Science Daily: Pharmacology News

JUNE 27, 2023

In a pair of articles, they report that, in experiments with flakes of semiconductor materials -- each only a single layer of atoms thick -- they detected signatures of 'fractional quantum anomalous Hall' (FQAH) states. Scientists and engineers have announced a significant advancement in developing fault-tolerant qubits for quantum computing.

Research 188

Research Engineering 188

Chemical Biology and Drug Design

NOVEMBER 4, 2024

This review article comprehensively summarized the recent advancements in galantamine and its hybrid analogs as potential therapeutic agents for the management of AD. Some researchers hypothesized that the primary event associated with the cholinergic neurotransmitter (acetylcholine) is memory loss and cognitive impairment.

Disease 100

Disease Therapies Research 100

Chemical Biology and Drug Design

MAY 12, 2025

As the most effective gene editing method currently available, the CRISPR/Cas system has proven to be highly valuable in genomic research across a wide range of species since its discovery as a component of the adaptive immune system in bacteria. This goal is achieved through an RNA-guided procedure.

Treatment 100

Treatment Therapies DNA RNA 100

Chemical Biology and Drug Design

MAY 10, 2025

Exciting new research is exploring carprofen's broader therapeutic possibilities, extending beyond its original anti-inflammatory role. With ongoing research pushing the boundaries of its potential, carprofen remains a promising candidate for innovation in drug development and treatment strategies.

Small Molecule 100

Small Molecule Drug Development Science Therapies 100

Drug Patent Watch

NOVEMBER 26, 2024

In the ever-evolving landscape of pharmaceutical research and development, drug repurposing has emerged as a promising strategy to bring new treatments to patients more quickly and cost-effectively. This article delves into the intricate world of drug repurposing… Source

Drugs 96

Drugs Pharmaceuticals Treatment Research 96

Science Daily: Pharmacology News

APRIL 22, 2025

A powerful clinical artificial intelligence tool developed by biomedical informatics researchers has demonstrated remarkable accuracy on all three parts of the United States Medical Licensing Exam (Step exams), according to a new article.

Doctors 195

Doctors Licensing Licensing Research 195

Drug Target Review

JULY 7, 2025

Persistent challenges with NHP use Despite their biological relevance, using live NHPs in research poses several major challenges: Ethical concerns NHPs, due to their advanced cognition and social behaviour, are at the centre of ongoing ethical debates. Supply chain disruptions Availability is a critical bottleneck in NHP-based research.

Drug Research 52

Drug Research Research Animal Testing Drugs 52

Science Daily: Pharmacology News

SEPTEMBER 27, 2023

A new article has analyzed another understudied behavior in baleen (filter-feeding) whales such as humpback whales in different populations across the northern and southern hemispheres. The research also emphasizes that the behavior was similar in different individuals, regardless of where in the world it occurred.

Research 215

Research 215

Science Daily: Pharmacology News

APRIL 15, 2025

A new journal article examines how the study of seals in particular can benefit human health, and synthesizes various research on the topic.

Nurses 147

Nurses Research 147

Drug Discovery Today

DECEMBER 7, 2023

A team led by Research Professor Gintautas Tamulaitis from Vilnius University Life Sciences Center (VU LSC) revealed a novel protection mechanism in CRISPR-Cas antiviral defense system. The article “Ribosomal stalk-captured CARF-RelE ribonuclease inhibits translation following CRISPR signaling” was published in the journal Science.

Science 113

Science Virus Research 113

Drug Target Review

DECEMBER 23, 2024

To explore these challenges further, we spoke with Cheng Wang, a postdoctoral researcher at the University at Buffalo. Wangs research focuses on developing mechanistic mathematical models to quantitatively characterise ADC-induced toxicities. This provides a strong starting point for new ADC development, Wang explained.

Research 52

Research Treatment Therapies Drug Development 52

Chemical Biology and Drug Design

MARCH 26, 2025

In this article, we present the synthesis of novel 3-phenyl-1-((1-aryl-1 H -1,2,3-triazol-5-yl)methyl)spiro[indoline-3,2-oxiran]-2-one derivatives by the regioselective reaction of sulfur ylides with 1,2,3-triazole-tethered isatins and their anticancer effects on hepatocellular carcinoma (HCC) cells HepG2 and HCCLM3.

