Drug Target Review

DECEMBER 13, 2023

About the author Dr Sayoni Das SVP Bioinformatics at PrecisionLife Sayoni leads the research and development of bioinformatics pipelines that generate biological insights from PrecisionLife’s core technology and support drug discovery programmes.

Bioinformatics 145

Bioinformatics Disease Regulations Immune Response 145

Chemical Biology and Drug Design

JANUARY 15, 2024

The expression of ANKRD22 in LUAD and its enriched pathway were analyzed by bioinformatics analysis. Bioinformatics analysis, qRT-PCR, and western blot showed that ANKRD22 was highly expressed in LUAD, which had a positive connection with M2 marker genes. Mitochondrial membrane potential was assessed using the JC-1 probe.

Bioinformatics 100

Bioinformatics Treatment Research 100

Broad Institute

JANUARY 24, 2024

Through Terra, researchers can gain access to genomics and other data modalities used for biomedical research, as well as run state-of-the-art workflows developed by Broad and wider bioinformatics community. Expanding Terra onto Azure enhances support for enterprises and data scientists worldwide.

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Bioinformatics Compliance Science Research 140

Drug Target Review

AUGUST 11, 2023

1 The study reveals a novel bioinformatic approach and tool that holds the potential to empower researchers in designing vaccines capable of inducing a stronger immune response. Empowering vaccine development Through sophisticated computer simulations, the researchers made a significant discovery.

Vaccine 98

Vaccine Immune Response Bioinformatics Virus 98

Chemical Biology and Drug Design

MARCH 28, 2023

Pharmacodynamic targets of metformin were predicted using the Bioinformatics Analysis Tool for the molecular mechanism of traditional Chinese medicine (BATMAN), Drugbank, PharmMapper, SwissTargetPrediction, and TargetNet databases.

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The Open Targets Blog

OCTOBER 31, 2023

 To address this disparity, the USA’s Research to Accelerate Cures and Equity (RACE) for Children Act as of 2020 requires any company designing a clinical trial for an antineoplastic therapy to include a pediatric trial component if the gene target is on the FDA’s Pediatric Molecular Target Lists (PMTL).  By

Bioinformatics 67

Bioinformatics Engineering Clinical Trials Therapies 67

SCIENMAG: Medicine & Health

JULY 6, 2023

EMBL’s European Bioinformatics Institute (EMBL-EBI) has launched the Pathogens Portal – an online platform that enables researchers, clinicians, and policymakers to access the most comprehensive collection of biomolecular data about pathogens.

Bioinformatics 69

Bioinformatics Research 69

Chemical Biology and Drug Design

JULY 4, 2023

Genes related to acacetin and esophageal cancer were predicted by bioinformatics analysis. In this work, esophageal squamous carcinoma cell lines were subjected to increasing doses of acacetin, and the proliferative, migrative, invasive and apoptotic phenotypes were evaluated by a series of in vitro experiments.

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Elrig

MARCH 25, 2025

There will also be a poster award for early-career professionals recognising the research that the next generation of scientists bring to drug discovery. There, he worked with the GENCODE consortium to establish foundational lncRNA gene annotations, which are considered a standard reference in the field.

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RNA Bioinformatics Science Pharmacokinetics 59

Chemical Biology and Drug Design

JULY 13, 2023

Bioinformatics analysis was performed to predict the molecular targets of COP. Cell counting kit-8 (CCK-8), scratch healing assay, Transwell assay, and flow cytometry were used to detect cell growth, migration, invasion, and cell cycle progression.

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Regulations Bioinformatics Treatment Drugs 100

Crown Bioscience

NOVEMBER 6, 2024

Mouse Clinical Trials (MCTs) are a cornerstone of preclinical oncology research, providing valuable insights into drug efficacy and biomarker discovery. However, the success of these trials hinges on precise study design, appropriate model selection, and rigorous data analysis.

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Clinical Trials Bioinformatics Trials Research 52

Chemical Biology and Drug Design

FEBRUARY 20, 2024

Moreover, bioinformatics analysis has suggested that hsa_circRNA_103820 possesses potential peptide-coding ability. Abstract N6-methyladenosine (m6A) modification and m6A-related RNA-binding proteins (RBPs) play vital roles in various aspects of circRNA metabolism.

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Bioinformatics RNA Regulations Research 100

Chemical Biology and Drug Design

JANUARY 5, 2024

Homeobox B7 (HOXB7) expression in CRC was analyzed and detected by bioinformatics analysis, quantitative real-time PCR or western blot. Following the treatment of 0, 1.94, 7.75, or 19.36 μM μM THA, CRC cell viability, apoptosis, migration, and invasion were evaluated by methyl tetrazolium, flow cytometry, wound-healing, and transwell assays.

