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New research improves the safety and effectiveness of ADC cancer treatments

Drug Target Review

To explore these challenges further, we spoke with Cheng Wang, a postdoctoral researcher at the University at Buffalo. Wangs research focuses on developing mechanistic mathematical models to quantitatively characterise ADC-induced toxicities. This provides a strong starting point for new ADC development, Wang explained.

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Synthesis Methods and Therapeutic Journey of Carprofen and Its Derivatives: A Review

Chemical Biology and Drug Design

Exciting new research is exploring carprofen's broader therapeutic possibilities, extending beyond its original anti-inflammatory role. With ongoing research pushing the boundaries of its potential, carprofen remains a promising candidate for innovation in drug development and treatment strategies.

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Scientific workflow for hypothesis testing in drug discovery: Part 1

Drug Target Review

In drug discovery and biological research, the scientists workflow often follows a structured and iterative approach to ensure accuracy, reproducibility and scientific integrity. At the heart of any research is the scientific question. This acts as a safeguard against false positives and misinterpretation of the data.

RNA 52
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Cell Line-Derived Xenografts: A Reliable Platform for Preclinical Cancer Drug Testing

Crown Bioscience

In the complex landscape of oncology research and drug development, reliable preclinical models are crucial. This article explores the pivotal role of CDX models in preclinical cancer research, emphasizing their utility in drug discovery and development processes.

Drugs 52
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How to use in vitro models to study and overcome drug resistance in oncology

Crown Bioscience

As researchers look to understand and overcome drug resistance, they need precise, controllable, and scalable models that allow them to isolate and study resistance mechanisms effectively. Drug resistance remains one of the most pressing challenges in oncology drug development, as it is the leading cause of treatment failure.

Drugs 52
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Time for change: non-human primates in drug research

Drug Target Review

Persistent challenges with NHP use Despite their biological relevance, using live NHPs in research poses several major challenges: Ethical concerns NHPs, due to their advanced cognition and social behaviour, are at the centre of ongoing ethical debates. Supply chain disruptions Availability is a critical bottleneck in NHP-based research.

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Key assays and analytical techniques for the development of antibody drug conjugates

Crown Bioscience

This article introduces key assays and models available to research teams looking to investigate ADC mechanisms and develop the next generation of this exciting new drug category.

Drugs 52