Drug Target Review

JULY 21, 2025

There she pioneered integrative cheminformatics and bioinformatics strategies for understanding drug molecular mechanisms, winning the Chemistry Theory Outstanding Thesis Award in 2023. She then went on to earn a PhD at the University of Cambridge under the mentorship of Andreas Bender, a renowned figure in AI drug discovery.

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Drug Target Review

JUNE 14, 2025

I began in bioinformatics, conducting lab-based genomics work but soon felt the need to dive deeper into the computational side. Ian Kerman (IK): My name is Ian Kerman and I’m currently a data science and AI solutions architect at Certara. I’ve been in the scientific informatics space for over 15 years.

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Laboratories Science Bioinformatics Molecular Biology 69

Elrig

MARCH 25, 2025

Prof Rory Johnson is an Associate Professor at University College Dublin, where his research focusses on uncovering the roles of long noncoding RNAs (lncRNAs) in human health and disease using an interdisciplinary combination of bioinformatic and experimental methods.

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RNA Bioinformatics Science Pharmacokinetics 59

Drug Target Review

JULY 14, 2025

There she pioneered integrative cheminformatics and bioinformatics strategies for understanding drug molecular mechanisms, winning the Chemistry Theory Outstanding Thesis Award in 2023. She then went on to earn a PhD at the University of Cambridge under the mentorship of Andreas Bender, a renowned figure in AI drug discovery.

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Drug Target Review

JUNE 26, 2025

Ian earned an MS in computer science, focusing on machine learning, from the Georgia Institute of Technology, as well as an MS in biology, alongside undergraduate degrees in bioinformatics and molecular biology, from the University of California, San Diego.

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Chemical Biology and Drug Design

APRIL 20, 2023

Our data imply that a precise selection of bioinformatics tools can facilitate the identification of miRNAs that impact mRNA translation at different stages of the cell cycle. The ability of these six miRNAs to impact the cell cycle in colorectal cancer may be concluded.

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Practical Cheminformatics

JANUARY 16, 2024

Following up on Part I and Part II, the third post in this series is a collection of review articles published in 2023 that I found helpful.

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Targeted Protein Degradation Small Molecule Computational Chemistry Bioinformatics 135

Drug Target Review

DECEMBER 13, 2023

The article mentions that TLR4 antagonists have been identified as potential candidates for repurposing long COVID treatment. We also identified the genes ATP9A and INSR in long COVID that we had hypothesised contributes to dysregulated insulin signalling in subgroups of ME/CFS patients.

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Chemical Biology and Drug Design

JANUARY 15, 2024

The expression of ANKRD22 in LUAD and its enriched pathway were analyzed by bioinformatics analysis. Bioinformatics analysis, qRT-PCR, and western blot showed that ANKRD22 was highly expressed in LUAD, which had a positive connection with M2 marker genes. Mitochondrial membrane potential was assessed using the JC-1 probe.

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Chemical Biology and Drug Design

MARCH 28, 2023

Pharmacodynamic targets of metformin were predicted using the Bioinformatics Analysis Tool for the molecular mechanism of traditional Chinese medicine (BATMAN), Drugbank, PharmMapper, SwissTargetPrediction, and TargetNet databases.

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Chemical Biology and Drug Design

JULY 4, 2023

Genes related to acacetin and esophageal cancer were predicted by bioinformatics analysis. In this work, esophageal squamous carcinoma cell lines were subjected to increasing doses of acacetin, and the proliferative, migrative, invasive and apoptotic phenotypes were evaluated by a series of in vitro experiments.

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Chemical Biology and Drug Design

JULY 13, 2023

Bioinformatics analysis was performed to predict the molecular targets of COP. Cell counting kit-8 (CCK-8), scratch healing assay, Transwell assay, and flow cytometry were used to detect cell growth, migration, invasion, and cell cycle progression.

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Chemical Biology and Drug Design

FEBRUARY 20, 2024

Moreover, bioinformatics analysis has suggested that hsa_circRNA_103820 possesses potential peptide-coding ability. Abstract N6-methyladenosine (m6A) modification and m6A-related RNA-binding proteins (RBPs) play vital roles in various aspects of circRNA metabolism.

