Codon

JUNE 5, 2025

Certain CRISPR components can add short DNA sequences from the genomes of defeated viruses into the bacterium’s own genome, creating a type of protective “memory.” The core of the CRISPR immune response is a guide RNA (gRNA) that binds to a CRISPR-associated (Cas) protein. Visit our website to get a copy.

DNA 79

DNA RNA Clinical Trials Engineering 79

SugarCone Biotech

JULY 6, 2025

A post-ASCO update on tumor targets DLL3, B7H3 and HER3 July 2025 Paul D Rennert, SugarCone Biotech LLC Introduction: DLL3, B7H3 and HER3 are compelling tumor antigens to target with cancer therapeutics. Clinical development is extensive, as detailed by @ByMadeleineA at ApexOnco ( [link] ; [link] ).

Drug Development 56

Drug Development Drugs Clinical Trials Therapies 56

Codon

APRIL 14, 2025

DNA sequencing and synthesis costs have dropped precipitously, in part, because maintaining Carlson curves became a rallying point for the field. ” Asimov Press (2025). For starters, we not only need faster, cheaper options (supply) but also people excited to use them (demand). ” by Heidi Huang. Cite: Malina, S.

Protein Expression 91

Protein Expression Engineering Research RNA 91

Broad Institute

FEBRUARY 11, 2025

Mapping mRNA through its life cycle within a cell By Corie Lok February 11, 2025 Breadcrumb Home Mapping mRNA through its life cycle within a cell Xiao Wangs studies of how and where RNA is translated could lead to the development of better RNA therapeutics and vaccines.

RNA 52

RNA DNA Science Vaccine 52

Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform By Corie Lok May 14, 2024 Breadcrumb Home Merkin Prize in Biomedical Technology awarded to F. Merkin Prize in Biomedical Technology for his development of an efficient, scalable method of producing RNA and proteins in the laboratory.

RNA 84

RNA Production Molecular Biology Laboratories 84

Codon

SEPTEMBER 29, 2024

But, regardless of which was first, they all operated with the same core data as their mechanism for understanding life: messenger RNA ( mRNA ). The 2025 genetic network paper fit that bill exactly. Collections of mRNA have been understood as a proxy for cell states for decades. As such, they were quietly abandoned.

Engineering 144

Engineering Virus DNA Therapies 144

Codon

MAY 15, 2023

3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. Known as a "search-and-replace" gene-editing tool, prime editors can delete or replace DNA up to 10,000 bases in length, or substitute one base for another. Read more in Cell. ( #1 , #2 ) (Video credit: Gong Y.

DNA 52

DNA Bioinformatics Engineering Virus 52

Codon

MAY 15, 2023

3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. Known as a "search-and-replace" gene-editing tool, prime editors can delete or replace DNA up to 10,000 bases in length, or substitute one base for another. Read more in Cell. ( #1 , #2 ) (Video credit: Gong Y.

DNA 52

DNA Bioinformatics Engineering Virus 52

Broad Institute

MAY 29, 2025

New technique expands cells to sequence DNA and capture fine structural details By Allessandra DiCorato May 29, 2025 Breadcrumb Home New technique expands cells to sequence DNA and capture fine structural details Using this method, scientists discovered key protein and gene activity changes in aging and in a rare disease called progeria.

DNA 133

DNA RNA Cell Biology Disease 133

Broad Institute

MAY 15, 2025

Evolved gene editor inserts entire genes in human cells By Allessandra DiCorato May 15, 2025 Breadcrumb Home Evolved gene editor inserts entire genes in human cells The new system is the first to use a DNA-mobilizing enzyme called a CRISPR-associated transposase to make targeted gene-sized edits at therapeutically useful levels in human cells.

