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Building Korro Bio: A CEO’s Perspective on Innovation and Risk Management

LifeSciVC

Founding Vision: Harnessing RNA Editing for Transformative Medicine Korro Bio’s story began in 2018, co-founded by a remarkable group: Jean-François Formela, M.D. Academic specializing in RNA editing). The ability of modifying RNA enabled us to sidestep many of the potential risks associated with permanent DNA editing.

RNA 67
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The Long Road to End Tuberculosis

Codon

In 2018, GlaxoSmithKline (GSK) piloted a new vaccine that may outmatch the BCG vaccine in treating pulmonary TB in adults. Researchers in 2018 tested out another TB vaccine, called H4:IC31 , against two control groups — a placebo arm and an arm receiving a BCG booster. The researchers were left with 40 drug candidates.

Vaccine 113
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The Magic of Fast Feedback Loops

Codon

This idea drives “directed evolution,” for which Frances Arnold won the 2018 Nobel Prize in Chemistry. As long as we have a way to select the outcome we want, and it's reachable through repeated small steps (genomic mutation), we can selectively influence evolutionary processes.

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Sarepta to lay off about 500 employees after Duchenne gene therapy setbacks

BioPharma Drive: Drug Pricing

Aside from the Duchenne medicines it sells, Sarepta intends to focus resources moving forward on a group of RNA-based medicines it’s developing with Arrowhead Pharmaceuticals. Among them are treatments for spinocerebellar ataxia, Huntington’s disease and facioscapulohumeral muscular dystrophy. Track how they’re performing.

Therapies 304
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Tensor factorization + single-cell rna-seq

Broad Institute

Tensor factorization + single-cell rna-seq By lcopelan@broadinstitute.org August 8, 2024 Tensor factorization + single-cell rna-seq Neriman Tokcan UMass Boston MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall (..)

RNA 40
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GRouNdGAN: GRN-guided simulation of single-cell RNA-seq data using causal generative adversarial networks

Broad Institute

Our results show that GRouNdGAN is a stable, realistic, and effective simulator with various applications in single-cell RNA-seq analysis.

RNA 40
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Q&A: New approaches are needed to find better cancer drug targets

Broad Institute

Since 2018, the Cancer Dependency Map (DepMap) Consortium , an academic-industrial partnership launched by the Broad, has uncovered several potential drug targets by systematically screening cancer models in search of genetic dependencies. Initially, there were two approaches: small hairpin RNA (shRNA)-based and now CRISPR-based experiments.

Drugs 128