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Researchers map communities of single cells in metastatic breast cancers

Broad Institute

Researchers map communities of single cells in metastatic breast cancers By Corie Lok October 30, 2024 Breadcrumb Home Researchers map communities of single cells in metastatic breast cancers The team compared different single-cell and spatial profiling methods to explore the diversity of cells in metastatic breast cancer biopsies.

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Time for change: non-human primates in drug research

Drug Target Review

Persistent challenges with NHP use Despite their biological relevance, using live NHPs in research poses several major challenges: Ethical concerns NHPs, due to their advanced cognition and social behaviour, are at the centre of ongoing ethical debates. Supply chain disruptions Availability is a critical bottleneck in NHP-based research.

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Total Synthesis of Tagitinins, Goyazensolide and RelatedFuranoheliangolides and their Covalent Interaction withImportin-5 (IPO5)

Covalent Modifiers

W Liu, R Patouret, E Peev, S Barluenga, N Winssinger Helvetica Chimica Acta , 2024 [link] Herein, we detail an extension of our research on the synthesis of a small library of furanoheliangolides and the characterization of the covalent interaction between goyazensolide and IPO5.

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Boosters and Biologics: Is Space-Based Biomanufacturing Real?

LifeSciVC

Merck, Bristol-Myers Squibb, Amgen, Eli Lilly, and Gilead have all conducted microgravity research in orbit. With respect to the latter, Mercks microgravity research on Keytruda is an informative case study. Despite the progress made, microgravity research projects to date have been exploratory, small-scale one-offs.

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NGS is evolving: collaboration and tech lead the way

Drug Target Review

Research by Markets and Markets projects the market to grow from $12.13 1 Emergen Research attributes this to the advantages of high-throughput sequencing technologies and declining sequencing costs​. 2 This trend reflects the increasing demand for genomic sequencing in research, clinical diagnostics and other applications.

RNA
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Astellas, Mitsubishi Research Institute Team Up to Support Japanese Pharma Startups

The Pharma Data

Mitsubishi Research Institute and Astellas Forge Collaborative Initiative to Support Japanese Drug Discovery Startups and Boost Global Innovation Mitsubishi Research Institute, Inc. Comments from Astellas’ Chief Research & Development Officer Tadaaki Taniguchi, M.D, MRI) and Astellas Pharma Inc.

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Regulator and Funder? FDA’s Orphan Products Grants Program awards significant funding to help move promising treatments through clinical development

FDA Law Blog: Drug Discovery

In October, FDA announced seven new clinical trial grants awarded in fiscal year (FY) 2024 – including one for a Phase 3 trial – totaling $17.2 million to clinical researchers over the next four years to advance the development of medical products for rare diseases. million over the next four years. million over four years.