Sat.Nov 23, 2024 - Fri.Nov 29, 2024

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Delay and pay: Climate tipping point costs quadruple after waiting

Science Daily: Pharmacology News

The cost of reversing the effects of climate change -- restoring melted polar sea ice, for example -- quickly climbs nearly fourfold soon after a tipping point is crossed, according to new work. Much work has been done to explore the environmental costs tied to climate change. But this new study marks the first time researchers have quantified the costs of controlling tipping points before and after they unfold.

Research 363
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New data could help Merck expand use of cardiovascular drug

BioPharma Drive: Drug Pricing

Positive results from a study of Winrevair could help the drugmaker achieve sales growth past top-seller Keytruda’s upcoming patent expirations this decade.

Drugs 293
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Long COVID Brain Fog: Could the Lungs Hold Clues?

Drugs.com

TUESDAY, Nov. 26, 2024 -- The “brain fog” of long COVID might be due to impaired lung function following a person’s infection, a new small-scale study says.Reduced gas exchange in the lungs – oxygen coming in, carbon dioxide going out -- appears to.

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How to Scale Up with Cohere: Insights from Aidan Gomez

BenchSci

Last month, we welcomed Aidan Gomez, CEO and Co-founder of Cohere, for our Scale Up series. As a leader in AI, Aidan co-authored the influential " Attention is All You Need " paper during his time at Google and has since co-founded Cohere , the leading data security-focused enterprise AI company. With the explosion of advancements in AI and its growing impact on industries worldwide, including drug discovery, our team was eager to hear Aidan’s unique technical perspective on building and scaling

Drugs 72
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Science Daily: Pharmacology News

A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report. Dubbed the NanoGripper, the nanorobotic hand also could be programmed to interact with other viruses or to recognize cell surface markers for targeted drug delivery, such as for cancer treatment.

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Scientists Develop Whole New Form of Effective Asthma Treatment

Drugs.com

THURSDAY, Nov. 28, 2024 -- Geoffrey Pointing says its hard to describe the distress of an asthma or COPD flare-up.“Honestly, when you're having a flare up, it's very difficult to tell anybody how you feel - you can hardly breathe,” Pointing, 77, of.

Treatment 278
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The paradox of data in precision medicine

Drug Target Review

As the journey toward realising the full potential of precision medicine continues, one question frequently arises among pharma executives and biotech founders: why is progress so slow? A significant part of the answer may lie in the limitations of current technology in handling complex, multi-modal data – data that is crucial for advancing drug discovery and identifying new targets.

Science 59
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Unexplained heat-wave 'hotspots' are popping up across the globe

Science Daily: Pharmacology News

A striking new phenomenon is emerging: distinct regions are seeing repeated heat waves that are so extreme, they fall far beyond what any model of global warming can predict or explain. A new study provides the first worldwide map of such regions, which show up on every continent except Antarctica like giant, angry skin blotches.

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Roche’s TIGIT-targeting drug for cancer fails its biggest test

BioPharma Drive: Drug Pricing

Long-awaited results released Tuesday showed adding tiragolumab to Roche's immunotherapy Tecentriq did not extend survival in a closely followed Phase 3 study called SKYSCRAPER-01.

Drugs 260
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Twice-Yearly Injection 96% Effective in Preventing HIV Infection

Drugs.com

THURSDAY, Nov. 28, 2024 -- People whose partners have HIV must remember to take antiretroviral pills every single day or risk infection themselves.But researchers have come up with a way to avoid that daily hassle – an injectable drug that patients.

Research 278
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Biotech leader champions targeted cancer treatments and diversity

Drug Target Review

In the world of biopharmaceuticals, Dr Catherine Pickering stands out as a pioneering leader. As the CEO of iOnctura, an innovative oncology biopharmaceutical company she co-founded in 2017, Catherine has played a key role in advancing the development of highly targeted small molecules aimed at revolutionising cancer treatment. Her journey in drug R&D and business development has been marked by significant achievements, including leading groundbreaking efforts to treat neglected cancers and

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Clinical trial reveals twice-yearly injection to be 96% effective in HIV prevention

Science Daily: Pharmacology News

Recent results from a recent clinical trial indicate that a twice-yearly injection of Lenacapavir offers an overall 96% reduced risk of acquiring HIV. This makes Lenacapavir significantly more effective than the standard daily oral PrEP (pre-exposure prophylaxis).

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Amgen obesity drug cuts weight in study, but results miss Wall Street’s high mark

BioPharma Drive: Drug Pricing

Shares in Amgen fell by double digits Tuesday on results for the company’s MariTide shot, which is viewed as a potential rival to Wegovy and Zepbound.

Drugs 216
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Diabetes Drug Metformin Might Help Fight Lung Cancer

Drugs.com

WEDNESDAY, Nov. 27, 2024 -- Already the go-to drug of choice for millions with type 2 diabetes, metformin might also fight lung cancer if those patients have it as well, new research shows.Metformin appears to help boost the benefits of.

