Science Daily: Pharmacology News
DECEMBER 12, 2024
Neanderthal genes make up 1-2% of the genomes of non-Africans. Scientists analyzed the lengths of regions of Neanderthal DNA in 58 ancient Eurasian genomes of early modern humans and determined that the introgressed genes result from interbreeding between Homo sapiens and Neanderthals about 47,000 years ago, over a single, extended period of about 7,000 years.
Drug Patent Watch
DECEMBER 12, 2024
Identifying branded drugs with a low likelihood of generic entry has become a crucial strategy for companies looking to expand their product portfolio through in-licensing. This approach not only helps maintain market exclusivity but also ensures a steady revenue stream for pharmaceutical companies. In this comprehensive guide, we’ll explore the intricacies of identifying such drugs and leveraging them for successful in-licensing opportunities.
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Science Daily: Pharmacology News
DECEMBER 12, 2024
A research team has developed an ultra-thin, flexible film that could power next-generation wearable devices using body heat, eliminating the need for batteries.
addgene Blog
DECEMBER 12, 2024
Prime Editing: Precise and Flexible CRISPR Editing Over 75,000 pathogenic genetic variants have been identified in humans and cataloged in the ClinVar database. Previously developed genome editing methods using nucleases and base editors have the potential to correct only a minority of those variants in most cell types. But prime editing, a CRISPR technique developed in David Lius lab in 2019, has added considerably more precision and flexibility to the CRISPR editing world.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Science Daily: Pharmacology News
DECEMBER 12, 2024
Nearly all living organisms use the same genetic code, a complicated mechanism by which genetic information is translated into proteins, the building blocks of life. A new study suggests conventional wisdom about how the code evolved is likely flawed.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
DECEMBER 12, 2024
Stars similar to the Sun produce a gigantic outburst of radiation on average about once every hundred years per star. Such superflares release more energy than a trillion hydrogen bombs and make all previously recorded solar flares pale in comparison. This estimate is based on an inventory of 56450 sun-like stars. It shows that previous studies have significantly underestimated the eruptive potential of these stars.
Metabolite Tales Blog
DECEMBER 12, 2024
The Current State of Biotransformation Science Industry Survey of In Vitro and In Vivo Practices, Clinical Translation, and Future Trends To end this year of highlighted papers around the subject of biotransformation and metabolism, we feature a paper published by the Translatability of MetID In Vitro Systems Working Group, a subgroup of the International IQ Consortium.
Science Daily: Pharmacology News
DECEMBER 12, 2024
Few genomes have been sequenced from early modern humans, who first arrived in Europe when the region was already inhabited by Neanderthals. An international team has now sequenced the oldest modern human genomes to date. The genomes were recovered from seven individuals who lived between 42,000 and 49,000 years ago in Ranis, Germany and Zlaty kun, Czechia.
Perficient: Drug Development
DECEMBER 12, 2024
Welcome to our ongoing series on Universal Design for Healthcare! In this segment, well explore the importance of Visual Disabilities in Healthcare. Creating a healthcare environment that is accessible to individuals with visual disabilities is crucial for delivering equitable and high-quality care. Universal design principles aim to make healthcare facilities, services, and information accessible to all, including those with visual impairments.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Science Daily: Pharmacology News
DECEMBER 12, 2024
Researchers have discovered a protein variant that serves as a knob for regulating the body's innate immune response. The findings could lead to new therapies for Long COVID, autoimmune disorders, and more.
Drug Channels
DECEMBER 12, 2024
This week, Im rerunning some popular posts while I prepare for tomorrows Drug Channels Outlook 2025 live video webinar. During the webinar, I'll share some thoughts on how vertical integration will affect the buy-and-bill channel. Click here to see the original post from September 2024. Time for DCIs annual update on the channels for provider-administered drugs.
Science Daily: Pharmacology News
DECEMBER 12, 2024
Researchers have synthesized new molecules able to quickly capture significant amounts of carbon dioxide from the air, an important tactic in climate change mitigation.
Chemical Biology and Drug Design
DECEMBER 12, 2024
Compounds 7h and 7 in HTB-9 and compounds 7a and 7 in HT-29 cell line demonstrated most cytotoxic activity among all compounds. These compounds expectedly increased apoptosis, activated caspase 3/7, and inhibited migration in both cell lines compared to controls. As a remarkable result, a greater apoptotic index was observed in HT-29 cells treated with compound 7 than those of cisplatin-treated cells.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Science Daily: Pharmacology News
DECEMBER 12, 2024
A new analysis reveals that overfishing has caused populations of chondrichthyan fishes -- sharks, rays, and chimaeras -- to decline by more than 50 per cent since 1970. To determine the consequences, a team of researchers developed an aquatic Red List Index (RLI) which shows that the risk of extinction for chondrichthyan has increased by 19 per cent.
Chemical Biology and Drug Design
DECEMBER 12, 2024
This diagram illustrates the proposed mechanism by which Schisandrin A (SchA) affects hepatocellular carcinoma (HCC) cells. SchA induces reactive oxygen species (ROS) generation in mitochondria, leading to oxidative stress and mitochondrial dysfunction. This cascade activates AMP-activated protein kinase (AMPK), which inhibits the mTOR pathway, resulting in decreased cell proliferation and increased apoptosis.
