Drug Target Review

OCTOBER 30, 2024

8 With the widespread use of induced pluripotent stem cells (iPSCs), organoids can now be generated from the skin or blood cells of both healthy volunteers and disease patients, opening the door to studying various diseases and creating individually customised potential treatments. Organoids in cancer research. Nat Rev Cancer. Cell Stem Cell.

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The Pharma Data

JUNE 16, 2025

Importantly, ANDEMBRY is the only prophylactic treatment that offers convenient once-monthly subcutaneous administration with a citrate-free formulation — a feature designed to ease administration, improve tolerability, and enable greater independence for patients. when directly comparing ANDEMBRY to placebo.

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SCIENMAG: Medicine & Health

JUNE 15, 2023

A new therapy is on the horizon for patients with metastatic colorectal cancer who have run out of treatment options. Credit: Vanderbilt University Medical Center A new therapy is on the horizon for patients with metastatic colorectal cancer who have run out of treatment options.

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Drug Discovery Today

JANUARY 29, 2020

This new development from a collaborative team of international scientists shows promise for the treatment of herpes simplex (cold sore virus), respiratory syncytial virus, hepatitis C, HIV, and Zika virus to name a few.

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New Drug Approvals

APRIL 11, 2025

2] The label also has a warning about liver toxicity and the need to monitor liver blood tests at baseline and then monthly for at least six months after initiating treatment with fitusiran or after a dose increase of fitusiran. [2] 2] [3] Names Fitusiran is the international nonproprietary name. [4] Fitusiran 1711.0g/mol,

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Clinical Trials FDA FDA Approval Trials 107

Broad Institute

NOVEMBER 7, 2023

While RA therapies targeted to specific inflammatory pathways have emerged, only some patients’ symptoms improve with treatment, emphasizing the need for multiple treatment approaches tailored to different disease subtypes. They also found that patients’ CTAPs were dynamic and could change over time in response to treatment.

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SCIENMAG: Medicine & Health

MARCH 15, 2024

The liver is not only the largest internal organ but also vital for human life as a metabolic center. It also possesses remarkable self-healing powers: even when large portions are removed, such as during surgery, they quickly regenerate in healthy individuals.

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Drug Discovery Today

NOVEMBER 10, 2022

A team of surgeons and scientists from the UK, Sweden and Canada, funded by Rinri Therapeutics, has confirmed secure surgical access to the central core of the human cochlea The research, published in Scientific Reports, is critical to the first in-human trials of new cell, gene and drug therapies for the inner ear, and will assist with treatment for (..)

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ASPET

NOVEMBER 17, 2023

Benzodiazepine pharmacoresistance develops when treatment of status epilepticus (SE) is delayed. This response may result from gamma-aminobutyric acid A receptors (GABA A R) internalization that follows prolonged SE; this receptor trafficking results in fewer GABA A R in the synapse to restore inhibition.

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Drug Target Review

APRIL 7, 2025

Susceptibility or risk biomarkers can detect the likelihood of a patient developing a disease or medical condition, which is crucial for treatments that are most effective before the onset of symptoms. A biomarker is a measurable indicator of a biological process, disease state, or response to a treatment.

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SCIENMAG: Medicine & Health

SEPTEMBER 17, 2023

The early treatment of obesity in children is effective in both the short and long term, researchers from Karolinska Institutet report in a study published in The International Journal of Obesity.

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Treatment International Research 52

National Institute on Drug Abuse: Nora's Blog

MARCH 6, 2025

Advancing reduction of drug use as an endpoint in addiction treatment trials astewart Thu, 03/06/2025 - 09:59 Nora's Blog March 18, 2025 Image Getty Images/ SolStock This blog was also published in the American Society of Addiction Medicine (ASAM) Weekly on March 18, 2025.&

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The Pharma Data

JUNE 16, 2025

TEV-56278 is a first-in-class anti-PD1-IL2 ATTENUKINE therapy designed by Teva’s internal team of innovative scientists. This innovative approach stimulates and strengthens their activity against the tumor while reducing the collateral damage — the side effects typically related to IL-2 — frequently seen with less-targeted treatments.

