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Defying Darwin: Scientists discover worms rewrote their DNA to survive on land

Science Daily: Pharmacology News

Their entire genome broke into pieces and was randomly reassembled an event so extreme it stunned researchers. Instead, scientists discovered that certain marine worms experienced an explosive genetic makeover when they transitioned to life on land over 200 million years ago.

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'Well-man' thrown from castle identified from 800-year-old Norse saga

Science Daily: Pharmacology News

A new study describes how researchers used ancient DNA to corroborate the events of the saga and discover details about the 'Well-man,' blending history and archaeology with science and setting a precedent for future research on historical figures.

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Cells of the future: A key to reprogramming cell identities

Science Daily: Pharmacology News

The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just simply copying the genetic information; a well-orchestrated sequence of molecular events has to happen at the right time.

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Oldest modern human genomes sequenced

Science Daily: Pharmacology News

Although they separated early, the Neanderthal DNA in their genomes traces back to an admixture event common to all people outside Africa, that the researchers date to around 45,000-49,000 years ago, much later than previously thought.

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Rare Disease Day 2025: Rally for Rare Event Recap

Conversations in Drug Development Trends

The day inspires multiple events, such as fundraisers and scientific symposia, to bring together all the critical stakeholders who tirelessly work to make life better for those affected by rare diseases. In an incredible feat of collaboration, they were able to rapidly put together a new event called Rally for Rare.

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Use of CRISPR/Cas9 with Homology-Directed Repair (HDR) to Gene-Edit Topoisomerase II{beta} in Human Leukemia K562 Cells: Generation of a Resistance Phenotype [Chemotherapy, Antibiotics, and Gene Therapy]

ASPET

DNA topoisomerase IIβ (TOP2β/180; 180 kDa) is a nuclear enzyme that regulates DNA topology by generation of short-lived DNA double-strand breaks primarily during transcription. TOP2β/180 can be a target for DNA damage-stabilizing anticancer drugs, whose efficacy is often limited by chemoresistance.

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How chromosome imbalances can drive cancer

Broad Institute

Such large-scale changes in DNA have been difficult to study. We began to think that these shorter events could give us signals about whether cancer cells were selecting for certain chromosome changes.” The findings, published today in Nature , could lead to new ways of guiding cancer treatment or developing targeted drugs.

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