article thumbnail

The next phase of the multiomics evolution, powered by AI

Drug Target Review

The dynamic behaviour of RNA transcripts, the regulation and modification of proteins, the lipid composition of membranes, the structural organisation of cells and the spatial context of tissues all play critical roles in disease progression and therapeutic response.

RNA
article thumbnail

Leveraging agonist antibodies to address immunological diseases

Drug Target Review

Agonist antibodies of immune checkpoint regulators These represent a groundbreaking class of immunotherapeutic agents that mimic the natural function of endogenous ligands by binding to specific cell-surface receptors. This approach augments the strength of achieving immune homeostasis.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Pharmaceutical Negotiations Decoded: Lessons from the Trenches

Drug Patent Watch

Lessons from Past Pharmaceutical Negotiations Case Study: Merck and Schering-Plough Merger The 2009 merger between Merck and Schering-Plough, valued at $41.1 Negotiators must navigate complex compliance requirements, including anti-bribery laws, transparency regulations, and industry codes of conduct.

article thumbnail

Into the Ashtray: FDA’s Previous Proposal to Ban Menthol Cigarettes

FDA Law Blog: Biosimilars

For some background (which is covered in more detail in one of our previous posts on the subject ), in 2009, Congress specifically exempted tobacco or menthol when it prohibited all other flavored cigarettes under the Family Smoking Prevention and Tobacco Control Act (TCA)s Special Rule for Cigarettes. 111-58, at 38-39 (2009).

FDA
article thumbnail

AZVUDINE

New Drug Approvals

2009, 52, 2971−2978. (11) 8] It received its current name in 2009, when researchers at Roche independently discovered it as a Hep C RNA polymerase inhibitor in vitro. [4] 8] It received its current name in 2009, when researchers at Roche independently discovered it as a Hep C RNA polymerase inhibitor in vitro. [4] 11) Wang, Q.;

RNA
article thumbnail

The 3Rs Principles in Cosmetic and Self-care Industry: the Regulation that Prioritises Animal Welfare

biobide

With an increased focus on animal welfare , the beauty industry has undergone a shift towards the 3Rs Principle application and all surrounding regulations. In 2009 this ban was expanded to include a ban on the use of any ingredient tested on animals for cosmetic products.

article thumbnail

Tick Tock re Tik Tok and FDA’s OPDP

Eye on FDA

FDA’s OPDP began considering an approach to regulating social media long before Tik Tok came into being. Studying DTC on broadcast television isn’t going to get us there and an approach to regulating promotional speech in social media is increasingly not platform agnostic. In fact, the medium does matter.

FDA