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Tibor Viktor Szalai, Vincenzo di Lorenzo, Nikolett Péczka, Levente M. Mihalovits, László Petri, Qirat F. Ashraf, Elvin D. de Araujo, Viktor Honti, Dávid Bajusz, and György M. Keserű ACS Medicinal Chemistry Letters 2025 16 (6), 991-997 DOI: 10.1021/acsmedchemlett.4c00622 The STAT family of transcription factors are important signaling hubs, with several of them, particularly STAT3, being emerging oncotargets already investigated in clinical trials.
THURSDAY, June 12, 2025 — A newly approved shot could soon help protect babies from respiratory syncytial virus (RSV), the top cause of hospitalization in U.S. infants. The U.S. Food and Drug Administration (FDA) has approved a monoclonal.
Drug Discovery 101 – Webinar Recording Starting a career in drug discovery can feel overwhelming, but breaking down the process makes it more approachable. Our Drug Discovery 101 webinar outlines the entire process from start to finish. Here’s what you need to know to begin your journey in the field. The Basics of Drug Discovery Finding the Right Target The first step in drug discovery is all about identifying and confirming a target—something in the body that a drug can influence to impro
Valued at $1.25 billion, the deal expands BioNTech’s cancer drug portfolio and heads off royalty costs it could have owed CureVac in ongoing patent litigation.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Bleximenib Shows Promise in AML When Combined with Venetoclax and Azacitidine, According to Johnson & Johnson’s Phase 1b Data Presented at EHA 2025 Johnson & Johnson today presented new and promising Phase 1b data demonstrating strong antileukemic activity and a favorable safety profile for bleximenib (JNJ-75276617) in combination with venetoclax (VEN) and azacitidine (AZA) in patients with acute myeloid leukemia (AML) who harbor KMT2A gene rearrangements (KMT2Ar) or NPM1 mutations (NPM1
Scientists have uncovered a previously unknown type of molecular motion inside DNA-based droplets: instead of spreading randomly, guest molecules advance in an organized wave. This surprising discovery opens the door to understanding how cells might organize internal processes without membranes. Using customizable DNA condensates as experimental models, the team showed how molecular waves emerge through precise DNA interactions.
EULAR 2025: Rilzabrutinib Shows Promise in IgG4-Related Disease — Reduction in Flares and Disease Activity Rilzabrutinib , a Bruton’s tyrosine kinase (BTK) inhibitor currently in clinical development, demonstrated a significant and sustained reduction in disease flares and key disease activity markers in patients with IgG4-related disease (IgG4-RD) , according to new data presented at the European Alliance of Associations for Rheumatology (EULAR) 2025 Congress in Barcelona, Spain (June 11–14).
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EULAR 2025: Rilzabrutinib Shows Promise in IgG4-Related Disease — Reduction in Flares and Disease Activity Rilzabrutinib , a Bruton’s tyrosine kinase (BTK) inhibitor currently in clinical development, demonstrated a significant and sustained reduction in disease flares and key disease activity markers in patients with IgG4-related disease (IgG4-RD) , according to new data presented at the European Alliance of Associations for Rheumatology (EULAR) 2025 Congress in Barcelona, Spain (June 11–14).
Bristol Myers Squibb Highlights Targeted Protein Degradation Advances, Including CELMoD Agents and BCL6 Ligand-Directed Degrader, at EHA 2025 in Milan, Italy Bristol Myers Squibb today revealed new and updated data from its growing portfolio of targeted protein degradation programs during the 2025 European Hematology Association (EHA) Annual Congress, which is currently underway from June 12-15 in Milan, Italy.
The Importance of Proper CDMO Selection for Rare Disease Drug Programs swheeler Thu, 06/12/2025 - 15:18 Thu, 07/17/2025 - 13:00 Resource Type Webinar Chris Olson Promotion Start Wed, 06/18/2025 - 09:00 Promotion End Thu, 12/18/2025 - 09:00 Factors to consider when selecting a CDMO for a rare disease drug: Available capacity and flexibility Financial stability Expertise in formulation development Strong technical experience with difficult to manufacture products Expertise in global regulatory com
Novartis’ Fabhalta Shows Meaningful Hemoglobin Improvement in PNH Patients, Reinforcing Benefit of Oral Monotherapy Novartis recently announced positive results from its APPULSE-PNH study — a Phase IIIB trial evaluating Fabhalta® (iptacopan) in adult patients with paroxysomal nocturnal hemoglobinuria (PNH) who have a baseline hemoglobin (Hb) level of 10 g/dL or greater and have previously been treated with standard C5 inhibitor therapy (eculizumab or ravulizumab).
