Drug Target Review

APRIL 7, 2025

This receptor is also expressed in the brain, where it helps to regulate dopamine release, making it a therapeutic target for the treatment of insomnia, pain, depression and Parkinson’s disease. 2020) Structural and functional characterization of G proteincoupled receptors with deep mutational scanning, eLife , 9. 2022.02.002.

Fragment Screening 52

Fragment Screening Drugs Biophysical Assays Small Molecule 52

DrugBank

JUNE 18, 2025

In 2020, the FDA halted Johnson & Johnson’s COVID-19 vaccine production at a contract manufacturing facility after discovering quality control issues. For example, the FDA’s Breakthrough Therapy Designation grants priority review to medicines demonstrating substantial improvement over existing treatments.

Drug Development 52

Drug Development Clinical Trials Compliance Drugs 52

PPD

DECEMBER 16, 2024

The impact of lengthening timelines Ballooning timelines in clinical trials have a profound impact on drug development, driving up operational costs and delaying market access for promising new treatments. Key roadblocks, ranging from a surge in trial volume to rising costs, make it harder to keep clinical trials on track.

Drug Development 52

Drug Development Clinical Trials Compliance Trials 52

New Drug Approvals

APRIL 25, 2025

8] Therefore, it may serve as a new addition to combination therapy with conventional cancer treatment, such as chemotherapy. Combining inavolisib with palbociclib and fulvestrant might improve treatment of breast cancer. [14] World Health Organization (2020). Hz, 1H), 6.41 (dd, J=8.8, Hz, 1H), 6.16 (d, J=7.2 Hz, 1H), 5.02-4.89

FDA 57

FDA FDA Approval Therapies Trials 57

New Drug Approvals

MAY 9, 2025

Randomization was stratified based on whether the ESR1 mutation was detected or not, prior treatment with fulvestrant, and presence of visceral metastasis. [2] Randomization was stratified based on whether the ESR1 mutation was detected or not, prior treatment with fulvestrant, and presence of visceral metastasis. [2] 8 February 2023.

FDA 62

FDA Pharmacokinetics Therapies Treatment 62

SugarCone Biotech

MARCH 24, 2025

Other mechanisms that cancer cells use to escape from TCE treatment are less expected. This provides ample flexibility to optimize the treatment modality to attack specific cancers. CD58 is a protein that interacts with the CD2 protein that is expressed on T cells to upregulate T cell activation. doi: 10.1073/pnas.1716266115

Immune Response 64

Immune Response Therapies Treatment Disease 64

Codon

NOVEMBER 3, 2024

In the 1924 novel, The Magic Mountain , Thomas Mann describes a sanatorium patient named Anton Ferge as he undergoes a painful tuberculosis (TB) treatment. Over time, the frequency of resistance gene variants in the population will continue increasing because only the bacteria lacking those variants will die with treatment.

Vaccine 115

Vaccine Trials Therapies Treatment 115

Chemical Biology and Drug Design

DECEMBER 30, 2024

In 2020, two selective RET inhibitors, selpercatinib and pralsetinib were approved by the US FDA. However, high treatment costs and clinically acquired resistance (e.g., ABSTRACT RET (Rearranged during transfection) kinase is a validated target for non-small cell lung cancer (NSCLC).

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FDA Therapies Treatment Research 100

Codon

JUNE 5, 2025

.” Four years earlier, in 2019, Gray had become the first patient with sickle cell anemia — a genetic disorder that causes red blood cells to become sticky and rigid — to receive an experimental treatment using CRISPR genome editing. Therapeutics The first Cas13-based clinical trial was approved in 2024.

DNA 83

DNA RNA Clinical Trials Engineering 83

New Drug Approvals

JUNE 15, 2025

Its sodium salt is used for the treatment of generalised myasthenia gravis (a disease that leads to muscle weakness and tiredness) in adults whose immune system produces antibodies against acetylcholine receptors. 6] [9] [10] It is a complement inhibitor that is injected subcutaneously (under the skin). [6] 24 September 2024. . April 2018).

FDA 57

FDA Treatment Clinical Trials Production 57

BioPharma Drive: Drug Pricing

JUNE 11, 2025

Like many other biotechnology firms, it’s seen its stock price fall significantly during a sector-wide pullback, with shares losing more than three quarters of their value since 2020. Still, a deal Nuvation cut last year to acquire AnHeart Therapeutics has given it a chance to rebound.

