Broad Institute

OCTOBER 21, 2024

An innovative diagnostic approach developed by researchers at the Broad Institute of MIT and Harvard and at Massachusetts General Hospital could one day help patients get the most effective treatment faster, which could reduce the need for broad-spectrum antibacterials. Bartlett Fellowship of the Antibiotic Resistance Leadership Group.

RNA

SCIENMAG: Medicine & Health

JUNE 11, 2023

Abu Dhabi, UAE (June 12): A team of researchers at NYU Abu Dhabi, led by Associate Professor of Biology Youssef Idaghdour and working in collaboration with clinicians at several Abu Dhabi hospitals, investigated the association between microRNAs, a class of small RNA molecules that regulate genes, and COVID-19 severity among 259 unvaccinated COVID-19 (..)

Research

Broad Institute

OCTOBER 23, 2024

By Leah Eisenstadt, Broad Communications October 23, 2024 Credit: Courtesy of the Broadbent family Brian and Julia Broadbent are raising their daughters Claire, top left, and Emma, seated, who is the first person to be diagnosed with a rare genetic disorder caused by the long noncoding RNA CHASERR.

DNA

Broad Institute

JUNE 18, 2024

By Allessandra DiCorato June 18, 2024 Credit: Jon Arizti-Sanz SHINE, a rapid diagnostic test developed by Pardis Sabeti's lab in 2020, uses paper strips and CRISPR enzymes to identify specific sequences of viral RNA in samples. Then, in 2022, they began adapting the assay to detect other viruses they knew were always circulating: influenzas.

Virus

SCIENMAG: Medicine & Health

JULY 27, 2023

Philadelphia, July 28, 2023—In a step forward in the development of genetic medicines, researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased (..)

RNA

Broad Institute

AUGUST 19, 2024

Jude Children’s Research Hospital have discovered that oleic acid, one of the most abundant fatty acids in the body, restores a healthy balance of vaginal microbes in a laboratory model of BV. Using RNA sequencing and working with the Broad’s Metabolomics Platform and collaborators at St. Paper cited Zhu M et al.

Hospitals

Broad Institute

JULY 19, 2024

By Boston Children's Hospital July 19, 2024 Credit: Scott-Hewitt N, et al. These new findings — published in Cell by researchers at Boston Children's Hospital and the Broad Institute of MIT and Harvard — suggest C1q may be involved in age-related cognitive changes and neurodegenerative conditions. DOI: 10.1016/j.cell.2024.05.058.

Protein Production

Broad Institute

OCTOBER 17, 2024

An innovative diagnostic approach developed by researchers at the Broad Institute of MIT and Harvard and at Massachusetts General Hospital could one day help patients get the most effective treatment faster, which could reduce the need for broad-spectrum antibacterials. Bartlett Fellowship of the Antibiotic Resistance Leadership Group.

RNA

Broad Institute

NOVEMBER 7, 2023

To more precisely define cellular drivers of RA, an international research consortium co-led by researchers from the Broad Institute of MIT and Harvard and Brigham and Women’s Hospital analyzed tissues from RA donors at the single-cell level, integrating multiple forms of analysis to stratify RA by six subtypes of inflammation.

Treatment

Broad Institute

MARCH 6, 2024

Related news New project aims to map cellular variation in the healthy human brain Researchers from the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have uncovered a strikingly similar suite of changes in gene activity in brain tissue from people with schizophrenia and from older adults. They analyzed 1.2

Medical Schools

Broad Institute

OCTOBER 16, 2024

William Studier receives the 2024 Merkin Prize in ceremony at the Broad Institute for developing technology used to produce millions of doses of COVID-19 vaccines The groundbreaking, scalable technology is widely used in laboratories around the world today to efficiently produce large amounts of protein and RNA. Merkin (left) and F.

Vaccine

The Pharma Data

MARCH 8, 2021

Phase 2a study enrolled 202 non-hospitalized adults who had signs or symptoms of COVID-19 within 7 days and confirmed active SARS-CoV-2 infection. Findings from the primary efficacy and safety endpoints and additional secondary objectives will be presented at an upcoming medical meeting. This press release features multimedia.