Research 100

Research 100

Science Daily: Pharmacology News

AUGUST 28, 2023

A new article describes the 266 fossil species as one of the richest and most diverse groups of three-million-year-old fauna ever found in New Zealand. At least ten previously unknown species will be described and named in future research.

Treatment 189

Treatment Research 189

Crown Bioscience

JUNE 23, 2025

As researchers look to understand and overcome drug resistance, they need precise, controllable, and scalable models that allow them to isolate and study resistance mechanisms effectively. Drug resistance remains one of the most pressing challenges in oncology drug development, as it is the leading cause of treatment failure.

Drugs 52

Drugs Drug Development Therapies Treatment 52

Chemical Biology and Drug Design

FEBRUARY 15, 2024

This article highlights the various structural features along with the structure–activity relationship (SAR) of nitrogen-containing heterocyclics that play a key role in binding at target sites for potential antidepressant action.

Drugs 189

Drugs Research 189

Crown Bioscience

JULY 1, 2025

This article introduces key assays and models available to research teams looking to investigate ADC mechanisms and develop the next generation of this exciting new drug category.

Drugs 52

Drugs Drug Development Therapies Research 52

Drug Patent Watch

DECEMBER 10, 2024

The pharmaceutical industry has undergone significant changes over the past decade, with a growing trend towards outsourcing key aspects of research, development, and manufacturing to third-party vendors. The Rise of Integrated CDMOs The global biotechnology and pharmaceutical services outsourcing market size was valued at $70.48

Drug Development 86

Drug Development Compliance Pharmaceutical Companies Drugs 86

Advarra

AUGUST 8, 2024

The EU AI Act’s implications extend into clinical research, where AI is increasingly utilized for tasks like medical image analysis, natural language process for endpoint analysis, and generating/analyzing data for synthetic control arms. Non-EU companies must comply with the AI Act if their AI systems are used in the EU market.

Clinical Research 98

Clinical Research Research Clinical Trials Compliance 98

Drug Target Review

MAY 3, 2024

Machine learning’s role in life sciences research As we move towards more generalised AI models, neural networks and natural language interfaces, we’re starting to see machine learning take the place of higher order reasoning and data analysis “sense making.” It’s too early to tell but I’m optimistic.

Research 116

Research Science Cell Based Assays Disease 116

Drug Patent Watch

MARCH 3, 2025

Breaking Down Barriers: The Power of Global Research Collaborations in Generic Drug Development As the world grapples with the complexities of healthcare, one thing is clear: the need for innovative solutions has never been more pressing. Read the full article here: [link] Share your thoughts in the comments below!

International 71

International Drug Development Drugs Treatment 71

Drug Patent Watch

NOVEMBER 19, 2024

Recent trends and advancements in technology, research, and collaboration are reshaping the landscape of generic drug development, leading to new opportunities and challenges for pharmaceutical companies. This article delves into the future of partnerships in generic drug… Source

Drug Development 105

Drug Development Pharmaceutical Companies Drugs Pharmaceuticals 105

Drug Target Review

JANUARY 14, 2025

Operating a workflow, such as the one described in Figure 1, involves several key considerations that affect both the accuracy of results and the efficiency of the research process. Defining the research question A well-defined research question is the cornerstone of an effective scientific workflow in drug discovery.

Drugs 69

Drugs Protein Expression Science Research 69

LifeSciVC

MAY 14, 2025

Merck, Bristol-Myers Squibb, Amgen, Eli Lilly, and Gilead have all conducted microgravity research in orbit. With respect to the latter, Mercks microgravity research on Keytruda is an informative case study. Despite the progress made, microgravity research projects to date have been exploratory, small-scale one-offs.

Science 96

Science Production Research Drugs 96

Chemical Biology and Drug Design

DECEMBER 15, 2023

Given the substantial body of evidence supporting the neuroprotective potential of exendin-4 in various research models, this article is dedicated to exploring the promising role of exendin-4 as a therapeutic agent for the treatment and management of Alzheimer's disease and Parkinson's disease.

