Science - Drug Discovery Digest

David Liu receives Breakthrough Prize in Life Sciences

Broad Institute

APRIL 5, 2025

David Liu receives Breakthrough Prize in Life Sciences By Corie Lok April 5, 2025 Breadcrumb Home David Liu receives Breakthrough Prize in Life Sciences Liu is honored for the development of base editing and prime editing, two gene editing technologies transforming medicine. In 2013, Broad founding director Eric S.

Science

Science Clinical Trials DNA Disease

Researchers make breakthrough in bioprinting functional human heart tissue

Science Daily: Pharmacology News

JANUARY 22, 2025

The breakthrough science focused on replicating heart tissues, bringing research closer to generating functional, bioprinted organs, which would have broad applications in disease modelling, drug screening and regenerative medicine.

Research

Research Science Disease Drugs

Long shot science leads to revised age for land-animal ancestor

Science Daily: Pharmacology News

MAY 29, 2025

The fossils of ancient salamander-like creatures in Scotland are among the most well-preserved examples of early stem tetrapods -- some of the first animals to make the transition from water to land. Thanks to new research, scientists believe that these creatures are 14 million years older than previously thought.

Science

Science Research

Too Much Cinnamon May Interfere With Some Medications, Study Shows

Drugs.com

MAY 5, 2025

MONDAY, May 5, 2025 Consuming too much cinnamon might affect how your body absorbs some medications, new research shows.The study published in the June issue of the journal Food Chemistry: Molecular Sciences looked at how cinnamon and its key.

Science

Science Research

Bispecific cancer drugs, data caveats and funding alarms: 3 takeaways from ASCO

BioPharma Drive: Drug Pricing

JUNE 4, 2025

Doctors also wrestled with how best to use new bispecific antibodies, and expressed concern about looming cuts to science funding. Breast cancer study results impressed at this year’s meeting, but raised new questions.

Doctors

Doctors Science Drugs

Study shows addressing working memory can help students with math difficulty improve word problem-solving skills

Science Daily: Pharmacology News

APRIL 21, 2025

Results showed that improving working memory helped both students with and without math difficulties and can help educators more effectively by helping teach the science of math, study authors argue.

Science

This mind-bending physics breakthrough could redefine timekeeping

Science Daily: Pharmacology News

JUNE 11, 2025

The discovery not only challenges long-held beliefs about how clocks and physics work, but could also lead to powerful new tools in science, technology, and beyond. Even better, this trick doesn't require a matching increase in energy use.

Science

US bird populations continue alarming decline

Science Daily: Pharmacology News

MARCH 13, 2025

State of the Birds Report, produced by a coalition of leading science and conservation organizations, reveals continued widespread declines in American bird populations across all mainland and marine habitats, with 229 species requiring urgent conservation action. The 2025 U.

Science

Scientists uncover 230 giant ocean viruses that hijack photosynthesis

Science Daily: Pharmacology News

JUNE 6, 2025

These massive viruses once nearly invisible to science are now being exposed using powerful supercomputing and a new tool called BEREN. Scientists have uncovered over 200 new giant viruses lurking in ocean waters that not only help shape marine ecosystems but also manipulate photosynthesis in algae.

Virus

Virus Science Research

BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction

Covalent Modifiers

JUNE 16, 2025

Beltran Science , eadq2004 DOI: 10.1126/science.adq200 4 BBO-10203 is an orally available drug that covalently and specifically binds to the RAS-binding domain of phosphoinositide 3-kinase α (PI3Kα), preventing its activation by HRAS, NRAS, and KRAS. Lightstone, Bin Wang, Paul M. Wehn, Keshi Wang, Andrew G. Stephen, Anna E. Maciag, Aaron N.

Science

Science Drugs

Boosters and Biologics: Is Space-Based Biomanufacturing Real?

LifeSciVC

MAY 14, 2025

If thats not compelling enough, space can at least offer a mental respite from our terrestrial woes no gravity, no tariffs, no anti-science agenda. Which begs the question, is space-based biomanufacturing science fiction or science fact? Science Fiction or Science Fact? Why Space, Why Drugs, and Why Now?

Science

Science Production Research Drugs

The oldest ant ever discovered found fossilized in Brazil

Science Daily: Pharmacology News

APRIL 24, 2025

A 113-million-year-old hell ant that once lived in northeastern Brazil is now the oldest ant specimen known to science, finds a new report. The hell ant, which was preserved in limestone, is a member of Haidomyrmecinae -- an extinct subfamily that only lived during the Cretaceous period.