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Drug Target Review

JUNE 11, 2025

Drug development faces significant challenges: long timelines, high costs , complex processes and low probabilities of success (PoS), exacerbated by the shift towards more complex molecules, biologics and cell and gene therapies, hindering patient access to vital treatments. flash (powering the free Google App tier) and Claude Sonnet 3.5.

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Drug Patent Watch

DECEMBER 9, 2024

Taxol: From Pacific Yew to Cancer Treatment Taxol (paclitaxel), a widely used cancer drug, was originally isolated from the bark of the Pacific yew tree. Artemisinin: Nobel Prize-Winning Malaria Treatment Artemisinin, derived from the sweet wormwood plant, has become a crucial treatment for malaria.

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Drugs Drug Development Pharmaceuticals Production 89

Common Sense for Drug Policy Blog

APRIL 21, 2024

Agonist Treatment for Cannabis Use Disorder "Cannabinoid agonist treatment is unlikely to be an approach relevant to all cannabis users seeking treatment, as evidenced by the large numbers of individuals who did not complete the study screening process, and the modest 12-week treatment retention rates. JAMA Intern Med.

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Conversations in Drug Development Trends

OCTOBER 29, 2024

In this way, regulators can evaluate proposed trial designs and therapies in terms of what value the trial will provide to participants and how well new treatments might serve the affected populations.

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Translation

JUNE 11, 2025

Current treatments offer limited efficacy and are often accompanied by severe side effects. NXI Therapeutics brings not only strong science, but a clear strategy for international growth. Their work on BET inhibitors addresses a long-standing challenge in immunology with real potential to change the standard of care.

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The Pharma Data

JUNE 6, 2025

Sanofi Highlights Robust Pipeline of Innovations in Rare Blood Disorders at ISTH 2025 Sanofi is poised to take center stage at the 33rd Congress of the International Society on Thrombosis and Haemostasis (ISTH), set to be held in Washington, D.C., from June 21 to 25, 2025. In the U.S.,

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Drug Discovery Today

MARCH 1, 2022

People suffering from COVID-19 could have several different SARS-CoV-2 variants hidden away from the immune system in different parts of the body, finds new research published in Nature Communications by an international research team.

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Drug Target Review

NOVEMBER 11, 2024

However, despite impressive advancements, many patients still do not respond to current immunotherapy treatments. Recently, mitazalimab, Alligator Bioscience’s stimulatory monospecific CD40 antibody, has demonstrated success as a potential first-line treatment for pancreatic cancer. References 1 Borbath I, Geboes P, Laethem J-L, et al.

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The Pharma Data

JUNE 13, 2025

Currently, treatment options for patients with relapsed or refractory disease remain limited, and prognosis is poor. Standard single-target CD19-directed CAR T-cell therapies typically enable long-term remissions in roughly 40% of patients, emphasizing a significant unmet need for new and more effective treatment strategies.

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Chemical Biology and Drug Design

JANUARY 15, 2024

Subsequently, the ultrasonic diagnostic apparatus was adopted to assess and compare the left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), left ventricular internal diameter at end diastole (LVIDd), and left ventricular internal diameter at end systole (LVIDs) in rats.

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The Premier Consulting Blog

JANUARY 14, 2025

The FDAs expedited programs are intended to facilitate and advance the development and review of new drugs and biologics to address unmet medical needs in the treatment of serious or life-threatening conditions, such as cancer. first or second line setting), considering clinical, scientific, regulatory, and operational factors.

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Drug Target Review

DECEMBER 11, 2024

By employing advanced analytical techniques like high-resolution mass spectrometry (HRMS) and carefully calibrating systems with optimal internal standards (IS), we effectively mitigate matrix effects and provide reliable preclinical toxicology data. These solutions must contain analytes and internal standards at known concentrations.