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FDA Drugs Therapies Science 270

New Drug Approvals

JUNE 29, 2025

2020/0062765) was dissolved in ethanol (604 mL) at 50℃. Medical uses Taletrectinib is indicated for the treatment of adults with locally advanced or metastatic ROS1-positive non-small cell lung cancer. [1] 1] [2] It is used as the salt, taletrectinib adipate. [1] 1] Taletrectinib is a kinase inhibitor. [1] 1] It is taken by mouth. [1]

International 62

International FDA Clinical Trials Treatment 62

The Pharma Data

JULY 3, 2025

Biologic drug sales in Canada reached $10 billion in 2020 , representing nearly one-third of all pharmaceutical expenditures in the country, according to Health Canada. Pegfilgrastim-based biologics like NEULASTA® are widely prescribed in oncology treatment regimens and have been among the top biologic expenditures.

Marketing 52

Marketing Biosimilars Pharmaceutical Companies Pharmaceuticals 52

New Drug Approvals

JULY 8, 2025

It is being investigated as a potential treatment for various herpes infections, including those resistant to traditional antivirals like acyclovir. Pritelivir (development codes AIC316 or BAY 57-1293 ) is a direct-acting antiviral drug in development for the treatment of herpes simplex virus infections (HSV).

Virus 62

Virus DNA Clinical Trials Treatment 62

New Drug Approvals

APRIL 18, 2025

Formula C 27 H 29 Cl 2 FN 2 OS Crinecerfont , sold under the brand name Crenessity , is a medication used for the treatment of congenital adrenal hyperplasia. [1] Jump up to: a b c d e f g h i j k l m n o p q “FDA Approves New Treatment for Congenital Adrenal Hyperplasia” U.S. 8 May 2020). 1] It is taken by mouth. [1]

FDA 62

FDA FDA Approval Drugs Trials 62

New Drug Approvals

APRIL 19, 2025

This has a positive impact on the treatment of patients when reduction of heart rate without decrease in arterial blood pressure is desired. [9] Treatment of phenol 143 with bromo epoxide 144 in the present of K2CO3 afforded ether 145 in 76% yield. 9] It is used as landiolol hydrochloride.

FDA 62

FDA Clinical Trials Treatment Trials 62

National Institute on Drug Abuse: Nora's Blog

NOVEMBER 25, 2024

Contrary to worries that syringe services programs (SSPs) will encourage or promote drug use, evidence shows that they more often do the opposite, linking people with addiction to effective treatment and even helping prevent overdose deaths. Unfortunately, prejudices against harm-reduction continue to impede the reach of SSPs.

Drugs 119

Drugs Treatment Disease Science 119

Codon

NOVEMBER 1, 2024

Amodei also imagines the ways AI could accelerate biological research and yield miraculous cures in the 21st century; everything from the prevention and treatment of nearly all infectious and inherited diseases to the elimination of most cancers. Today, the same feat can be done for about $0.10.

DNA 133

DNA RNA Molecular Biology Laboratories 133

Drug Patent Watch

JANUARY 13, 2025

As we delve into the intricate world of biosimilar market dynamics, we’ll explore how these complex molecules are reshaping treatment paradigms across diverse patient populations. from 2020 to 2025[1]. .”[1] from 2020 to 2025[1]. billion by 2025, growing at a CAGR of 34.2% billion by 2025, growing at a CAGR of 34.2%

Biosimilars 61

Biosimilars Marketing Treatment Small Molecule 61

BioPharma Drive: Drug Pricing

JULY 9, 2025

The Food and Drug Administration approved Verona’s Ohtuvayre in June 2024 for maintenance treatment of COPD in adults. The Food and Drug Administration approved Verona’s Ohtuvayre in June 2024 for maintenance treatment of COPD in adults. Published July 9, 2025 By Kristin Jensen post share post print email license Merck & Co.

Clinical Trials 277

Clinical Trials Drugs Therapies Licensing 277

Broad Institute

JULY 17, 2025

She was previously a member of the Broad scientific community, beginning in 2006 as a core faculty member and later, Broad’s chair of the faculty from 2015 to 2020. She is also co-founder of the Human Cell Atlas.

Science 110

Science Disease Treatment Vaccine 110

Drug Patent Watch

JANUARY 7, 2025

As healthcare professionals, it’s our responsibility to educate patients about generic drugs and empower them to make informed decisions about their treatment options. ” WHO.int, 2020. However, many individuals still harbor misconceptions and doubts about the efficacy and safety of generic alternatives. ” JAMA, 2016.

Drugs 71

Drugs FDA Doctors Trials 71

National Institute on Drug Abuse: Nora's Blog

JUNE 12, 2025

1 The drug crisis in America has demanded a sustained focus to extinguish those fires by expanding treatment access and overdose prevention and reversal strategies—and encouragingly, data show that overdose fatalities have been declining since 2023.

Research 82

Research Treatment Clinical Trials Trials 82

Drugs.com

JULY 6, 2023

Centers for Disease Control and Prevention estimates that there were nearly 68,000 new cases of acute hepatitis C in 2020 and over 107,000 newly reported cases of chronic hepatitis C? THURSDAY, July 6, 2023 -- Did you know the U.S. To help you.

