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Something in the Air – Environmental DNA Update

PLOS: DNA Science

DNA is the calling card of life. In and on our bodies, traces of DNA sequences other than our own announce the presence of many microbes, our microbiome. “It seemed like it would be hard to get intact large fragments of DNA from the air, but that’s not the case. . We’re finding a lot of informative DNA.

DNA 56
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Evolved prime editors are smaller and more efficient for therapeutic applications

Broad Institute

Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory evolution and engineering methods to develop improved versions of the gene-editing tool. Reverse transcriptase proteins that copy RNA templates into strands of DNA are found naturally in all plant and animal cells and in many viruses.

DNA 145
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Women in Stem with Dr Emily Leproust

Drug Target Review

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. These are synthetic, not the live virus, so do not pose a risk of infection.

DNA 116
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Viral Vectors 101: An Introduction to AAV

addgene Blog

Adeno-associated virus (AAV) is a single stranded, Parvoviridae DNA virus, packaged in a non-enveloped icosahedral capsid, that can be used to express genes of interest in cell and animal models. This post was contributed by guest blogger Didem Goz Ayturk with edits and updates from Addgenies Karen Guerin and Susanna Stroik.

Virus 67
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The immune system’s role in lung cancer risk

Drug Target Review

Dr Chowell spent a year as a visiting graduate student at the Moe Win Laboratory for Information and Decision Systems at MIT. During residency, he conducted laboratory research with Dr Timothy Chan investigating predictors of response to immunotherapy as part of the American Board of Radiology Holman Research pathway.

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Phages could help to tackle antimicrobial resistance

Drug Target Review

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. Its presence elsewhere would indicate something is wrong. But what, exactly?”

RNA 59
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New insights into the role of viral capsids in gene therapy safety

Drug Target Review

2 Structure and function of AAV capsids in gene therapy Wild-type AAV is composed of a protein shell (capsid) that contains a single-stranded DNA genome encoding proteins involved in viral replication, structure and assembly. Adeno-associated virus as a delivery vector for gene therapy of human diseases. Labcompare. 2024;9(1):78.