The Pharma Data

JANUARY 31, 2021

Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, SARS-CoV-2 is also an RNA virus that has a trimeric spike (S) protein on its viral envelope. The Company launched its first commercial product, HEPLISAV-B® [Hepatitis B Vaccine (Recombinant), Adjuvanted], in February 2018 , following U.S.

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Drug Target Review

AUGUST 24, 2023

She joined the company in November 2018 with more than 10 years of experience in drug discovery and non-clinical development of immunomodulatory drugs in the immuno-oncology space. Author bio: Christine Schuberth-Wagner Christine Schuberth-Wagner serves as Chief Scientific Officer at CatalYm. in North America) in late 2017.

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The Pharma Data

JUNE 26, 2021

Sanofi Pasteur, the vaccines global business unit of Sanofi and Translate Bio (NASDAQ: TBIO), a clinical-stage messenger RNA (mRNA) therapeutics company, have initiated a Phase 1 clinical trial evaluating an mRNA-based investigational vaccine against seasonal influenza. JUNE 22 , 2021.

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The Pharma Data

MARCH 11, 2021

Sanofi Pasteur, the vaccines global business unit of Sanofi, and Translate Bio (NASDAQ: TBIO), a clinical-stage messenger RNA (mRNA) therapeutics company, today announced the start of the Phase 1/2 clinical trial for MRT5500, an mRNA vaccine candidate against SARS-CoV-2, the virus that causes COVID-19.

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The Pharma Data

MARCH 3, 2022

In 2018, Shalev and colleagues reported the benefits of verapamil in a one-year clinical study of Type 1 diabetes patients, finding that regular oral administration of verapamil enabled patients to produce higher levels of their own insulin, thus limiting their need for injected insulin to regulate blood sugar levels.

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The Pharma Data

DECEMBER 3, 2020

Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, SARS-CoV-2 is also an RNA virus that has a trimeric spike (S) protein on its viral envelope. The Company launched its first commercial product, HEPLISAV-B® [Hepatitis B Vaccine (Recombinant), Adjuvanted], in February 2018, following U.S.

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Drug Target Review

APRIL 3, 2024

She joined the company in November 2018 with more than 10 years of experience in drug discovery and non-clinical development of immunomodulatory drugs in the immuno-oncology space. About the author Christine Schuberth-Wagner PhD, MBA Chief Scientific Officer (CSO) Christine Schuberth-Wagner serves as Chief Scientific Officer at CatalYm.

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The Pharma Data

DECEMBER 2, 2020

She is currently the CEO of Twentyeight-Seven, a biotech company focused on novel RNA biology that she co-founded alongside prominent Harvard investigators. Prior to Mitobridge, she was a co-founder and start-up CEO of Epizyme (NASDAQ:EPZM), a leader in novel epigenetic therapeutics for cancer.

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The Pharma Data

JULY 6, 2021

Fitusiran is an investigational, subcutaneously administered small interference RNA therapy in development for the treatment of people with hemophilia A or B, with or without inhibitors and has the potential to transform treatment as it would be the only prophylactic therapy with as few as six injections per year. a Sanofi Company.

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The Pharma Data

MARCH 23, 2022

Back in 2018, researchers tested a broad-spectrum antiviral candidate called remdesivir/VEKLURY, which acts as a nucleotide decoy to get incorporated into the viral RNA genome and stop viral polymerase. In fact, antiviral therapies designed to treat viruses such as hepatitis C (Sofosbuvir/SOVALDI) work by blocking viral polymerase.

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Metabolite Tales Blog

JANUARY 26, 2023

Table 1 – Small molecule drugs approved by the FDA in 2022 and the major reported route of biotransformation *Note: 17 small molecule drugs as classified in C&EN ( [link] i.e. excluding antibody-drug conjugates, antibodies, proteins, radioligands and small interfering RNA). Sugano, 2018. Curr Drug Metab. 20(4): 254-265.

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The Pharma Data

AUGUST 3, 2021

As part of Sanofi’s endeavor to accelerate the application of messenger RNA (mRNA) to develop therapeutics and vaccines, the company has entered into a definitive agreement with Translate Bio (NASDAQ: TBIO), a clinical-stage mRNA therapeutics company, under which Sanofi will acquire all outstanding shares of Translate Bio for $38.00

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The Pharma Data

AUGUST 31, 2020

About the cobas HIV-1/HIV-2 Qualitative Test cobas HIV-1/HIV-2 Qualitative for use on the cobas 6800/8800 Systems is an in vitro nucleic acid amplification test for the qualitative detection and differentiation of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) RNA in human serum and plasma. .

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The Pharma Data

OCTOBER 29, 2021

During the study, conducted at spots in Europe, Canada and Israel, people living with HIV who initiated treatment with Biktarvy between June 2018 and September 2020 completed questionnaires at birth and 12 months. Gilead presented an analysis of case- reported issues after 12 months of treatment with Biktarvy from the BICSTaR study.

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Dark Matter Blog

AUGUST 27, 2020

A few years ago, at Arrakis Therapeutics, we set out to conquer a strange new territory, drugging RNA structures with small molecules. In fact, it was these early pharmaceutical successes that gave us the confidence that we would ultimately succeed in systematically drugging a wide range of RNA structures.

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Drug Target Review

SEPTEMBER 4, 2023

I had earlier proposed the use of Palmatine and Silver Nitrate in the efficacy against the RNA structure of the COVID-19 virus. 2018): Ubiquitin Proteasome pathway proteins as potential drug targets in parasite Trypanosoma cruzi, Scientific Reports. (8):8399. link] Ojewale Kayode (2018). Suruchi, A., and Sameena, K. Nilmar, S.

