The Pharma Data

OCTOBER 19, 2020

Spectrum’s self-contained saliva collection kit provides critical sample consistency while suspending and neutralizing viral RNA transcripts completely inactivating the live virus. “The SDNA-1000 was engineered to innovate molecular diagnostic applications using saliva,” said Jeremy Johnson, VP of Engineering at Spectrum Solutions.

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Drug Target Review

DECEMBER 5, 2024

2,3 Engineering both the capsid and DNA cargo improves the safety and efficacy of rAAV vectors and expands their clinical applications. Adeno-associated virus as a delivery vector for gene therapy of human diseases. Adeno-associated virus-based gene therapy for lifelong correction of genetic disease. Labcompare. 2024;9(1):78.

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The Pharma Data

JUNE 25, 2021

“These data show consistent, high levels of efficacy and reaffirm the ability of the vaccine to prevent COVID-19 amid ongoing genetic evolution of the virus. Variant Virus Strains. against the original virus strain, 86.3% It is packaged in a ready-to-use liquid formulation in 10-dose vials. Glenn, M.D.,

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The Pharma Data

OCTOBER 14, 2020

The research is part of an ongoing collaboration between Columbia University and Tonix that focuses on T cell and antibody responses to SARS-CoV-2 (CoV-2), the virus that causes COVID-19. The research encompasses two projects. The study led by Dr. Ilya Trakht, Ph.D., About TNX-1800.

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Codon

JUNE 5, 2025

If the same virus invades the cell a second time, the gRNA’s spacer sequence will bind to the matching viral DNA sequence, then be cut by the Cas protein. pyogenes protein — whose compactness makes them far easier to package into viral vectors and deliver into the human body.

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Broad Institute

JANUARY 14, 2025

Building on previous work by the vector-engineering lab of Ben Deverman at the Broad, the team developed a pair of adeno-associated viruses (AAVs) to package and deliver the base-editing machinery to brain cells. But the researchers needed to deliver the base editors to the brain.

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Broad Institute

JUNE 27, 2024

To deliver CHARM throughout the brain, the team collaborated with scientists in the lab of Ben Deverman , senior director of vector engineering at the Broad and a co-author of the study. They used an engineered adeno-associated virus (AAV) that crosses the blood-brain barrier after intravenous administration.

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Codon

FEBRUARY 13, 2024

doi: 10.2210/rcsb_pdb/goodsell-gallery-048 The Virus that Cures It’s been over 25 years since the science magazine Discover first ran an extraordinary article about how a long-forgotten medical treatment, used in the former Soviet country of Georgia, could save us from the growing threat of untreatable, drug-resistant infections.

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Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. Genetic engineering can be used to eradicate mosquitoes in two ways: Through gene drives or the “sterile insect technique.” in bioRxiv.

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Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. Genetic engineering can be used to eradicate mosquitoes in two ways: Through gene drives or the “sterile insect technique.” in bioRxiv.

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Codon

APRIL 2, 2023

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. Read Biological Engineering mScarlet3: a brilliant and fast-maturing red fluorescent protein. Read Inhalable nanoparticles, packaged with mRNA or CRISPR systems, efficiently edit lung cells. Gungabeesoon J.

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Drug Target Review

MAY 22, 2024

Secondly, circRNAs can be engineered for more efficient protein expression by carefully selecting and optimising the IRES element, a sequence motif derived from viruses and used to initiate cap-independent translation from circRNA. We are now running follow-up experiments to track the advantage long-term.

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Agency IQ

JANUARY 19, 2024

Prevention of viral contamination is especially important as it may not be apparent that cells have been contaminated with a virus using conventional detection methods. Likewise, the selection of a cell line that was developed using a virus increases the risk of potential viral contamination.

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Codon

JULY 27, 2023

But for a recent paper out of Nanjing, China, researchers engineered another enzyme and showed that, when mixed with FAST-PETase, the two worked together to break down plastic twice as fast as the Texas enzyme alone. Two of these proteins are about 30% the size of Cas9 , and thus much easier to package into viruses for gene therapy.

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Codon

JULY 27, 2023

But for a recent paper out of Nanjing, China, researchers engineered another enzyme and showed that, when mixed with FAST-PETase, the two worked together to break down plastic twice as fast as the Texas enzyme alone. Two of these proteins are about 30% the size of Cas9 , and thus much easier to package into viruses for gene therapy.

