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Designing antibodies to think before they bind

Drug Target Review

Engineering against resistance: the case of AP402 HER2-positive breast cancer already presents a therapeutic challenge, marked by aggressive tumour growth driven by overexpression of the HER2 receptor. The outcome is a bispecific designed to overcome resistance and activate the immune system precisely where it is needed.

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The Long Road to End Tuberculosis

Codon

During vaccination, the BCG strain normally primes immune cells to destroy infections, and owing to its similarity to M. tuberculosis , the same immune cells cross-react with the pathogen. It is responsible for over one million deaths per year (and is projected to rise ten times over by 2050). tuberculosis.

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Scientists discover network of cells and genes involved in Crohn’s disease complication

Broad Institute

Cell network In 2023, Xavier’s lab used single-cell RNA sequencing to create the largest known atlas of single cells from routine biopsies of Crohn’s patients. One group of cells, a subpopulation of fibroblasts deep in the intestine, expressed particularly high levels of collagen and were present in patients with strictures.

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Decoding stem cells for personalised regenerative medicine

Drug Target Review

In research published in Scientific Reports , 1 investigators focused on mesenchymal stem cells (MSCs), known for their potential in treating cell defects and regulating immune responses. In the lab, they labelled RNA molecules with fluorescent markers, enabling them to easily locate them within individual cells.

RNA
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Second-Generation mRNA COVID-19 Vaccine Candidate, CV2CoV, Demonstrates Improved Immune Response and Protection in Preclinical Study

The Pharma Data

Better activation of innate and adaptive immune responses was achieved with CV2CoV, resulting in faster response onset, higher titers of antibodies, and stronger memory B and T cell activation as compared to the first-generation candidate, CVnCoV. “In Induction of innate immunity was investigated via specific cytokine markers.

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mRNA Therapeutics: Revolutionizing Treatment Beyond Vaccines

DrugBank

Introduction Messenger RNA (mRNA) technology has emerged as one of the most significant medical breakthroughs. Once delivered into the body, the mRNA instructs cells to produce these antigens, which are then presented to the immune system. Another challenge is the potential for unintended immune responses.

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Targeting the immunotherapy potential of cytokines IL-12 and IL-18 with new advancements in protein engineering

Drug Target Review

Natural killer (NK) cells are another immune cell type that, as the name suggests, also have potent cell-killing activity, and have a well-known role in the anti-tumour immune response. In the context of a tumour microenvironment, Tregs are often present in high numbers, preventing an effective immune response to the tumour.