Bioinformatics 100

Bioinformatics Cell Biology Treatment Research 100

Chemical Biology and Drug Design

AUGUST 20, 2023

Bioinformatics analysis predicted cathepsin B (CTSB) as a target of hederagenin to modulate NOD-like receptor (NLR) pathway. NLRP3 inhibitor MCC950 attenuated HG-induced fibrosis of renal cells, and its activator nigericin reversed the suppressive effect of hederagenin on HG-induced fibrosis.

Bioinformatics 100

Bioinformatics Protein Expression Research 100

Chemical Biology and Drug Design

JANUARY 1, 2024

Then, Bioinformatics was applied to sort out the candidate interacting with Stachydrine as well as its expression and downstream target in BC. Abstract Considering the therapeutic efficacy of Stachydrine on breast cancer (BC), this study aims to decipher the relevant mechanism.

Bioinformatics 100

Bioinformatics Regulations Disease Research 100

Chemical Biology and Drug Design

DECEMBER 28, 2023

In present study, LINC00460 was screened out through bioinformatics analysis. The prognostic value of long noncoding RNA (lncRNA) LINC00460 has been reported in cervical cancer. However, its effect on DDP sensitivity in cervical cancer remains poorly understood. The sensitivity to DDP was investigated using an CCK8 assay.

Bioinformatics 100

Bioinformatics RNA Regulations Drugs 100

Chemical Biology and Drug Design

AUGUST 9, 2023

Bioinformatics and functional analyses indicated that these proteins were predominantly involved in protein synthesis and translation. Our investigation indicated that plumbagin markedly inhibited the LoVo cells proliferation, and induced the apoptosis in LoVo cells, simultaneously induced G0/G1 phase cell cycle arrest.

Bioinformatics 100

Bioinformatics Protein Expression Treatment Research 100

Chemical Biology and Drug Design

JUNE 21, 2023

Hsa-miR-503-5p expression in LUAD and the target gene downstream of hsa-miR-503-5p was predicted by bioinformatics analysis. Abstract The study aimed to assess the role of hsa-miR-503-5p in cisplatin resistance and angiogenesis in LUAD and its underlying mechanisms.

Regulations 100

Regulations Protein Expression Bioinformatics Drugs 100

Chemical Biology and Drug Design

MARCH 14, 2023

The bioinformatics website, dual luciferase reporter assay, and quantitative real-time polymerase chain reaction were applied to analyze the network among EVO, lncRNA, miR-152-3p, and mRNA. Abstract Evodiamine (EVO) has been demonstrated to promote apoptosis of ovarian cancer cells, and upregulate miR-152-3p level in colorectal cancer.

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Regulations Bioinformatics Drugs Research 100

Nvidia Developer: Drug Discovery

JANUARY 2, 2024

Learn how the Francis Crick Institute is using NVIDIA Clara Parabricks to enable key parts of TRACERx EVO, a new program that builds on the discoveries made in.

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Research Bioinformatics Science Drugs 86

Drug Target Review

DECEMBER 6, 2024

In drug discovery and biological research, the scientists workflow often follows a structured and iterative approach to ensure accuracy, reproducibility and scientific integrity. At the heart of any research is the scientific question. This acts as a safeguard against false positives and misinterpretation of the data.

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RNA Drugs Research Science 52

SCIENMAG: Medicine & Health

JULY 24, 2023

In this study, the authors proposed and tested a new bioinformatic approach and tool that allows researchers to […]

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Vaccine Bioinformatics Immune Response Virus 60

Drug Target Review

JULY 12, 2023

Many cell lines used in pancreatic cancer research, for example, are generally not genetically aligned with most patients in the clinic. If researchers continue to use an intuitive approach of chronically suppressing the MAPK pathway, we will likely continue to see the same results in patients with little improvement.

Biochemical Assays 98

Biochemical Assays Treatment Bioinformatics Disease 98

Crown Bioscience

OCTOBER 11, 2024

Mathematical Modeling of Tumor Growth Curves and Its Application in Biomarker Discovery for Anti-Tumor Drugs Breaking down the data from our recent research In last month’s issue of Cancer Research Communications, scientist Drs.

Bioinformatics 52

Bioinformatics Science Research Drugs 52

Crown Bioscience

MARCH 12, 2025

The integration of artificial intelligence (AI) and bioinformatics into oncology research has revolutionized how we approach drug discovery, tumor modeling, and patient-specific therapy design.

