Remove Engineering Remove Immune Response Remove RNA
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Designing antibodies to think before they bind

Drug Target Review

With a background in neurobiology, immuno-oncology and bispecific engineering, JJ now leads the development of antibody candidates designed to go further. The main challenge was engineering a molecule that could precisely engage p95HER2 and simultaneously trigger immune activation through CD137. They are starting points.

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Case study: gget’s new Open Target module

The Open Targets Blog

  “Sam has an exceptional talent in software engineering, and his contributions reflect a deep understanding of both the technical and biological aspects required for bioinformatics tool development,” says Laura Luebbert, now a postdoctoral fellow in the Sabeti lab at the Broad Institute of MIT and Harvard and Harvard University.

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A Visual Guide to Genome Editors

Codon

The core of the CRISPR immune response is a guide RNA (gRNA) that binds to a CRISPR-associated (Cas) protein. In wild microbes, Cas9 cuts DNA using two separate RNA molecules, called the CRISPR RNA (crRNA) and trans-activating RNA (tracrRNA). Visit our website to get a copy. Join Asimov Press.

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The Long Road to End Tuberculosis

Codon

If present before vaccination, memory immune cells primed to destroy the environmental relatives might cross-react with and neutralize the BCG strain before it has a chance to set up an immune response against itself and M. Testing the engineered cells against four common drugs, I found that the M. tuberculosis.

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Engineers design more powerful RNA vaccines

Science Daily: Pharmacology News

By adding synergistic self-adjuvanting properties to Covid-19 RNA vaccines, researchers showed they could significantly boost the immune response generated in mice.

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The role of CRISPR in microbiome engineering breakthroughs

Drug Target Review

When faced with a viral threat, bacterial cells developed an immune response by capturing and copying DNA fragments of viruses. It was also discovered that the Cas enzyme was responsible for DNA cleavage. Using a synthetic guide RNA (gRNA), scientists can target a specific DNA sequence and employ Cas9 to cut it.

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Targeting the immunotherapy potential of cytokines IL-12 and IL-18 with new advancements in protein engineering

Drug Target Review

Natural killer (NK) cells are another immune cell type that, as the name suggests, also have potent cell-killing activity, and have a well-known role in the anti-tumour immune response. In the context of a tumour microenvironment, Tregs are often present in high numbers, preventing an effective immune response to the tumour.