Twist Bioscience

APRIL 3, 2025

Learn More > Variant Libraries Order Now TCR Libraries New Combinatorial Variant Library Spread Out Low Diversity Libraries Site Saturation Libraries Enzyme Screening Kits New Watch how Twist builds variant libraries for your perfect application Synthetic Controls Order Now Liquid Biopsy cfDNA Pan-Cancer Reference Standards v2 New Infectious Disease (..)

RNA

Science Daily: Pharmacology News

JUNE 18, 2025

Their entire genome broke into pieces and was randomly reassembled an event so extreme it stunned researchers. Instead, scientists discovered that certain marine worms experienced an explosive genetic makeover when they transitioned to life on land over 200 million years ago.

DNA

Science Daily: Pharmacology News

FEBRUARY 12, 2025

This comparison can offer an inkling of what might await us in the future.

DNA

Codon

JULY 10, 2025

The event hosts will provide snacks and drinks, and the winning teams will get signed copies of our DNA books and free hats. A science fiction time travel novel in which a protagonist extracts traces of DNA from letters and engineers herself to be immune to poison. Please RSVP to join.

Engineering

Codon

JULY 21, 2025

Dwarves aren’t made out of individual cells; they don’t have DNA (yet), though they do have eyelids. Its explanatory power wasn’t even reliant on DNA. Even if an understanding of DNA wasn't necessary to come up with the theory of evolution, genes and their underlying pieces are very mechanistic.

Science

Science Daily: Pharmacology News

OCTOBER 25, 2024

A new study describes how researchers used ancient DNA to corroborate the events of the saga and discover details about the 'Well-man,' blending history and archaeology with science and setting a precedent for future research on historical figures.

DNA

Science Daily: Pharmacology News

DECEMBER 20, 2023

The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just simply copying the genetic information; a well-orchestrated sequence of molecular events has to happen at the right time.

DNA

Science Daily: Pharmacology News

DECEMBER 12, 2024

Although they separated early, the Neanderthal DNA in their genomes traces back to an admixture event common to all people outside Africa, that the researchers date to around 45,000-49,000 years ago, much later than previously thought.

DNA

ASPET

MARCH 20, 2024

DNA topoisomerase IIβ (TOP2β/180; 180 kDa) is a nuclear enzyme that regulates DNA topology by generation of short-lived DNA double-strand breaks primarily during transcription. TOP2β/180 can be a target for DNA damage-stabilizing anticancer drugs, whose efficacy is often limited by chemoresistance.

DNA

Broad Institute

JUNE 28, 2023

Such large-scale changes in DNA have been difficult to study. We began to think that these shorter events could give us signals about whether cancer cells were selecting for certain chromosome changes.” The findings, published today in Nature , could lead to new ways of guiding cancer treatment or developing targeted drugs.

DNA

PLOS: DNA Science

MARCH 28, 2024

million DNA bases. The exons are nestled amongst the much longer introns, which are DNA sequences that are not represented in the final protein. It delivers a shortened dystrophin gene, just 4,558 DNA bases. Proteins called histones wrap around DNA at regular intervals, winding the molecule into units that resemble tiny spools.

FDA Approval

PLOS: DNA Science

JULY 13, 2023

Although the researchers followed all of these events with color-labeled DNA, the details of how the cells at the injury site are reprogrammed into a state of stemness are still a mystery. It’s a little like comparing instructions for building a zeppelin (DNA) to actually building one from specific parts (RNA).

RNA

PLOS: DNA Science

NOVEMBER 2, 2023

Vague Definitions and Examples from Nature All genetics textbooks, including mine, relate the convergence of experimental evidence that led Watson and Crick to deduce DNA’s structure. ” The 1952 textbook explains heredity through trait variations, which have long been observed without knowing the role of DNA.

DNA

The Pharma Data

DECEMBER 23, 2020

Additionally, Phase 1 clinical data found INO-4800 to have a favorable safety and tolerability profile with no serious adverse events reported; only six Grade 1 adverse events (AEs) were observed, primarily minor injection site reactions. . Through week 8, no serious adverse events were reported.

DNA

Drug Target Review

SEPTEMBER 8, 2023

However, recent insights indicate that it also operates beyond the nucleus, orchestrating initial events at the cell surface that trigger the activation of T cells. The cell’s nucleus, containing compacted DNA, is centrally positioned within the cell.

Regulations

DrugBank

OCTOBER 17, 2024

This proactive approach to safety monitoring can lead to the early detection of rare or unexpected adverse events, facilitating timely interventions and risk mitigation strategies. Machine learning algorithms can be trained on historical data to identify patterns and anomalies indicating potential safety concerns.

Drug Development

PLOS: DNA Science

MARCH 7, 2024

The researchers searched the DNA of humans and other primates for clues to how we lost our tails. They discovered that a bit of repetitious DNA, called an Alu sequence, inserted into a gene associated with tail development early in the ape lineage. That event blocked synthesis of the protein that signals formation of the tailbone.

DNA

DrugBank

APRIL 24, 2025

Epigenetics , the study of changes in gene activity that occur without altering the DNA sequence, has revolutionized our understanding of gene expression regulation. DNA methylation involves adding methyl groups to cytosine residues in CpG dinucleotides , a process catalyzed by DNA methyltransferases (DNMT).

DNA

The Pharma Data

SEPTEMBER 11, 2021

By leveraging our unique ability to manufacture DNA at scale, we can construct proprietary antibody libraries precisely designed to match sequences that occur in the human body. The core of the platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip.

DNA

sptlabtech

FEBRUARY 13, 2023

SLAS San Diego 2023 has come and gone, and SPT Labtech were thrilled to be exhibiting at this premier event for life sciences and laboratory automation. As a global leader in laboratory automation, we're proud to have been a part of this exciting event, showcasing our latest products and services to attendees from all around the world.

