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A new study finds that with bold and coordinated policy choices -- across emissions, diets, food waste, and water and nitrogen efficiency -- humanity could, by 2050, bring global environmental pressures back to levels seen in 2015.
In 2023, the first CRISPR Cas9-based therapeutic, which is based on a design Zhang developed in 2015, was approved for clinical use to treat sickle cell disease. This and other molecular tools developed by Zhang have accelerated biomedical research worldwide. Lisa Yang and Hock E.
First launched in 2015 and renewed in 2020, the program began as a recognition that while a majority of cardiovascular disease can be associated with lifestyle factors such as tobacco consumption, diet, and level of physical activity, genomics can influence an individual’s predisposition to cardiovascular disease, age of onset, and severity.
Merck applied for a patent term extension on the reissued patent, claiming the start of the regulatory review period as April 2004 and termination at the approval of the BRIDION NDA in December 2015. With this long regulatory review period, the PTO granted the statutory-maximum five-year patent term extension.
2015) Regulating the intersection of metabolism and pathogenesis in Gram-positive bacteria. Atkinson DE (1977) Cellular energy metabolism and its regulation. Academic Press. Stryer L (1975) Biochemistry. WH Freeman and Company, San Francisco. Richardson AR, Somerville GA, Sonenshein AL. Microbiology Spectrum 3(3):MBP-0004-2014.
Some who assert the value of QSAR-like ML models for drug design appear to treat drug design as an exercise in prediction and I've been crapping on for quite a few years (see this post from January 2015) is that it is more appropriately seen in a Design of Experiments framework (generate the necessary data as efficiently as possible).
As a result, there has been a slow adoption of advanced manufacturing technologies by the industry, with only 16 approved applications or supplemental applications that incorporated an advanced manufacturing technology between 2015-late 2022 as reported in the GAO study.
Standard of Care for the Treatment of Patients With ER+/HER2- Advanced Breast Cancer” at ClinicalTrials.gov ^ Jump up to: a b c Wardell SE, Nelson ER, Chao CA, Alley HM, McDonnell DP (October 2015). Jump up to: a b c Garner F, Shomali M, Paquin D, Lyttle CR, Hattersley G (October 2015). 22 (5): 713724. doi : 10.1530/ERC-15-0287.
5] In December 2015, the FDA once again gave gepirone a negative review for depression due to concerns of efficacy. [12] Firth S (30 November 2015). The FDA rejected approval for gepirone in 2002 and 2004. [5] However, in 2012 it once again failed to convince the FDA of its qualities for treating anxiety and depression. [5]
5] US FDA Center for Drug Evaluation and Research (CDER) Guideline (2015): Nonclinical Safety Evaluation of Reformulated Drug Products and Products Intended for Administration by an Alternate Route. 4] ICH = International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use.
Cas12 Discovery Cas12 was initially characterized in 2015 by Feng Zhang’s lab at the Broad Institute 5 and was quickly adopted as a complementary genome editor to Cas9. Although the full roles of IscB and IsrB are not known, they are thought to help these transposons spread more easily.
2015 Apr;35(3):377-387. [Content Brief] [2]. Dillingham BC, et al. VBP15, a novel anti-inflammatory, is effective at reducing the severity of murine experimental autoimmune encephalomyelitis. Cell Mol Neurobiol. Content Brief] [3]. Heier CR, et al. Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy.
Zoetis and Elanco have previously been the target of CVM complaints about their promotion: Of 10 ULs issued by CVM re advertising since 2014, Zoetis received 4 one in 2025, 2023, 2018 and 2016 and Elanco received 2 ULs 1 in 2018 and another in 2015. The allegations in the Warning Letters are serious, but thats not why theyre so interesting.
Okajima M, Takamura M, Taniguchi T (August 2015). March 2015). . “The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors” British Journal of Pharmacology. 144 (3): 31722. doi : 10.1038/sj.bjp.0706048. PMC 1576008. PMID 15655528. 4 (3): 2517. doi : 10.5492/wjccm.v4.i3.251.
Over the past decade (2015-2024), looking only at meaningful exits above $100M values: M&As of private biotechs have had a median and average of $270M and $600M, respectively. Company exit value is, of course, a function of the market cycle: in hot markets, crazy valuations and exits can happen; in cooler markets, more modest returns.
She was previously a member of the Broad scientific community, beginning in 2006 as a core faculty member and later, Broad’s chair of the faculty from 2015 to 2020. Regev is currently Executive Vice President at Genentech, a member of the Roche Group. She is also co-founder of the Human Cell Atlas.
Talk title coming soon By Nadya Karpova June 4, 2025 Talk title coming soon Lorin Crawford Microsoft Research New England (MSR) Add to calendar Talks Search - Any - Fall 2025 Spring 2025 Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)
From 2015 to 2019, between 500 and 4000 t of kava were exported from Vanuatu, Fiji and Tonga [ 5 , 6 ]." "Kava continues to be a strong trading commodity among Pacific Island countries with long-standing cultural and social significance, the benefits of which are especially important to agrarian economies [ 4 ].