DNA 133

DNA Laboratories RNA Disease 133

Codon

MAY 8, 2025

If so, then here's a question: How much information is in your DNA? When I first looked into this question , I thought it was simple: Human DNA has about 3.1 Each base pair can take one of four values (A, T, C, or G) It takes 2 bits to encode one of four possible values (00, 01, 10, or 11) Thus, human DNA contains 6.2

DNA 75

DNA RNA Molecular Biology Regulations 75

Broad Institute

APRIL 3, 2025

Scientists have developed a way to scale up spatial genomics and lower costs By Allessandra DiCorato April 3, 2025 Breadcrumb Home Scientists have developed a way to scale up spatial genomics and lower costs A new computational approach eliminates time-intensive imaging, enabling high-resolution spatial mapping of gene expression in tissue.

DNA 119

DNA RNA Molecular Biology Laboratories 119

Broad Institute

JANUARY 27, 2025

A genome-wide atlas of cell morphology reveals gene functions By Allessandra DiCorato January 27, 2025 Breadcrumb Home A genome-wide atlas of cell morphology reveals gene functions PERISCOPE, a technique for genome-wide imaging screens, is helping Broad scientists understand the connections between genes and traits. Online January 27, 2025.

DNA 131

DNA RNA Science Research 131

Codon

FEBRUARY 16, 2025

Building a Circuit Much like electronic circuits, which use wires and transistors to create or process signals, a synthetic gene circuit is a network of biological parts — DNA, RNA, and proteins — that process inputs and generate outputs. Elowitz inserted his assembled DNA into E. 3 Subscribe to Asimov Press.

DNA 94

DNA RNA Engineering Small Molecule 94

Codon

APRIL 10, 2025

That’s astonishingly small, roughly equal to the weight of the DNA inside a single hummingbird cell. The other 30 percent — the so-called “dry mass” — is composed of everything else: DNA, RNA, proteins, lipids, and ions. Similar considerations apply for DNA, RNA, and all the other molecules, too.

DNA 94

DNA RNA Engineering Research 94

Codon

FEBRUARY 19, 2025

The same model can also generate brand-new DNA sequences at the scale of yeast chromosomes or small bacterial genomes. AI Architectures Before explaining how Evo 2 could make bioengineering more predictable, it helps to first understand how AI models actually “learn” the language of DNA.

DNA 105

DNA Laboratories Engineering RNA 105

Broad Institute

MARCH 27, 2025

A Novo Nordisk - Broad collaboration is connecting Denmark-based and Broad researchers By Corie Lok March 27, 2025 Breadcrumb Home A Novo Nordisk - Broad collaboration is connecting Denmark-based and Broad researchers The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease has built a bridge between Danish and Broad scientists.

Research 75

Research DNA Regulations Disease 75

Broad Institute

JANUARY 16, 2025

By Allessandra DiCorato January 16, 2025 Credit: Scott Sassone, Broad Communications Tara McDonald (left) and Steve McCarroll (right) are coauthors of a new paper describing a biological mechanism underlying Huntington's disease. The researchers found that DNA tracts with 40 or more CAG repeats grow until they are hundreds of repeats long.

Disease 130

Disease DNA Medical Schools RNA 130

Drug Target Review

MAY 8, 2025

Unlike other therapeutic modalities being developed for HD that would require ongoing treatment to maintain efficacy, our gene editing therapy is intended to make a permanent, precise modification to the DNA itself. We observed robust AAV vector distribution across key brain regions along with significant guide RNA and nuclease expression.

Disease 111

Disease Treatment DNA Therapies 111

Codon

MAY 15, 2025

Random mutations in DNA bring about this genetic variation, and mating between unrelated individuals mixes the mutations amongst the population. Most vertebrates in the study, including the lab mouse, Mus musculus , acquire one mutation for every 100 million DNA bases per generation. percent of the mouse’s DNA.

DNA 76

DNA Laboratories RNA Regulations 76

Broad Institute

FEBRUARY 5, 2025

Mutations in two gene pairs point to a promising drug target in 5 percent of adult cancers By Allessandra DiCorato February 5, 2025 Breadcrumb Home Mutations in two gene pairs point to a promising drug target in 5 percent of adult cancers Targeting the PELO gene could be a way to kill tumor cells in cancers with one of two common genetic mutations.

