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Building better brain models for Parkinson’s disease and beyond

Drug Target Review

The search for effective treatments for neurodegenerative diseases like Parkinson’s disease has long been hindered by the brain’s complexity and the absence of adequate models for drug discovery. From stem cell to organoid The process of developing a usable organoid from stem cells takes time.

Disease 52
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Time for change: non-human primates in drug research

Drug Target Review

Importantly, this roadmap complements earlier FDA initiatives supporting the use of NAMs, 8 signalling a sustained federal commitment to reducing animal use in science without compromising patient safety. To overcome these hurdles, stakeholders must invest in collaborative research, transparent data sharing and regulatory science.

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2025 Merkin Prize in Biomedical Technology awarded to pioneers of CAR T-cell therapy

Broad Institute

The $400,000 prize, to be shared among the four winners, recognizes their role in creating and advancing a technology that has reshaped how physicians treat leukemia, lymphoma, and multiple myeloma, and is now showing promise in treating autoimmune and infectious diseases. We treated our first patient with CD19 CAR T cells back in 2007.

Therapies 119
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Levers for Biological Progress

Codon

Amodei also imagines the ways AI could accelerate biological research and yield miraculous cures in the 21st century; everything from the prevention and treatment of nearly all infectious and inherited diseases to the elimination of most cancers. This essay focuses on how we might do both, specifically for the cell. Even the humble E.

DNA 132
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Scientists reveal how energy is delivered into the cells major 'shipping port'

Science Daily: Pharmacology News

A team of scientists has answered a long-standing question in cell biology, uncovering how the cell's main energy currency, ATP, is transported into the endoplasmic reticulum (ER). Disrupted energy transport could affect diseases such as type 2 diabetes, cancer, and neurodegenerative disorders.

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Patient-derived organoids in disease modelling

Drug Target Review

How can PDOs revolutionise drug discovery and deepen our understanding of disease? Patient-derived organoids (PDOs) are proliferative 3D cell structures derived from tissue samples of both healthy and diseased tissue. What sets PDOs apart from traditional 2D cell and animal models used in drug discovery?

Disease 122
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Condensate biology: advancing drug discovery for complex diseases

Drug Target Review

In this article, we will delve into the world of condensate biology and explore the groundbreaking research projects undertaken to discover the potential they hold for diseases such as amyotrophic lateral sclerosis ( ALS ) and colorectal cancer. Klein notes the importance of Dewpoint’s disease-agnostic approach.

Disease 98