Congressional Research Service, Washington, DC: Library of Congress, March 6, 2015. Constitutional Analysis of Suspicionless Drug Testing Requirements for the Receipt of Governmental Benefits. Last accessed July 21, 2025.
FRIDAY, July 19, 2024 -- A German man has become the seventh person to apparently be cured of HIV, researchers report.The 60-year-old man, referred to as the “next Berlin Patient,” was treated with a stem cell transplant in October 2015 for acute my.
9, 2024 -- Cases of a tick-borne parasitic disease have steadily increased in recent years, a new study shows.Rates of babesiosis increased an average 9% a year in the United States between 2015 and 2022, researchers reported in. WEDNESDAY, Oct.
Borophene, the atomically thin version of boron first synthesized in 2015, is more conductive, thinner, lighter, stronger and more flexible than graphene, the 2D version of carbon. Move over, graphene. There's a new, improved two-dimensional material in the lab.
A new survey of climate experts reveals that a majority believes the Earth to be headed for a rise in global temperatures far higher than the 2015 Paris Agreement targets of 1.5 to well-below 2 degrees Celsius.
In particular, they found that icefield-wide, rates of glacier area shrinkage were five times faster from 2015-2019 relative to 1948-1979. The team looked at records going back to 1770 and identified three distinct periods in how icefield volume changed.
far, there have been at least 29 million illnesses and 370,000 hospitalizations related to the flu -- the most since the 2015-2016 season, according to the. FRIDAY, Feb. 21, 2025 -- The current flu season is shaping up to be the worst in a decade.So
Rates of babesiosis, a tick-borne parasitic disease, increased an average of 9% per year in the United States between 2015 and 2022 and four in 10 patients were found to be co-infected with another tick-borne illness such as Lyme disease, according to a new study.
2, 2020 — In adolescents and young adults (AYAs), cancer has a unique epidemiological pattern and is a growing concern, with an increased rate of cancer from 1973 to 2015, according to a study published online Dec. The study included 497,452 AYAs diagnosed with cancer from 1973 to 2015. WEDNESDAY, Dec. 1 in JAMA Network Open.
The groundbreaking detection of gravitational waves in 2015, caused by the coalescence of two black holes, opened a new window into the universe. Black holes, some of the most captivating entities in the cosmos, possess an immense gravitational pull so strong that not even light can escape.
Since its introduction in 2015 by the Boyden Lab , ExM has been steadily growing in popularity with an abundance of protocols and examples of applications from across disciplines now available.
The proportion of students reporting attention deficit hyperactivity disorder or chronic health and/or psychological disabilities has increased between 2015 and 2021. Medical students who reported a disability to their school increased by more than 25% during the COVID-19 pandemic, a study shows.
TBD By lcopelan@broadinstitute.org August 31, 2023 Yuhan Hao Neptune Bio Related Resources [link] MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)
9, 2015, hangs just outside Nicole Hashemi’s Iowa State University laboratory. AMES, Iowa – A research poster dated Dec. It introduces a major project for Hashemi and her research group. And it’s evidence that scientific persistence sometimes equals scientific advancement. Credit: Photo by Christopher Gannon/Iowa State University.
As recently as 2015, researchers concluded that anywhere from 50-80% of pre-clinical animal (in vivo) research data was irreproducible,1 representing a monetary loss of more than $28 billion. PLOS Biology 13(6): e1002165.
According to the World Health Organization (WHO), between 2015 and 2021, 48% of mothers exclusively breastfed, meaning that their babies were not given any other food or liquids. Exclusive breastfeeding for the first six months of life is proven to protect both mother and child health.
A team of scientists from the Institut Pasteur has used the database of the National Reference Center for Meningococci to trace the evolution of invasive meningococcal disease cases in France between 2015 and 2022, revealing an unprecedented resurgence in the disease after the easing of control measures imposed during the COVID-19 epidemic.
2015 March 3 [2022 December 15]; 2015(8):7-12. This research was published in JCI Insight. References 1 English FA, Kenny LC, McCarthy FP. Risk factors and effective management of preeclampsia. Dovepress [Internet]. Available from: [link]
Royal colleges in the UK have received more than £9 million in marketing payments from drug and medical devices companies since 2015, but do not always disclose the payments publicly, finds an investigation published by The BMJ today.
Fortunately, my 2022 FOIA efforts (described below) extracted purchases by 340B covered entity type for 2015 through 2021. Shortly after I published the article below, HRSA posted public data about 340B covered entity purchases on its website. Alas, HRSA neglected to post any historical data.
The odds against such an encounter would appear to be overwhelming since Ash lives in California while this was my first visit to the USA since 2015. Ash and I have actually known each other for about 15 years but we’d never before met in real life.
Indigenous females living “off reserve” face many disparities in health care access, use and unmet needs, found new research in CMAJ (Canadian Medical Association Journal) [link] The study included 2902 First Nations, 2345 Métis, 742 Inuit and 74 760 non-Indigenous females of reproductive age (aged 15–55 years) obtained from the Canadian (..)
A key element of the 2015 Paris Agreement, a legally binding international treaty on climate change, is the commitment to limit average global temperatures increases to well below […]
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