Alta Sciences

MARCH 1, 2024

Norbert Makori and Pierre Jolicoeur: The Benefits of Combining Preclinical and Bioanalytical for Your Gene Therapy Studies pmjackson Fri, 03/01/2024 - 22:20 Recent advances in gene therapy have allowed for diseases to be approached differently. q: How can Altasciences support sponsors’ Gene Therapy Programs?

Therapies 52

Therapies Laboratories Molecular Biology RNA 52

Codon

JULY 10, 2025

To celebrate the new issue, we are also releasing new merchandise (custom-designed shirts, hats, and posters) and hosting a biology trivia night in San Francisco on July 23 ! The event hosts will provide snacks and drinks, and the winning teams will get signed copies of our DNA books and free hats. Please RSVP to join.

Engineering 58

Engineering DNA Molecular Biology Laboratories 58

Dark Matter Blog

JULY 16, 2021

The only subject in school that held my interest was biology. As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. Last stops at RNA My last roles in biotech were where my original passion began: DNA and RNA. I obtained my Ph.D.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

Drug Target Review

JUNE 11, 2024

When choosing my bachelor’s degree, the choice was between pursuing a career in biology or in computer science. Biology won that battle, and I pursued a bachelor’s and master’s degree in biochemistry and molecular biology.

Engineering 64

Engineering Science Molecular Biology Doctors 64

Codon

JUNE 5, 2025

The treatment, now known as Casgevy, became the first CRISPR-based therapy to gain FDA approval, in 2023. Certain CRISPR components can add short DNA sequences from the genomes of defeated viruses into the bacterium’s own genome, creating a type of protective “memory.” pyogenes , making it more specific.

DNA 81

DNA RNA Clinical Trials Engineering 81

Codon

FEBRUARY 13, 2024

Tom Ireland writes about the companies and technologies that are reimagining phage therapy. Soon after its publication, scientists, journalists, and investors were revisiting ‘phage therapy’ as a promising alternative to our failing antibiotics. Read it on our website here. Illustration by David S. Fast forward to 2023.

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Therapies Virus DNA Clinical Trials 137

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? How does Circio’s circVec technology aim to enhance the potency and reduce the cost of current gold-standard gene therapy? DNA vectors in mouse models?

Therapies 59

Therapies RNA Protein Expression DNA 59

Codon

JULY 27, 2023

But what happens if you restore these cone cells, using gene therapy? They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.”

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

But what happens if you restore these cone cells, using gene therapy? They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.”

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide.

DNA 52

DNA Therapies Engineering Clinical Trials 52

BMG Labtech

MARCH 8, 2023

In biology , scientific research on cell metabolism focuses on different topics such as understanding the fundamental metabolic processes, metabolic changes and their role in diseases (including cancer cell and tumor metabolism), the development of therapies, the identification of unknown metabolic processes and metabolites, etc.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

NOVEMBER 1, 2024

I’ve chosen these two because I think they are the linchpin by which we’ll be able to build broadly useful AI models for cell and molecular biology. Synthesizing a single human protein-coding gene costs several hundred dollars and even a simple PCR machine (used for amplifying DNA) costs between $1,500 and $50,000.

DNA 132

DNA RNA Molecular Biology Laboratories 132

Codon

JUNE 18, 2024

Even after a half-century of molecular biology research, scientists didn’t know until recently how gas vesicles physically trap gas while occluding water. By combining DNA from multiple organisms and inserting it into E. angstroms, or roughly twice the length of a single carbon-carbon bond. megaterium.

Engineering 71

Engineering Laboratories International Clinical Trials 71

Codon

MARCH 12, 2023

Notes on Progress is a monthly roundup of papers and ideas about biology and the future. “The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. Biology is a Burrito. A new base editor to edit mitochondrial DNA.

DNA 52

DNA Engineering Therapies RNA 52

Codon

DECEMBER 17, 2023

Molecular biology, as the field came to be called 3 , pushed biology from an object of study, driven forward by gentleman scientists and precocious country clergymen, into a tool with which to solve urgent problems. Recombinant DNA technologies were invented in the 1970s.

Engineering 52

Engineering Molecular Biology Doctors DNA 52

Drug Target Review

MARCH 25, 2025

The convergence of advanced research tools, a growing understanding of tumour biology, and urgent unmet patient needs makes this the perfect moment to reignite focus on DNA Damage Response in cancer therapy.

DNA 52

DNA Therapies Clinical Trials Clinical Pharmacology 52

Drug Target Review

DECEMBER 12, 2024

As a result, patients receiving ESC-derived therapies must also take immunosuppressive drugs potentially for life. The process can yield a renewable stockpile of cells for everything from CAR-T cancer therapies to tissue and organ transplants. This can trigger an immune response that causes the body to reject these therapeutic cells.

Therapies 59

Therapies DNA Molecular Biology Immune Response 59

Drug Target Review

FEBRUARY 20, 2025

Throughout her career, she has focused on advancing therapeutic drug discovery and developing genetic therapies, making significant contributions to the field. One prominent project is my work using antibodies to deliver adeno-associated virus (AAV) gene therapies to targeted cells in the body.

Virus 52

Virus Therapies Molecular Biology Treatment 52

Codon

AUGUST 10, 2023

Journal of Molecular Biology (1961). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. . & Xie X.S. Nature (2011).

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

Codon

MAY 29, 2025

These abilities are precisely what make them promising as potential therapies, particularly as we find ways to enhance their safety profiles. This is the step after the initial transcription of DNA into mRNA by RNA Polymerase II, the protein to which alpha amanitin binds. In both cases, peptide and protein production stops.

Drugs 107

Drugs DNA RNA Laboratories 107

Codon

AUGUST 10, 2023

Journal of Molecular Biology (1961). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. . & Xie X.S. Nature (2011).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52