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New Drug Approvals

SEPTEMBER 23, 2024

Target: DNA/RNA Synthesis Pathway: Cell Cycle/DNA Damage Huntington’s disease (HD) is a progressive, autosomal dominant neurodegenerative disorder of the brain, having symptoms characterized by involuntary movements, cognitive impairment, and mental deterioration. SCHEME PATENT PTC Therapeutics Inc., SCHEME PATENT PTC Therapeutics Inc.,

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Codon

APRIL 14, 2025

This idea drives “directed evolution,” for which Frances Arnold won the 2018 Nobel Prize in Chemistry. As long as we have a way to select the outcome we want, and it's reachable through repeated small steps (genomic mutation), we can selectively influence evolutionary processes.

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Broad Institute

MAY 2, 2024

In 2018, she graduated with a bachelor’s degree in computer science and biology and joined the lab of Gad Getz at the Broad Institute of MIT and Harvard to complete her master’s. But as an undergraduate at MIT, Martin found she could study biology and computer science and still row.

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KIF1A

MAY 4, 2024

Later, she developed an interest in the RNA world, specifically focusing on alternative splicing and its correlation with neuron cell properties within and across cell types. Jamie Woych Jamie received her BS in Biochemistry from SUNY New Paltz in 2018.

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Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform By Corie Lok May 14, 2024 Breadcrumb Home Merkin Prize in Biomedical Technology awarded to F. Merkin Prize in Biomedical Technology for his development of an efficient, scalable method of producing RNA and proteins in the laboratory.

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New Drug Approvals

SEPTEMBER 29, 2024

2018 ; Ding et al., In addition, older dogs had bacterial antigens and ribosomal RNA in their brains, consistent with systemic infection seen in humans. Epub 2018 Oct 3 PubMed. Epub 2018 Jan 30 PubMed. In preclinical work from other labs, infection with P. 2017 ; Ilievski et al., In human neurons grown in culture, P.

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Codon

APRIL 19, 2023

“In 2018, it was found in Myanmar.” This fruit is discarded more than any other food in grocery stores, according to a 2018 study from Sweden. Most of this genetic material codes for proteins: DNA is transcribed into RNA, which is then translated into proteins. From Elitzur T. in Plant Physiology (2016).

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Codon

APRIL 19, 2023

“In 2018, it was found in Myanmar.” This fruit is discarded more than any other food in grocery stores, according to a 2018 study from Sweden. Most of this genetic material codes for proteins: DNA is transcribed into RNA, which is then translated into proteins. From Elitzur T. in Plant Physiology (2016).

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The Pharma Data

OCTOBER 30, 2020

Veklury is a nucleotide analog RNA polymerase inhibitor and works by stopping replication of SARS-CoV-2. Previously approved under an Emergency Use Authorization (EUA), Veklury is now fully cleared for the treatment of hospitalized patients with COVID-19. It is widely available in U.S. hospitals. months vs. 9.6

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Codon

SEPTEMBER 22, 2024

In 2018, Saitou’s team reported the first method to coax human PGC-like cells into the oogonia stage. Epigenetic CRISPR tools are targeted to a particular DNA sequence using a guide RNA molecule. At this point, the follicle is ready to release the mature egg.

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PLOS: DNA Science

MARCH 30, 2023

Comparing genome sequences is important because they provide a 4-letter language in the bases A, C, G, and T (for DNA) or A, C, G, and U (for RNA). For those who claim nothing’s being done to prevent future pandemics, please look at GISAID. The agency started tracking it in 2013, and the spread accelerated in 2015.

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The Pharma Data

NOVEMBER 29, 2021

About the Merck and Eisai Strategic Collaboration In March 2018, Eisai and Merck, known as MSD outside the United States and Canada, through an chapter, entered into a strategic collaboration for the worldwideco-development andco-commercialization of LENVIMA.

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Broad Institute

OCTOBER 27, 2024

Our proposed method will be evaluated on synthetic zero-inflated count datasets, simulated single-cell RNA sequencing (scRNA-seq) data, and real-world multi-sample multi-condition scRNA-seq datasets.

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Codon

FEBRUARY 19, 2025

ESM is a protein language model that captures certain aspects of protein structure and function, for example, but is blind to DNA or RNA-level features that drive cell behavior. Evo 2 was trained on DNA sequences but can make predictions about myriad aspects of biology, including RNA stability and protein structures.

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Codon

NOVEMBER 3, 2024

In 2018, GlaxoSmithKline (GSK) piloted a new vaccine that may outmatch the BCG vaccine in treating pulmonary TB in adults. Researchers in 2018 tested out another TB vaccine, called H4:IC31 , against two control groups — a placebo arm and an arm receiving a BCG booster. The researchers were left with 40 drug candidates.

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Drug Target Review

NOVEMBER 27, 2024

As precision medicines, including RNA interference (RNAi) and oligonucleotide therapies, become more prominent, the importance of advanced techniques in streamlining biomarker validation and expediting the regulatory review process becomes even clearer. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences.

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Codon

AUGUST 10, 2023

Artificial Life (2018). Nature Biotechnology (2018). Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. Science (2018). eLife (2018). Link Modelling and analysis of gene regulatory networks , by Karlebach G. & & Shamir R. Nucleic Acids Research (2010).

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Codon

MAY 29, 2025

This deadly structure allows it to kill its victims by preventing their cells from making messenger RNA (mRNA) through inhibition of the enzyme RNA Polymerase II. The ADC approach allows healthy cells to avoid the deadly effects suffered by the cancer cells as their RNA polymerase II enzymes are shut down.

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Codon

AUGUST 10, 2023

Artificial Life (2018). Nature Biotechnology (2018). Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. Science (2018). Link In vitro integration of ribosomal RNA synthesis, ribosome assembly, and translation , by Jewett M.C. & Shamir R. & Gersbach C.A.

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