Science

How AI will reshape pharma by 2025

Drug Target Review

DECEMBER 20, 2024

Smith identifies three key obstacles preventing broader acceptance of AI: Communication gaps : Pharmaceutical and computational science communities often struggle to understand each others technical languages, making collaboration difficult.

Clinical Trials

Clinical Trials Trials Pharmaceuticals Drug Development

Synthesis Methods and Therapeutic Journey of Carprofen and Its Derivatives: A Review

Chemical Biology and Drug Design

MAY 10, 2025

The literature review was conducted using four databases: Web of Science, ScienceDirect, Scopus, Embase, and Reaxys. This review delves into these emerging areas, highlighting how carprofen's molecular structure and derivatives can be leveraged to expand its therapeutic reach.

Small Molecule

Small Molecule Drug Development Science Therapies

With AI, researchers predict the location of virtually any protein within a human cell

Broad Institute

MAY 19, 2025

Funding This research is funded by the Eric and Wendy Schmidt Center at the Broad Institute, the National Institutes of Health, the National Science Foundation, the Burroughs Welcome Fund, the Searle Scholars Foundation, the Harvard Stem Cell Institute, the Merkin Institute, the Office of Naval Research, and the Department of Energy.

Research

Research Engineering Science Disease

The next phase of the multiomics evolution, powered by AI

Drug Target Review

JUNE 17, 2025

Meet the author Dr Francisco Garcia, SVP of software & informatics at Element Biosciences Francisco brings over 20 years of experience leading the development of software and instrumentation for the life sciences industry.

RNA

RNA Engineering DNA Disease

Scientists engineer CRISPR enzymes that evade the immune system

Broad Institute

JANUARY 9, 2025

In the future, they hope their methods may also help scientists design delivery vehicles to evade the immune system.

Engineering

Engineering Immune Response Therapies DNA

AI-Designed Enzymes

Codon

FEBRUARY 13, 2025

A new paper , published today in Science , suggests a way forward. This is because the protein structural databases used to train these models consist overwhelmingly of structures gleaned from protein crystals or other “frozen” images. The resultant distortion has made computational enzyme design exceptionally difficult.

Small Molecule

Small Molecule Engineering Production DNA

Genome of near-extinct northern white rhino offers hope for reviving the species

Science Daily: Pharmacology News

MAY 14, 2025

The northern white rhinoceros is one of the rarest animals on Earth, with just two females left and no natural way for the species to reproduce. Now, scientists have mapped the entire genome of a northern white rhino.

Healthy eating in midlife linked to overall healthy aging

Science Daily: Pharmacology News

MARCH 24, 2025

Maintaining a healthy diet rich in plant-based foods, with low to moderate intake of healthy animal-based foods and lower intake of ultra-processed foods, was linked to a higher likelihood of healthy aging -- defined as reaching age 70 free of major chronic diseases and with cognitive, physical, and mental health maintained, according to a new study. (..)

Disease

'Cosmic joust': Astronomers observe pair of galaxies in deep-space battle

Science Daily: Pharmacology News

MAY 21, 2025

Astronomers have witnessed for the first time a violent cosmic collision in which one galaxy pierces another with intense radiation. Their results show that this radiation dampens the wounded galaxy's ability to form new stars.

Zebrafish protein unlocks dormant genes for heart repair

Science Daily: Pharmacology News

JANUARY 2, 2025

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement.

Therapies

Therapies Research

Boosting evolution: How humans unintentionally altered the skulls of pigs

Science Daily: Pharmacology News

FEBRUARY 10, 2025

Short snouts and a flat profile -- within a span of 100 years, humans have significantly changed the shape of the skulls of German domestic pigs. This is likely down to new breeding practices introduced at the beginning of the 20th century.

Research

Infant with rare, incurable disease is first to successfully receive personalized gene therapy treatment

Science Daily: Pharmacology News

MAY 15, 2025

A research team has developed and safely delivered a personalized gene editing therapy to treat an infant with a life-threatening, incurable genetic disease. The infant, who was diagnosed with the rare condition carbamoyl phosphate synthetase 1 (CPS1) deficiency shortly after birth, has responded positively to the treatment.

Treatment

Treatment Therapies Disease Research

Leprosy existed in America long before arrival of Europeans

Science Daily: Pharmacology News

MAY 29, 2025

Long considered a disease brought to the Americas by European colonizers, leprosy may actually have a much older history on the American continent.