Drugs 279
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Ladders to Cures (L2C) Accelerator

Broad Institute

Ladders to Cures (L2C) Accelerator By Maria Nemchuk November 25, 2024 Breadcrumb Home Ladders to Cures (L2C) Accelerator The Ladders to Cures (L2C) Accelerator aims to catalyze progress across the research ecosystem and accelerates advances leading to treatments and cures for patients with rare genetic diseases. We are a community of scientists, physicians, patient advocacy groups, AI/machine learning experts and biopharma veterans working together to gain new mechanistic insights and advance tr

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First new treatment for asthma attacks in 50 years

Science Daily: Pharmacology News

A recent trial finds an injection given during some asthma and COPD attacks is more effective than the current treatment of steroid tablets, reducing the need for further treatment by 30%.

Treatment 320
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How Intra-Cellular surprised Wall Street by breaking character

BioPharma Drive: Drug Pricing

The biotechnology company, which sees itself as "pretty conservative," recently put out an ambitious long-term revenue forecast for its schizophrenia and depression medicine Caplyta.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Biden Will Move to Have Medicare, Medicaid Cover GLP-1 Weight-Loss Meds

Drugs.com

TUESDAY, Nov. 26, 2024 -- The outgoing Biden administration will propose that pricey GLP-1 obesity medications such as semaglutide (Wegovy), and tirzepatide (Zepbound) be covered by Medicare and Medicaid.However, the move would have to be approved.

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Meet the ZoBio SPR Team: Advancing Drug Discovery Around the Clock

Zobio

Drug discovery doesn’t sleep, and neither does our SPR (Surface Plasmon Resonance) team. While the Assay Group takes a well-deserved weekend break and goes for dinner tonight, our relentless SPR team is tirelessly screening compounds, revealing critical insights that help drive discovery forward. Meet the Team: Each of our SPR machines brings unique strengths to the lab, earning their names and personalities for how they support our research.

Drugs 52
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Astronomers may have discovered the answer to a mysterious stellar event

Science Daily: Pharmacology News

Researchers have made a record-breaking astrophysical discovery while simultaneously uncovering a possible explanation for the rare and extreme astrophysical event known as long-period radio transients.

Research 317
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Roche to buy cell therapy developer Poseida for $1B

BioPharma Drive: Drug Pricing

The deal suggests Roche sees substantial promise in Poseida’s technology, as the offer is 215% above the biotech’s closing share price on Monday.

Therapies 167
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Stroke Guidelines Updated, With Focus on Women and GLP-1s

Drugs.com

MONDAY, Nov. 25, 2024 -- Women, especially those who had high blood pressure during pregnancy or entered menopause before age 45, are among those with a greater risk for stroke.They and other high-risk groups are the focus of new stroke prevention.

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Pharma AI is Changing Clinical Trials by Optimizing Patient Selection

Reprocell

In recent years, the pharmaceutical industry has increasingly harnessed artificial intelligence (AI) to make clinical trials more efficient and effective. One of the most powerful applications of AI in this space is its ability to help researchers identify patient groups most likely to benefit from specific drugs. By making patient selection and recruitment processes more targeted, AI-driven tools not only improve trial outcomes but also accelerate the journey of new drugs to market.

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Uranus's swaying moons will help spacecraft seek out hidden oceans

Science Daily: Pharmacology News

A new computer model can be used to detect and measure interior oceans on the ice covered moons of Uranus. The model works by analyzing orbital wobbles that would be visible from a passing spacecraft. The research gives engineers and scientists a slide-rule to help them design NASA's upcoming Uranus Orbiter and Probe mission.

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Biohaven muscle drug misses goal of SMA study, but advances in obesity

BioPharma Drive: Drug Pricing

The setback likely removes one competitor to an emerging spinal muscular atrophy medicine from Scholar Rock, but sets the stage for a pair of readouts with implications for weight loss research.

Drugs 167
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Could the Common Thyroid Medicine Levothyroxine Weaken Bones?

Drugs.com

MONDAY, Nov. 25, 2024 -- New research suggests that a thyroid medication often prescribed to older Americans may be linked to a common problem in old age -- bone loss. Levothyroxine is a synthetic hormone often prescribed to treat hypothyroidism.

Research 279
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Chemical Biology and Drug Design

Cover Image © molekuul_be/Shutterstock.

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Simple secret to living a longer life

Science Daily: Pharmacology News

Increasing physical activity levels could extend your life up to 11 more years according to new research using accelometry data. The study found that for the least active people in the population, a single one-hour walk could return a benefit of six additional hours of life.

Research 312
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Kronos, Idorsia plan layoffs; PTC shelves ALS drug

BioPharma Drive: Drug Pricing

Kronos is cutting 83% of its workforce, while Idorsia is considering eliminating as many as 270 jobs. Elsewhere, PTC disclosed negative Phase 2 results for its ALS drug candidate utreloxastat.

Drugs 144