Tue.May 14, 2024

article thumbnail

Weight loss drug could be a gamechanger for cardiovascular disease

Drug Discovery World

Semaglutide (the active ingredient in Wegovy and Ozempic) can produce clinically meaningful weight loss and delivers significant cardiovascular benefits, according to two studies presented at the European Congress on Obesity (ECO). The studies are based on the Semaglutide and Cardiovascular Outcomes (SELECT) trial, the largest and longest clinical trial of the effects of semaglutide on weight in over 17,000 adults.

Disease 147
article thumbnail

People without an inner voice have poorer verbal memory

Science Daily: Pharmacology News

The vast majority of people have an ongoing conversation with themselves, an inner voice, that plays an important role in their daily lives. But between 5-10 per cent of the population do not have the same experience of an inner voice, and they find it more difficult to perform certain verbal memory tasks, new research shows.

Research 119
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Trending Sources

article thumbnail

Meet the researcher: Dr Henrik Jespersen

Drug Discovery World

DDW’s Megan Thomas talks to Dr Henrik Jespersen, Head of Melanoma Oncology, at Oslo University Hospital. MT: Where do you work, and can you tell us what you’re working on at the moment? HJ: I work as a clinical oncologist at Oslo University Hospital where I am head of melanoma oncology. I have a particular interest in tumour immunology and the melanoma subtype that arises in parts of the eye called uveal melanoma.

Research 147
article thumbnail

2023 was the hottest summer in two thousand years

Science Daily: Pharmacology News

Researchers have found that 2023 was the hottest summer in the Northern Hemisphere in the past two thousand years, almost four degrees warmer than the coldest summer during the same period.

Research 115
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

New podcast: A new paradigm of appetite and hunger

Drug Discovery World

In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Tien Lee, CEO of Aardvark Therapeutics, a San Diego-based biotech company in Phase II studies of its drug, ARD-101, a type 2 bitter taste receptor (TAS2R) which is taken orally and remains in the human gut unlike GLP-1 which is systemic.

article thumbnail

Virtual reality becomes more engaging when designers use cinematic tools

Science Daily: Pharmacology News

Cinematography techniques can significantly increase user engagement with virtual environments and, in particular, the aesthetic appeal of what users see in virtual reality.

113
113

More Trending

article thumbnail

Navigating Trust and Data in Healthcare Marketing

Perficient: Drug Development

In the ever-evolving landscape of healthcare, trust reigns supreme. As consumers increasingly rely on data to inform their decisions, the healthcare industry faces a pressing need to not only meet but exceed expectations. With disruptive forces emerging from various corners, healthcare organizations find themselves in a race to create personalized experiences that foster lasting engagement and trust.

Marketing 111
article thumbnail

Deterrents to trial participation among ethnic minorities revealed

Drug Discovery World

Safety and health concerns, time investment, and lack of support are the top three barriers to participation in clinical studies among ethnic minorities, according to a new report. The study examined the motivators and deterrents of clinical trial participation among ethnic minorities and outlined strategies sponsors can utilise to minimise deterrents and promote diversity in their research. “Diversity in clinical trials isn’t a nice to have, it’s a medical necessity.

Trials 130
article thumbnail

Artificial intelligence tool detects male-female-related differences in brain structure

Science Daily: Pharmacology News

Artificial intelligence (AI) computer programs that process MRI results show differences in how the brains of men and women are organized at a cellular level, a new study shows. These variations were spotted in white matter, tissue primarily located in the human brain's innermost layer, which fosters communication between regions.

106
106
article thumbnail

A new paradigm of appetite and hunger

Drug Discovery World

In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Tien Lee, CEO of Aardvark Therapeutics, a San Diego-based biotech company in Phase II studies of its drug, ARD-101, a type 2 bitter taste receptor (TAS2R) which is taken orally and remains in the human gut unlike GLP-1 which is systemic.

article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

More Studies Support Wegovy's Long-Term Weight-Loss Benefits

Drugs.com

TUESDAY, May 14, 2024 -- Semaglutide -- the active ingredient in the blockbuster weight-loss drugs Ozempic and Wegovy -- can produce long-term weight and heart health benefits, a pair of new studies show.Researchers found that overweight and obese.

