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Allosteric Covalent Inhibitors of the STAT3 Transcription Factor from Virtual Screening

Covalent Modifiers

4c00622 The STAT family of transcription factors are important signaling hubs, with several of them, particularly STAT3, being emerging oncotargets already investigated in clinical trials. Keserű ACS Medicinal Chemistry Letters 2025 16 (6), 991-997 DOI: 10.1021/acsmedchemlett.4c00622

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Accelerate Clinical Trials with Methylation-Based ctDNA Detection

Fierce BioTech

Accelerate Clinical Trials with Methylation-Based ctDNA Detection Download now to learn from biopharma industry leaders about how methylation-based ctDNA detection for precise MRD and response monitoring can accelerate your clinical trials.

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New tRNA tech aims to rewrite rare disease treatment

Drug Target Review

Accelerating drug development with basket trials One of the strategies that Alltrna is employing to accelerate the development of its tRNA therapeutics is the use of basket trials. While commonly used in oncology, the basket trial approach is novel for rare genetic diseases.

Disease 80
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Why radiopharmaceuticals are gaining ground in the fight against cancer

Drug Target Review

“Protocol development can be a complex and meticulous process,” he explains, “as it’s crucial to ensure that trial candidates meet the necessary inclusion criteria.” Prior treatments and patient histories often introduce variables that can affect outcomes, making thoughtful trial design essential for generating reliable data.

Therapies 100
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AI-Designed Enzymes

Codon

Traditionally, scientists discover enzymes in nature and adapt them through trial and error. They synthesized DNA encoding each protein variant, expressed the proteins in E. These molecular machines power various cellular processes, from converting sugar into energy to switching genes on and off.

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Case Study: Two Examples of Successful Automation Integration at Altasciences for Pharmacokinetic Studies

Alta Sciences

Motivated by our success, we are actively working to enhance the automation and optimization of sample dilution and reagent addition for ELISA and ECLIA assays to support large pharmacokinetic clinical trials. Automated workflows ensure higher quality, better efficiency, and consistency across projects of all sizes.

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David Liu receives Breakthrough Prize in Life Sciences

Broad Institute

The organization has honored Liu for the development of the gene editing platforms base editing and prime editing, which can correct the vast majority of known disease-causing genetic variations and have already been used in at least 15 clinical trials, with life-saving results.

Science 144