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Bioinformatics RNA Regulations Research 100

Chemical Biology and Drug Design

JANUARY 5, 2024

Homeobox B7 (HOXB7) expression in CRC was analyzed and detected by bioinformatics analysis, quantitative real-time PCR or western blot. Following the treatment of 0, 1.94, 7.75, or 19.36 μM μM THA, CRC cell viability, apoptosis, migration, and invasion were evaluated by methyl tetrazolium, flow cytometry, wound-healing, and transwell assays.

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Chemical Biology and Drug Design

AUGUST 20, 2023

Bioinformatics analysis predicted cathepsin B (CTSB) as a target of hederagenin to modulate NOD-like receptor (NLR) pathway. NLRP3 inhibitor MCC950 attenuated HG-induced fibrosis of renal cells, and its activator nigericin reversed the suppressive effect of hederagenin on HG-induced fibrosis.

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Protein Expression Bioinformatics Research 100

Chemical Biology and Drug Design

JANUARY 1, 2024

Then, Bioinformatics was applied to sort out the candidate interacting with Stachydrine as well as its expression and downstream target in BC. Abstract Considering the therapeutic efficacy of Stachydrine on breast cancer (BC), this study aims to decipher the relevant mechanism.

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Chemical Biology and Drug Design

DECEMBER 28, 2023

In present study, LINC00460 was screened out through bioinformatics analysis. The prognostic value of long noncoding RNA (lncRNA) LINC00460 has been reported in cervical cancer. However, its effect on DDP sensitivity in cervical cancer remains poorly understood. The sensitivity to DDP was investigated using an CCK8 assay.

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RNA Bioinformatics Regulations Drugs 100

Chemical Biology and Drug Design

AUGUST 9, 2023

Bioinformatics and functional analyses indicated that these proteins were predominantly involved in protein synthesis and translation. Our investigation indicated that plumbagin markedly inhibited the LoVo cells proliferation, and induced the apoptosis in LoVo cells, simultaneously induced G0/G1 phase cell cycle arrest.

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Protein Expression Bioinformatics Treatment Research 100

Chemical Biology and Drug Design

JUNE 21, 2023

Hsa-miR-503-5p expression in LUAD and the target gene downstream of hsa-miR-503-5p was predicted by bioinformatics analysis. Abstract The study aimed to assess the role of hsa-miR-503-5p in cisplatin resistance and angiogenesis in LUAD and its underlying mechanisms.

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Regulations Protein Expression Bioinformatics Drugs 100

Chemical Biology and Drug Design

MARCH 14, 2023

The bioinformatics website, dual luciferase reporter assay, and quantitative real-time polymerase chain reaction were applied to analyze the network among EVO, lncRNA, miR-152-3p, and mRNA. Abstract Evodiamine (EVO) has been demonstrated to promote apoptosis of ovarian cancer cells, and upregulate miR-152-3p level in colorectal cancer.

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Regulations Bioinformatics Drugs Research 100

Chemical Biology and Drug Design

FEBRUARY 7, 2024

We assessed the effect of HSYA and NF-κB signaling pathway-related genes by bioinformatics analysis and conducted molecular docking to assess the interaction of HSYA with a combined protein residue molecule ligand. Western blot was employed to investigate NF-κB transcription factors in chondrocyte metabolism.

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Drug Target Review

MAY 24, 2024

More explanation and practical tips for using these technologies will be explored in future articles. According to a prominent article ten years back, 4 data scientists spend up to 80 percent of their time mired in the mundane labour of collecting and preparing unruly digital data, before it can be explored for useful nuggets.

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RNA DNA Bioinformatics Science 59

Dark Matter Blog

AUGUST 31, 2020

Today, we are pleased to announce that our article describing one such platform: “ PEARL-seq, A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions ” was published in ACS Chemical Biology.

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RNA Small Molecule Bioinformatics Computational Chemistry 52

The Pharma Data

JANUARY 24, 2021

He has published more than 200 articles and book chapters. Diversigen provides consultative end-to-end solutions for sequencing, bioinformatics, and statistical analysis for the study of the microbiome of living organisms and environments. About Diversigen Inc. Diversigen, Inc. is a subsidiary of OraSure Technologies Inc.