Disease 189

Disease Therapies Treatment Research 189

Drug Patent Watch

FEBRUARY 11, 2025

The Dark Side of Innovation: How Companies Use Drug Patents to Block Competitors As we celebrate the breakthroughs in medical research and the development of life-saving treatments, it's essential to acknowledge the complex landscape of pharmaceutical innovation. Read the full article here What do you think?

Drugs 87

Drugs Treatment Marketing Production 87

Drug Patent Watch

MAY 15, 2025

"Unlocking the Secrets of the FDA's Orange and Purple Books: Insider Tips from a Drug Patent Research Expert As the pharmaceutical industry continues to evolve at breakneck speed, staying ahead of the curve requires more than just a keen eye for innovation it demands a deep understanding of the regulatory landscape.

FDA 77

FDA Research Biosimilars Drugs 77

Chemical Biology and Drug Design

JULY 3, 2025

This comprehensive approach offers a streamlined and cost-effective pathway for drug design and development, providing valuable insights for researchers in the field of therapeutic drug production. In conclusion, structural modification of centaureidin resulted in enhanced antioxidant and cytotoxic activities.

Drug Development 100

Drug Development Drugs Therapies Production 100

Drug Patent Watch

FEBRUARY 12, 2025

The generic drug development process involves several stages, from patent research to regulatory approvals. Here are a few: Thorough Patent Research : Conducting comprehensive patent research is critical to identifying potential patent challenges and developing a robust strategy to overcome them.

Drug Development 63

Drug Development Drugs Compliance Regulations 63

Drug Patent Watch

DECEMBER 11, 2024

In this article, we will delve into the key criteria for selecting a CDMO, highlighting the essential factors to consider and the importance of effective communication and cultural fit. Your Drugs Development Stage The stage of your drug development is a critical factor in selecting a CDMO.

Pharmaceutical Companies 96

Pharmaceutical Companies Compliance Pharmaceuticals Drug Development 96

Drug Target Review

DECEMBER 6, 2024

In drug discovery and biological research, the scientists workflow often follows a structured and iterative approach to ensure accuracy, reproducibility and scientific integrity. At the heart of any research is the scientific question. This acts as a safeguard against false positives and misinterpretation of the data.

RNA 52

RNA Drugs Research Science 52

Chemical Biology and Drug Design

JUNE 9, 2025

ABSTRACT Despite extensive research, the topic of anti-PD-L1 small-molecule inhibitors remains elusive. GJ19 showed the most potent anti-PD-L1 effects with an IC 50 of 32.06 nM. GJ19 (i.p., 15 mg/kg) effectively suppressed tumor growth with a TGI of 56.8% in a B16-F10 melanoma mouse model.

Small Molecule 100

Small Molecule Research 100

KIF1A

FEBRUARY 10, 2024

Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. And just like it can be challenging to play a new game without knowing all the rules, one hurdle for gene therapy research and development has been a lack of a playbook.

Therapies 111

Therapies Clinical Trials FDA Disease 111

Chemical Biology and Drug Design

JANUARY 30, 2025

ABSTRACT Cyclin-dependent kinase 9 (CDK9) is considered as an important target in the research of antitumor drugs. In general, SAR of 9H purine CDK9 inhibitors is systematically described in this paper, resulting in the discovery of two compounds ( B2 and B5 ) with further research value.

Research 100

Research Drugs 100

Chemical Biology and Drug Design

JUNE 7, 2023

This article utilized template-based molecular docking of peptides and receptors to identify six highly valuable mutation sites. Subsequent amino acid multi-site mutations were conducted to establish a virtual polypeptide library.

Treatment 177

Treatment Research 177

KIF1A

MARCH 16, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. Read the Article The post ScienceSaturday: March 16, 2024 appeared first on KIF1A.

Disease 105

Disease Clinical Development Research Treatment 105

Quanticate

JULY 5, 2024

Good Clinical Practice (GCP) affects a variety of entities, including sponsors, contract research organisations (CROs), and investigator sites. In our article we look into the potential implications of E6(R3) for the future of clinical studies and how organisations can best prepare for these changes.

Clinical Research 111

Clinical Research Drug Development Treatment Research 111

KIF1A

JANUARY 27, 2024

Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. This study also highlights the diversity of HSP types: across 18 patients, researchers identified 15 different spastic paraplegia subtypes.

Therapies 111

Therapies Small Molecule DNA Treatment 111