Disease

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Science Daily: Pharmacology News

NOVEMBER 27, 2024

A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report.

Virus

Virus DNA Treatment Research

Scientists can reverse brain aging in fruit flies by preventing buildup of a common protein

Science Daily: Pharmacology News

OCTOBER 28, 2024

Buildup of a protein called filamentous actin, or F-actin, in the brain inhibits the removal of cellular wastes, including DNA, lipids, proteins and organelles. The resulting accumulation of waste diminishes neuronal functions and contributes to cognitive decline.

DNA

DNA Research

UV light and CT scans helped scientists unlock hidden details in a beautifully-preserved fossil Archaeopteryx

Science Daily: Pharmacology News

MAY 14, 2025

Archaeopteryx is the fossil that clearly demonstrated Darwin's views. It's the oldest known fossil bird, and it helps show that all birds -- including the ones alive today -- emerged from dinosaurs. And while the first Archaeopteryx fossil was found more than 160 years ago, scientists are continuing to learn new things about this ancient animal.

Novel stem cell therapy repairs 'irreversible' corneal damage in clinical trial

Science Daily: Pharmacology News

MARCH 4, 2025

Results from a phase 1/2 clinical trial of a novel stem cell treatment for cornea injuries found 14 patients treated and tracked for 18 months had a more than 90% success rate at restoring the cornea's surface and improvements in vision.

Clinical Trials

Clinical Trials Trials Therapies Treatment

A new technology for extending the shelf life of produce

Science Daily: Pharmacology News

MAY 21, 2025

Researchers developed a way to extend the shelf life of vegetables by injecting them with melatonin using biodegradable microneedles.

Research

Brain training game offers new hope for drug-free pain management

Science Daily: Pharmacology News

JUNE 2, 2025

A trial of an interactive game that trains people to alter their brain waves has shown promise as a treatment for nerve pain -- offering hope for a new generation of drug-free treatments.

Drugs

Drugs Treatment Trials

Single psilocybin trip delivers two years of depression relief for cancer patients

Science Daily: Pharmacology News

JUNE 16, 2025

Psilocybin, the active ingredient in magic mushrooms, might just revolutionize how depression and anxiety are treated in cancer patients. In a groundbreaking trial, a single dose combined with therapy significantly reduced emotional suffering, and these effects often lasted over two years.

Therapies

Therapies Trials Research

Are you curious? It might help you stay sharp as you age

Science Daily: Pharmacology News

MAY 7, 2025

Psychology literature has shown that curiosity tends to decline with age. Psychologists shows one type of curiosity can increase well into old age, contradicting prior research. Older adults who maintain curiosity and want to learn new things relevant to their interests may be able to offset or even prevent Alzheimer's disease.

Disease

Disease Research

Brain-wide activity change visualized as geometric patterns

Science Daily: Pharmacology News

FEBRUARY 21, 2025

Researchers have applied a visualization technique to depict the brain's activity related to visual perception as geometric patterns. They visualized different shapes as the ever-changing neuronal activity in the temporal and frontal lobes of the brain during object recognition and recalling memories.

Research

Scientists discover how aspirin could prevent some cancers from spreading

Science Daily: Pharmacology News

MARCH 5, 2025

Scientists have uncovered the mechanism behind how aspirin could reduce the metastasis of some cancers by stimulating the immune system.

Clinical Trials

Clinical Trials Trials Drugs

DNA nanorobots can alter artificial cells

Science Daily: Pharmacology News

JANUARY 13, 2025

Scientists have succeeded in controlling the structure and function of biological membranes with the help of 'DNA origami'. The system they developed may facilitate the transportation of large therapeutic loads into cells. This opens up a new way for the targeted administration of medication and other therapeutic interventions.

DNA

Scientists discover class of crystals with properties that may prove revolutionary

Science Daily: Pharmacology News

MAY 21, 2025

Researchers have discovered a new class of materials -- called intercrystals -- with unique electronic properties that could power future technologies.

Research

Cyberbullying in any form can be traumatizing for kids

Science Daily: Pharmacology News

MAY 15, 2025

New research shows that cyberbullying should be classified as an adverse childhood experience due to its strong link to trauma. Even subtle forms -- like exclusion from group chats -- can trigger PTSD-level distress. Nearly 90% of teens experienced some form of cyberbullying, accounting for 32% of the variation in trauma symptoms.

