 🧪 Papers AI + Bio Protein-specific signal peptides for mammalian vector engineering. Evolutionary-scale prediction of atomic-level protein structure with a language model. DeepBindGCN: Integrating molecular vector representation with graph convolutional neural networks for accurate protein-ligand interaction prediction.

Virus 52

Virus RNA Engineering Small Molecule 52

Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals.

Engineering 140

Engineering Protein Production RNA Vaccine 140

Codon

MARCH 24, 2024

Credit: Universität Würzburg Archives His key insight hinged upon the fact that living cells are essentially bags of liquid filled with enzymes, or proteins that speed up chemical reactions. Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on.

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Engineering Vaccine Production RNA 87

Codon

MAY 30, 2023

The researchers first compared the editing efficiency of different versions of IscB when coupled with 'ωRNA,' which guides the enzyme to the right spot on the DNA. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome. Science Advances.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

The researchers first compared the editing efficiency of different versions of IscB when coupled with 'ωRNA,' which guides the enzyme to the right spot on the DNA. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome. Science Advances.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

AUGUST 10, 2023

Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. Science (2018). Science (2017). Science (2010). Science (2016). Science (2023). Link Biocontainment of genetically modified organisms by synthetic protein design , by Mandell D.J. Science (2014).

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DNA Cell Biology Molecular Biology Engineering 98

Codon

AUGUST 10, 2023

Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. Science (2018). Science (2017). Science (2010). Science (2016). Science (2023). Link Biocontainment of genetically modified organisms by synthetic protein design , by Mandell D.J. Science (2014).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

MAY 29, 2025

This deadly structure allows it to kill its victims by preventing their cells from making messenger RNA (mRNA) through inhibition of the enzyme RNA Polymerase II. Without mRNA, there is no "message" for our cells' ribosomes to translate into peptides or proteins by linking together amino acids.

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Drugs DNA RNA Laboratories 109