DNA

DrugBank

JANUARY 29, 2025

Gene Therapy Gene therapy operates on the principle of modulating the DNA blueprint of cells to induce a therapeutic response. The AAV genome, comprising single-stranded DNA, can persist in the host cell nucleus as an episome or integrate into the host genome at a specific site on chromosome 19.

Therapies

Broad Institute

JULY 11, 2024

IDH1 normally facilitates the activity of enzymes called demethylases, which remove chemical flags called methylation marks from DNA, allowing genes to be transcribed into RNA. In cells with mutant IDH1, this gene is silenced due to the buildup of 2HG, but mIDH1 inhibitors allow demethylases to facilitate cGAS expression.

Treatment

Drug Target Review

DECEMBER 5, 2024

2 Structure and function of AAV capsids in gene therapy Wild-type AAV is composed of a protein shell (capsid) that contains a single-stranded DNA genome encoding proteins involved in viral replication, structure and assembly. Therefore, vectors based on these serotypes may enable targeted gene delivery and optimal transduction efficiency.

Therapies

The Pharma Data

DECEMBER 14, 2020

. The current standard of care for GBM consists of de-bulking surgery followed by combined treatments with fractionated ionizing radiation (IR) and the DNA alkylating agent temozolomide (TMZ). Over the period of treatment, tumors can evolve and begin to overexpress MGMT and therefore become largely resistant to TMZ.

Clinical Trials

The Pharma Data

DECEMBER 2, 2020

Any forward-looking statements contained in this press release speak only as of the date hereof, and Twist Bioscience specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise. View source version on businesswire.com: [link]. Source link.

DNA

The Pharma Data

OCTOBER 18, 2020

(NASDAQ:CDXC) today highlighted a new study published in The European Molecular Biology Organization Journal looking at the effect of nicotinamide riboside (NR) on maintaining telomeres, the protective regions at the end of DNA strands. Telomeres are “caps” at the end of chromosomes that protect DNA from getting worn away as cells replicate.

DNA

The Pharma Data

DECEMBER 28, 2020

Amphastar’s newly approved synthetic peptide product was determined by the FDA to be bioequivalent and therapeutically equivalent to Eli Lilly’s Glucagon Emergency Kit for Low Blood Sugar, which has a recombinant DNA (rDNA)-origin. You can locate these reports through the Company’s website at [link] and on the SEC’s website at www.sec.gov.

FDA

The Pharma Data

OCTOBER 19, 2020

Its second drug candidate, WP1244, is a novel DNA binding agent that has shown in preclinical studies that it is 500 times more potent than the chemotherapeutic agent daunorubicin in inhibiting tumor cell proliferation. These statements relate to future events, future expectations, plans and prospects. .

Clinical Trials

The Pharma Data

MARCH 30, 2021

Targeted radioligand therapy is a type of precision medicine combining two key elements: a targeting compound, or ligand, and a radioactive isotope, causing DNA damage that inhibits tumor growth and replication. We believe this technology has the potential to transform many patients’ lives.”. Source link:[link].

Therapies

The Pharma Data

DECEMBER 16, 2020

Its second drug candidate, WP1244, is a novel DNA binding agent that has shown in preclinical studies that it is 500 times more potent than the chemotherapeutic agent daunorubicin in inhibiting tumor cell proliferation. These statements relate to future events, future expectations, plans and prospects. .

FDA Approval

PPD

AUGUST 5, 2024

To avoid misleading conclusions, it is important to carefully substantiate details such as clinical importance, frequency of events and the effect of the intervention on each component of the composite endpoint.

Clinical Trials

The Pharma Data

JANUARY 21, 2021

Session: Tumor Biology: Focus on EGFR Mutation, DNA Repair and Tumor Microenvironment Mini Oral Session Date and Time: January 31, 2021, 17:20 SGT (January 31, 2021 1:20 a.m. PT) Presentation Number: MA13.07. Access to the presentations is available to members of IASLC and can be found here: [link].

Pharmaceuticals

Dark Matter Blog

APRIL 4, 2023

In contrast, with RNA there is an extensive literature on inferring 2D structure from low-stoichiometry modification of the RNAs using chemical probes followed by sequencing to map those events. And unproductive interactions between the RNA target and the DNA barcodes complicated DEL screening.

Small Molecule

The Pharma Data

DECEMBER 13, 2020

Due to the COVID -19 pandemic, the event will be hosted virtually. TAIPEI and SAN DIEGO , Dec. 13, 2020 /PRNewswire/ — Senhwa Biosciences, Inc.

Small Molecule

Elrig

FEBRUARY 23, 2023

That’s why we created the Research & Innovation (R&I) Conference over 5 years ago, now one of ELRIG’s renowned flagship events. 2. Connect and collaborate to propel your career As an in-person event created and attended by those who truly know the value of collaboration, R&I offers an unparalleled networking opportunity.

Research

DrugBaron

OCTOBER 17, 2022

These come in many flavours: it could be a technology thread (editing DNA, protein degraders or engineered stem cells for example), deep expertise in a particular indication (“we are the leaders in endometriosis”), or focus on a particular biological mechanism (antigen-presenting cells, mitophagy, caspases or a million other possibilities).

Pharma Companies

The Pharma Data

NOVEMBER 23, 2020

“Environmental sensitivity and corporate responsibility have been part of our DNA since our inception,” said Martine Rothblatt , Ph.D., SILVER SPRING, Md. and RESEARCH TRIANGLE PARK, N.C. , Chairman and Chief Executive Officer of United Therapeutics. View original content: [link]. SOURCE United Therapeutics Corporation.

Bioinformatics