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
The sensitization effect of δ-tocotrienol on paclitaxel against breast and prostate cancer is associated with its ability to suppress PD-L1-mediated cancer-promoting activity by inhibiting the JAK2-STAT3 axis. ABSTRACT Vitamin E can exert either a cancer preventive effect or improve the therapeutic efficacy of chemotherapeutic drugs against multiple types of cancer.
By Ram Aiyar, CEO of Korro Bio, as part of the From The Trenches feature of LifeSciVC It has been an extraordinary journey so far and one that continues to humble, inspire and motivate me every day. I’ve had the honor and responsibility of building a visi on that is ambitious while being grounded in scientific rigor. Over the last 4.5 years, Korro has been built by mitigating one layer of risk at a time.
GSK Licenses Shigella Vaccine Candidate to Bharat Biotech in Push for Global Health Equity GSK today announced a significant step forward in the battle against Shigella a leading cause of diarrhoeal disease and death in children under five by licensing its Shigella vaccine candidate, altSonflex1-2-3 , to Bharat Biotech International Limited (BBIL). This strategic collaboration aims to enable the continued clinical development and eventual delivery of a low-cost, effective Shigella vaccine to chi
Protein sequence alignment—comparing protein sequences for similarities—is fundamental to modern biology and medicine. It illuminates gene functions by. Protein sequence alignment—comparing protein sequences for similarities—is fundamental to modern biology and medicine. It illuminates gene functions by reconstructing evolutionary relationships, technically called homology inference, that can inform drug development.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Dapirolizumab Pegol Shows Disease Activity Reduction and Fatigue Improvement in SLE at EULAR 2025 UCB and Biogen today presented additional and detailed results from the Phase 3 PHOENYCS GO study evaluating dapirolizumab pegol (DZP), a novel, Fc-free, anti-CD40 Ligand (anti-CD40L) biologic candidate for the treatment of Systemic Lupus Erythematosus (SLE).
The future of cell biology and virtual cell models is dependent on measuring and analyzing data at scale. Single-cell experiments have been growing at an. The future of cell biology and virtual cell models is dependent on measuring and analyzing data at scale. Single-cell experiments have been growing at an incredible rate over the last 10 years, beginning with hundreds of cells and now moving towards new data generation efforts with billions of cells.
Tal Shnitzer By Rose Circeo June 12, 2025 Tal Shnitzer, Ph.D. Senior Machine Learning Scientist Tal Shnitzer is a senior machine learning scientist in the ML4H team at the Broad Institute. She develops machine learning algorithms for disease risk prediction and classification using various biomedical modalities, ranging from clinical measurements such as echocardiograms to wearable sensor data such as Fitbit recordings.
Schematic of the mechanism of LYC in treating osteoporosis through the ESR1/PI3K/AKT pathway. LYC upregulates ESR1 expression and thus leads to the activation of the PI3K/AKT pathway, thereby inducing hBMSC osteogenic differentiation and attenuating osteoporosis development. ABSTRACT Osteoporosis is a widespread metabolic bone disorder. Lycopene (LYC), a potent antioxidant in tomatoes, has been shown to exhibit anti-osteoporosis effects.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Danielle Pace By Rose Circeo June 12, 2025 Danielle Pace Senior Machine Learning Scientist Danielle Pace is a senior machine learning scientist in the Machine Learning for Health team at the Broad Institute of MIT and Harvard. She develops machine learning models that use large clinical datasets, including medical images, electronic health records, ECGs, and genetics, to better understand disease, learn useful data representations, and predict disease risk.
