Drug Target Review

SEPTEMBER 28, 2023

I originally wanted to be a doctor but that’s a second-tier track in France. They needed reference materials for the disease in order to develop and validate diagnostic tests. Researchers were able to use our synthetic RNA controls as a reference to verify and validate assays. I’m a CEO with a background in chemistry.

DNA 116

DNA Organic Chemistry Science Virus 116

Drug Target Review

AUGUST 29, 2023

I then chose to do my doctoral research at the Perelman School of Medicine at the University of Pennsylvania, which provided me with great scientific training, critical thinking, and communication skills. As a woman in STEM, what unique perspectives or strengths do you believe you bring to your work?

Science 98

Science Disease Molecular Biology Treatment 98

Drug Target Review

JUNE 11, 2024

For instance, in my field, people easily understand the value a medical doctor brings, but few appreciate the essential role biochemistry plays in understanding how the body works, how diseases start, how drugs are discovered, etc. As a woman in STEM, what unique perspectives or strengths do you believe you bring to your work?

Engineering 64

Engineering Science Molecular Biology Doctors 64

Broad Institute

JUNE 21, 2023

Common genetic variants associated with cardiometabolic disease can produce phenotype changes of such small effect that they can be difficult to characterize.

Small Molecule 52

Small Molecule Cell Based Assays Medical Schools Disease 52

The Pharma Data

DECEMBER 2, 2020

She is currently the CEO of Twentyeight-Seven, a biotech company focused on novel RNA biology that she co-founded alongside prominent Harvard investigators. Lisa began her career as Assistant Professor at Washington University School of Medicine, following a post-doctoral cardiovascular fellowship at the University of Chicago.

Pharmaceuticals 52

Pharmaceuticals Synthetic Chemistry RNA Disease 52

Elrig

APRIL 29, 2024

She has played a key role inbuilding the target identification platform and a proprietary database of transcriptome-wide, functional RNA structures. Interactive Q&A session: Pose your questions directly to the experts and get tailored insights to your interests and concerns.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Elrig

JUNE 18, 2024

Supporting yourself to be compassionate and understanding will help those around you too (and often make you a better researcher too) Question 2 – What measures can be put in place to make therapy more accessible to doctoral and early career researchers?

Science 52

Science Therapies RNA Research 52

The Pharma Data

SEPTEMBER 6, 2021

This study further showcases Roche’s commitment to identifying meaningful treatment options for patients with breast cancer through a comprehensive development programme that includes early and late-stage HR-positive, HER2 positive and triple-negative forms of the disease. Lung Cancer Highlights. Comprehensive genomic profiling.

Treatment 52

Treatment Therapies DNA Trials 52

Drug Target Review

NOVEMBER 29, 2023

Our primary focus is to design and develop RNA therapies for liver diseases. Using humans as the model, we use an approach called deep phenotyping to explore the relationships between cells, genes, biological pathways and patterns of disease. Why are you focusing on liver disease?

Therapies 102

Therapies Disease RNA Engineering 102

Broad Institute

DECEMBER 6, 2023

Cytokines are also targeted by drugs for many diseases such as rheumatoid arthritis, COVID-19, and cancer, but until now, scientists haven’t had a comprehensive view of how different immune cells respond to different cytokines because the immune system is so complex. For many immune-mediated diseases, there's no cure or treatment.

Immune Response 138

Immune Response RNA Disease Medical Schools 138

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. What do you like about rowing?

Science 124

Science Medical Schools Hospitals Disease 124

Broad Institute

OCTOBER 11, 2023

He also read everything he could about her disease, including emerging evidence that suggested that the immune system could recognize and kill Merkel cell carcinoma. His mother had a presentation of the disease that suggested her immune system was already on the job.

Research 137

Research Immune Response Clinical Trials Therapies 137

Broad Institute

FEBRUARY 11, 2025

Mapping mRNA through its life cycle within a cell By Corie Lok February 11, 2025 Breadcrumb Home Mapping mRNA through its life cycle within a cell Xiao Wangs studies of how and where RNA is translated could lead to the development of better RNA therapeutics and vaccines. I wasnt trained at MIT, and I had never lived in Boston before.

RNA 52

RNA DNA Science Vaccine 52

Broad Institute

OCTOBER 4, 2023

Today, scientists use such reactions to produce the customizable DNA and RNA molecules that enable genetic sequencing, drug and vaccine development, pathogen tests, cancer diagnostics, and more. It is because we had the Fellowship that we could buy our very first DNA and RNA synthesizer in the lab.”

