PLOS: DNA Science

MARCH 28, 2024

million DNA bases. The exons are nestled amongst the much longer introns, which are DNA sequences that are not represented in the final protein. It delivers a shortened dystrophin gene, just 4,558 DNA bases. Proteins called histones wrap around DNA at regular intervals, winding the molecule into units that resemble tiny spools.

FDA Approval 96

FDA Approval Treatment FDA DNA 96

LifeSciVC

JUNE 12, 2025

The ability of modifying RNA enabled us to sidestep many of the potential risks associated with permanent DNA editing. We aimed to achieve this by modifying and modulating proteins by precisely changing a single alphabet on RNA with the use of an oligonucleotide (think short stretches of chemically modified RNA or DNA).

RNA 68

RNA Protein Expression DNA Science 68

PLOS: DNA Science

JULY 13, 2023

Although the researchers followed all of these events with color-labeled DNA, the details of how the cells at the injury site are reprogrammed into a state of stemness are still a mystery. It’s a little like comparing instructions for building a zeppelin (DNA) to actually building one from specific parts (RNA).

RNA 98

RNA DNA Research Disease 98

Broad Institute

MAY 21, 2025

To make the MM-like score more clinically accessible, the team is developing a test based on liquid biopsies instead of bone marrow biopsies to collect DNA. The score, called an MM-like score, assesses the severity of disease and risk of progression to active cancer, with higher scores indicating faster progression.

DNA 52

DNA Disease Bioinformatics Hospitals 52

PLOS: DNA Science

NOVEMBER 2, 2023

Vague Definitions and Examples from Nature All genetics textbooks, including mine, relate the convergence of experimental evidence that led Watson and Crick to deduce DNA’s structure. ” The 1952 textbook explains heredity through trait variations, which have long been observed without knowing the role of DNA.

DNA 105

DNA Disease Science Doctors 105

The Pharma Data

DECEMBER 23, 2020

Additionally, Phase 1 clinical data found INO-4800 to have a favorable safety and tolerability profile with no serious adverse events reported; only six Grade 1 adverse events (AEs) were observed, primarily minor injection site reactions. . Through week 8, no serious adverse events were reported.

DNA 40

DNA Vaccine Clinical Trials Immune Response 40

Twist Bioscience

APRIL 3, 2025

Learn More > Variant Libraries Order Now TCR Libraries New Combinatorial Variant Library Spread Out Low Diversity Libraries Site Saturation Libraries Enzyme Screening Kits New Watch how Twist builds variant libraries for your perfect application Synthetic Controls Order Now Liquid Biopsy cfDNA Pan-Cancer Reference Standards v2 New Infectious Disease (..)

RNA 52

RNA Virus Licensing Licensing 52

Drug Target Review

SEPTEMBER 8, 2023

However, recent insights indicate that it also operates beyond the nucleus, orchestrating initial events at the cell surface that trigger the activation of T cells. The cell’s nucleus, containing compacted DNA, is centrally positioned within the cell.

Regulations 98

Regulations Research DNA Immune Response 98

DrugBank

OCTOBER 17, 2024

This proactive approach to safety monitoring can lead to the early detection of rare or unexpected adverse events, facilitating timely interventions and risk mitigation strategies. Machine learning algorithms can be trained on historical data to identify patterns and anomalies indicating potential safety concerns.

Drug Development 98

Drug Development Metabolic Stability Clinical Trials Drugs 98

PLOS: DNA Science

MARCH 7, 2024

The researchers searched the DNA of humans and other primates for clues to how we lost our tails. They discovered that a bit of repetitious DNA, called an Alu sequence, inserted into a gene associated with tail development early in the ape lineage. That event blocked synthesis of the protein that signals formation of the tailbone.

DNA 52

DNA RNA Research Science 52

DrugBank

APRIL 24, 2025

Epigenetics , the study of changes in gene activity that occur without altering the DNA sequence, has revolutionized our understanding of gene expression regulation. DNA methylation involves adding methyl groups to cytosine residues in CpG dinucleotides , a process catalyzed by DNA methyltransferases (DNMT).

DNA 52

DNA Drugs Therapies Regulations 52

The Pharma Data

SEPTEMBER 11, 2021

By leveraging our unique ability to manufacture DNA at scale, we can construct proprietary antibody libraries precisely designed to match sequences that occur in the human body. The core of the platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip.

DNA 52

DNA Bioinformatics Production Engineering 52

sptlabtech

FEBRUARY 13, 2023

SLAS San Diego 2023 has come and gone, and SPT Labtech were thrilled to be exhibiting at this premier event for life sciences and laboratory automation. As a global leader in laboratory automation, we're proud to have been a part of this exciting event, showcasing our latest products and services to attendees from all around the world.