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PLOS: DNA Science

OCTOBER 12, 2023

The package insert for the drug, Elevidys , warns of adverse effects of acute liver injury and inflammation around the heart and muscles. First, adeno-associated virus (AAV) delivers the genes, rather than the adenovirus (AV) that had entered cells in Jesse’s liver that weren’t the targets. Cardiac markers were okay.

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Codon

MAY 2, 2023

Once the mosquito factory has made all these insects, they are packaged into boxes or cups and then released in “strategic” areas within a city, like near swampy water or in dengue-ridden neighborhoods. But I do know this: Genetic engineering has endowed us with a radical ability to control our environments.

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Codon

MAY 2, 2023

Once the mosquito factory has made all these insects, they are packaged into boxes or cups and then released in “strategic” areas within a city, like near swampy water or in dengue-ridden neighborhoods. But I do know this: Genetic engineering has endowed us with a radical ability to control our environments.

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Codon

JUNE 26, 2023

I’m writing long essays for Asimov every other week and my work at MIT, where I’m helping to design a genetic engineering curriculum for undergraduates, has reached its crescendo. Anyone who has tried to engineer a cell knows how tedious it can be. A phage is a virus that infects bacteria. ” So take it easy!

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Codon

JUNE 26, 2023

I’m writing long essays for Asimov every other week and my work at MIT, where I’m helping to design a genetic engineering curriculum for undergraduates, has reached its crescendo. Anyone who has tried to engineer a cell knows how tedious it can be. A phage is a virus that infects bacteria. ” So take it easy!

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Codon

NOVEMBER 1, 2024

Making a computer-designed protein in the laboratory requires, first, that scientists synthesize a string of DNA encoding the protein, insert that DNA into living cells, and then isolate the proteins churned out by the engineered cells. The world’s supply of insulin is now made by engineered microbes.

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Agency IQ

NOVEMBER 3, 2023

The prebiotic may either feed the probiotic that it is packaged with, or it may feed another beneficial microbe that is intended to complement the activity of the probiotic. However, the term synthetic biotic is typically reserved for genetically engineered bacteria that intend to target a specific condition.

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The Pharma Data

FEBRUARY 22, 2021

1,7-14 It was engineered to have greater inhibitory potency for JAK1 versus JAK2, JAK3 and TYK2. RINVOQ (upadacitinib) [Package Insert]. Discovered and developed by AbbVie scientists, RINVOQ is an oral, once daily, selective and reversible JAK inhibitor studied in several immune-mediated inflammatory diseases. ClinicalTrials.gov.

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Codon

MAY 30, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. This means that IscB base editors might be easier to package inside of AAVs, which can only store 4,700 bases of DNA for gene therapies.

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Codon

MAY 30, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. This means that IscB base editors might be easier to package inside of AAVs, which can only store 4,700 bases of DNA for gene therapies.

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SugarCone Biotech

APRIL 8, 2025

CAR-T cell therapeutics that are created ex vivo thus, genetically engineered outside of the patient, then reinfused - have been approved for use in treating blood cancers. Lentivirus particles readily package genetic sequences for delivery into cells, particularly if the genetic construct is small, generally less than 5500 nucleotides (5.5

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Codon

FEBRUARY 9, 2025

To achieve this, E11 Bio synthesizes protein barcodes (short peptides with unique amino acid sequences), packages them into AAV vectors (engineered, non-harmful viruses for drug delivery), and delivers these into the brain tissue.

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Codon

FEBRUARY 2, 2025

” By the 1850s, the Capitol was renovated to include a ventilation system featuring 14-foot rotary fans driven by subterranean steam engines. In 1965, Congress mandated labeling on all cigarette packaging that warned consumers about the risks of smoking. This included the most rudimentary of ventilation tools: windows.

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Drug & Device Law

JULY 31, 2023

Smith rejected plaintiff’s analogy between books and drug package inserts. May 13, 2015) (contract involving multiple, identical “software package[s]” governed by UCC). Page Engineering Co. , So far, the would-be liability expanders haven’t done very well. 1145, 1165 n.135 1989), aff’d mem. , 2d 309 (Pa. 2d 641, 663 (Wyo.

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Drug & Device Law

DECEMBER 19, 2022

one HDPE resin to another HDPE resin) of a packaging component that may affect the impurity profile of the drug product. All of these changes to genetically engineered products could affect their safety and effectiveness. glass to high density polyethylene (HDPE), HDPE to polyvinyl chloride, vial to syringe) or composition (e.g.,

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