Drugs 105
article thumbnail

Researchers discover the universe's oldest stars in our own galactic backyard

Science Daily: Pharmacology News

Astronomers discovered three of the oldest stars in the universe, and they live in our own galactic neighborhood. The stars are in the Milky Way's 'halo' -- the cloud of stars that envelopes the entire main galactic disk -- and they appear to have formed between 12 and 13 billion years ago, when the very first galaxies were taking shape.

article thumbnail

Summer of 2023 Was Hottest in 2,000 Years

Drugs.com

TUESDAY, May 14, 2024 -- High temperatures across the Northern Hemisphere last summer were scorching and frequent enough to make it the hottest summer in two millennia, new research shows.Weather records based on scientific instruments only goes.

article thumbnail

WASP-193b, a giant planet with a density similar to that of cotton candy

Science Daily: Pharmacology News

Astronomers have just discovered WASP-193b, an extraordinarily low-density giant planet orbiting a distant Sun-like star.

103
103
article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

Science Shows How Night Shifts Help Bring on Disease

Drugs.com

TUESDAY, May 14, 2024 -- Night shift work can increase a person’s risk of chronic disease, and a new study reveals one possible explanation for this.It appears that just a few days on a night shift schedule throws off body rhythms tied to.

Disease 98
article thumbnail

6 Principles of Our Rare Disease Methodology That Drive Success for Our Sponsors

Conversations in Drug Development Trends

By: Amy Raymond, Derek Ansel, Nathan Chadwick, & Juliane Mills When choosing a CRO for a rare disease study, what truly sets them apart is their methodology: the CRO’s mindset, their approach to each unique study, and their agility in navigating the inherent complexities of rare disease research. The team’s ability to apply insights and proven strategies from their experience in rare disease research brings concepts to reality, getting medications to patients faster.

Disease 82
article thumbnail

About 8,000 Women Per Month Are Getting Abortion Pills Despite Their States' Bans

Drugs.com

TUESDAY, May 14, 2024 -- While some states have moved to severely curb women's access to abortion, including abortion pills, over 8,000 women living in those states are getting the pills by mail each month from states without such.

98
article thumbnail

Another IRA Surprise: Part B Coinsurance Inflation Adjustments Are Increasing Patient Costs

Drug Channels

Contrary to what you may have heard, the Inflation Reduction Act’s (IRA) inflation rebates for Medicare Part B drugs do not always save money for seniors. As we document below, a growing share of Part B drugs have inflation-adjusted coinsurance rates that have been increasing , not declining. In many cases, the coinsurance rate declines only briefly before rebounding back to the standard 20% rate.

Drugs 77
article thumbnail

Vaping Rates Fall Among Teens, But Still Too High

Drugs.com

TUESDAY, May 14, 2024 -- Vaping rates among U.S. kids in grades 9 through 12 fell to 5% in 2021, the latest year for which data is available. That's down from a peak of 7.2% of teens who vaped in 2019, a new report finds.However, the 5% vaping rate.

98
article thumbnail

Mixed public opinion on polygenic embryo screening for IVF

Science Daily: Pharmacology News

Survey reveals nearly three-quarters of U.S. adults support using emerging technology to screen embryos during IVF for risk of developing certain health conditions or traits that arise from more than one gene. Only about one-third of respondents approved of using the technology to predict traits unrelated to disease. Nearly all expressed concerns about potential negative outcomes for individuals or society.

Disease 76
article thumbnail

San Francisco Set to Ban 'Forever Chemicals' in Firefighter Gear

Drugs.com

TUESDAY, May 14, 2024 -- San Francisco is on the verge of passing a ban on "forever chemicals" in the protective clothing firefighters wear while battling blazes.City lawmakers are expected to pass an ordinance on Tuesday that will prohibit.

98
article thumbnail

FogPharma, Artbio join forces to design a different radiopharma drug

BioPharma Drive: Drug Pricing

The biotechs aim to marry FogPharma’s polypeptide science with Artbio’s lead-based radiopharmaceutical technology in one of the industry’s hottest fields.