Trials

The Pharma Data

NOVEMBER 30, 2020

from the New York City (NYC) Department of Health and Mental Hygiene (DOHMH), and colleagues used mandatory DOHMH reporting data to identify individuals younger than 21 years hospitalized in NYC (March 1 to June 30, 2020) with findings suggestive of MIS-C. percent of COVID-19 hospitalizations among younger patients, they accounted for 34.4

Hospitals

The Pharma Data

NOVEMBER 7, 2020

Now a study from investigators at Hospital for Special Surgery (HSS) and Brigham and Women’s Hospital in Boston has found that the synovial fluid and blood of people experiencing checkpoint inhibitor-induced arthritis is populated by a type of T cells rarely seen in people with other types of inflammatory arthritis. www.hss.edu.

Nurses

Broad Institute

JULY 11, 2024

Reporting in Science , researchers at Massachusetts General Hospital and the Broad Institute of MIT and Harvard have made a surprising discovery about these drugs. IDH1 normally facilitates the activity of enzymes called demethylases, which remove chemical flags called methylation marks from DNA, allowing genes to be transcribed into RNA.

Treatment

Broad Institute

MARCH 8, 2024

Senegal has a very strong clinical infrastructure, including a strong hospital network with incredible resources like West Africa’s Reference Center for Infectious Disease Diagnostics. Tags: Infectious Disease DNA sequencing RNA sequencing Nature Communications. Online January 25, 2024. DOI: 10.1038/s41467-024-44800-7.

Research

Broad Institute

DECEMBER 13, 2023

One study was led by senior authors Evan Macosko , an institute member at the Broad and associate professor and attending psychiatrist at Massachusetts General Hospital, and Fei Chen , a core institute member at the Broad and an assistant professor in the Department of Stem Cell and Regenerative Biology at Harvard University.

DNA

Broad Institute

JUNE 30, 2023

Related Articles Study finds how a genetic variant raises diabetes risk through an unexpected mechanism Related People Anne Carpenter Melina Claussnitzer Related programs Imaging Platform Metabolism Program Novo Nordisk Foundation Center for Genomic Mechanisms of Disease The field of microscopy has advanced immensely over the last fifty years in its (..)

Small Molecule

The Pharma Data

JULY 12, 2021

The Phase 3 portion of the global MOVe-OUT trial studying molnupiravir in non-hospitalized adult patients with laboratory-confirmed COVID-19 and at least one risk factor associated with poor disease outcomes is underway. About Molnupiravir.

Clinical Trials

The Pharma Data

OCTOBER 30, 2020

percent of viral RNA at day 11. The percentage of patients with a COVID-19-related hospitalization or emergency department visit was 1.6 The researchers found that the mean decrease from baseline in the log viral load for the entire population was ?3.81 at the time of the interim analysis, for elimination of more than 99.97 fold lower.

RNA

The Pharma Data

DECEMBER 21, 2020

Part 1 Trial Design Part 1 of the trial enrolled 24 hospitalized adults diagnosed with moderate to severe COVID-19 confirmed by PCR. Galidesivir treatment was associated with a more rapid decline in viral RNA levels in the respiratory tract in an apparent dose-dependent manner.

Clinical Trials

The Pharma Data

OCTOBER 19, 2020

” The Caris Precision Oncology Alliance comprises over 40 academic, hospital and community-based cancer institutions, including 17 NCI-designated Comprehensive Cancer Centers.

Clinical Trials

The Pharma Data

DECEMBER 13, 2020

Dr. Zhang completed his postdoctoral fellowship at Harvard Medical School/Boston Children’s Hospital. She started her career as a General Surgeon at Zhongshan Hospital of Chongqing. Prior to that, he held various oncology research and development positions at Merrimack Pharmaceuticals and Archemix. He received his B.S.

Medical Schools

The Pharma Data

MARCH 5, 2021

This will be adapted to the needs of messenger RNA vaccine production for CureVac’s CVnCoV, the manufacturing of which is highly complex. Production will take place in a new high-tech production facility that was already under construction at the Novartis Kundl, Austria site.

