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New global model shows how to bring environmental pressures back to 2015 levels by 2050

Science Daily: Pharmacology News

A new study finds that with bold and coordinated policy choices -- across emissions, diets, food waste, and water and nitrogen efficiency -- humanity could, by 2050, bring global environmental pressures back to levels seen in 2015.

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Feng Zhang awarded the National Medal of Technology and Innovation

Broad Institute

In 2023, the first CRISPR Cas9-based therapeutic, which is based on a design Zhang developed in 2015, was approved for clinical use to treat sickle cell disease. This and other molecular tools developed by Zhang have accelerated biomedical research worldwide. Lisa Yang and Hock E.

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Broad Institute and Bayer extend their cardiovascular alliance

Broad Institute

First launched in 2015 and renewed in 2020, the program began as a recognition that while a majority of cardiovascular disease can be associated with lifestyle factors such as tobacco consumption, diet, and level of physical activity, genomics can influence an individual’s predisposition to cardiovascular disease, age of onset, and severity.

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The Issue with Reissue: PTE Edition

FDA Law Blog: Biosimilars

Merck applied for a patent term extension on the reissued patent, claiming the start of the regulatory review period as April 2004 and termination at the approval of the BRIDION NDA in December 2015. With this long regulatory review period, the PTO granted the statutory-maximum five-year patent term extension.

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Microbiological Applications: Bacterial Metabolism | BMG LABTECH

BMG Labtech

2015) Regulating the intersection of metabolism and pathogenesis in Gram-positive bacteria. Atkinson DE (1977) Cellular energy metabolism and its regulation. Academic Press. Stryer L (1975) Biochemistry. WH Freeman and Company, San Francisco. Richardson AR, Somerville GA, Sonenshein AL. Microbiology Spectrum 3(3):MBP-0004-2014.

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Assembling data sets for training ML bioactivity models

Molecular Design

Some who assert the value of QSAR-like ML models for drug design appear to treat drug design as an exercise in prediction and I've been crapping on for quite a few years (see this post from January 2015) is that it is more appropriately seen in a Design of Experiments framework (generate the necessary data as efficiently as possible).

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FDA Programs to Support Advanced Manufacturing: Where Innovation Meets Regulation

The Premier Consulting Blog

As a result, there has been a slow adoption of advanced manufacturing technologies by the industry, with only 16 approved applications or supplemental applications that incorporated an advanced manufacturing technology between 2015-late 2022 as reported in the GAO study.

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