Science Daily: Pharmacology News
DECEMBER 12, 2024
Researchers have uncovered in anglerfish a specialized motor neuron population for the first dorsal fin used for 'fishing'. When the first dorsal fin evolved from a swimming and buoyancy aid to a hunting tool, the motor neurons shifted their position in the central nervous system. The findings have implications for understanding the potential of evolutionary processes of vertebrates, including humans.
Chemical Biology and Drug Design
DECEMBER 12, 2024
The inhibitory profile of triaminopyrimidines was expanded and low nM IC 50 alky and aryl variants of CK-1-41 were discovered. Docking supported previous work indicating allosteric inhibition of caspase-1. Analogs with electrophilic warheads were created and inhibited caspase-1 in a partially reversible, time-dependent manner with experimental and docking results supporting allostery.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
DECEMBER 12, 2024
Researchers are linking human activity to increased gene transfer from soil bacteria to humans.
Drug Patent Watch
DECEMBER 12, 2024
The pharmaceutical industry relies heavily on Contract Development and Manufacturing Organizations (CDMOs) to outsource various stages of drug development and manufacturing. With the increasing complexity of drug development and the need for efficient, cost-effective solutions, selecting the right CDMO is crucial. Evaluating CDMO performance is a critical step in this process, ensuring that the chosen partner can meet the required standards and deliver high-quality products.
Science Daily: Pharmacology News
DECEMBER 12, 2024
In a new study, scientists describe how different traits used to choose mates in barn swallow populations are driving the bird to diverge, which could eventually lead to the formation of new species.
The ChEMBL-og
DECEMBER 12, 2024
Use your well-deserved Christmas holidays to spend time with your loved ones and explore the new release of ChEMBL 35! This fresh release comes with a wealth of new data sets and some new data sources as well. Examples include a total of 14 datasets deposited by by the ASAP ( AI-driven Structure-enabled Antiviral Platform) project, a new NTD data se t by Aberystwyth University on anti-schistosome activity, nine new chemical probe data sets, and seven new data sets for the Chemogenomic library of
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
DECEMBER 12, 2024
Scientists have a new method for studying faults that could improve earthquake forecasts, shedding light on where quakes start, how they spread, and where the biggest impacts might be.
Perficient: Drug Development
DECEMBER 12, 2024
In today’s digital marketing landscape, delivering personalized and cohesive customer experiences across multiple channels is essential. Salesforce Marketing Cloud Advertising Studio empowers businesses to integrate their advertising efforts with customer data, enabling targeted and effective campaigns. This blog explores the features, benefits, and practical applications of Advertising Studio, providing insights into how it can enhance your marketing strategy.
Science Daily: Pharmacology News
DECEMBER 12, 2024
A new study has mapped 35 years of river changes on a global scale. The work has revealed significant effects on both downstream (44% decrease in water flow) and upstream (17% flow increase) rivers, including flooding, ecosystem disruption, hydropower development interference and insufficient fresh water supplies.
Perficient: Drug Development
DECEMBER 12, 2024
Social media is a pivotal component of any marketing strategy in today’s digital era. Salesforce Marketing Cloud Social Studio offers a comprehensive platform for managing, scheduling, creating, and monitoring social media posts. This enables businesses to effectively engage with their audience and monitor their brand presence across various social channels.
FDA Law Blog: Biosimilars
DECEMBER 12, 2024
By Larry K. Houck Administrative Law Judge (ALJ) John Mulrooney conducted a prehearing conference hearing on Monday, December 2nd, to kick off the public hearing on the Department of Justices (DOJs) notice of proposed rulemaking (NPRM) to reschedule marijuana. The NPRM seeks to reschedule marijuana from schedule I of the federal Controlled Substances Act (CSA) to schedule III.
Perficient: Drug Development
DECEMBER 12, 2024
Let me take you on a journey. Imagine youre a manager of a large library with books scattered across countless shelves. Some visitors come asking for books by title, others by author, and some want a list of all available books in a specific genre. You cant prepare every possible answer in advance. Instead, you need a system to adapt on the fly to their ever-changing questions.
Alta Sciences
DECEMBER 12, 2024
Get Started on Your Gene Therapy Preclinical Studies Today! blussier Thu, 12/12/2024 - 18:23 HTML Our Sacramento Team is Ready to Support Your Next Gene Therapy NHP Study With over 31,000 square feet of space and 20 animal rooms, our state-of-the-art preclinical facility in Sacramento, California, is equipped to take on your discovery and PK/PD research needs in nonhuman primates (NHPs).
Perficient: Drug Development
DECEMBER 12, 2024
Imagine youre a small business owner. Every morning, you log into Salesforce, but instead of spending hours sorting through leads, crafting follow-up emails, and analyzing customer feedback, you find it all done for you. Your CRM didnt just sit thereit worked while you slept. Sounds incredible, right? Welcome to 2025, where Salesforces Einstein GPT is transforming CRM as we know it.
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