Research

Heat from the sun affects seismic activity on Earth

Science Daily: Pharmacology News

MARCH 4, 2025

Researchers explore the likelihood that Earth's climate, as affected by solar heat, plays a role in seismic activity.

Research

New lipid nanoparticle platform delivers mRNA to the brain through the blood-brain barrier

Science Daily: Pharmacology News

FEBRUARY 17, 2025

Scientists have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a challenge that has long been limited by the protective nature of the blood-brain barrier.

RNA

RNA Treatment Disease Drugs

Ginger vs. Cancer: Natural compound targets tumor metabolism

Science Daily: Pharmacology News

JUNE 10, 2025

Scientists in Japan have discovered that a natural compound found in a type of ginger called kencur can throw cancer cells into disarray by disrupting how they generate energy. While healthy cells use oxygen to make energy efficiently, cancer cells often rely on a backup method.

Why are urban children more prone to allergies?

Science Daily: Pharmacology News

MAY 14, 2025

Evidence of a unique T cell may explain why urban children are more prone to allergies than rural children. Differences in the development of the gut microbiome may be an underlying cause.

Breakthrough in clean energy: Palladium nanosheets pave way for affordable hydrogen

Science Daily: Pharmacology News

MARCH 4, 2025

Hydrogen energy is widely recognized as a sustainable source for the future, but its large-scale production still relies on expensive and scarce platinum-based catalysts.

Production

Production Research

Birds nested in Arctic alongside dinosaurs

Science Daily: Pharmacology News

MAY 29, 2025

Spring in the Arctic brings forth a plethora of peeps and downy hatchlings as millions of birds gather to raise their young. The same was true 73 million years ago, according to a new article. The paper documents the earliest-known example of birds nesting in the polar regions.

David Liu receives Breakthrough Prize in Life Sciences

Researchers make breakthrough in bioprinting functional human heart tissue

Trending Sources

Long shot science leads to revised age for land-animal ancestor

Too Much Cinnamon May Interfere With Some Medications, Study Shows

Bispecific cancer drugs, data caveats and funding alarms: 3 takeaways from ASCO

Study shows addressing working memory can help students with math difficulty improve word problem-solving skills

This mind-bending physics breakthrough could redefine timekeeping

US bird populations continue alarming decline

Scientists uncover 230 giant ocean viruses that hijack photosynthesis

BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction

Boosters and Biologics: Is Space-Based Biomanufacturing Real?

The oldest ant ever discovered found fossilized in Brazil

How AI will reshape pharma by 2025

Synthesis Methods and Therapeutic Journey of Carprofen and Its Derivatives: A Review

With AI, researchers predict the location of virtually any protein within a human cell

The next phase of the multiomics evolution, powered by AI

Scientists engineer CRISPR enzymes that evade the immune system

AI-Designed Enzymes

Genome of near-extinct northern white rhino offers hope for reviving the species

Healthy eating in midlife linked to overall healthy aging

'Cosmic joust': Astronomers observe pair of galaxies in deep-space battle

Zebrafish protein unlocks dormant genes for heart repair

Boosting evolution: How humans unintentionally altered the skulls of pigs

Infant with rare, incurable disease is first to successfully receive personalized gene therapy treatment

Leprosy existed in America long before arrival of Europeans

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Scientists can reverse brain aging in fruit flies by preventing buildup of a common protein

UV light and CT scans helped scientists unlock hidden details in a beautifully-preserved fossil Archaeopteryx

Novel stem cell therapy repairs 'irreversible' corneal damage in clinical trial

A new technology for extending the shelf life of produce

Brain training game offers new hope for drug-free pain management

Single psilocybin trip delivers two years of depression relief for cancer patients

Are you curious? It might help you stay sharp as you age

Brain-wide activity change visualized as geometric patterns

Scientists discover how aspirin could prevent some cancers from spreading

DNA nanorobots can alter artificial cells

Scientists discover class of crystals with properties that may prove revolutionary

Cyberbullying in any form can be traumatizing for kids

Heat from the sun affects seismic activity on Earth

New lipid nanoparticle platform delivers mRNA to the brain through the blood-brain barrier

Ginger vs. Cancer: Natural compound targets tumor metabolism

Why are urban children more prone to allergies?

Breakthrough in clean energy: Palladium nanosheets pave way for affordable hydrogen

Birds nested in Arctic alongside dinosaurs

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