DNA 52

DNA RNA Science Protein Expression 52

The Pharma Data

AUGUST 16, 2021

The antiviral agent incorporates RNA-like building blocks into the RNA genome of the virus. If this genetic material is further replicated, defective RNA copies are produced and the pathogen can no longer spread. When it enters the cell, it is converted into RNA-like building blocks. Molnupiravir has a lot of potential.”

RNA 52

RNA Virus Clinical Trials Drugs 52

Codon

JULY 27, 2023

CNGA3-achromatopsia is a hereditary disease that causes people to see in shades of gray. There’s a TV show where a bunch of doctors are walking through a hospital corridor. They’re talking about a patient who has a rare genetic disease. How do transcription factors couple up with the correct RNA molecule?

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

CNGA3-achromatopsia is a hereditary disease that causes people to see in shades of gray. There’s a TV show where a bunch of doctors are walking through a hospital corridor. They’re talking about a patient who has a rare genetic disease. How do transcription factors couple up with the correct RNA molecule?

Therapies 52

Therapies RNA DNA Engineering 52

Codon

AUGUST 27, 2024

Doctors in training are told that when they hear hoofbeats, they should think horses, not zebras; rare diseases are the exception, not the rule. Sometimes, though, novel diseases do emerge, and as COVID-19 demonstrated, they can surprise us. This is the third essay of four in our pandemic mini-issue.

DNA 112

DNA Laboratories Hospitals Virus 112

The Pharma Data

MAY 13, 2021

WITHOUT doctors, physical therapists or chiropractors. Our Unique Solution Has Been Featured All Over The Media, From Hallmark, The Doctors, Atlanta Live & Arizona Midday…. I Have A Doctorate In Pharmacy, But Everything I Learned About Pain Relief In Pharmacy School Is Dead Wrong! And then got my Doctor of Pharmacy (Pharm.

Pharmacy 52

Pharmacy Doctors Production Therapies 52

Broad Institute

JANUARY 30, 2024

Bhattacharyya wears many coats today, splitting his time between the Broad and the infectious disease ward at MGH, where a diagnostic method he developed at Broad is now being tested to see if it helps patients quickly receive the best antibiotics for their infections.

Hospitals 137

Hospitals Virus Medical Schools Science 137

Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. Across the tree of life, organisms strictly require exactly one of the two chiral forms of their molecular building blocks — amino acids, nucleotides of RNA and DNA. 4 As far as we know, right-handed proteins never occur naturally.

RNA 105

RNA DNA Vaccine Virus 105

The Pharma Data

NOVEMBER 18, 2020

.” Federal health officials have said the first doses of the vaccines will most likely go to health care workers who are at high risk for exposure, as well as to people who are most vulnerable to the disease, such as older people. Doctors say this reflects India’s younger and leaner population. Meanwhile, Moderna Inc.

FDA Approval 52

FDA Approval FDA Vaccine Virus 52

The Pharma Data

NOVEMBER 17, 2020

Until now, Reynolds had ignored infectious disease experts who say masks are one of the most effective tools to control the spread of the virus, the Post reported. developed its vaccine in collaboration with researchers from the Vaccine Research Center, part of the National Institute of Allergy and Infectious Diseases.

Vaccine 52

Vaccine Virus RNA Hospitals 52

NIH Director's Blog: Drug Development

JANUARY 5, 2016

This gene-editing system consists of a short segment of RNA that is attached to an enzyme. The RNA is preprogrammed to find a distinct short sequence of DNA and deliver the enzyme, which acts like a scalpel to slice the sequence out of the genome. It’s fast and pretty precise. deaths from unintentional overdoses.

Vaccine 52

Vaccine Science Disease Engineering 52

The Pharma Data

DECEMBER 23, 2020

One person familiar with the list said it included the lipids that encase the RNA material in both the Moderna and Pfizer vaccines, the Times reported. ” Several infectious disease experts said Monday the variant may not have even originated in Britain, the Washington Post reported.