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The Pharma Data

NOVEMBER 25, 2021

The International Cancer Genome Consortium (ICGC) is further enabling cancer research worldwide by making a massive collection of cancer data available for analysis via Microsoft’s Azure cloud computing platform.

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International Research Government Treatment 52

The Pharma Data

JUNE 11, 2025

This decision represents a pivotal moment in the evolution of treatment convenience for patients with certain B-cell malignancies, while reinforcing BRUKINSA’s stronghold in the BTK inhibitor market. The agency has officially approved a new tablet formulation of BRUKINSA® (zanubrutinib) for all five of its previously approved indications.

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The Pharma Data

JUNE 15, 2025

According to the data, the combination demonstrated a high ORR and a strong depth of response in a patient population with limited treatment options and poor outcomes under standard care. were penta-drug refractory, having been exposed to additional lines of treatment. Among these: 84.4% had previously received a bispecific antibody.

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The Pharma Data

JUNE 6, 2025

Designed to serve a diverse international audience—including patients, healthcare providers, business partners, and investors—the site embodies the company’s twin commitments to scientific rigor and human empathy. In September, we celebrate the 50th anniversary of the company I founded in 1975.

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Pharmaceuticals Science Disease International 40

New Drug Approvals

JUNE 15, 2025

Its sodium salt is used for the treatment of generalised myasthenia gravis (a disease that leads to muscle weakness and tiredness) in adults whose immune system produces antibodies against acetylcholine receptors. . 6] [9] [10] It is a complement inhibitor that is injected subcutaneously (under the skin). [6] April 2018). 90 (15 Supplement).

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Drug Patent Watch

DECEMBER 18, 2024

Consider using a variety of claim types, including: Compound claims Method of treatment claims Formulation claims Dosage regimen claims Each type of claim offers different protections and can be valuable in different scenarios. Method claims related to diagnostic tests and personalized treatment regimens are becoming increasingly important.

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ASPET

SEPTEMBER 28, 2023

Status epilepticus (SE) is a life-threatening development of self-sustaining seizures that becomes resistant to benzodiazepines when treatment is delayed. Benzodiazepine pharmacoresistance is thought in part to result from internalization of synaptic GABA A receptors, which are the main target of the drug.

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Therapies Treatment International Drugs 100

Alta Sciences

SEPTEMBER 13, 2023

Four Pain Models Altasciences Uses to Assess Treatments During Clinical Trials pmjackson Wed, 09/13/2023 - 17:01 September is pain awareness month, and the importance of pain management and continued research into effective analgesics is integral to helping patients suffering from various pain conditions.

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Advarra

MARCH 6, 2025

For more than 35 years, Advarra has been committed to protecting the rights and welfare of clinical trial participants while helping to improve healthcare outcomes, advancing medical knowledge, and bringing innovative, life-extending treatments to market that benefit millions of patients worldwide.

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SCIENMAG: Medicine & Health

OCTOBER 20, 2023

Now an international team led by the Hudson Institute of Medical Research has found a way to determine which species are important and how they interact to create a healthy microbiome. The more diverse species in your gut, the better it is for your health. Credit: Hudson Institute of Medical Research The more diverse species […]

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Treatment Disease International Research 52

FDA Law Blog: Biosimilars

DECEMBER 4, 2023

A prescription not issued in the usual course of professional treatment or in legitimate, authorized research is not a prescription within the meaning of the CSA and the pharmacist knowingly filling it, along with the prescriber issuing it, is subject to penalties. 21 U.S.C. § 829; 21 C.F.R. Complaint ¶ 58. Complaint ¶ 59.

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The Pharma Data

JUNE 13, 2025

This opinion paves the way for the eventual authorization of Zenrelia for marketing across the European Union (EU) — a crucial step forward in delivering much-needed treatment options for dogs suffering from pruritic skin disorders.

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