article thumbnail

Gene editing extends lifespan in mouse model of prion disease

Broad Institute

A long-awaited strategy Vallabh and Minikel have been studying prion disease since 2012, after Vallabhs mother passed away from a form of the disease called fatal familial insomnia and Vallabh found out that she had inherited the disease-causing mutation. This has the potential to be a really promising strategy.

article thumbnail

Vamorolone

New Drug Approvals

2012, 23, 821−828. (73) 2012, 23, 821−828. “Drug Approval Package: Agamree” U.S. .; Damsker, J.; Nagaraju, K.; McCall, J. Connor, E. Novel approaches to corticosteroid treatment in Duchennemusculardystrophy.Phys.Med.Rehabil. 73) Singh, A.; Schaeffer, E. Reilly, C. 2018, 38, 320−324. (74) 74) Liu, X.; Gutierrez, J.

FDA
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

A Visual Guide to Genome Editors

Codon

pyogenes protein — whose compactness makes them far easier to package into viral vectors and deliver into the human body. This in vivo editing strategy also requires genome editors to be packaged so that they can be delivered to the correct cells in a desired tissue or organ. Visit our website to get a copy. Join Asimov Press.

DNA
article thumbnail

Private equity firms back PCI Pharma in bet on drug production

BioPharma Drive: Drug Pricing

PCI helps biopharmaceutical companies manufacture and package drug products used in clinical trials as well as commercially. Frazier Healthcare Partners acquired it from Catalent Pharma in 2012 and sold a majority stake to Partners Group four years later. and reportedly values PCI at $10 billion, according to The Wall Street Journal.

article thumbnail

AZVUDINE

New Drug Approvals

Detailed numbers are provided by Genuine in the slides and the medication package insert. [14] Common (> 1%) side effects include nausea, elevated blood lipids, fever, insomnia, tiredness, and diarrhea. 17] Azvudine is toxic to the reproductive system of rats and rabbit. Zheng L, Wang Q, Yang X, Guo X, Chen L, Tao L, et al. PMID 22452880.

RNA
article thumbnail

Mining Ring Systems in Molecules for Fun and Profit

Practical Cheminformatics

In addition, the core code for extracting ring systems from molecules has been incorporated into the latest version of my pip installable useful_rdkit_utils package. In a 2012 paper, Peter showed how molecular descriptors can be used to characterize ring systems and perform similarity searches. Mühlbacher, J., Schuffenhauer, A., &

article thumbnail

Could Propecia Up Young Men’s Suicide Risk?

The Pharma Data

Information from the World Health Organization indicates that over the past 10 years, reports of suicidal ideation among young men using the drug have increased, rising significantly after 2012, the researchers said. No such warning is on the package insert now. ” Traish also thinks that the U.S. 11 in JAMA Dermatology.