Vaccine

Codon

JUNE 11, 2024

Hospitals harness this speed to sequence and analyze tumor DNA within 6 hours , more than twice as fast as similar analyses performed using traditional next-generation sequencing , such as Illumina. Their solution was to fuse hairpins, little loops made from RNA or DNA, at various positions along the DNA strand that was being sequenced.

DNA

Drug Target Review

FEBRUARY 5, 2024

Scientists from Cincinnati Children’s Hospital and the University of Kentucky have investigated how spiny mice can regenerate lost tissue. They are using this new understanding to initiate regeneration in other types of mice, which could be translated into humans in the future.

Laboratories

The Pharma Data

APRIL 22, 2023

” Uncovering cancer immune system suppression: A three-part investigation As the basis of their investigation, the team profiled primary and metastatic lymph node tumours from 14 patients with head and neck squamous cell cancers, using single cell RNA sequencing. .”

Medical Schools

The Pharma Data

JUNE 26, 2021

Sanofi Pasteur, the vaccines global business unit of Sanofi and Translate Bio (NASDAQ: TBIO), a clinical-stage messenger RNA (mRNA) therapeutics company, have initiated a Phase 1 clinical trial evaluating an mRNA-based investigational vaccine against seasonal influenza. JUNE 22 , 2021.

Clinical Trials

Drug Target Review

AUGUST 16, 2024

I graduated with my BS in physiology and later attended the University of Michigan Medical School.

Medical Schools

Broad Institute

JUNE 21, 2023

Cell Painting uses six fluorescent dyes to image eight different components of a cell: the nucleus, nucleoli, mitochondria, endoplasmic reticulum (ER), golgi apparatus, cytoplasmic RNA, f-actin cytoskeleton, and plasma membrane.

Small Molecule

The Pharma Data

NOVEMBER 29, 2020

PH1 affects patients of all ages,” said Sally-Anne Hulton, consultant pediatric nephrologist, Birmingham Women’s and Children’s Hospital NHS Trust, UK. It is an RNA interference (RNAi) therapeutic. Typically, it is children who suffer from the disease. Oxlumo decreases oxalate production.

FDA

The Pharma Data

OCTOBER 28, 2021

Dr Laurence Slama, CARISEL investigator, l’Hôtel Dieu Hospital, Paris, said “ Despite some original enterprises around enforcing long- acting cabotegravir and rilpivirine, the CARISEL study interim findings showed that healthcare brigades and people living with HIV continued to feel positive about the authority as the study progressed.

Pharmaceutical Companies

LifeSciVC

JULY 1, 2024

The central dogma of molecular biology is that information generally (with few exceptions) flows from DNA to RNA to Protein. Here are the twelve pieces of advice for college and early career STEM folks, using scientific metaphors to frame some life lessons I’ve picked up along the way. Remember life’s Central Dogma.

Science

The Pharma Data

JANUARY 13, 2021

“It certainly would be very helpful, having one dose instead of two,” said Dr. Aaron Glatt, chair of the department of medicine and a hospital epidemiologist at Mount Sinai South Nassau Hospital in Oceanside, N.Y. If you only have to give one dose, that would be great.”

Vaccine

Drug Target Review

JUNE 11, 2024

My PhD work was focused on understanding how different helicases – small machines that unwind DNA and RNA – work and characterise them using biochemistry and biophysics tools. Thanks to our work, the device will be usable in community care and at home, making sure patients remain stable and outside hospitals.

Engineering

The Pharma Data

NOVEMBER 16, 2020

It combines Moderna’s mRNA (messenger RNA) delivery platform with the stabilized SARS-CoV-2 spike immunogen (S-2P) developed by NIAID scientists. principal investigator of the NIAID-funded Harvard HIV Vaccine Clinical Trials Unit at Brigham and Women’s Hospital in Boston; and Brandon Essink, M.D., El Sahly, M.D., Baden, M.D.,

Clinical Trials

Drug Target Review

JULY 1, 2024

Using the 10X Genomics Chromium platform, we conducted ribonucleic acid (RNA) sequencing on the midbrain’s PAG region in animals treated with SRP-001, ApAP and a vehicle control, focusing on gene expression changes related to pain processing. Sinai Hospital, New York, and a Vascular Surgery Fellowship from Yale University.

Treatment