Treatment 299

Treatment Disease 299

New Drug Approvals

JULY 18, 2025

3] It was discovered for the treatment of hepatitis C [4] and has since been investigated for use against other viral diseases such as AIDS and COVID-19 , [2] [5] for which it was granted conditional approval in China. [6] It was approved in China in 2021 as a first-in-class treatment for human immunodeficiency virus (HIV).

RNA 62

RNA Clinical Trials Trials Virus 62

National Drug & Alcohol Research Centre Blog

DECEMBER 4, 2023

Kendal Chidwick NDARC’s Kendal Chidwick discusses the findings from a recently published study that examined how patterns of opioid agonist treatment medicines have changed over the past decade. Other changes around this time aimed at improving treatment accessibility included increased use of take-home doses and telehealth appointments.

Treatment 133

Treatment Community Pharmacies Pharmacy International 133

Science Daily: Pharmacology News

AUGUST 28, 2023

Fossils of the world's oldest known flax snails, an extinct sawshark spine, and great white shark teeth have all been found in a mound of sand excavated from beneath Mangere Wastewater Treatment Plant in 2020.

Treatment 189

Treatment Research 189

Eye on FDA

FEBRUARY 10, 2021

Looking now to a review of enforcement by the Office of Prescription Drug Promotion (OPDP) in 2020, we see a different picture. The collection of letters issued by OPDP during 2020 can be found here. We instead see the same pace as we have the past several years – that is anemic levels of enforcement.

FDA 77

FDA Biosimilars Drugs Treatment 77

Drug Discovery Today

APRIL 26, 2020

To mark the 30th Anniversary of World Haemophilia Day, Sobi have released the 2020 Haemophilia Index which examines the quality of life for people with haemophilia in Europe, including the UK and the reach of humanitarian aid across the globe.

Treatment 100

Treatment 100

The Pharma Data

NOVEMBER 1, 2020

Vancouver-based Algernon Pharmaceuticals plans to conduct a late-stage study to evaluate an orally delivered drug, NP-120 (ifenprodil), as a COVID-19 treatment. The drug was originally developed in the 1990s by Sanofi to treat peripheral circulatory disorders and it is still used in generic form in Japan.

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Pharmaceuticals Treatment Research Drugs 98

SCIENMAG: Medicine & Health

JULY 5, 2023

But a study published by The BMJ today finds that less than half of approved first indications for new drugs in the US and Europe between 2011 and 2020 add substantial therapeutic value over existing treatments […]

Treatment 67

Treatment Drugs Disease 67

National Institute on Drug Abuse: Nora's Blog

MARCH 6, 2025

Advancing reduction of drug use as an endpoint in addiction treatment trials astewart Thu, 03/06/2025 - 09:59 Nora's Blog March 18, 2025 Image Getty Images/ SolStock This blog was also published in the American Society of Addiction Medicine (ASAM) Weekly on March 18, 2025.&

Treatment 69

Treatment Trials Clinical Trials Drugs 69

Eye on FDA

AUGUST 18, 2020

But it is not likely to surprise anyone that the first half of 2020 has caused not only an increase in communication from FDA, but a focus as well. Approvals – There were 54 press statements regarding approvals so far in 2020, comparing to 42 approvals announced in 2019.

FDA 61

FDA Production Drugs Therapies 61

Broad Institute

JUNE 18, 2024

By Allessandra DiCorato June 18, 2024 Credit: Jon Arizti-Sanz SHINE, a rapid diagnostic test developed by Pardis Sabeti's lab in 2020, uses paper strips and CRISPR enzymes to identify specific sequences of viral RNA in samples.

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Virus RNA Laboratories Medical Schools 144

Drug Target Review

OCTOBER 5, 2023

This innovative approach involves the extraction of a patient’s own stem cells from either their bone marrow or blood , followed by a course of chemotherapy and antibody treatment. The research team identified 231 individuals diagnosed with relapsing-remitting MS, with 174 of them having undergone aHSCT treatment before the year 2020.

Therapies 116

Therapies Treatment Clinical Trials Disease 116

The Pharma Data

MAY 16, 2021

The UK’s National Institute for Health and Care Excellence (NICE) has recommended Merck’s Keytruda (pembrolizumab) for National Health Service use as first-line treatment for adults with untreated metastatic colorectal cancers with high levels of microsatellite instability or DNA mismatch repair deficiency. billion in 2020.

Treatment 52

Treatment DNA Drugs 52

Drug Target Review

SEPTEMBER 21, 2023

The findings supported the possibility put forward by Cotton et al (2016) concerning the chance of repurposing these drugs for adulticidal treatment. The available treatment for that is minor surgery -to remove the nodules. With accessible and effective treatments, this is feasible. doi: 10.1002/14651858.CD011146.pub2.

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Drugs Treatment Disease Research 105