Broad Institute

DECEMBER 13, 2023

The other study was led by senior authors Xiao Wang , a Broad core institute member, a Merkin Institute Fellow, and an assistant professor of chemistry at MIT, and Jia Liu, an assistant professor of engineering at Harvard University. Related news Researchers map brain cell changes in Alzheimer’s disease Courtesy of the Chen and Macosko labs.

DNA 140

DNA Virus Research Engineering 140

The Pharma Data

OCTOBER 19, 2020

Spectrum’s self-contained saliva collection kit provides critical sample consistency while suspending and neutralizing viral RNA transcripts completely inactivating the live virus. Qualified commercial RNA extraction chemistries include Perkin Elmer, Thermo Fisher, Roche, and Qiagen.

RNA 52

RNA DNA Engineering Virus 52

The Pharma Data

DECEMBER 8, 2020

The company’s product candidates consist of novel human cells engineered to produce the crucial proteins, enzymes or factors needed by patients living with chronic diseases such as hemophilia, diabetes and lysosomal storage disorders. Laying down a new track for RNA processing, Remix launched with $81 million in financing.

RNA 52

RNA Therapies Disease Protein Expression 52

The Pharma Data

JANUARY 17, 2021

It received FDA guidance January 5 th and is in the midst of preparing the first package of investigational new drug (IND) applications – usually with an n-of-1, for individual patients. That’s not the case with RNA-targeted drugs. Working closely with Ionis, “We connect the need to the drug development engine.

Disease 52

Disease Clinical Trials Small Molecule Treatment 52

Broad Institute

JUNE 27, 2024

To deliver CHARM throughout the brain, the team collaborated with scientists in the lab of Ben Deverman , senior director of vector engineering at the Broad and a co-author of the study. They used an engineered adeno-associated virus (AAV) that crosses the blood-brain barrier after intravenous administration. Online June 27, 2024.

Disease 142

Disease Therapies Clinical Trials Engineering 142

Codon

APRIL 2, 2024

A gene encoding green fluorescent protein was placed alongside one of the three promoters, and as the engineered cells cycled from one gene to the next, they blinked between green—dark—green—dark. The RNA Exporter , which was developed by Felix Horns and others in my lab, is one example. Elowitz: It’s a mix.

RNA 57

RNA Engineering Molecular Biology Synthetic Chemistry 57

Codon

APRIL 2, 2023

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. Read Biological Engineering mScarlet3: a brilliant and fast-maturing red fluorescent protein. Read Inhalable nanoparticles, packaged with mRNA or CRISPR systems, efficiently edit lung cells. Gungabeesoon J.

DNA 52

DNA RNA Engineering Licensing 52

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context.

Therapies 59

Therapies RNA Protein Expression DNA 59

Codon

JULY 27, 2023

But for a recent paper out of Nanjing, China, researchers engineered another enzyme and showed that, when mixed with FAST-PETase, the two worked together to break down plastic twice as fast as the Texas enzyme alone. Because it turns out that at least half of them , in humans, also bind to RNA molecules. RNA export systems.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

But for a recent paper out of Nanjing, China, researchers engineered another enzyme and showed that, when mixed with FAST-PETase, the two worked together to break down plastic twice as fast as the Texas enzyme alone. Because it turns out that at least half of them , in humans, also bind to RNA molecules. RNA export systems.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. Genetic engineering can be used to eradicate mosquitoes in two ways: Through gene drives or the “sterile insect technique.” Stahl et al.

Vaccine 52

Vaccine DNA Virus Engineering 52

Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. Genetic engineering can be used to eradicate mosquitoes in two ways: Through gene drives or the “sterile insect technique.” Stahl et al.

Vaccine 52

Vaccine DNA Virus Engineering 52

Codon

MARCH 24, 2024

In the first real test of delivering a complex biomolecule to over a billion people, little has changed from how Genentech first approached manufacturing in the 1980s; Cells are genetically engineered and then grown in steel tanks. But this isn’t a problem with extracts.

Engineering 87

Engineering Vaccine Production RNA 87

Codon

JUNE 26, 2023

I’m writing long essays for Asimov every other week and my work at MIT, where I’m helping to design a genetic engineering curriculum for undergraduates, has reached its crescendo. Anyone who has tried to engineer a cell knows how tedious it can be. And it’s been my life for the last few weeks. A Mycoplasma cell.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

I’m writing long essays for Asimov every other week and my work at MIT, where I’m helping to design a genetic engineering curriculum for undergraduates, has reached its crescendo. Anyone who has tried to engineer a cell knows how tedious it can be. And it’s been my life for the last few weeks. A Mycoplasma cell.

DNA 52

DNA Therapies Engineering Clinical Trials 52

The Pharma Data

AUGUST 3, 2021

The company confirmed the tirzepatide SURPASS program has met global regulatory submission requirements for evaluating cardiovascular risk and its intention to submit the registration package to regulatory authorities by the end of 2021. The company announced the acquisition of Protomer Technologies Inc.,

Production 52

Production Marketing Research Government 52

Codon

MAY 30, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome.

DNA 52

DNA RNA Engineering Vaccine 52

Drug Target Review

MAY 8, 2025

Figure 2: LETI-101 is a complete gene editing system with Life Edits proprietary, compact LEG-B nuclease, packaged in an AAV5 vector for all-in-one delivery to the brain. To deliver our CRISPR editing system to the brain cells involved in the disease, we packaged it into AAV to make LETI-101.

Disease 111

Disease Treatment DNA Therapies 111

SugarCone Biotech

APRIL 8, 2025

CAR-T cell therapeutics that are created ex vivo thus, genetically engineered outside of the patient, then reinfused - have been approved for use in treating blood cancers. Lentivirus particles readily package genetic sequences for delivery into cells, particularly if the genetic construct is small, generally less than 5500 nucleotides (5.5

Therapies 56

Therapies RNA Packaging Virus 56

Codon

OCTOBER 27, 2024

tuberculosis known as rpoB , which codes for part of its RNA polymerase. Engineers at Khon Kaen University in Thailand are developing one such technique based on Raman scattering , a phenomenon in which compounds excited with one wavelength of light emit photons in a different part of the electromagnetic spectrum.

Immune Response 105

Immune Response Doctors Disease Laboratories 105