Advancing Recovery Research Image Getty Images Westend61 area Thu, 06/12/2025 - 10:09 Nora's Blog June 17, 2025 Image Getty Images Westend61 In a recent commentary in The New England Journal of Medicine , my colleagues John Kelly, Howard Koh, and I likened the addicted brain to a house on fire—a crisis requiring urgent efforts to contain the damage and preserve life. 1 The drug crisis in America has demanded a sustained focus to extinguish those fires by expanding treatment access and o
Merck Animal Health Wins Positive EU CVMP Opinion for NUMELVI (atinvicitinib) Tablets for Dogs Merck Animal Health, a division of Merck & Co known as MSD Animal Health outside the United States and Canada today announced a significant milestone in its ongoing mission to provide innovative solutions for pets. The European Medicines Agency’s Committee for Veterinary Medicinal Products (CVMP) has issued a positive opinion for NUMELVI™ (atinvicitinib) Tablets for Dogs — a new, first-in-class tre
The UK’s Advanced Research and Invention Agency (ARIA) is often referred to as a “UK DARPA” While ARIA is no DARPA clone, many features of the agency are admittedly DARPA-inspired, such as the use of term-limited program managers, which ARIA calls program directors. These program directors serve as chief visionaries for their programs as well as fund and actively manage teams of coordinated external researchers towards a program's well-defined goal.
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
THURSDAY, June 12, 2025 — A hallmark of accelerated aging appears to be linked to an increased risk of dementia and stroke, a new study says.Shorter telomere length in a person’s white blood cells is associated with the two brain diseases, res.
DNA sequencing with the Blended Genome Exome (BGE) By Rose Circeo June 12, 2025 Breadcrumb Home DNA sequencing with the Blended Genome Exome (BGE) The Primer on Medical and Population Genetics is a series of informal weekly discussions of basic genetics topics that relate to human populations and disease. Experts from across the Broad Institute community give in-depth introductions to the basic principles of complex trait genetics, including human genetic variation, genotyping, DNA sequencing me
THURSDAY, June 12, 2025 — Most folks tap away at their smartphone for fun, communication or information.But such tapping may also help them track the progress of a rare degenerative brain disease, researchers say.Five simple smartphone-measured t.
Viruses closely related to the deadly MERS coronavirus are lurking in bats and one group, known as HKU5, may be just one mutation away from making the jump to humans. A new study reveals how these viruses bind to cell receptors and even shows signs of adapting to human-compatible versions of those receptors.
"Revolutionizing the Industry: How Innovations in Generic Drug Manufacturing Are Transforming Products and Reducing Costs As the pharmaceutical industry continues to evolve, one thing is clear: the future of generic drugs is not just about cheaper alternatives, but about better, more effective treatments. At the forefront of this revolution are innovations in generic drug manufacturing and formulation, which are transforming products and reducing costs.
A team of scientists has discovered a direct link between the smell of food and feelings of fullness at least in lean mice. This brain circuit, located in the medial septum and triggered by food odors, helps animals eat less by making them feel satiated even before taking a bite. But intriguingly, obese mice lacked this response, highlighting how excess weight may interfere with this satiety mechanism.
About 100 million adults and 100 million children worldwide have the red, flaky, itchy skin of the most common form of eczema, atopic dermatitis, according to the NIH. The condition stems from a misdirected immune response to a substance – an allergen – that does not actually present a threat. Although the exact causes of eczema aren’t well understood, a new study points to an unexpected protective factor: owning a dog.
Reef "beauty salons" staffed by tiny cleaner fish aren t just for parasite removal they may also shape the microbial life of the entire ecosystem. A fascinating new study shows these bustling fish stations influence which microbes move around the reef, possibly helping or harming coral health. Cleaner gobies, it turns out, don t just offer spa treatments to their fish clients they may also serve as tiny microbiome engineers of the sea.
THURSDAY, June 12, 2025 — A person’s smartwatch can capture a lot of data about their health – and a new study says most folks are willing to share it with doctors.About 94% of people who wear smartwatches or activity trackers are open to sharing da.
Data from NASA's James Webb Space Telescope has revealed dozens of small galaxies that played a starring role in a cosmic makeover that transformed the early universe into the one we know today.
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