Science 75
article thumbnail

Melanoma Can Strike Black Americans, Often With Deadlier Results

Drugs.com

TUESDAY, May 14, 2024 -- Melanoma, while rare among Black Americans, is often detected later with devastating consequences, a new study finds.Black people are frequently diagnosed with melanoma at later stages, increasing their risk of death.

98
article thumbnail

Bayer details layoffs as company shake-up continues

BioPharma Drive: Drug Pricing

The reduction of 1,500 roles in the first quarter is part of CEO Bill Anderson’s plan to shrink Bayer’s bureaucracy and “radically realign” its culture.

70
article thumbnail

U.S. Drowning Deaths Rising Again After Years of Decline

Drugs.com

TUESDAY, May 14, 2024 (HeathDay News) -- Following decades of declines, drowning deaths are once again climbing in the United States, new government data shows. More than 4,500 people died from drowning each year in 2020 through 2022, 500 more per.

article thumbnail

Young whale's journey highlights threats facing ocean animals

Science Daily: Pharmacology News

A young whale's journey across the Mediterranean highlights the many threats facing ocean animals, researchers say.

article thumbnail

Sands Capital raises $555M fund amid upturn in biotech ‘crossover’ investing

BioPharma Drive: Drug Pricing

The firm, one of the sector’s more active crossover investors, closed the fund during a surge in the financings that bridge biotechs to the public markets.

article thumbnail

What to Expect During the NDA Review Process

thought leadership

Compiling and submitting a New Drug Application ( NDA) submission is a complicated and intensive activity. Once you have submitted your application to FDA, you may be curious about what can you expect to hear and when. Below are some of the common questions we receive from Sponsors about what to expect during the NDA review process.

FDA 64
article thumbnail

Perficient Earns Data Cloud Expert Specialization

Perficient: Drug Development

We’re excited to announce our Data Cloud Expert specialization! This is the highest level of Salesforce-validated expertise for Data Cloud. This achievement isn’t just a milestone, it’s a testament to our commitment to revolutionizing how businesses leverage their data to drive business outcomes, unlock trapped data, and enhance customer experiences.

article thumbnail

The Role of Key Opinion Leaders in Rare Disease Clinical Trials

Cytel

Written by Angela Vinken and Patti Arsenault Key Opinion Leaders (KOLs) — i.e., trusted, well-respected experts — are crucial in clinical research, especially in rare diseases. They have the expertise, network, and experience to add great scientific value to clinical research and can influence and shape the trajectory of clinical research within their professional communities.

article thumbnail

Salesforce Health Cloud – Summer ’24 Edition: Have you heard of AI?

Perficient: Drug Development

The Summer ‘24 release preview is out and will be generally available by mid-June! The latest release from Salesforce brings critical feature improvements for our friends in the Healthcare & Life Sciences (HLS) industry. Of course, the hot topic in Tech over the last year has been Artificial Intelligence (AI). As Salesforce continues to beef up its AI offerings, the HLS industry using Health Cloud will reap the benefits of new and improved generative AI features that make a substantial diff

article thumbnail

Utilising engineered peptides for immunotherapy

Drug Target Review

How do hydrophobicity, electrostatic charge, and secondary confirmation of helical polypeptides influence the stimulation of innate immune pathways in antigen-presenting cells (APCs)? These physical properties directly affect physical disruption of membrane integrity, which can activate endoplasmic reticulum (ER) stress to initiate pro-inflammatory signalling specifically in APCs.

article thumbnail

New patent for Blueprint Medicines drug GAVRETO

Drug Patent Watch

Annual Drug Patent Expirations for GAVRETO Gavreto is a drug marketed by Blueprint Medicines and is included in one NDA. It is available from one supplier.

Drugs 59
article thumbnail

The Role of Work Arrangements in the Future of Work

NIOSH Science Blog: Drugs

The National Institute for Occupational Safety and Health (NIOSH) Future of Work Initiative hosted a webinar to address the role of work arrangements in the future of work. Among the changes anticipated in the Future of Work is an increasing prevalence of nonstandard work arrangements, such as contingent, platform-based, seasonal, on-call, or other “nonstandard” work.