Protein Production 100

Protein Production DNA Drugs RNA 100

Codon

APRIL 28, 2025

This was before DNA clones could produce these proteins synthetically, and few researchers were willing to endure the grueling work of collecting and cutting jellyfish. Prasher used those sequences to design short, synthetic DNA probes that matched what he believed the corresponding DNA would look like.

DNA 77

DNA Engineering Research Virus 77

Broad Institute

JANUARY 7, 2025

A clinical genomicist harnesses team-based science to help rare-disease patients By Allessandra DiCorato January 7, 2025 Breadcrumb Home A clinical genomicist harnesses team-based science to help rare-disease patients Heidi Rehm convinced labs and scientists to work together and share data.

Disease 121

Disease Science Laboratories Medical Schools 121

Codon

MAY 5, 2025

Higher speeds allowed scientists to exploit ever-slighter density variations, separating increasingly smaller particles — from tiny biological molecules like viruses or DNA to uranium isotopes sifted at the atomic level. Because the substance came from the nucleus, Miescher named it nuclein — today known as nucleic acid (or DNA).

DNA 58

DNA Engineering Science Laboratories 58

Codon

MAY 29, 2025

This deadly structure allows it to kill its victims by preventing their cells from making messenger RNA (mRNA) through inhibition of the enzyme RNA Polymerase II. The ADC approach allows healthy cells to avoid the deadly effects suffered by the cancer cells as their RNA polymerase II enzymes are shut down.

Drugs 105

Drugs DNA RNA Laboratories 105

Broad Institute

MAY 20, 2025

Scientists build cell line atlas of deadly cancers of the bile ducts and gallbladder By Leah Eisenstadt May 20, 2025 Breadcrumb Home Scientists build cell line atlas of deadly cancers of the bile ducts and gallbladder Researchers reveal new subtypes and potential therapeutic targets for biliary tract cancers, which lack effective treatments.

Medical Schools 133

Medical Schools Bioinformatics Treatment Hospitals 133

SugarCone Biotech

APRIL 8, 2025

The most typical genetic cargo for LNP-mediated in vivo CAR T cell production is messenger RNA (mRNA). Current development efforts that focus on DNA delivery by LNP in vivo are advancing rapidly; large payloads can be accommodated which is very useful. Biotech companies using LNP-based delivery for in vivo CAR T production.

Therapies 56

Therapies RNA Packaging Virus 56

Codon

DECEMBER 1, 2024

Many students are taught that the Central Dogma is simply “DNA → RNA → protein.” In 1956, Crick was working on a lecture that would bring together what was then known about the “flow of information” between DNA, RNA, and protein in cells.

RNA 134

RNA DNA Molecular Biology Virus 134

Codon

MAY 19, 2025

PCR tests, by contrast, detect the virus’s genetic material, its RNA, rather than its surface proteins. Even a tiny amount of viral RNA can be multiplied millions of times, making PCR far more sensitive than antigen tests (typically 93 to 98 percent ). This amplification process takes only a couple of hours.

Virus 72

Virus RNA Laboratories Hospitals 72

Codon

MAY 12, 2025

Proteins and DNA usually unravel in such scalding environments, yet researchers who descended in submarines in 1982 found entire colonies thriving at these extreme temperatures. They also shield their genomes using an enzyme called reverse gyrase , which burns ATP energy molecules to wrap DNA in a heat-protective supercoil.

DNA 65

DNA RNA Research Regulations 65

Codon

FEBRUARY 23, 2025

In January 2025, the incoming Trump administration issued a 90-day freeze on PEPFAR while it conducts a “programmatic efficiencies” review. Researcher Jerome Horwitz at the Michigan Cancer Foundation developed it as a potential cancer treatment by chemically-modifying thymine, a DNA building block. By February, the U.S.

Clinical Trials 77

Clinical Trials Virus Vaccine DNA 77