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How AI and LLMs are transforming drug discovery: part 1

Drug Target Review

The opportunity lies in packaging AI into controlled environments where we understand inputs, possible outputs, and have monitoring systems. What makes this an exciting time is that laboratory automation technology has matured significantly in recent years. These two halves of the problem are coming together.

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Q&A: One scientist’s bold vision to make on-demand treatments routine for life-threatening rare genetic diseases

Broad Institute

Based on a technology developed by Broad Institute core member David Liu’s laboratory, the treatment is the first in a series of new medicines being tested to treat rare diseases by repairing patients’ particular genetic misspellings. The team that treated K.J. He needed a personalized, one-of-a-kind therapy.

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A Visual Guide to Gene Delivery

Codon

For the former, clinicians extract a patient’s cells, engineer them in a laboratory, and then infuse them back into the body. Some diseases are caused by mutations in large genes that exceed the packaging limits of existing vectors like adeno-associated virus (AAV).

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A Visual Guide to Genome Editors

Codon

pyogenes protein — whose compactness makes them far easier to package into viral vectors and deliver into the human body. This in vivo editing strategy also requires genome editors to be packaged so that they can be delivered to the correct cells in a desired tissue or organ.

DNA
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Best CDMO Practices for Startups: Navigating the Complex World of Contract Development and Manufacturing

Drug Patent Watch

Take the time to clearly define your technical needs, from drug substance manufacturing to packaging requirements. A CDMO should have a mature data integrity program in place, especially in the laboratory. Assessing Your Technical Needs Every drug is unique, and so are its manufacturing requirements.

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Edwin Cohn and the Harvard Blood Factory

Codon

This skillset, shared by Oncley and several others who later become key fixtures in Cohn’s laboratory, proved invaluable to wartime efforts when it became clear that many protein purification experiments would require extensive modification of instruments to work at scale. Curious researchers from external laboratories often attended.

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Levers for Biological Progress

Codon

” Nobody really knows without trying it out in the laboratory. For one, life itself grows and develops slowly, and the many steps required to “do” biological research in the laboratory are often tedious and manual. Even in vitro experiments — or those done in the laboratory — are relatively slow because E.

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