DNA 52

DNA Laboratories Production Science 52

Broad Institute

JULY 11, 2024

IDH1 normally facilitates the activity of enzymes called demethylases, which remove chemical flags called methylation marks from DNA, allowing genes to be transcribed into RNA. In cells with mutant IDH1, this gene is silenced due to the buildup of 2HG, but mIDH1 inhibitors allow demethylases to facilitate cGAS expression.

Treatment 72

Treatment Immune Response Drugs Virus 72

DrugBank

JANUARY 29, 2025

Gene Therapy Gene therapy operates on the principle of modulating the DNA blueprint of cells to induce a therapeutic response. The AAV genome, comprising single-stranded DNA, can persist in the host cell nucleus as an episome or integrate into the host genome at a specific site on chromosome 19.

Therapies 52

Therapies DNA RNA Disease 52

Drug Target Review

DECEMBER 5, 2024

2 Structure and function of AAV capsids in gene therapy Wild-type AAV is composed of a protein shell (capsid) that contains a single-stranded DNA genome encoding proteins involved in viral replication, structure and assembly. Therefore, vectors based on these serotypes may enable targeted gene delivery and optimal transduction efficiency.

Therapies 52

Therapies Virus DNA Compliance 52

The Pharma Data

DECEMBER 14, 2020

. The current standard of care for GBM consists of de-bulking surgery followed by combined treatments with fractionated ionizing radiation (IR) and the DNA alkylating agent temozolomide (TMZ). Over the period of treatment, tumors can evolve and begin to overexpress MGMT and therefore become largely resistant to TMZ.

Clinical Trials 52

Clinical Trials DNA Drugs Therapies 52

The Pharma Data

DECEMBER 2, 2020

Any forward-looking statements contained in this press release speak only as of the date hereof, and Twist Bioscience specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise. View source version on businesswire.com: [link]. Source link.

DNA 52

DNA Licensing Licensing Pharmaceuticals 52

The Pharma Data

OCTOBER 18, 2020

(NASDAQ:CDXC) today highlighted a new study published in The European Molecular Biology Organization Journal looking at the effect of nicotinamide riboside (NR) on maintaining telomeres, the protective regions at the end of DNA strands. Telomeres are “caps” at the end of chromosomes that protect DNA from getting worn away as cells replicate.

DNA 52

DNA Molecular Biology Disease Trials 52

The Pharma Data

DECEMBER 28, 2020

Amphastar’s newly approved synthetic peptide product was determined by the FDA to be bioequivalent and therapeutically equivalent to Eli Lilly’s Glucagon Emergency Kit for Low Blood Sugar, which has a recombinant DNA (rDNA)-origin. You can locate these reports through the Company’s website at [link] and on the SEC’s website at www.sec.gov.

FDA 52

FDA Production Biosimilars FDA Approval 52

The Pharma Data

OCTOBER 19, 2020

Its second drug candidate, WP1244, is a novel DNA binding agent that has shown in preclinical studies that it is 500 times more potent than the chemotherapeutic agent daunorubicin in inhibiting tumor cell proliferation. These statements relate to future events, future expectations, plans and prospects. .

Clinical Trials 52

Clinical Trials Trials Pharmaceuticals Treatment 52

The Pharma Data

MARCH 30, 2021

Targeted radioligand therapy is a type of precision medicine combining two key elements: a targeting compound, or ligand, and a radioactive isotope, causing DNA damage that inhibits tumor growth and replication. We believe this technology has the potential to transform many patients’ lives.”. Source link:[link].

Therapies 52

Therapies Licensing Licensing Protein Expression 52

The Pharma Data

DECEMBER 16, 2020

Its second drug candidate, WP1244, is a novel DNA binding agent that has shown in preclinical studies that it is 500 times more potent than the chemotherapeutic agent daunorubicin in inhibiting tumor cell proliferation. These statements relate to future events, future expectations, plans and prospects. .

FDA Approval 52

FDA Approval FDA Pharmaceuticals Clinical Trials 52

PPD

AUGUST 5, 2024

To avoid misleading conclusions, it is important to carefully substantiate details such as clinical importance, frequency of events and the effect of the intervention on each component of the composite endpoint.

Clinical Trials 98

Clinical Trials Trials Clinical Research Disease 98

The Pharma Data

JANUARY 21, 2021

Session: Tumor Biology: Focus on EGFR Mutation, DNA Repair and Tumor Microenvironment Mini Oral Session Date and Time: January 31, 2021, 17:20 SGT (January 31, 2021 1:20 a.m. PT) Presentation Number: MA13.07. Access to the presentations is available to members of IASLC and can be found here: [link].