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DrugBank

MARCH 15, 2023

We also author and regularly update our comprehensive Help Center materials and are able to quickly connect users with the right articles and pieces of information at the right time. We also author articles alongside Customer Success, research and write blogs , and host webinars. We also host product demonstrations.

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Licensing Licensing International Bioinformatics 52

The Open Targets Blog

APRIL 19, 2022

The training of this ML model ( Word2Vec skip-gram , see figure below) uses a set of normalised entities as the result of a process that takes the matched label on the literature, grounds it into entities and disambiguates it so no matter how it appears on the article, the same entity matches across the whole corpus.

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Disease Bioinformatics FDA Production 52

Vial

DECEMBER 5, 2023

Improvements in bioinformatics, robotics, liquid handling, and nucleic acid preparation will continue to transform NGS sequencing methods. In addition, they provided recommendations on why, when, and how researchers can benefit from using DL methods to analyze human genomic data. Satam et al.

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Clinical Trials Trials RNA Bioinformatics 52

Chemical Biology and Drug Design

JUNE 11, 2024

RNA sequencing (RNA-seq) and bioinformatics analyses of HCC cells were utilized to elucidate the mechanism underlying the effects of BRU in HCC. However, the exact mechanism of BRU in the treatment of hepatocellular carcinoma (HCC) remains unknown.

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Chemical Biology and Drug Design

NOVEMBER 27, 2023

Moreover, bioinformatic analysis and cell viability test showed A6 plays anticancer role by regulating Best1 and HIST1H2BJ. A total of 153 genes were increased, and the expression of 81 genes was decreased.

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Agency IQ

OCTOBER 12, 2023

Joneckis said that CBER has “some limited uses that we have seen in external submissions, mostly in the bioinformatics area,” but not as many as CDER. Regarding artificial intelligence (AI), an important topic at RAPS Convergence, the two centers discussed external and internal use cases.

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Drug Target Review

DECEMBER 28, 2023

Recent advances in bioinformatics show clonal neoantigens are the best targets for immunotherapy, as I will elucidate below. Using powerful bioinformatics technology developed and validated with sequence data from the TRACERx study, researchers are able to identify clonal neoantigens from a patient’s unique tumour profile.

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PLOS: DNA Science

MAY 16, 2024

Other genomic databases were retooled for the huge datasets that COVID was generating, such as the Cloud Institute for Microbial Bioinformatics, begun in 2014 and rechristened the COVID-19 Genomics UK Consortium ( COG-UK ). And so variants alpha, delta, omicron emerged,” write the authors of the Frontiers in Science paper.

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Codon

APRIL 16, 2023

BMC Bioinformatics. Read There’s a news article that breaks down this work. Read Retracted Covid-19 articles: significantly more cited than other articles within their journal of origin. Read Deep learning of genomic contexts predicts protein co-regulation and function. McCafferty C.L. Favate J.S. Debès C.

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Engineering DNA RNA Science 52

Codon

AUGUST 28, 2024

This article concludes our mini-issue. 5 But it could match up to one of the threats in your reference database, so you opt to throw a battery of bioinformatics tools at it. BLAST is covered in every introductory bioinformatics course and the 1990 paper introducing has over 110,000 citations. Bioinformatic results from HMMScan.

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Chemical Biology and Drug Design

APRIL 19, 2025

RNA sequencing and bioinformatic analyses were conducted to identify differentially expressed genes, followed by functional pathway enrichment analysis. Human cardiomyocyte AC16 cells were subjected to hypoxic conditions and treated with Dex and TPO. Cellular responses, including proliferation, apoptosis, and autophagy, were assessed.

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Chemical Biology and Drug Design

FEBRUARY 5, 2025

Bioinformatic analyses were performed to identify potential target genes and pathways regulated by luteolin/quercetin during adipogenesis. Differentially expressed genes (DEGs) involved in luteolin and quercetin action that regulate adipogenic differentiation were identified using RNA sequencing (RNA-seq).

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RNA Bioinformatics Regulations Research 100

Chemical Biology and Drug Design

MARCH 4, 2025

Network pharmacology and bioinformatics analysis showed that the role of FA in treating IS was associated with oxidative stress. The Nrf2 inhibitor ML385 was used for the rescue experiments. Topological analysis of the PPI network revealed 11 key genes, which were closely associated with the Nrf2 pathway.

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