Bioinformatics 52

Bioinformatics Therapies Research Drugs 52

Drug Target Review

MARCH 19, 2024

In the current study undertaken by an international team of researchers, co-led by Dr William Reay, we used the genetics of retinol itself as a way to proxy its effect in thousands of traits, including brain structure, vision, and the immune system through causal modelling.

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Laboratories Bioinformatics International Research Laboratories 105

Chemical Biology and Drug Design

FEBRUARY 7, 2024

We assessed the effect of HSYA and NF-κB signaling pathway-related genes by bioinformatics analysis and conducted molecular docking to assess the interaction of HSYA with a combined protein residue molecule ligand. Western blot was employed to investigate NF-κB transcription factors in chondrocyte metabolism.

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The Pharma Data

NOVEMBER 25, 2020

In the course of the strategic research alliance that was announced in June 2020, Egle will validate novel tumor-infiltrating regulatory T-cell (Treg) targets against which Takeda will develop potential therapies.

Research 52

Research Bioinformatics Pharmaceutical Companies Engineering 52

Broad Institute

MARCH 8, 2024

Organizing Committee By Rose Circeo March 8, 2024 Breadcrumb Home Organizing Committee Sumaiya Iqbal, Co-chair Group Leader, Bioinformatics and Computational Biology, CDoT Wengong Jin, Co-chair Postdoc, Eric and Wendy Schmidt Center Holly Soutter, General Committee Member Director, Biochemistry and Biophysics, CDoT Eric Sigel, General Committee Member (..)

Bioinformatics 52

Bioinformatics Science Research Drugs 52

Broad Institute

MARCH 8, 2024

Organizing Committee By Rose Circeo March 8, 2024 Breadcrumb Home Organizing Committee Sumaiya Iqbal, Co-chair Group Leader, Bioinformatics and Computational Biology, CDoT Wengong Jin, Co-chair Postdoc, Eric and Wendy Schmidt Center Holly Soutter, General Committee Member Director, Biochemistry and Biophysics, CDoT Eric Sigel, General Committee Member (..)

Bioinformatics 52

Bioinformatics Science Research Drugs 52

SCIENMAG: Medicine & Health

SEPTEMBER 14, 2023

Led by researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI), Cold Spring Harbor Laboratory (CSHL), and the Massachusetts Institute of Technology (MIT), the work focuses on understanding why some tumours fail to respond to immune checkpoint blockade (ICB) […]

Bioinformatics 52

Bioinformatics Laboratories Research 52

Crown Bioscience

JANUARY 9, 2024

I am excited to share with you a significant advancement in the field of cancer research, the culmination of recent efforts by my team and me. We have published our study on " SynAI " in the journal " Bioinformatics Advances " (November 2023).

Bioinformatics 52

Bioinformatics Drugs Treatment Research 52

Drug Target Review

MARCH 28, 2024

1 Researchers have also observed a correlation between greater translatability of natural products and increased progression through clinical trials. This can allow researchers to routinely uncover about 10,000 distinct molecules per plant sample, each of which has the potential to interact with human biology and inspire new medicines.

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Production Drugs Small Molecule Bioinformatics 128

The Open Targets Blog

OCTOBER 24, 2023

Amir Feizi is the Director of Bioinformatics at OMass Therapeutics, a spinout from Professor Dame Carol Robinson’s Laboratory at the University of Oxford. Their work was recently published in Bioinformatics. We chat with him about otargen, and the importance of sharing open-source resources within the bioinformatics community.

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Bioinformatics Packaging Pharmaceutical Companies Pharma Companies 62

Nvidia Developer: Drug Discovery

DECEMBER 19, 2023

The applications of artificial intelligence for enzyme generation is an exciting field of research with direct applications in the life sciences. Improved methods for functional annotation are a vital component in enzyme research, enabling the identification and characterization of the functions of newly discovered enzymes.

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Science Small Molecule Bioinformatics Research 102

Broad Institute

JULY 10, 2023

Thanks in part to her research, more geneticists are now studying a wider diversity of people and accounting for genetic ancestry in their analyses. Through this work, Martin is showing how a methodical, data-driven kind of social justice can help improve equity in scientific research and lead to better science.

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The Pharma Data

JANUARY 24, 2021

His research focuses on the role of the microbiome in immune defense and disease resistance. “We Diversigen provides consultative end-to-end solutions for sequencing, bioinformatics, and statistical analysis for the study of the microbiome of living organisms and environments. (NASDAQ: OSUR), today announced that Eric Pamer, M.D.,

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