Pharmaceuticals 52

Pharmaceuticals Clinical Trials Licensing Licensing 52

Dark Matter Blog

APRIL 4, 2023

In contrast, with RNA there is an extensive literature on inferring 2D structure from low-stoichiometry modification of the RNAs using chemical probes followed by sequencing to map those events. And unproductive interactions between the RNA target and the DNA barcodes complicated DEL screening.

Small Molecule 52

Small Molecule RNA Fragment Screening DNA 52

The Pharma Data

DECEMBER 13, 2020

Due to the COVID -19 pandemic, the event will be hosted virtually. TAIPEI and SAN DIEGO , Dec. 13, 2020 /PRNewswire/ — Senhwa Biosciences, Inc.

Small Molecule 40

Small Molecule FDA Clinical Trials Treatment 40

Elrig

FEBRUARY 23, 2023

That’s why we created the Research & Innovation (R&I) Conference over 5 years ago, now one of ELRIG’s renowned flagship events. 2. Connect and collaborate to propel your career As an in-person event created and attended by those who truly know the value of collaboration, R&I offers an unparalleled networking opportunity.

Research 40

Research Disease Science Drugs 40

DrugBaron

OCTOBER 17, 2022

These come in many flavours: it could be a technology thread (editing DNA, protein degraders or engineered stem cells for example), deep expertise in a particular indication (“we are the leaders in endometriosis”), or focus on a particular biological mechanism (antigen-presenting cells, mitophagy, caspases or a million other possibilities).

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Pharma Companies Pharmaceuticals Drug Development Production 100

The Pharma Data

NOVEMBER 23, 2020

“Environmental sensitivity and corporate responsibility have been part of our DNA since our inception,” said Martine Rothblatt , Ph.D., SILVER SPRING, Md. and RESEARCH TRIANGLE PARK, N.C. , Chairman and Chief Executive Officer of United Therapeutics. View original content: [link]. SOURCE United Therapeutics Corporation.

Bioinformatics 40

Bioinformatics Pharmaceutical Companies DNA Government 40

The Pharma Data

SEPTEMBER 6, 2021

LinkedIn Live event – COVID-19 and Cancer: Reshaping Patient Care in the Context of the Pandemic Today and Tomorrow. Join this event on Roche’s LinkedIn page here. Fusion and rearrangement (RE) detection using DNA and RNA-based comprehensive genomic profiling (CGP) of sarcomas. Roche Oncology Newsroom.

Treatment 52

Treatment Therapies DNA Trials 52

Vial

DECEMBER 5, 2023

Among others, NGS has led to the identification of disease-causing variants and novel drug targets and an improved understanding of complex biological events, e.g., the heterogeneity of tumors. It has become a fundamental tool for researchers to explore the complexities of genetic information and conduct genetic-informed drug development.

Clinical Trials 52

Clinical Trials Trials RNA Bioinformatics 52

Dark Matter Blog

JULY 16, 2021

As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. Last stops at RNA My last roles in biotech were where my original passion began: DNA and RNA. The most important event for me at Biogen was meeting my wife Sue. 49 years ago, when I was 16 years old, I wanted to do exactly what I am doing now.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

LifeSciVC

JULY 1, 2024

The central dogma of molecular biology is that information generally (with few exceptions) flows from DNA to RNA to Protein. Our lives are the result of non-random choices we make in the background of random events and fortune. Remember life’s Central Dogma. Both skill and luck are important in our lives and careers.

Science 93

Science Immune Response Molecular Biology RNA 93

The Pharma Data

OCTOBER 28, 2020

The Company’s patented Target Selector liquid biopsy technology platform captures and analyzes tumor-associated molecular markers in both circulating tumor cells (CTCs) and in circulating tumor DNA (ctDNA).

Virus 40

Virus DNA Laboratories Disease 40

DrugBank

JUNE 27, 2023

In contrast, non-coding mutations have effects on gene expression, transcript stability, and the physical state of the DNA itself (e.g., Inheritance and Recombination Events Mendelian inheritance explains how certain traits are passed from parents to their children following a very specific pattern of recessive and dominant traits.

Disease 98

Disease Treatment Drugs Clinical Trials 98

The Pharma Data

OCTOBER 21, 2020

These findings speak to how the regimen of cabotegravir and rilpivirine may be adapted to meet the needs of people living with HIV who have events in their lives that could cause them to miss an injection appointment.”. This step is essential in the HIV replication cycle and is also responsible for establishing chronic infection.

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Clinical Development Therapies Clinical Trials Treatment 52