Vaccine 52

Vaccine Government Virus Medical Schools 52

The Pharma Data

NOVEMBER 10, 2020

The vaccine uses a technology never before used: Each injection contains lipid nanoparticles — fat bubbles — that surround a strip of genetic material called messenger RNA, the Post reported. Doctors say this reflects India’s younger and leaner population. Worldwide, the number of reported infections passed 50.7

Treatment 52

Treatment Vaccine Hospitals RNA 52

The Pharma Data

NOVEMBER 9, 2020

The vaccine uses a technology never before used: Each injection contains lipid nanoparticles — fat bubbles — that surround a strip of genetic material called messenger RNA, the Post reported. Doctors say this reflects India’s younger and leaner population. Worldwide, the number of reported infections nearly 50.5

Vaccine 52

Vaccine Virus RNA Trials 52

Drug Target Review

APRIL 1, 2025

Advances in biotechnology are driving significant progress in the treatment of rare diseases, making it possible to develop targeted therapies for previously untreatable conditions. This recognition highlights the potential impact of the companys work in addressing rare neurological diseases. billion by 2032.

Disease 52

Disease Therapies Clinical Trials Cell Biology 52

keypoint

JANUARY 8, 2025

Dr. Cheruiyot is a post-doctoral fellow at the Joslin Diabetes Center, Harvard Medical School (HMS) I n the lab of Dr. Jean Schaffer, s he studies molecular mechanisms underlying protein synthesis in pancreatic beta cells, and alterations of such mechanisms in diabetes.

Medical Schools 59

Medical Schools RNA Laboratories Doctors 59

Codon

FEBRUARY 19, 2025

Researchers today often spend months trying to figure out whether a genetic mutation causes disease, simply because laboratory experiments are slow. ESM is a protein language model that captures certain aspects of protein structure and function, for example, but is blind to DNA or RNA-level features that drive cell behavior.

DNA 107

DNA Laboratories Engineering RNA 107

Elrig

MARCH 10, 2025

The free-to-attend event will bring together scientists, researchers and entrepreneurs from across the drug discovery community working on proteins, RNA, cell and gene therapies, PROTACs, as well as the application of big data to support target identification, biomarkers and the development of big molecules.

Research 52

Research Laboratories Medical Schools Engineering 52

PLOS: DNA Science

FEBRUARY 20, 2025

With infectious diseases on the rise, she asked me to repost CDC’s Adult Vaccine Assessment Tool. Of course, Carly is too young to recall many infectious diseases from personal experience – but she knows I can. And the disease returns when vaccination lapses. My daughter Carly has an annual physical approaching.

Vaccine 91

Vaccine Science RNA Disease 91

Broad Institute

NOVEMBER 6, 2024

Doctors currently don’t have effective targeted treatments, so they often have to stop the anti-tumor therapy or give large amounts of steroids, which have their own undesired side effects such as lowering the efficacy of the ICI anti-tumor treatment. Tags: Cancer RNA sequencing Paper Cited Blum S, Zlotoff D, et al.

Immune Response 125

Immune Response Medical Schools Clinical Trials Treatment 125

Codon

MAY 5, 2025

Educated in Vienna as a doctor of mechanical engineering and physics, Zippe’s passion was aeronautical engineering. This allowed for the isolation, purification, and study of minute amounts of DNA, RNA, proteins, and cells — tasks ill-suited to the larger centrifuges.

DNA 58

DNA Engineering Science Laboratories 58

Codon

JANUARY 26, 2025

Astrologers of the time believed that the disease’s periodic return was influenced by the location of the stars. By contrast, smallpox and measles vaccines are more than 95 percent effective at preventing disease, a level sufficient to have eradicated smallpox entirely. Formaldehyde had precedent in medicine.

Vaccine 114

Vaccine Immune Response Virus Clinical Trials 114

Codon

OCTOBER 27, 2024

The Most Deadly Infectious Disease “Each successive episode of bleeding left him weaker than before,” wrote Mary Doria Russell of Doc Holliday, the gunslinging gambler, in her eponymous book, Doc. .’ ” Doc suffered from tuberculosis, or TB, a bacterial disease caused by Mycobacterium tuberculosis.

Immune Response 106

Immune Response Doctors Disease Laboratories 106

Codon

FEBRUARY 23, 2025

When tests showed that zidovudine did not work against cancer, though, Horwitz set it aside — but told his peers that this molecule, as well as similar DNA base mimics, were “a very interesting set of compounds that were waiting for the right disease.” Subscribe to Asimov Press! Always free.

Clinical Trials 80

Clinical Trials Virus Vaccine DNA 80